Vilprafen - instruction from the procurement. Dzhozamitsin (Vilprafen) - macrolide antibiotics for special vipads

josamicin INN

describe diyuchy speech(INN) Josamitsin *

pharmacology: Pharmacological diya - antibacterial ... Reversely linking to the 50S subunit of ribosomes, the synthesis of the protein and the multiplication of microbial cells (bacteriostatic effect). When it is set, high concentrations are ignited at high concentrations of bactericidal activity. Volodya a wide range diets, including gram-positive (Staphylococcus spp., which produce and do not produce penicylinase, Streptococcus spp., Bacillus anthracis, Corynebacterium diphtheriae) and gram-negative (Borderworms, bacillus gonorrhoeae) microorganisms (Legionella spp, Mycoplasma spp., Chlamydia spp., Ureaplasma urealyticum) and anaerobes (Peptococcus, Peptostreptococcus, Clostridium perfringens, Bacteroides fragillis).

Shown: Infectious-igniting disease dikhalnyh noblesі ENT organs: angina, pharyngitis, laryngitis, sinusitis, otitis media, Tonsilitis and paratonsillitis, bronchitis, pneumonia, bronchiectatic ailments; dental infections (gingivitis, periodontitis); Infections of small wounds and soft tissues (vugri, pioderma, furunculosis, Siberian, beshikhove zapalennya, Lymphadenitis, lymphadenitis, venereal lymphogranuloma); Infections of the secular nobles (prostatitis, urethritis); diphtheria, scarlet fever, whooping cough, gonorrhea, syphilis, chlamydiasis, ornitosis, dysentery, dacryocystitis, blepharitis.

Prototype indications: Hypersensitivity (including up to ін. Macrolіdіv), important damage to the function of the liver.

Intercourse to zasosuvannya: Vagitnist, breastfeeding, lithuanian vіk.

Stagnation during vaginosity and breastfeeding: It can be done for an hour of vaginosity, as well as cleansing, the effect of therapy is changing the potential risk for the fetus. For an hour, lіkuvannya slіd pinch the chest vigodovuvannya.

Pobichna diya: On the side of the organs in the intestinal tract: tongue deposits, anorexia, nudota, ovens, bloating, flatulence, abdominal pain, diarrhea, melena, liver damage, liver transaminases (AST, ALT) activity, cholestatic hepatitis, colitis.

Інші: swelling of feet, impaired hearing, dysbacteriosis, candidiasis, allergic reactions (kropiv'yanka, visip), even more rarely - a feverish woman

Vzaєmodia: Trust in vivedennya to theophilin (accept side effects) Astemіzolu i terfenadine (pіdvischuєtsya rizik rozvitku shlunochkovih aritmіy. Potentsіyuє vasoconstrictor dіyu alkaloїdіv rіzhkіv. Poslablyuє efekt hormonal kontratseptivіv. Zmenshuє efektivnіst bactericidal antibіotikіv i lіnkomіtsinu (vzaєmno). Pіdvischuє kontsentratsіyu cyclosporin (rizik rozvitku nefrotoksichnostі) mіdazolamu, triazolam, digoxin i bromocriptine in Plasma Halmus metabolism of disopiramide, vivennya (T1 / 2) carbamazepin.

Overdose: symptoms: to improve the turn of the side effects.

lykuvannya: symptomatic therapy.

Ways of storing that dosi: All the middle, between the priyoms of the їzhі. The tablets are not rozzhovyuchi, washed down with a small amount of water. grow upі children over 14 years old - 1-2 g / day in 2-3 priyomi. Lіkuvannya zvychanykh i kulyastikh vugrіv - 500 mg 2 times for a dobout with a stretch of 2-4 teaspoons, 500 mg for a dobout with a stretch of 8 teaspoons. children especially in the case of a suspension of 6-14 times (weight of tila ponad 21 kg) - a dose of 30-45 ml / dob, 1-6 times (weight of 10-21 kg) - 15-30 ml / dob, 3 ms - 1 pik ( masa tila 5.5-10 kg) - 7.5-15 ml / dobu, divided into 3 doses.

Zapobіzhny come in: In order to prevent the occurrence of resistant strains, it is necessary to minimize the triviality of the course (if streptococcal infections not less than 10 days), do not overshoot and do not add a dose, if you take omissions. For every hour of therapy, it is necessary to monitor the EKG (especially in sick people who immediately take digoxin), control the function of the liver. In case of ailments for diabet Slide vrahovuvati, about 5 ml of suspension to replace 3.25 g of glucose. People who are sick should be prescribed in smaller doses and carry out the treatment under the control of the drug.

Special notes: Suspension of the vikoristovuvati over a stretch of 4 vials from the first view of the bottle.

