Nise is a heavenly warehouse. Nise - as a supplement to help you take the pills correctly

Nise (NISE, Nice, Nimesulid, Nimesil) - non-steroidal anti-combustion devices (refineries) of another generation of Ingibitors, which are used for the development of pain syndromes in the development of ethology.

Pharmacological diya Niza

The active component of Nise is a specific or highly selective isoform of the cyclooxygenase (COX) enzyme - COX-2, class bellows-aniliniv. Liky has an anti-fiery, anti-sickness and fever-lowering effect, with a new profile of gastrointestinal safety.

Nise according to the instructions you can zupinite drive (stream):

• Osvita prostaglandin E2 in the presence of inflammation and in the structures of the central and peripheral nervous systems - a decrease in the concentration of E2 attaches the activity of prostaglandin receptors to the EP-type, as well as an anti-firing and analgesic effect;
• Synthesis of endoperoxides and thromboxane A 2 - induction of thrombosis;
• Vivilennya gistaminu - lowering the steps of bronchial spasms;
• Synthesis of interleukin-6, urokinase, metalloproteases (collagenase, elastase) - pereshkozhaє ruinuvannyu proteoglikanіv і, as inheritance, ruining collagen cartilage tissue;
• The activity of myloperoxidase is a galmu affirming toxins in a drop of acidity, and an antioxidant effect.

Reducing the number of side effects allows a slight infusion of Nise on the natural setting of prostaglandin E2 with arachidonic acid. By means of phosphorylation Nise activates glucocorticoid receptors. Tsespriyє to make the antiapaline drug stronger.

Nise is seen as a high level of absorption, at the same time, it does not flow into the level of absorption, and it doesn’t fit into the level of absorption. The maximum concentration of the drug in the blood plasma is fixed in 1.5-2 years from the reception.

Form vipusku Nise

Bezsumnivna perevaga to the drug - form vipusku. Quite a wide range of specialties, such as storing the drug, and an increase in the list of ailments, with which Nise bring laxity.

Form vipusk:

• Nise tablets. Revenge 100 mg of nimesulide. Blister has 10 pieces;
• Disperse tablets Nise. Revenge 50 mg of nimesulide. Blister has 10 pieces;
• Suspension Nise is oral. Place 50 mg of nimesulide in 5 ml. Bottle 60 ml, special dozing cup;
• Gel Nise 1% Reveal 10 mg of nimesulide in 1 g. Tube 20 g і 50 g.

Nise tablets are recommended for use in growing up in cases of painful syndromes during a growing period. Suspension Nise is useful for children with pain. If you need an oil refinery for the most recent supply, the perfect vibe is Nise gel. Before the warehouse, the gel does not enter the deteriorating components, so it is recommended to vikoristovuvati for an hour to aggravate osteochondrosis, osteoarthritis, radiculitis. Behind the eyes, Nise gel is good to help you with inflammation of the ligaments and tendons, post-traumatic inflammation of soft tissues, bursitis and blows.

Shown to fuck Nise

Nise, for instructions, testimony prior to suction during treatment:

• Arthritis of the developmental etiology - rheumatoid, psoriasis and ankylosing spondyloarthritis, gout;
• arthralgia;
• Suglobovy syndrome with aggravated gout or rheumatism;
• Mіalgії of rheumatic and non-rheumatic walking;
• Bursitis, tendon inflammation and ulceration;
• Osteoarthritis, osteochondrosis, radiculopathy;
• Radikulita, lumbago, ishiasu;
• Post-traumatic impacts і firing of the support-arm apparatus і soft fabrics, razrivіv і stretching of the ligaments;
• Sick syndromes of a child's life - traumatic, pislyoperative, as well as headache and dentition, algodismenorrhea;
• feverish;
• Infectious and igniting illnesses.

Prototype

Prototypes are shown before the date of Nise, for instructions, є:

• Virazkov ailment of the shlunkovo-intestinal tract at phase zagostrennya;
• Pechinkova lack;
• Nirkova lack of;
• Aspirinova triada;
• Stagnant heart failure;
• Diabetes type 2;
• Sensitivity has been adjusted to the components of the character;
• Arterial hypertension;
• Vitality, lactation.

Children under 2 years of age are categorically opposed to using the drug in any kind of vigil. Children up to 12 years old do not take Nise in tablets, but only in a suspension.

Vikoristovuvati Nise gel is required only on small children with non-dermatological epidermis, without dermatoses and small infections in the area of ​​application.

How to save and add Nise

Regardlessly, see the development schemes of the Nise:

• Children older than 2 years - a suspension with a size of 3-5 mg per kg of weight 2-3 times per day, the triviality of reception is 5 days;
• Children older than 3 years - a suspension or dispersible tablets with a size of 3-5 mg per kg of weight 2-3 times per day;
• Children over 12 years old, or with a weight of 40 kg, the dosage has grown;
• Doroslі - Nise tablets or disperse tablets, 100 mg twice per dose, maximum (in times of severe pain) - no more than 400 mg per dose, triviality to take - 5-10 days.

Suspension and tablets Nise should be taken up to, if discomfort is felt in the area of ​​the slurry, it can be taken for the scheme of dispersed. Dispersible tablets - one tablet in a teaspoon (5 ml) of warm water, taken in the first place or immediately after.

The surface of the shkіri before the filling of the gel should be visibly and reliably hung. Apply the gel close to 3 cm on the area of ​​large incisions, evenly spreading over the surface, but not rubbing it. Vikoristovuvati 3-4 times for doba, the maximum dose is 5 mg per 1 kg of oil, the triviality of the intake is 10 days.

Pobichni di Niza

Nise, for help guides, you can find out about the damage:

• Herbal system - nudota, bloating, baking, diarrhea, virazkovo-erosive damage to the intestinal tract;
• The central nervous system - zamorochennya, headache;
• Hematopoietic system - thrombocytopenia, agranulocytosis, anemia;
• Allergic manifestations - bronchospasm, scintillation, anaphylactic shock.

