Valsartan is the maximum dobova dose. Tablets vіd vise Valsartan: instructions, prices and advice

At this statty, you can learn from the instructions and from the lykarsky drug valsartan... Presented by the guide to the site - from the survivors of the given name, as well as the thoughts of the users of the faqs from the victorious valsartan in their practice. There is a great way of actively giving your advice about the drug: it helped or did not help the person to get sick, because it was a delay in side effects, It may not be declared by the virobnik in the abstract. Analogs of valsartan with obvious structural analogs. Vikoristannya for lykuvannya arterial hypertensionі lowering the vice, heart failure in older adults, children, as well as during vaginosity and breastfeeding. Warehouse for the drug.

valsartan- antihypertensive disease. Є specific antagonist of angiotensin receptors 2. Advantageous antagonistic action on the AT1 receptor, which is indicative of the realization of effects in angiotensin 2.

During the blockade of AT1 receptors, the plasma concentration of angiotensin 2 increases, which can stimulate the unblocked AT2 receptor. Not volodya agonistic activity of AT1 receptors. The ratio of valsartan to AT1 receptors is approximately 20,000 times in food, down to AT2 receptors.

Chi will not drive ACE. Chi does not interact and does not block the receptor of the other hormones or the channels, which may more important for regulation of functions heart-vascular system... Do not infuse the level of zagalny cholesterol, triglycerides, glucose and secular acid into the blood plasma.

An ear of antihypertensive action of valsartan when consumed in a single dose in a single dose is promoted to last for 2 years after receiving, the maximum effect is reached for 4-6 years.

warehouse

Valsartan + additional speeches.

Pharmacokinetics

When valsartan is taken in the middle, it is rapidly absorbed from the intestinal tract, the feet are characterized by individual symptoms. The absolute availability in the middle becomes 23%. With the exchange rate change, pharmacokinetic parameters were not recognized. With the intake of valsartan from the young, the AUC decreases by 48%, with approximately 8 years later, the intake of the concentration of valsartan in the plasma is the same in the patients who took it in the heart. The change in AUC does not supervise clinically significant changes in the therapeutic effect. When taking valsartan 1 time, the cumulation is not significant. Concentration of valsartan in blood plasma of women and choloviks of boules is the same. The linkage with blood plasmas, especially with albumin, becomes 94-97%. Vivoditsya with feces - 70% and from the cross-section - 30%, even in an uninterrupted viglyad. In case of bilious cirrhosis or obstruction of the galls of the AUC, valsartan is reduced by about 2 times.

showing

• lіkuvannya arterial hypertension;
• treatment of chronic heart failure (2-4 functional class for NYHA classification) in patients who accept traditional therapy with diuretics, digitalis drugs, and also with adrenergic agents of APF and beta-blockers.

formy vipusku

Tablets, in the form of 40 mg, 80 mg, 160 mg.

Capsules 20 mg, 40 mg, 80 mg, 160 mg.

Instructions for sucking and sucking

Take vseredinu in a dose of 80 mg 1 time for doba or 40 mg 2 times for doba, every day. When the weather is adequate to the effect dobova dose can be done step by step.

The maximum dobov dose is 320 mg in 2 priyomi.

Pobichna diya

• arterial hypertension;
• posturally messy;
• postural hypotension;
• zamorochennya;
• head beel;
• diarrhea;
• nudota;
• addendum for bilirubin;
• deterioration of the function of nirok;
• pіdvischennya іvnya creatine and nitrogen sechovina (especially with chronic heart failure);
• hyperkalієmiya;
• neutropenia, decrease in hemoglobin and hematocrit;
• angioedema;
• visip;
• syrovatkov's ailment;
• vasculitis;
• stomachache;
• Significant weakness;
• cough;
• pharyngitis;
• promotion of the development of viral infections.

Prototype

• vagіtnіst;
• sensitivity to valsartan is increased.

Stagnation during vaginosis and breastfeeding

Valsartan is contraindicated until it is consumed with vaginosis.

It is impossible to see valsartan in breast milk in humans. Stagnation in the period of lactation ( thoracic treatment) is not recommended.

Experimental studies have shown that valsartan is seen in breast milk in schurids.

Zasosuvannya in children

The safety and efficiency of valsartan consumption in children has not been established, so there is no contraindication for children and adults in children under 18 years of age.

special requests

With hyponatriasis and / or a decrease in the amount of circulating blood, as well as during the therapy with high doses of diuretics in rare valsartan drops, hypotension can be affected. Before the cob of drinking, it is necessary to carry out a correction of the water-salt exchange.

In patients with renovascular hypertension, who developed suddenly as a result of stenosis of the nirkovo artery, during the period of their development they regularly monitored the level of serum and creatine in syrovatics. Dani about the safety of the provision of patients with CC less than 10 ml / min per day.