International non-patented name: josamycin

Likarska form: tablets, including a plaster shell

Warehouse for 1 tablet
active ingredinti
Josamicin - 500 mg
Dopomіzhnі Ingredієnti to the weight of the tablet 640 mg
microcrystalline cellulose - 101.0 mg, polysorbate 80 - 5.0 mg, silica coloide oxide - 14.0 mg, sodium carmellose - 10.0 mg, magnesium stearate - 5.0 mg, methyl cellulose - 0.12825 mg, polyethylene glycol 6000 - 0.3846 mg, talc - 2.0513 mg, titanium dioxide - 0.641 mg, aluminum hydroxide - 0.641 mg, copolymer of methacrylic acid and efiriv - 1.15385 mg

describe
Tablets, in a plavkovy shell of a white or mayzhe white color, Dovgasti, two-convex, cannabis from both sides.

Pharmacotherapeutic group: antibiotic, macrolide.

ATX code: J01FA07

Pharmacological authorities

Pharmacodynamics.
antibacterial drug s group of macrolides. Mechanism of tying with damage to the synthesis of a protein in microbial cells in the presence of a reverse linkage with a 50S-subunit of ribosome. In therapeutic concentrations, as a rule, there is little bacteriostatic effect, they develop and multiply bacteria. When it is set at high concentrations, it has a bactericidal effect.

Josamicin is active in the presence of gram-positive bacteria ( Staphylococcus spp., incl. Meticillin-sensitive plugs Staphylococcus aureus), Streptococcus spp., incl. Streptococcus pyogenes i S treptococcus pneumoniae, Corynebacterium diphtheriae, Listeria monocytogenes, Propionibacterium acnes, Bacillus anthracis, Clostridium spp. Peptococcus spp., Peptostreptococcus spp.), Gram-negative bacteria ( Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Bordetella spp. Brucella spp., Legionella spp., Haemophilus ducreyi, Haemophilus influenzae, Helicobacter pylori, Campylobacter jejuni), Sensitivity Bacteroides fragilis can be variable), Chlamydia spp., incl. C. trachomatis, Chlamydophila spp., incl. Chlamydophila pneumoniae(Previously called Chlamydia pneumoniae), Mycoplasma spp., incl. Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma spp. Treponema pallidum, Borrelia burgdorferi.

As a rule, it is not active, apparently enterobacteria, so it infuses slightly into the microflora shlunkovo-intestinal tract... Zberiga activity in case of resistance to erithromycin and other 14 and 15-membered macrolides. Resistance to Josamicine grows up, down to 14 and 15-membered macrolides.

Pharmacokinetics.
When I take josamycin in the middle, it gets wet from the shlunkovo-intestinal tract, but I don’t pour it on bioavailability. The maximum concentration of josamycin in plasma is reached after 1 year after receiving. When taken in a dose of 1 g, the maximum concentration in blood plasma becomes 2-3 μg / ml. Nearly 15% of josamycin is bound to plasma proteins. Dzhozamitsin kindly grows in organs and tissues (behind a vignette to the brain), flammable concentration, how to transpose plasma and save for a therapeutic period of trivial hour. Especially high concentrations of josamycin in the lungs, mydalins, slugs, sweat and tears. Concentration in sputum changes in plasma concentration in 8-9 times. Pass the placental bar'єr, secretion in breast milk. Josamicin is metabolized in the liver to the lowest active metabolites and is metabolized by the head in the mouth. The period for which the drug is administered is 1-2 years, however, it can be podovzhuvatisya in patients with damaged liver function. Excretion to the drug with nirkami does not change 10%.

Shown to sucking

Infectious diseases of the upper dysfunctional nobility and ENT organs:
tonsillitis, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis, diphtheria (as added to diphtheria toxoid), scarlet fever (in times of hypersensitivity to penicillin).

Infections of the lower dichally nobles:
gostry bronchit, zagostrennya chronic bronchitis, Posal carnial pneumonia, Including wiclicana with atypical fever, whooping cough, psittacosis.

Infections in dentistry:
gingivitis, pericoronitis, periodontitis, alveolitis, alveolar abscess.

Infections in ophthalmology:
blepharitis, dacryocystitis

Infections of small curtains and soft fabrics:
foliculitis, furuncle, furunculosis, abscess, Siberian fever, erysipelas, acne, lymphangitis, lymphadenitis, phlegmon, panaritus, early (including hypooperative) and diagnostics.

інфекції sectional system:
urethritis, cervicitis, epididymitis, prostatitis, chlamydia and / or mycoplasmas, gonorrhea, syphilis (with hypersensitivity to penicillin), venereal lymphogranuloma.