In people, the gel is filled with a lot of muscle reactions (sprinkling, sverbіzh, pochervonіnnya). Vidmina drug is optional.

An overdose of Nise can lead to a deterioration in the function of nirok, a pechinka deficiency, an increase in the arterial grip, an impairment of dichotomy, sudomi.

If you are taking any of these drugs, you need to take a consultation with a doctor. The drug can increase the effectiveness of both drugs and toxicity. Vzaєmodin nimesulіd in organism with digoxin, phenytoin, antihypertensive agents, diuretics, anticoagulants, other non-steroidal anti-inflammatory drugs, lithium drugs, hypoglycemic agents.

For the Nise widgoks otrimav to reach a wider extension. It’s a good idea to get over the drug, because it’s because I know the pain and lower the temperature for a trival hour. With a non-trivial stagnation, it is practical not to appear.

Antiapalny analgesics are sometimes taken in trivial courses, so it’s easy to take care of the food yourself safely and effectively. Before a group of such drugs, enter Nise - for the sake of painful, rarely negative side effects. It is important to respectfully learn instructions before you go to work.

Nise - pill warehouse

An active ingredient of the described medication є nimesulid in a dose of 100 mg per skin rump. Tsya Rechovina is a non-steroidal chemical with a group of sulfonanilides. Vono brings fermentation of enzymes, which take part in the synthesis of mediators in pain, bulking and burning. Є і additional components, which can be added to the Nise - warehouse, including:

• calcium hydrogen phosphate;
• corn starch;
• microcrystalline cellulose type 114;
• sodium carboxymethylcrochmal;
• magnesium stearate;
• coloidal silicon dioxide;
• talcum powder cleansing.

Nise pills - what kind of supplementary help?

To look at the pharmacological status is indicated only for symptomatic therapy, for the cause of illness and its interruption, it is not infused. Nise pills - shown before consumption:

• tooth і head bіl;
• pain in the operative period;
• arthralgia;
• post-traumatic pain;
• firing soft tissues, tendons and bands;
• mіalgії of rheumatic and іnshіgo prokhodzhennya;
• hot syndrome;
• neuralgia.

Medical predictions showed that nimsulid was not only used for bile, that it was thickened and burned, but that it was too much of a cartilage tissue, that it was ruined for collagen. The managers of such a series are aware of a number of musculoskeletal pathologies, for which there is also an effective Nise, it is shown before the start of any attack:

• suglobovy syndrome p_d hour of gouty zagostren;
• rheumatoid and psoriatic arthritis;
• ankylosing spondylitis;
• korintsevy syndrome;
• osteoarthritis;
• tenovaginit;
• ridge pain on aphids and scoliosis;
• osteoarthritis;
• tendinitis;
• radiculitis;
• pain with osteoporosis.

Yak take Nise in pills?

The presentation of the drug is quick and effective, but it is more important to follow the recommendations of the school. Bazhano beforehand consults with a doctor in front of him, like Piti Nise - the reception of licks in the wrong dose can provoke the diagnosis of negative side effects. In addition, it is necessary to clarify the triviality of the therapeutic course.

The descriptions of the medication are recognized overwhelmingly for people. For children of 12 years with a weight of 40 kg, Nise tablets can be taken in a standard dose of 100 mg. If it is less, the amount of nimesulide is insured at 3-5 mg per 1 kg. Babies up to 3 years of age do not receive the drug. As soon as the child has reached the designated vik, it is allowed to set aside Dispersion Nise - tablets for children, who are located near the water. The stench is dispensed in a dose of 50 mg of active ingredient in the skin pigultsi.

Yak take Nise for a toothache?

Protysapalny is on the basis of nimsulida vicorisation to relieve discomfort in advance and during dental procedures. In the given situations, the classic scheme is called Nise - tablets for toothache are taken 2 times per add, 1 piece (100 mg). The maximum dobov dose is 200 mg. Fakhіvtsі to please drink pіgulki in front of іzheyu, even if there are any inappropriate findings in the area of ​​the slunker or intestines, it is more daunting to eat pills for food. The triviality of the course is rooted individually, but is not guilty of overhauling 15 days.

Yak accept Nise with osteochondrosis?

Bil at the back, ignition processes and filling can also be effectively absorbed by nimesulid. In case of recurrence of osteochondrosis, the standard method is indicated, yak take Nise - 100 mg 2 times per add. Similarly, the tablets are used for symptomatic therapy of other musculoskeletal pathologies with pain syndrome. The triviality of the turn of the day starts out as a result of the turn of the key signs, but it takes 7-12 days.

The pharmacological problem is presented for additional help from the outlined problem, but do not expect it. Nise pills are recommended only when attacking aphids:

• til temperature;
• ignition processes, for example, menіngіtu;
• springs;
• overwhelm;
• stress;
• nedosipannya;
• change of weather minds;
• toothache;
• blows and blows;
• surgical engagement;
• lykuvalny procedures;
• noise;
• stribk_v arterial vise;
• osteochondrosis;
• infringement of nerve roots and other factors.

Nise tablets are ineffective, as the cause of pain syndrome є. In this case, do not help any anti-inflammatory non-steroidal medications. As a result of migraine attacks, it is better to take leaks, as they create a direct line without a mediocre expansion of the blood vessels in the brain, and block the sensitivity of the receptors of the tripartite nerve. To such leaks, there are trips.

Skіlki dіє pill Nise?

The triviality of the sickly and anti-fiery effect is due to the nature of the uncommon perceptions, the intensity of the cause. Nise tablets 100 mg block discomfort with a stretch of 0.5 dobi. The stage of pain relief is gradually decreasing, so that it is necessary to begin to vivodit to the body in 2-5 years. The maximum analgesic effect is observed after 20-25 minutes after taking a pill.

How many times a day can you take a Nise?