With a special protection you will be stuck with the children with the ruined prodigality of the female nobles.

In addition to the ingibuvannya system of renin in sickly patients, it is possible to change the function of nirok. at stasis іngіbіtorіv APFі antagonists of angiotensin receptors in patients with chronic heart deficiency, severe interruptions, spostering oliguria і / abnormally an increase in azotemia, rapidly developing hospitality nirkova lack with a risk of lethal result.

Inflow to the building of keruvati by transport means and mechanisms

lykarska vzaєmodiya

With a one-hour consumption of diuretics in high doses, the development of arterial hypotension is strong.

With a one-hour consumption of high-calorie-containing diuretics, heparin, biologically active additives, or substitution of salts, it is possible to waste calories, high-potency development of hypercritical substances.

With a one-hour consumption of endometacin, the antihypertensive effect of valsartan can be changed.

With a one-hour consumption of carbonate, the descriptions of the development of the toxicity of the lithium are described.

Likarsky analogs to the drug Valsartan

Structural analogs for diyuchy speech:

• Artinov;
• Valaar;
• Walz;
• Valz N (with hydrochlorothiazide);
• Valsartan Zenіva;
• Valsafors;
• Valsacor;
• Valsakor N;
• Vanatex Combi;
• dovan;
• Duopress;
• Before Diovan;
• Northvan;
• Tantordio;
• Tareg.

When there are analogs of a drug for a daily speech, you can go to the lower level for an illness, such as a supplementary drug, and an analogy for a drug.

• Ko-valsartan preparation instructions
• Warehouse for the drug Co-valsartan
• Shown to the drug Co-valsartan
• Mind the drug Co-valsartan
• The term of adherence to the drug Co-valsartan

ATX code: Sertsevo-angiotensin system (C)> Preparations that are injected on the renin-angiotensin system (C09)> Antagonism of angiotensin II in combination with other drugs (C09D)> Antagonism of angiotensin II in combination with C09 with diuretics> C09DA03)

Form vipusku, warehouse and packaging

Vkriti coated tablets red-brown color, round, two-convex.

Additional speeches: cellulose microcrystalline, crospovidone, silicon dioxide coloidal anhydrous, magnesium stearate.

Shell warehouse: Opadrai II 85G25455 chervonia (polyvinyl alcohol, talc, macrogol, titanium dioxide (E171), barvnik zaliza chervonium oxide (E172), barvnik zhovtiy "dormouse" (E110), lecithin).

10 pieces. - packs of middle contour (3) - packs of cardboard.
15 pcs. - packs of middle contour (2) - packs of cardboard.

Description of the drug CO-valsartan Backed up on the officially solidified instructions for the preparation of the drug and completed in 2015. Update date: 01.03.2016 r

Pharmacological diya

combinations antihypertensive drug, Before the warehouse, which includes valsartan and hydrochlorothiazide.

valsartanє selective blocker receptors for angiotensin II, we can use it for receiving vseredin. Vibirkovo is a receptor for AT 1 type receptor, which is based on the type of angiotensin II efficacy. Valsartan has little agonistic activity of AT 2 receptors. The rate of valsartan to receptors of the AT 1 type is approximately 20,000 times more, down to the AT 2 receptors.

Valsartan does not convert ACE, it is also like kinase II, which converts angiotensin I to angiotensin II and ruinu bradicinin. At the connection from the air flow to the ACE, it is possible to effect bradykinin and substance P, and when antagonizing the receptors in angiotensin II, the development of dry cough is small.

Valsartan does not enter into interaction and does not block the receptor of the other hormones, but rather the channels, which take part in the regulation of the functions of the heart-vascular system.

In case of arterial hypertension, valsartan lowers the arterial vise, does not flow into the heart rate.

When taken in the middle of a single dose of the drug, the antihypertensive effect develops in 2 hours, and the maximum reduction in the arterial grip can be reached for 4-6 years. The antihypertensive effect of taking the drug takes more than 24 hours. Combination with hydrochlorothiazide is effective in reducing arterial vise.

Hydrochlorothiazide- thiazide diuretic. A point of view of thiazide diuretics є cortical appearance of distal nircoval canaliculi, de-rosetting of the receptor, which may high sensitivity sensitivity to diuretics, and deduction of attracting transport of ions Na and Cl. Mechanism of dressing tiazides with the pump Na + Cl -, which, obviously, is being considered for competition for the transport of Cl. As a result of the recovery of sodium and chlorine ions, it grows approximately the same. At the same time, diuretic activity promotes a change in the volume of circulating plasmas, as well as the activity of renin, secretion of aldosterone, inducing calories from the grain, concentration, calcification. The connection between renin and aldosterone is interrupted by angiotensin II, which is why the antagonist of receptors in angiotensin II reduces the loss of calories, due to the absorption of hydrochlorothiazide.