Indigestion of the intestinal tract, association with H. pylori
Virazkova ailment slunk і twelve-fingered intestines, chronic gastritis that in.

Prototype

• hypersensitivity to Josamicin and other components in the preparation
• hypersensitivity to other macrolides;
• important damage to the function of the liver:
• children with weight less than 10 kg.

Vigor and lactation
Permitted stagnation in case of vaginosity and in the period thoracic treatment writing a lykarskoy assessment of corysty / rhizik. The European Public Health Organization recommends josamycin yak drug Vibor for the treatment of trash infections in vaginal women.

How to store that dosi

The name of the triviality of the treatment is to start with a licker, which can be stored from 5 to 21 days depending on the nature and severity of the infection. According to the recommendations of the WHO, the triviality of streptococcal tonsillitis is to blame for at least 10 days.

In the anti-chelikobacter therapy regimens, josamycin is prescribed in a dose of 1 g 2 times a day for 7-14 days in combination with the other drugs in standard doses (famotidine 40 mg / day or ranitidine 150 mg 2 r / day 2 r / day 2 / day 2 / day 1 + metronidazole 500 mg 2 r / day; omeprazole 20 mg (abolansoprazole 30 mg, abo pantoprazole 40 mg, abo ezomeprazole 20 mg, abo rabeprazole 20 mg) 2 r / day + amoxicilin 1 g 2 r / day + josamycin 1 g 2 r / day; omeprazole 20 mg (abo lansoprazole 30 mg, abo pantoprazole 40 mg, abo ezomeprazole 20 mg, abo rabeprazole 20 mg) 2 r / day + amoxicilin 1 g 2 r / day + josamycin 1 g 2 r / day + bismuth Tricali dicitrate 240 mg 2 r / day; famotidine 40 mg / day + furazolidone 100 mg 2 r / day + josamycin 1 g 2 r / day + Vismutu Tricali dicitrate 240 mg 2 r / day).

With the presence of atrophy of the mucus slurry with achlorhydria, susceptible to pH-measurement: Amoxicilin 1 g 2 r / day + josamycin 1 g 2 r / day + Vismutu Tricali dicitrate 240 mg 2 r / day.

It is recommended to take josamycin in a dose of 500 mg twice a day for two to four times a day, and 500 mg of josamycin once a day in an acceptable dose of 8 times a day in children who are very susceptible.

Pobichna diya

On the side of the shlunkovo-intestinal tract
Often - discomfort in the shlunk, nudota
Uncommon - abdominal discomfort, bloating, diarrhea
Ridko - stomatitis, constipation, decreased appetite
Much less - pseudomembranous colitis

Hypersensitivity reactions:
Ridko - kropiv'yanka, quinque and anaphylactoid reaction.
Much more rare - bullosic dermatitis, bagatoformna erythema, incl. Steven-Johnson syndrome.

On the side of the liver and bile nobles:
Duzhe Ridko - pechinkova dysfunction, zhovtyanytsya

Chuttya on the side of the organs:
In young people, I saw about a dose of late, passing hearing impairment
Inshі: duzhe rіdko - purple

Overdosing and receiving pardons
Until now, there is no information about the specific symptoms of overdose. In case of an overdose of subsequent allowances for the diagnosis of symptoms described in the section "Potential Effects", especially from the side of the intestinal tract.

Vzaєmodia with іnshy lіkarskiy zasob

іnshі antibiotics
Thus, bacteriostatic antibiotics in vitro can reduce the antimicrobial effect of bactericidal agents, as a result of a unique characteristic. Dzhozamitsin is not meant to be recognized at the same time with linkosamids, as it is possible to justify a decrease in their efficiency.

Xanthini
Those representatives of the macrolide group believe in the elimination of the xanthines (theophilin), but you can bring the signs of intoxication, Kliniko-Experimental to the effect of the least

antihistamines
With the use of josamycin and antihistamines for alcohol, terfenadine or astemizole may be used to develop arrhythmias that are dangerous for life.

alkaloids
Є About the occasion of the improvement of vasoconstriction due to the spilal sign of alkaloids in children and antibiotics from a group of macrolides, including one that is singlely wary of the ingestion of josamycin.

cyclosporine
Specificity of josamycin and cyclosporin can be caused by the administration of cyclosporine in blood plasma and increased risk of nephrotoxicity. Slide regularly monitor the concentration of cyclosporine in plasma.

digoxin
With a spinal sign of josamycin and digoxin, it is possible to increase the level of remaining in the blood plasma.

special requests
At the same time, it is important for mothers to develop the possibility of developing pseudomembranous colitis on the basis of josamycin, which is not safe for life.