It is recommended that the frequency of the vikoristannya of the opened medication be interleaved two times. In some rare situations, the drug can be allowed to often drink the Nise tablets - the anti-firing pills are allowed in the maximum additional dose of 400 mg. Vinyatkovy vipadki, if nimesulid are indicated 4 times a day, are organized in surgical practice. During the course of operations, the frequency of pain syndrome is intense, and the analgesic becomes stagnant in a higher dose.

Yak can you take Nise in tablets?

The triviality of symptomatic therapy is responsible for the specific situation. Only fakhіvets virіshu, but you can take nise for a few days. The maximum recommended triviality of the drug is 15 dB. Most often it is necessary to get caught up to an increase and a sign of heat - 7-10 days or less. In case of headaches, menstrual pains, toothaches, the medication is stagnant 2-3 dB or one-time.

Qi can you take Nise with alcohol?

Direct connections to the drive of one-hour victorian nimesulid and vzhivannya spirits of alcoholic beverages are not. Nise tablets help to relieve headache and fever on the other side of the hangover syndrome, quickly and effectively lagged. However, it is not recommended to use drug descriptions in parallel with alcohol and in the first place. Nise and alcohol are disgustingly crazy, for that, ethanol is old enough to be trimmed into the body of ridin. At the same time, in the same system, there will be accumulated nimesulid, which can provoke not unbeatable inheritances.

Nise tablets - pobichnі efekti

It is presented pharmacologic zіb seldom supervise with negative supportive appearances. Most of the tablets are well tolerated, less than 5% of patients can not take Nise - side effects include:

• zamorochennya;
• nervousness;
• seeing an unreasonable fear;
• no nightmares;
• drowsiness;
• swelling of denunciations;
• encephalopathy in the form of Reis syndrome;
• head b_l;
• Lyell's syndrome;
• reactions of immune hypersensitivity;
• shkirny visip (kropivyanka, eczema, dermatitis);
• anaphylactic shock;
• as much as possible;
• bagatoform erithema;
• angioedema;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis;
• dysuria;
• hyperkalієmiya;
• catching sight of the section;
• hematuria;
• nirkova lack of;
• interstitial nephritis;
• turns of embryos of colors;
• oliguria;
• nudota;
• constipation;
• gastritis;
• flatulence;
• diarrhea;
• blues;
• stomatitis;
• I have pain in epigastric disease;
• flush the soft style;
• zagostrennya virazkovoi ailments, perforation of the slunk or 12-paloi intestine;
• internal bleeding;
• hepatitis, including bliskavic form;
• cholestasis;
• medication zhovtyanitsya;
• adjustment of the indicator of transaminases;
• eosinophilia;
• anemia;
• pancytopenia;
• increased triviality bleeding;
• thrombocytopenia;
• purpura;
• aggravated attacks of bronchial asthma;
• zadishka;
• bronchospasm;
• arterial hypertension;
• melt;
• tachycardia;
• rozmitiy zir for the loss of yogh readings;
• hemorrhage;
• zagalnaya weakness, decrease in prasezdatnostі;
• low temperature drop.

People with singular illnesses suffer from the diagnosis of recurrent problems. In such situations, it is necessary to take special care of the vicoristovuvati Nise, side effects are often promoted with such pathologies:

• the destruction of the functions of nirok і slice mikhura;
• ailments of the eyes;
• arterial vice;
• heart-damned sickness;
• important liver damage.

Nimesulid to enter into chemical reactions with the other non-steroidal anti-fiery leaks, so overnight victorious Nise and similar analgesics can lead to the failure of odd side effects. It is not recommended to take the medication before the hour of planning the vagina. Established that the drug is negative for female fertility.

Nise tablets - contraindication

• recurrent polyosis of the nose, nasal sinuses or bronchial asthma and intolerance to acetylsalicylic acid and any other non-steroidal antiphlogistic lesions;
• hypersensitivity to medication;
• cerebrovascular, active shlunkov, intestinal or bleeding;
• Crohn's ailment in relapse stage;
• nonspecific vyrazkovy kolit pid hour sharpening;
• decompensated heart failure;
• erozіynі abo virazkovі urazhennya mucous membrane of the 12-palate intestine, shlunk;
• hemophilia and іnshі pathology, as well as sore throat;
• be active, if you are more active, including the lack of it;
• alcoholism;
• hyperkalієmiya;
• nirkova lack of creatine less than 30 ml / min.
• period of coronary artery bypass surgery;
• hepatotoxic reactions in the case of prescribed drugs with nimesulide in the warehouse;
• parallel to the stasis of potential hepatotoxic chemical speech.

Nyz in viglyadі gel vikoristovuyu with degenerative and inflammation of the musculoskeletal system, such as rheumatoid and psoriatic arthritis, lumpy syndrome with acute gout and rheumatism, radiculitis, osteochondrosis syndrome, corrosive arthritis, 'language.

Pharmacological diya:
The drug has anti-inflammatory, anti-inflammatory, anti-inflammatory and antiplatelet effects. Applying a prostaglandin to a prostaglandin, selectively ingibu COG2. Ridko can cause side effects in connection with the synthesis of prostaglandin in healthy tissues. Peroxidation of lipid peroxidation, does not allow for phagocytosis and hemostasis. When you take it all the way through the middle to do the good get wet from the shlunkovo-intestinal tract. The maximum concentration of the drug is reached in 1.5-2.5 years after receiving. The period of the last date is 3 years. The main metabolite in the warehouse is active hydroxynmesulide. Likarskiy zasіb biotransformat in the ovens. Visnovok zdіysnyuєtsya rely on nirkami. Chi is not cumulative with trivial stasis.

The drug in viglyadi gel is maє mistsevu anti-fiery sunburning dyu. With the help of my help, I can relax or know more in the slopes with Russia and calmness. Neutralize swelling and rancidity of slopes.