In ailments with a nircovy lack of treatment, it is necessary to carry out urahuvannya results of the general laboratory tests (ascertaining the endogenous creatinine).

As soon as there is a possibility of antibiotic resistance to antibiotics from a group of macrolides (microorganisms, antibiotics to spores due to the chemical structure of antibiotics, it can also be resistant to antibiotics).

Inflow to the building of keruvati by transport means and pratsyuvati with mechanisms
It was not added to the drug injected into the health of the keruvati by transport
by means of and practicality with folding mechanisms.

Form vipusku
Tablets vkriti plivkovyu shell 500 mg.
10 tablets in blister with aluminum / PVC. 1 blister at a time from the instructions and from the filling into a cardboard box.

Term of attachment
4 rock.
Vilprafen does not follow the end of the term of attachment indicated on the packaging.

Umovi zberigannya
Captured at a temperature of 25 ° C in the stolen form of light.
Zberigati lykarskiy zabit in the nights inaccessible for children!

Mind that term zberigannya
Adopt a recipe for a liquor

Applicant restratsії (vlasnik RU)
Astellas Pharma Europe B.V., Elisabethof 19, 2353 EB Leiderdorp, Niderlandi /
"Astellas Pharma Europe B. V.", Elisabethhof 19, 2353 EW Leiderdorp, The Netherlands.

Virobnik

Filling bag (first packaging)
Montefarmako S.p.A., Italy
ABO ZAT "ORTAT", Russia

Packing bag (secondary / tretin packaging)
Montefarmako S.p.A., Italy
abo Temmler ITALIA C.p. JL, ITALIA
ABO ZAT "ORTAT", Russia

Whiteness control
Temmler ITALIA SRL, ITALIA
ABO ZAT "ORTAT", Russia

For wash the packaging at ORTAT ZAT
Virobnik
Montefarmaco S.p.A., Italy / Montefarmaco S.p.A.
Via Galilei, n. 7, 20016 Pero (MI), Italia

Packing bag and release control
ZAT "ORTAT", Russia
157092, Kostromska region., Susaninskaya district, with. Pivnichne, mn Kharitonov.

Claims should be sent to the Moscow representative office of Astellas Pharma Yurop B.V. behind the address:
109147 Moscow, Marksistska st. 16, "Mosalarko Plaza-1" business center.

(2S, 3S, 4R, 6S) -6 - ([(2R, 3S, 4R, 5R, 6S) -6 - ([(4R, 5S, 6S, 7R, 9R, 10R, 11E, 13E, 16R) - 4- (Acetyloxy) -10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7- (2-oxoethyl) -1-oxaciclohexadeca-11,13-diun-6-il] oxy) -4 - (dimethylamino) -5-hydroxy-2-methyloxane-3-yl] oxy) -4-hydroxy-2,4-dimethyloxane-3-il-3-methylbutanoate.

Rechovina synthesize in viglyadі propionate.

Cheerful authorities

Shown to sucking

Dzhozamitsin priznachayut for likuvannya gostrich or chronic ailments, like viclikans sensitive to the point of being microorganisms.

Preparations based on the given speech vikoristovuyu:

• at , Paratonsillitis, ;
• for lіkuvannya, as it is not possible to vikoristovuvati;
• in case of chronic and gostromy, psittacosis ;
• for the treatment of ophthalmologic infections, blepharitis , ;
• yaksho viklikana atypical zbudnik;
• with ailments periodontium, gingiviti, іnshikh dental infections;
• how the ailing beshikhov has a keen sense of sensitivity to;
• at pioderma , Siberian spine, furunculosis, venereal lymphogranuloma і vugrah ;
• paciєnti z , і;
• within the framework of complex therapy , , Змішанихінфекцій.

Prototype

Josamicin increases plasma concentration.

Mind the sale

For the recipe.

Umovi zberigannya

They save drugs to take revenge on the word in a cool, dark place.

Term of attachment

special requests

It’s just an hour of therapy with the help of a patient. pseudomembranous colitis Then you need to pinch the pills when you take them. It is not recommended to take a chance to reduce intestinal peristalsis.

Falsely from the Rivnya KK, from individuals who are suffering from get sick nirok it is necessary to carry out a correction of the dosage of the drug.

novonarogenim

Antibiotic is not possible for premature babies. During the hour of being treated with new children, it is necessary to respectfully control the function of the liver.

litnim

Correction of reconnection for letters is carried out according to the recommendations of the doctor.

With alcohol

The supply of antibiotics with alcohol should be produced until the date of supply of antibiotics on the stove and nirka.

Josamicine for vaginosis and lactation

A consultation with a doctor can be given at.