Nise way of sucking and dosing:
The drug is taken in the middle. For older adults, take two doses of 100 mg per day. When consumed, the dose may be increased to a maximum of 400 mg.
Fakhivtsi recommend that you take the suspension or the tablets until the end of the day, or if there is any discomfort, you can take the product into the slurry.

Nise, representations in viglyadі dispersing tablets, later in water (one tablet per teaspoon) and take nadalі іzhі.
Children older than two years old should drink in suspensions, children older than three years - in suspensions or dispersing tablets. More older children (from 12 years) can take pills. The optimal dose for them should be rozrahovuvati, spiraling on the mass: 3-5 mg per kg. Children who have reached a weight of 40 kg can take liquors at an older dose - two times a day, 100 mg each.

Nise at the viglyadi apply the gel to the shkіra. Before the cym, I will need an area of ​​shkіri slіd relylno vimiti і visushiti. Stovpchik to the gel, make it 3 cm long, apply on the most sickly dish and rub it to a thin equal ball. Qiu procedure must be carried out 3-4 times a day.

Vikoristovuvati the product can last 10 days.

Nise's counter-indications:
The drug has contraindications for acute ailments of the slunk-intestinal tract in the stage of aggravation, increased sensitivity to components of the vein, liver deficiency, "aspirin" asthma, normal deficiency. It is also not a product of congestive heart failure, another type of diabetes, arterial hypertension, vaginosis, lactation. For children up to 12 years of contraindications, the product is in the form of tablets;

For vikoristannya Niz gel є additional indications: treatment of epidermis, dermatosis and development of infections in the area of ​​application.

Nyse byproducts:
In case of any given symptoms, such side effects are: headache, drowsiness, foulness, nausea, diarrhea, bloating, stove, more in the shlunk, pain in the shlunk, small intestinal hepatitis, toxins purpura, oliguria, ridinis, anemia, leukopenia, thrombocytopenia, agranulocytosis, hematuria, temporal activity of "pecinous" transaminases. There may also be some developmental allergic reactions, such as anaphylactic shock or shkirny visip.

With vicious gel, there may be vicious miscellaneous reactions: sprinkling, sverbіzh, peeling shkіri. As long as there is no transitory change to the color of the shkiri, then it is not necessary to skip the liquor. When the gel is applied to the large children of the child, it is not possible to have systemic side effects, such as the power when taking the tablets and the food.

In that case, as well as be-a-kind of side-effects, then pinch it at first and turn to the doctor for a consultation.

availability:
In case of vaginosti and lactation, the consumption of the given product is hardened. If there is a need for the implantation of Nise, then you should pinch the breast.

Overdose:
Symptoms of overdose are the result of the improvement of the turn of side reactions. As a rule, the price of the deterioration of the function of nirok, the lack of pechink, the development of the shlunkovo-intestinal tract, sudomi, the reduction of dichanenia, the development of the arterial vise.

If any of the symptoms appear, then it is inaccurate to take the drug and prevent the treatment: in the first place, there will be no needles, to take away the actives, and to carry out symptomatic therapy. Obviously, the antidote is not іsnu. Hemodialis and forcing duresis do not bring necessary results.

Vikoristannya with іnshim drugs:
The drug can increase the efficiency and toxicity of certain drugs as a result of competing products for contact with plasma proteins. Nise vzaєmodin with phenytoin, digoxin, antihypertensive products, lithium products, diuretics, oil refineries, cyclosporine, methotrexate, anticoagulants, oral hypoglycemic drugs.

Vipusk form:
The drug is expanded in viglyadi tablets 100mg, dispersible tablets 50mg, suspension 50mg / 5ml for receiving vseredin, also in viglyadi gel 1%.

Umovi zberigannya:
Nise, representations in the form of ultra-fine and dispersing tablets, must be taken in the stolen form of light, dry mixture. The temperature of the goiter is not crop'yazana perevischuvati 25 ° C. The maximum period of the goiter becomes 3 rocks.

Nise gel is stored at temperatures up to 25 ° C, freezing is hardened. The period of adherence to the product of the warehouse is 2 years.

Nise at a viglyadi suspension or tablets of an extraordinary and dispersed type are admitted from pharmacies for a prescription of a drug. Nise gel is used until over-the-counter products.

Sinonymi:
Nimesulide, apon, Aktasulid, MESULID, Coxtral, Nimegesik, Nimika, Nimesil, NIMULIDU, Prolid, flolid.

Nise warehouse:
Chemistry warehouse of Nise in tablets and dispersible tablets is ready for use.
The main active speech is є nimesulid. Additional elements: calcium phosphate, microcrystalline cellulose, corn starch, magnesium stearate, croscarmellose sodium, coloidal silicon dioxide, talc, aspartame, flavoring.

Niz's chemistry warehouse near the suspension for receiving all the way to the product in the form of tablets. Nimesulid - the main active speech. Additional words: sorbitol, sucrose, propylparaben, methylparaben, citric acid and monohydrate, xanthan gum, polysorbate 80, cholinergic gum WS, pineapple flavoring No. 1 and purified water.

Chemist warehouse gel offensive. Nimesulid is the main element of the game. Additional words: propylene glycol, N-methyl-2-pyrolidone, PEG-400, isopropanol, hydroxyanisole butylation, carbomer-940, thymserosal, potassium phosphate, flavor, water.

dodatkovo:
With a trivial zasosuvannі given lіkarskogo zasobu requires continuous control over the robot nirok. Individuals of the kidnapped person with heart-shaped and sickly and іnshiye ill-fated children will be welcomed with protection.

Slid uniquely consumed the gel for the preparation of the skin, in the wounds, in the eyes and in the skin of the body. Pislya vikoristannya gel hands slid retally vimiti.

Oscillations of the product can be caused by drowsiness and tampering, it is necessary for the protection of the patients, the activity of which is due to the quick reaction and due respect, for example to the waters.

Uwaga!
Before taking a medication "Nise" it is necessary to consult a doctor.
The instructions are given on a weekly basis for learning about Nise».