Preparations in which to revenge (Analogs of Dzhozamitsin)

Naybilsh extended analogs of Josamicin: , Vilprafen Solutab .

Vilprafen is widely used for the treatment of bacterial and fungal diseases.

The drug is administered to a group of macrolides - antibiotics, which are supplemented for days with penicilins. Viyavlyak is bacteriostatic, and in high doses it is bactericidal. Practically, I will increase metabolism in the body, and its surplus and metabolism will be transferred from the section.

At the end of the day, you will know all the information about Vilprafen: I will repeat the instructions from the stasis to the given drugstore, the average prices in pharmacies, and so they saw the wrong analogs of the drug, and so they saw the people already stagnated. Do you want to overshadow your thought? Be affectionate, write in the comments.

Clinical-pharmacological group

Antibiotic group macrolide.

Mind that term zberigannya

Adopt a recipe for a liquor.

prices

Skіlki kostu Vilprafen? The average price in pharmacies is about 600 rubles.

Form vipusk and warehouse

The drug Vilprafen is dispensed in the form of tablets for reception in the middle in carton packs in blisters of 10 pieces. The skin tablet is covered with a plush shell of a white color and a horizontal notch on one side.

• active speech: josamycin - 500 mg,
• additional words: microcrystalline cellulose, polysorbate 80, silicon oxide coloide, sodium carboxymethylcellulose, magnesium stearate, hydroxypropylmethylcellulose, Macrogol 6000, talc, titanium dioxide

pharmacological effect

The bactericidal effect of active speech in the drug is zoomed in by the fact that josamycin is connected to the great subunit of the ribosomal membrane (50S), does not allow the transport RNA to fail, and also to block the translocation of peptides in the A-center, in the translocation of the mucus membrane on the power of the cells) and drive internal cells of amino acids.

The range of diy goes to the warehouse of Vilprafen josamycin to reach a wide range.

Rechovina is active in gram-positive aerobic microorganisms, including:

1. It is seen by organism during ignition processes of peptococci;
2. Peptostreptococci, which provoke the development of infections;
3. staphylococci;
4. Zbudnik Sibirsky Virazka - anthrax bacillus;
5. Bacteria of the genus Corynebacterium, є diphtheria pathogens;
6. Clostridium perfringens - abnormalities of gas gangrene and toxic infection of people;
7. Streptococcus.

Active Vilprafen and generally gram-negative microorganisms, including:

1. Hemophilus, which is the cause of hemophilic infections, middle menningitis, gastric pneumonia, pericarditis, septicemia, etc.;
2. Neisserii, є such illnesses as gonorrhea and meningit;
3. Deyakikh types of shigeli, which provoke the development of dysentery;
4. Bacteroids of frailis, such as children of infectious diseases, who develop in case of previous injuries, surgical involvement, with immunodeficiency, etc .;

Shown to sucking

According to the instructions, Vilprafen designates for the treatment of the onset of infectious and ignition diseases, for the treatment of microorganisms, sensitive to Josamycin:

1. psittacosis;
2. Infections in ophthalmology (dacryocystitis, blepharitis);
3. Infections in dentistry (pericoronitis, periodontitis and alveolar abscess);
4. Opіkovі and early (including those from the operative) іnfections;
5. , Venereal lymphogranuloma, (with allergy to penicilin abo);
6. Іnfections of ENT organs and upper distal paths, including paratonsillitis;
7. Іnfections of lower dichal nobles, including pozalіkarnyih, hospitality i (zagostrennya);
8. (Vilprafen is recognized for the presence of hypersensitivity to antibiotics in the penicilin series);
9. (In complex therapy at once with diphtheritic antitoxin);
10. Infections of statutory organs and secular nobles (, and epididymites, microplasma infections and / or rubbish);
11. Infections of soft tissues and shkiri (furunculosis, furuncle, Siberian virazka, acne, abscess, foliculitis, lymphadenitis, panaritism, lymphangitis and phlegmon);
12. Entrapment of the slunk-intestinal tract, wiklicans, including і і.

Prototype

The drug has contraindications in case of severe damage to the functions of the liver, or in the presence of an increased sensitivity to the components of the drug.

Stagnation in vaginosis and lactation

The drug is not considered to be vaginally due to the fact that it is important damage in the robot's oven, sensitivity to storage components.

Instructions for storing

1. For the treatment of rosacea - 500 mg 2 times / dob for 10-15 days.
2. For lykuvannya pioderma - 500 mg 2 times / dob for 10 days.
3. For the treatment of urogenital chlamydiasis - 500 mg 2 times / dob for 12-14 days.
4. For the treatment of chronic periodontitis, with abscess formation of the periodontal cyst - 500 mg 2 times / add for 12-14 days.
5. In case of extreme and conglobate (conglobate) vugras, use 500 mg 2 times / addition with a stretch of 1-4 times, dal - 500 mg 1 time / day in an additional therapy for 8 types.