Nise is a highly effective drug for any kind of pain. Yogo is grasped by hand, and the process is developed to finish quickly.

Nise - description and diyu

Nise is applied to non-steroidal anti-flue gasoline (NPZZ), carried out in the form of tablets. The drug is released by the company "Dr. Reddys Laboratories" (India). Part of 20 tablets - 240 rubles. Інші form vipusku - a gel for the latest vicoristannya, granules for powder for preparing a suspension.

Diyucha Niz tablets - nimesulid 100 mg.

On a viglyad tablet bili, trocha zhovtuvati, smooth, double-convex. Likas also include a number of supplementary words - calcium hydrophosphate, cellulose, starch, magnesium stearate, talc. Yak din Nise? Price - zestless pills, active speech, which is carried to the class of sulfonanilids. attributed to the vision of cyclooxygenase, yak є in front of mediators zapalennya (prostaglandin).

The drug also gives fever-lowering effects. Win usuv show pain and fiery etiology. Likki shvidko get wet all the way, with a whole lot of diminishing moisture. Nimesulid seemingly penetrates into the synovial place, which is widely stagnated in the history of rheumatological ailments.

Shown up to sucking

Nayposhirenіshim shown before taking pills є angular syndrome. The drug can be taken as an arthralgia of a growing nature - until it is used for such ailments:

Likewise, the middle of the indication before the intake of Nise tablets is rheumatoid arthritis, which, with acute symptoms of severe pain, is severe. Leaks can be taken with a headache. The tablets will help, if there are inappropriate symptoms of viklikana with convulsive spasm, mіgrennyu. In dentistry, Nise is often recognized in case of toothache - the effect will be rotated with a visible tooth, carried out by dental operations. Yak timchasoviy zakid tablets serve for carozy pain in the teeth.

Petey Nise is recommended as an emergency for post-traumatic conditions - breaking the joints, fracture.

Doroslim can help with osteochondrosis and associated inflammation, such as cortical syndrome, ischiasis, lumbodynia. Pain in meat can also serve as an indication before taking Nise tablets.

Prototype of tablets

Likas are allowed for children from 12 years. Until the end of the day, the decision must be made until a counter-indication. Also, in the abstract, the following is indicated for the fence on the basis of the refinery's data:

Drug addiction and alcoholism can also serve as contraindications prior to therapy. Niz is a nasty mess with alcohol, alcohol can be used to provoke bleeding from the organs of poisoning. With vaginosti, lactation, Nise does not accept, it is necessary to know the permissions of the deputy. I will protect with a short course of p'yut pills for ischemia of the heart, diabetes, increased cholesterol, palini. Preservation of the need to take out and during the therapy with antiplatelet agents, to build up the shelter, in the summer.

Pobichna diya

Some projects in Denmark are being developed earlier, but not on the other drugs of the refinery group. Protest, the list of їх is approximately the same as before and after the hour of dealing with them. Allergy can appear as shkіrnyh forms, as well as asthma, impaired dikhannya, nabryak Kvinke, anaphylaxis.

Mossy development of dermatitis, itching of shkіri і eritemi, toxic epidermal necrolysis.

The nervous system is built up at the reception of Nyz, because of confusion and nervousness, fear, but such phenomena are infrequent. In some cases, encephalopathy - Reye's syndrome - was indicated. The visual system reacts with the following signs:

Often there are reactions from the intestinal tract - nudity, furnaces, abdominal pain, epigastria. You can mother a little bit of a belly, carry it, and grow up to develop constipation. In important cases, the intestines, empty mouth, intestinal bleeding and perforation of the slunk are inflamed. In the midst of secondary events, there is also a change in liver symptoms, zhovtyanytsya, hepatitis. Є Risik development of healthy pooshennya, p_vischennya vise, weakness, flushing.

Instructions for storing

How much do you take in tablets? Dozuvannya guilty is taken by the doctor, especially, if you plan to use the course. The dose is guilty but minimal (if possible), the course - the shortest, most effective. The order of therapy will come:

Tolerance of an overdose of the refinery is not without reason. Tse can wicklikati the importance of a fall from blues, tediousness, apathy or drowsiness. High risk of bleeding from the intestinal tract, perforation of the shlunk. The grip may move rapidly. In the most serious problems, a nirk deficiency develops, and the dichotomy breaks down. Therapy is symptomatic, in case of early occurrence (4 years old) followed by vomiting and taking sorbents and carrying.

Analogs of Nise tablets

Among analogs є the cheapest preparations from a group of refineries, Hocha Nise is not an expensive preparation, with a whole lot of yakisny.

It is not possible to immediately accept the cost, as I reduce the blood loss, and the Nise. Tse seriozno pіdvischuє nebezpeku bleeding. With the development of any damage, the term should be applied to the therapy, there may be traces for the stenosis, the disk of the healthy nerve.

Likki zdatnі zatrimuvaty rіdinu in fabrics, that with problems with nirkami and heart, take care of your need for protection. We are averse to chronic pathologies of the intestinal tract, we must simultaneously feed the other preparations of this group, so that we can reduce the risk of aggravation of the ignition process.

warehouse

diyucha speech: nimesulide;

1 tablet to take revenge on nimesulida 100 mg

additional speeches: Calcium hydrogen phosphate, microcrystalline cellulose, corn starch, sodium starch (type A), coloidal silicon dioxide, talc, magnesium stearate.

Lykarska form

Pills.

Basic physical and chemical authorities: round, smooth, two-shaped tablets from white to soft color.

pharmacological group

Non-steroidal antiapalny drugs.

ATC code M01A X17.

Pharmacological authorities

Pharmacological.

Nimesulid is an oil refinery of a group of methanesulfonanilids, which is anti-fiery, anti-inflammatory and anti-inflammatory. Likuvalnaya action nimesulidu was amazed by the fact that it is in conjunction with the cascade of arachidonic acid. Nimesulid selectively ingibu COX II (cyclooxygenase II) and induces the synthesis of prostaglandins in the ignition.