Tablets slid kovtati, not rozzhovyuchi, with a small amount of rіdini, mіzh priyomami yzhі. Name the triviality of the lykuvannya viznacha lykar. According to the recommendations of the WHO, the triviality of the treatment of streptococcal infections is guilty of becoming not less than 10 days.

Nemovlyat and children in the age of up to 14 years are advised to prescribe the drug in the form of a suspension. Dobova dose should be 30-50 mg / kg body weight, divided into 3 doses. In newborns and children, up to 3 msec, the dose should be taken up to the exact amount of the child.

Before implantation, the vial of suspension should be stripped.

Vicious Effects

With the correct intake of the drug and the exact definition of the dose indicated in the instructions for the dose, Vilprafen can be tolerated by the patients, however, in some cases of possible development of the onset of side effects:

1. Allergic reactions of shkiri:, Visip, anaphylactic shock in the bowels of the ridkish vipadkakh.
2. Shlunkovo-intestinal tract: nudity, pain in the abdomen, sleepiness, stove, bluing, unbroken diarrhea, development of the ignition process in the intestines of ridkisnyh vipadkah.
3. On the side of the stove and zhovchivi nobles: Increased activity of pechinkovyh transminases, rarely destructed in the current of the female and the func- tion of the female chef for the development of the female child.

Overdose

Apparently, until the present hour of the fall, overdose did not occur. In case of an overdose of the patient, it is necessary to allow for the improvement of side effects, as well as symptomatic therapy.

special requests

1. In patients with a nircovy deficiency, it is necessary to correct the dosage regimen according to the CC value.
2. Dzhozamitsin does not recognize premature babies. When stasis in newborns, it is necessary to control the function of the liver.
3. In the development of pseudomembranous colitis, josamycin is followed by scasuvati and indicates a specific therapy. Drugs that reduce intestinal motility are contraindicated.

There is a possibility of antibiotic resistance to antibiotics of a group of macrolides (for example, microorganisms, antibiotics, antibiotics, antibiotics, antibiotics can be susceptible to antibiotics).

lykarska vzaєmodiya

1. Vilprafen galmu elimination of xanthines, which can provoke development of intoxication.
2. It is recommended to have a unique one-hour consumption of Vilprafen with other antibiotics. This can lead to a decrease in efficiency.
3. An instant antibiotic intake with cyclosporine can lead to an increase in the concentration of the remaining one, and then the control of this level is followed by a stretch of the drug.
4. Taking Vilprafen can reduce the effectiveness of hormonal contraceptives, so it is recommended that non-hormonal contraceptives be eliminated.
5. Complex storage of Vilprafen with antihistamines, including astemizole and terfenadine, increases the concentration of residues, which can lead to the development of severe heart arrhythmias, which can clutter up the life.

Preparations for revenge Josamycin (Josamycin, ATC code (ATC) J01FA07):

Vilprafen (Dzhozamitsin) - official instructions for storing. Prescription drug, the information is designated only for the health protection fahivts!

Clinical-pharmacological group:

Antibiotic group macrolidiv

Pharmacological diya

Antibiotic group macrolide. Viyavlyak bacteriostatic dіyu, as it is poured over to the synthesis of bіlka bacteria. When it is set, high concentrations are ignited at high concentrations of bactericidal activity.

There is a high activity of common internal microorganisms: Chlamydia trachomatis, Chlamydophila pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila; gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium diphtheriae; gram-negative bacteria: Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis; anaerobic bacteria: Peptococcus spp., Peptostreptococcus spp., Clostridium perfringens.

Slightly infused into enterobacteria, that is not enough to change the natural bacterial flora of the ShKT.

Effective with resistance to erithromycin. Resistance to Dzhozamitsin develops earlier, down to the other antibiotics from the group of macrolides.

Pharmacokinetics

soaktuvannya

When taken, josamycin is rapidly absorbed and absorbed from the intestinal tract. Acceptance does not pour in on accessibility. Cmax can be reached in 1-2 years or after receiving.

rospodil

I don’t overtake 15% of plasmas.

Particularly high concentrations are found in legends, flickering, sleepless, sweaty and sleazy days. The concentration of josamycin in the sputum changes the concentration in the plasma in 8-9 times. Accumulate in a copy of fabric. Penetrates through the placental bar, and is seen in breast milk.

metabolism

Josamicin is metabolized in the liver to the lesser active metabolites.

vivedennya

Vivoditsya head rank zhovch, vivedennya z the section to become less than 20%.