Nemesulid induces the enzyme myloperoxidase, as well as induces the decay of wild radicals into acidity, does not infuse into the processes of phagocytosis and chemotaxis, induces the decimation of the necrosis factor of powdered medicaments.

Pharmacokinetics.

Pislya received internally nimesulid quickly get wet from the shlunkovo-intestinal tract. The maximum concentration in blood plasma is reached in 2-3 years. Up to 97.5% of the mesulence is linked to blood plasma cells.

The drug is actively metabolized in the liver for the participation of CYP2C9, the cytochrome P450 enzyme. The main metabolic product, hydroxynmesulide, is pharmacologically active. The period of the day is from 3.2 to 6:00. Nemesulid to vivoditsya s organism s sowing - close to 50% of the dose taken. Closely 29% of the taken dose is excreted in the feces in the metabolized viglyad. Only 1-3% is vivodit s organism in an uninterrupted viglyad. The pharmacokinetic profile of a patient with a kidney disease does not change.

showing

Lіkuvannya ghostly pain. Lіkuvannya priminnoї dysmenorrhea.

Nimesulid slid zastosovuvati only as a preparation of another line.

Decision about the recognition of a number of steps to be taken on the basis of an assessment of all risks for a particular patient.

Prototype

Sensitivity is adjusted to nimesulid or to any component of the drug. Hyperergic reactions, such as malaria in the last (bronchospasm, rhinitis, kropivyanka), due to the intake of acetylsalicylic acid and any other non-steroidal anti-inflammatory drugs.

Hepatotoxic reactions to nimesulide, such as mali in the past.

Immediately zasosuvannya іnshih speeches with potential hepatotoxicity.

Alcoholism and drug addiction.

Dose for GOSTR surgical pathology.

Shlunkovo-intestinal bleeding or perforation in the anamnesis, tied in advance of the history of non-steroidal anti-festering diseases.

Vyrazka of the slunk or twelve-fingered intestine in the phase of zagostrenny, a history of virazka, perforation or bleeding in the herbal tract.

Evidence of cerebrovascular bleeding in the anamnesis or other hemorrhages, as well as illness, which is superficially bleeding.

Important damage to the throat of blood.

An important lack of heart.

Severe damage to the function of nirok.

Damage to the function of the stove.

Ailments with increased temperature and / or flu-like symptoms.

Children are up to 12 years old.

III trimester of vagina and breastfeeding year.

Vzaєmodіya with інshі lіkarskiye zasob and іnshі vidi vzaєmodіy

Pharmacodynamic interactions.

corticosteroids: rizik viniknennya is moving around the herbal tract or bleeding. Antiplatelet antiplatelet and selective antiplatelet serotonin uptake (SSSRIs): There is a risk of bleeding in the herb tract.

anticoagulant Oil refineries can use anticoagulants, such as warfarin or acetylsalicylic acid, through such a combination of anticoagulants, we have important problems with coagulation. However, such a combined therapy cannot be unique, it is necessary to conduct a retinal control of indicators of blood loss.

Diuretics, angiotensin-converting enzyme (ACE) and antagonizing angiotensin II: NPZP can lax diuretics and other antihypertensive drugs. In deyakih ailments of torn down funktsії nirok (napriklad have ailments of znevodnennyam abo patsієntіv lіtnogo vіku) odnochasne zastosuvannya іngіbіtorіv ACE antagonіstіv angіotenzinu II abo rechovin scho prignіchuyut cyclooxygenase system Mauger viklikati away pogіrshennya funktsії nirok i viniknennya gostroї nirkovoї nedostatnostі, yak, yak usually buvaє reverse. Tsі vzaєmodії slіd vrakhovuvati todі, if ailments stasoє nіmesulіd spіlno with angiotensives ACE or antagonists angiotensin II. Slide will be more protective, stuck to such a combination, especially with the children of the kidnapped vik. We’re sick to the extent of getting enough money, and the function of nirok is to control the ear for such a combination. Nimesulid will let go of furosemide from the vivenna of sodium and the lesser world - vivedennya kaliyu, as well as change the diuretic effect. Spilnya zasosuvannya furosemida and nimesulida we are ill because of the destructions of the nirk and heart function of the need for care.

In healthy individuals, I have a high degree of reduction in the effect of furosemide, straightening for the loss of sodium and the lesser world for the release of calories, and also for the reduction of the effect of furosemide. Immediately, the consumption of furosemide and furosemide should be reduced to a decrease (by approximately 20%) in the area under the curve "concentration-hour (AUC)" and the decrease in the cumulative ekskretsyi furosemide without changes in the level of furosemide.

Pharmacokinetic interactions with іnshih lykarskiye zasob.

Bully about those that the oil refineries change the level of health, how to produce the lithium in the blood plasma and the toxicity of the lithium to the increase. In case of recognized nimesulida we are ill, as we accept therapy with drugs lithium, then often control the level of lithium in the blood plasma.

Є clinically significant interactions with glibenclamide, theophilin, warfarin, digoxin, cimetidine and antacids (a combination of aluminum and magnesium hydroxide). Nemesulide adjusts the activity of the 2C9 enzyme. With a one-hour consumption with nimesulide of liquids, such as substrates for the enzyme, the concentration in blood plasma can move.

It is necessary to protect the patient if it is necessary to take less than 24 years or less in 24 years before taking methotrexate;

Through the infusion on nirkovi prostaglandins, ingibitori synthetases, before any nimesulids are introduced, it is possible to increase the nephrotoxicity of cyclosporine.

Effective drugs for nimesulide.

Tolbutamide, salicylic acid, valproic acid are vitamins and minerals. However, it is not affectionate for a drug in the blood plasma that can be infused with energy, and the process does not become clinically significant.

specialties

Nimesulid slid zastosovuvati only as a preparation of another line. The decision about the recognition of the name must be taken on the basis of the assessment of all risks for the patient.