Shown to preparation VILPRAFEN®

Hospitals and chronic infectious-ignition illnesses, microorganisms sensitive to the drug:

• Infections of the upper forms of the ecclesiastical paths and ENT organs (including angina, pharyngitis, tonsillitis, paratonsillitis, otitis media, sinusitis, laryngitis);
• scarlet fever (with increased sensitivity to penicillin);
• Infections of the lower types of dichally nobles (including bronchitis, chronic bronchitis, pneumonia, including atypical diseases);
• whooping cough;
• psittacosis;
• gingivit and periodontal ailments;
• blepharitis, dacrocystitis;
• іnfektsії shkіri and myky tissues (including pioderma, furunculosis, vughri, lymfangіt, lіmphadenіt);
• sibirska virazka;
• erysipelas (with allergy to penicilin abo);
• venereal lymphogranuloma;
• Infectious diseases of secular pathways and statutory organs (including urethritis, prostatitis, gonorrhea, syphilis / in case of hypersensitivity to penicillin /, chlamydian, microplasmic / including urethral malignancies)

dosage regimen

In case of extravagant and kulastic vugras, it is necessary to use 500 mg 2 times for a second stretch of the first 2-4 types, dal - 500 mg 1 time for an additional stretch of 8 types of therapy.

Tablets slid kovtati tsilimi, not roszhoyuchi, washed down with a small amount of ridini.

Name the triviality of the lykuvannya viznacha lykar. According to the recommendations of the WHO, the triviality of the treatment of streptococcal infections is guilty of becoming not less than 10 days.

When you take Vilprafen, you must take a dose of the drug safely if there is only one missed dose. However, as soon as you take the Chergovy dose, do not take the missed dose, you will need to turn to the usual mode of drinking. Do not take a double dose. Interruption in treatment, or before the hour of taking the drug, will change the success of the therapy.

Pobichna diya

On the side of the herbal system: rarely - the appearance of appetite, tediousness, baking, bloating, dysbacteriosis, diarrhea; In some cases, there is a transient increase in the activity of pecin transaminases, a deterioration in the flow of zhovch and zhovtyanitsa. The development of a pseudomembranous colitis in the development of a suitable drug is very important.

On the side of the organ of hearing: rarely - a dose-delayed loss of hearing.

Allergic reactions: in some vipads - kropivyanka.

Іnshі: in some cases - candidiasis.

Prototype indications prior to consumption for VILPAFEN®

• severe damage to the function of the liver;
• Sensitivity has been increased to antibiotics of a group of macrolides.

Prolongation of the drug VILPRAFEN® in case of vaginosis and years of breastfeeding

It is allowed to drink Vilprafen during vaginosis and in the period of lactation (breastfeeding) for indications.

Stagnation in case of deterioration of the function of the liver

The drug is contraindicated in case of swelling of the liver function.

Zasosuvannya in case of destructive functions of nirok

special requests

With the protection and control of the function of nirok, the drug should be prescribed to patients with nircovy deficiency.

If Vilprafen is recognized, there is a possibility of cross-resistance to antibiotics in a group of macrolides (for example, microorganisms, possible resistance to diseases, up to chemical antibiotics).

Overdose

Until now, there are reports about the specific symptoms of an overdose of Vilprafen. In case of an overdose of subsequent allowances, the increase in the number of secondary effects on the side of the herbal system.

lykarska vzaєmodiya

Bacteriostatic antibiotics can reduce the bactericidal effect of other antibiotics, such as penicillin and cephalosporin. That is why Vilprafen's one-hour recognition with antibiotics of significant groups, for example, with such infections as meningit and streptococcal tonsilopharyngitis, is a sign of a unique one.

With a one-hour consumption of Vilprafen with lincomycin, there can be a decrease in the effectiveness of both drugs (it is not the case that the combination is given).

Antibiotics of the macrolide group trust in the development of xanthines (theophilin), which can lead to a young toxicity. In clinical-experimental studies, it has been shown that josamycin can fix a smaller injection of theophiline, less antibiotics of the macrolide group.

With a one-hour consumption of Vilprafen and antihistamines, you can take terfenadine or astemizol, you can be relieved of the risk of arrhythmias.

Є About the occasion of the improvement of vasoconstriction in the case of an hourly depletion of macrolides and alkaloids. There is one type of incidence of the patient's tolerance to ergotamine when taking josamycin. I’ll look at the price, with a one-hour consumption of josamycin and ergotamina, the patient’s stance is controlled.