To reduce the risk of development of side effects, it is necessary to take the least effective dose at the lowest trivial rate of treatment. At the time of day-to-day efficiency of treatment (reduction of symptoms of illness), therapy should be improved.

Bully is caused by the occurrence of important reactions from the side of the liver, including with a lethal result in case of stagnation of nimesulida. In case of growth of liver enzymes, there is a sign of liver failure (for example, anorexia, nausea, bloating, abdominal pain, in the presence of increased stomach lumen, severing a dark color) and in laboratory Repeated recognition of such ailments to such ailments is contraindicated.

It is recommended to use a single one-hour intake of hepatotoxic drugs, analgesics, and other non-steroidal anti-pyretic drugs, including selective antioxidants in cyclooxygenase-2, and so on.

In the sick of the sick, the frequency of unwanted reactions at the refinery has been increased, especially the rate of bleeding and perforation in the herbal tract, which can be fatally insecure. Virazka, bleeding or perforation of the CT can clog the life of a sick person, especially in the anamnesis є data about those who have been diagnosed with similar diseases in case of stagnation of some old non-steroidal antiapalny thermals. Rizik of similar manifestations grow at once from an increase in the dosage of the refinery in ailments, which may have a history of vigor in the herbal tract, especially slowed down bleeding or perforation, and also in ailments of the latter. So we are ailing to fix the best possible effective dose. For cichons, as well as for quiet, low doses of acetylsalicylic acid and other drugs that are used to reduce the risk of rapid growth from the side of the grass

We are averse to toxic lesions of the herbal tract, especially in individuals who have been abducted, when there are any symptoms that occur in the area of ​​the herbal tract, especially about bleeding. The price is especially important at the cob stages of treatment. Khvorov, SSMSC priymayut suputnі preparations SSMSC mozhut pіdvischiti rizik viniknennya virazki abo krovotechі, yak takі kortikosteroїdi, anticoagulants, selektivnі іngіbіtori zvorotnogo zahoplennya serotonіnu, antitrombotsitarnі zasobi (atsetilsalіtsilova acid) neobhіdno proіnformuvati about neobhіdnіst dotrimuvatisya oberezhnostі at zastosuvannі nіmesulіdu.

In case of a diagnosis of an ailing person, who will reject nimesulid, bleeding, or the path of the herbal tract, it should be pinched.

Oil refinery plant with protection next to recognize the ailment with Crohn's ailment or nonspecific swelling colitis in anamnesis, oskilki nimesulid can be triggered before they become acute.

Suddenly, you can get rid of the disease with other drugs, such as oral contraceptives, anticoagulants, antiaggregants, you can get sick of Crohn's ailments and other diseases of the herbal tract.

Ailments due to arterial hypertension and / or heart deficiency in anamnesis, as well as ailments due to a history in the body and bulging due to the stagnation of the refinery and

Clinical prescriptions and epidemiological data allow the growth of antibiotics against those, especially in high doses and with trivial stagnation, can lead to insignificant risk of arterial thrombosis. For viklyuchennya risiku, the diagnosis of such manifestations in case of stagnation of nimesulidu is not enough. We are sick with uncontrolled arterial hypertension, grievous heart deficiency, established by ischemic ailment of the heart, with peripheral arteries and / or cerebrovascular retardation, but not with the started Likewise, it was followed by a retrospective assessment of the ailments due to the factors of risk of development of heart-bladder ailments, for example, in case of arterial hypertension, hyperlipidemia, hyperaemia, in case of chicken, before the prescribed drug.

We are sick because of nirkovyu or heart deficiency, the drug should be used to protect the function of nirok. At the time of failure, I will turn into a little pinch. It is necessary for the persons of the kidnapped person to carry out a retinal clinical control for the potential development of bleeding and perforation of the herbal tract, the deterioration of the function of nirok, liver and heart. Oskіlki nіmesulіd can be infused into the function of thrombocytes; However, nimesulid does not replace acetylsalicylic acid in the prevention of heart disease.

The stagnation of non-steroidal anti-fiery ones can mask the temperature increase, which is associated with the background bacterial infection. If there is an increase in temperature, or if there are flu-like symptoms in patients who are taking nimesulide, taking the drug should be seen.

Bully about the occurrence of severe mental reactions in case of stagnant refineries, which can cause fatal problems, for example, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis. The sick winners have a very high risk of such reactions, even with the previously assigned course of reaction, the development of reactions in a large number of reactions was diagnosed with a stretch of the first month of reaction. Nemesulid is necessary to be aware of the first signs of shkirny visipu, reduction of mucous membranes and other allergic manifestations.

Prolonged pregnancy may cause fertility problems and should not be recommended for women who are planning to become pregnant. Women who are smart enough to get in touch because they smell like being on the drive without any reason are not recommended to sign nimesulid.

Stagnation in the period of vaginosti or a year of breastfeeding.

The suppression of the synthesis of prostaglandins can be unpleasantly inserted into the vagina and / or the development of the fetus. Dani, rejected in case of epidemiological preliminaries, allow the growth of cerebrospinal fluid against those in the early terms of vaginosity of the intake of drugs, so as to reduce the synthesis of prostaglandin, it is possible to reduce the risk of gastric syndrome The absolute risk of the development of anomalies of the heart-vascular system and an increase in less than 1% is approximately 1.5%. Vvazhaєte, how risik to grow from the increase of dosage and triviality of consumption.

Do not take nimesulid in the I and II trimester of vaginosity without extreme need. If there is a need for a drug to be consumed, as it starts to get sick, or in the first and second trimester of vagineness, the least possible dose and the least possible amount of drug use.

In the third trimester of vaginosis, all of the synthesis of prostaglandins can lead to development in the fetus:

• pneumocardial toxic lesion (with the anterior closure of the arterial duct and hypertension in the system of the leg artery)
• dysfunction nirok, as it can progress to nirkova deficiency with the development of lack of water;

In mother and fetus in the end of vaginosity it is possible:

• an increase in the hour of bleeding, an antiaggregation effect, which can be inflicted upon the intake of even low doses of the drug
• the adjustment of the speedy sensation of the uterus, which can lead to a closure or an increase in the period of the canopy.

There are no contraindications to this in the III trimester of vaginosity.

Stagnation of nimesulida can diminish fertile function in women, which is not recommended for women who become overwhelmed. For women who find it difficult to stay with the driver, or go through the drive without any problems, then pinch it to me. If the visit was established when a message was lost, then the car was guilty but it was informed about it.

Yak oil refinery, which drives the synthesis of prostaglandin, nimesulid may occur before the closure of the Batalov duct, hypertension, oliguria, lack of water. Rizik development of bleeding, weakness of flatness and peripheral embryo. Be aware of the lack of nirkov in newborns, mothers who have lost some of the problems of vaginosity. Prior to the test, they showed an atypical reproductive toxicity to the drug, but they were not reliable.

Oskilki are unavoidable, because they penetrate nimesulid in breast milk, their intake is shown in the period of the breastfeeding year.

The state of affairs is injected into the speed of reaction in case of keruvannas by motor transport or other mechanisms. Pouring into the building of a keruvati by car and viconuvati robots, so they demand an additional respect without getting used to it. However, for the children, when they get stuck in the mess, they see it getting stuck or sleepy, then they go out of the carriage by motor transport or robots with mechanisms.

How to store that dosi

In order to reduce non-fatal secondary effects, you need to consume the least effective dose for a short hour.

The maximum triviality to the course is 15 dB.

Doroslі. 1 tablet (100 mg) 2 times for dobu - vrance and in the evening.

Individuals of the kidnapped vik. Correction of the dose is not required.

Children from 12 years of age. Correction of the dose is not required.

Patients with damaged functions of nirok. For patients with a slight or less degree of impairment of the function of nirok (clearance of creatinine 30-80 ml / day), a correction of the dose is not required, at that time, as the function of nirok is severely impaired (clearance of creatine<30 мл / ч) является противопоказанием к применению.

The drug is consumed internally by drinking, drinking a sufficient amount of ridini.

Some effects can be minimized by a short term of treatment, as it is necessary for the control of symptoms.

Children. The drug is contraindicated for children up to 12 years.

Overdose

Symptoms of a severe overdose of non-steroidal anti-fiery arthritis (refineries) are prone to be surrounded by such manifestations: apathy, drowsiness, nudity, blues, bile in epigastric delays. Tsi symptoms, as a rule, werewolves with supplementary therapy. You can diagnose slunk-intestinal bleeding, arterial hypertension, hostile deficiency, impairment, coma, protects of such manifestations are very rare. Bully about the anaphylactic reactions in case of intake of therapeutic doses of the refinery and in case of overdose. There is no specific antidote. Likuvannya overdose - symptomatic and susceptible. Danikh about taking a nimesulid for additional hemodialysis is not a good idea, but if you take a high step to the point of noticing blood plasmas (up to 97.5%), then it is not very effective, it will be effective. If symptoms of an overdose are evident, or if a large dose of the drug is consumed for 4:00 a.m., then the received patients can be identified: Forcing duresis, increasing sloughing, hemodialis and hemoperfusion can be ineffective in the case of a high level of hypersensitivity to blood plasma bleeding. Slid control of the function of the heart and the stove.

side reactions

On the side of the blood: anemia, eosinophilia, thrombocytopenia, pancytopenia, purpura.

On the side of the immune system: reactions of susceptibility to sensitivity, anaphylaxis.

Metabolic damage: hyperkalієmіya.

On the side of the psyche: feeling anxiety, nervousness, no nightmares.

On the side of the nervous system: zamorochennya, headache, drowsiness, encephalopathy (Reye's syndrome).

On the side of the organ zoru: unclear zoru, spread zoru.

On the side of the hearing organs and vestibular apparatus: vertigo (zamorochennya).

On the side of the heart-vascular system: tachycardia, hemorrhage, lability of the arterial vise, flushing, arterial hypertension.

On the side of the mental system: zadishka, asthma, bronchospasm.

Shlunkovo-intestinal tract: diarrhea, nudota, bloating, constipation, flatulence, gastritis, abdominal pain, dyspepsia, stomatitis, blooming of the black color, bleeding in the herbal tract, twisting and perforation of the two-fingered intestine, or a slurry.

On the side of the herbal system: hepatitis, mittviy (fulminant) hepatitis with a fatal result, including zhovtyanitsya, cholestasis, and the development of liver enzymes.

On the side of the shkіri: sverbіzh, shkіrnі visipannya, pіdvischena pіdlivіst, erythema, dermatitis, necrolithiasis, anioneurotic swelling, denunciations, multiforme erythema, Stevens-Johnson syndrome, toxic epidermal necrolysis.

On the side of the secular system: dysuria, haematuria, severity, embryos, nirkova deficiency, oliguria, interstitial nephritis.

Zagalny ruins: embryos, nezduzhannya, asthenia, hypothermia.

Laboratory indicators: the adjustment of the peat enzymes.

Most often, in the presence of non-steroidal anti-flue gases (refineries), side reactions occur from the side of the herbaceous tract. You can diagnose peptidic virazoks, perforation or bleeding in the herb tract, and sometimes obstruct life, especially in sick people. Bully about such side reactions when consuming a group of drugs, sickness, bloating, diarrhea, abdominal pain, constipation, dyspepsia, abdominal pain, black colorectomy, bloody fever from home general, arterial hypertension and heart failure, such as the reactions of children, such as the adoption of pukhir, Stevens-Johnson syndrome and toxic epidermal necrolysis.

Clinical and epidemiological advise about those, which are low oil refineries, especially at high doses and with trivial stagnation, can lead to a slight increase in the risk of arterial thrombosis, accelerated thrombotic

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