With a one-hour intake of Vilprafen and cyclosporine, it is possible to increase the level of cyclosporine in the blood plasma and the stem of the nephrotoxic concentration in the blood. Therefore, with a one-hour consumption of the drug, the concentration of cyclosporine in the blood plasma is regularly monitored.

With a one-hour consumption of josamycin and digoxin, it is possible to adjust the syrovat concentration of the rest.

In severe cases of macrolide therapy, anti-hormonal contraceptives may be ineffective (perhaps non-hormonal contraceptive methods may be used).

Mind that term zberigannya

The drug is available for a prescription.

Mind that term zberigannya

A list of Zberigati in a stolen light, inaccessible to children at a temperature of 25 ° C. Term of affinity - 4 rocks.

Vilprafen solutab - shown before the end of the day and the end of the day:

Shown to preparation VILPRAFEN® solutab

Infectious and igneous illnesses, microorganisms sensitive to the drug:

• іnfections of the upper spinal paths and ENT organs (pharyngitis, tonsillitis, paratonsillitis, laryngitis, otitis media, sinusitis);
• diphtheria (as an addition to the treatment with diphtheria antitoxin);
• scarlet fever (with hypersensitivity to penicillin);
• іnfektsії of the lower dichally nobles (gostry bronchitis, aggravated chronic bronchitis, postoperative pneumonia, including wiklican with atypical malignancies);
• whooping cough;
• psittacosis;
• Infections of empty mouth (gingivitis, pericoronitis, periodontitis, alveolitis, alveolar abscess);
• eye infections (blepharitis, dacryocystitis);
• іnfektsії shkіri and myky tissues (foliculitis, furuncle, furunculosis, abscess, acne, lymphangitis, lymphadenitis, phlegmon, panarice, wounds / including pislyoperatsіynі / і opіk)
• sibirska virazka;
• erysipelas (with hypersensitivity to penicillin);
• Infections of secular nobles and statutory organs (urethritis, cervicitis, epididymitis, prostatitis, wickedness and / or microplasmas);
• venereal lymphogranuloma;
• gonorrhea, syphilis (with hypersensitivity to penicillin);
• ailment of the intestinal tract, association with Helicobacter pylori (including virazkov ailment of the shlunk and two-fingered intestines, chronic gastritis).

Dose regimen for VILPRAFEN® solutab

Children at a vіtsі 1 roku may have an average weight of 10 kg.

Dobova dose for children with body weight is not less than 10 kg, it should be taken at a dose of 40-50 mg / kg body weight daily, divided into 2-3 doses: for children with body weight 10-20 kg, 250-500 mg (1 / 4-1 / 2 tablets, dispensed from water) 2 times for dob, for children with a weight of 20-40 kg, 500-1000 mg each (1 / 2-1 tablet, broken down for water) 2 times for dob, for children with weight tila more than 40 kg - 1000 mg (1 tablet) 2 times for dobu.

The name of the triviality of the disease is to start as a drug and to become from 5 to 21 days depending on the nature and severity of the infection. According to the recommendations of the WHO, the triviality of streptococcal tonsillitis is to blame for at least 10 days.

In the anti-chelikobacter therapy regimens, josamycin is prescribed in a dose of 1 g 2 for 7-14 days in combination with other drugs in standard doses:

• famotidine 40 mg / dobu or ranitidine 150 mg 2 times for dobu + josamycin 1 g 2 times for dobu + metronidazole 500 mg 2 times for dobu;
• omeprazole 20 mg (abolansoprazole 30 mg, or pantoprazole 40 mg, or ezomeprazole 20 mg, or rabeprazole 20 mg) 2 times for dobu + amoxicilin 1 g 2 times for dobu + josamycin 1 g 2 times for dobu;
• omeprazole 20 mg (abo lansoprazole 30 mg, abo pantoprazole 40 mg, abo ezomeprazole 20 mg, abo rabeprazole 20 mg) 2 times for dobu + amoxicilin 1 g 2 times for dobu + josamycin 1 g 2 times for dobu + bismuth Trikalі 240 mg 2 times for doba;
• famotidine 40 mg / dobu + furazolidone 100 mg 2 times for dobu + josamycin 1 g 2 times for dobu + bismuth Tricali dicitrate 240 mg 2 times for dobu).

With the presence of atrophy of the mucous slurry with achlorhydria, susceptible to pH-measurement: amoxicilin 1 g 2 times for dobu + josamycin 1 g 2 times for dobu + bismuth Tricali dicitrate 240 mg 2 times for dobu.

Dispersible tablets Vilprafen® Solutab can be used in different ways: the tablet can be poured in a whole, washed down with water or, before taking it, it can be broken by water. Tablets slid razchinyatiya, yak minimum, in 20 ml of water. Before the reception, the suspension was slowly mixed.