Pharmacokinetics

valsartan

soaktuvannya

After receiving the median C max in the plasma, it will be reached in 2-4 years. The average value of bioavailability becomes 23%. With the intake of valsartan, the AUC decreases by 40%, and the C max - by 50%, I wish, it is repaired from the eighth year after the intake of plasma concentration of valsartan, taken on the heart of the patient, however. The change in AUC does not lead to significant reductions in the therapeutic effect, so the drug can be used before or after.

rospodil

Equally important V d low (close to 17 liters). Valsartan in a significant world (by 94-97%) is associated with blood sugar, especially with albumin.

metabolism

Valsartan does not take intensive bio-transformation, only 20% of the dose taken is renewed before metabolism. Hydroxymetabolite is inactive and starts in plasma in low concentrations, which becomes less than 10% of the AUC for valsartan.

soaktuvannya

The pharmacokinetic curve of valsartan has a low multiexponential character (T 1 / 2α<1 ч и Т 1/2β - около 9 ч). Выводится преимущественно в неизмененном виде, выведение валсартана с калом составляет 83% величины абсорбировавшейся дозы, с мочой выводится около 13%. После в/в введения плазменный клиренс валсартана составляет около 0.62 л/ч (около 30% общего клиренса). Т1/2 составляет 6 ч.

Hydrochlorothiazide

soaktuvannya

If the received hydrochlorothiazide is wet in the middle of the water, it will take off quickly, an hour of reaching C max in plasma is about 2 years. In the middle, the AUC has a linear character and proportional dose in the therapeutic range. When taking all the middle, the absolute bioavailability of hydrochlorothiazide becomes 70%. The injection of hydrochlorothiazide into the bioavailability of hydrochlorothiazide is clinically insignificant.

rospodil

V d to become 4-8 l / kg. Hydrochlorothiazide clings to blood sugar (by 40-70%), and the main one is albumin. Hydrochlorothiazide accumulates in erythrocytes, which is 3 times concentrated in plasma.

metabolism

Hydrochlorothiazide is metabolized in an even small step. We are able to differentiate in a small amount by the metabolite 2-amino-4-chloro-m-benzenedisulfanamide.

vivedennya

The kinetics of growth and elimination is generally described as a biexponential decay function, T 1/2 in the thermal phase becomes 6-15 years. After 95%, the dose was soaked in the unchanged view of the nirkami, the path of passive filtration and active secretion in the enlightenment of nirk tubules.

Valsartan / hydrochlorothiazide

In case of alcohol intake with valsartan, the systemic bioavailability of hydrochlorothiazide decreases by about 30%. Immediately recognition of hydrochlorothiazide, on its own side, does not spoil the acidic injection on the kinetics of valsartan. Designated for not pouring into the effectiveness of the combined consumption of valsartan and hydrochlorothiazide. In the control of key presenters of the disease, there is a clear antihypertensive effect of this combination, which overrides the effect of the skin components of the okremo, as well as the effect of placebo.

Pharmacokinetics in special groups of patients

In children of kidnapped children, the systemic infusion of valsartan will have much more bends, in some cases with more young patients (an increase in AUC by 70% and T 1/2 by 35%), however, it should not be of the same class. Intercourse allowances allow for systemic clearence of hydrochlorothiazide lower in young patients (both healthy and suffering from arterial hypertension), lower than in healthy young volunteers.

Patients with a GFR of 30-70 ml / hv do not need a dose correction. There is no information about the use of the drug in patients with severe impairments to the function of nirok (GFR<30 мл/мин) и пациентов, находящихся на гемодиализе. Валсартан имеет высокую степень связывания с белками плазмы и не выводится при гемодиализе. Гидрохлоротиазид, напротив, выводится из организма при гемодиализе.

For patients with a lack of value, C max and AUC, hydrochlorothiazide will increase, and the rate of success will decrease. Patients with a nirk deficiency of a light and peaceful step are more likely to increase 3 times the AUC to hydrochlorothiazide, and for patients with a nirk deficiency of a severe step - an 8-fold increase in AUC. Hydrochlorothiazide of contraindications for patients with nirkovy lack of a difficult step.

The systemic infusion of valsartan in patients with weakly rotated and moderately damaged liver function was 2 times more than in healthy volunteers. We are given a donation to valsartan for children with important damage to the function of the liver in this hour.

The poisoning of the liver is not infused into the pharmacokinetics of hydrochlorothiazide, so a decrease in this dose is not required.

Shown to sucking

• treatment of arterial hypertension in older patients, in whom it is not possible to reach adequate control of AT during monotherapy with valsartan or hydrochlorothiazide.

dosage regimen

The drug is taken internally, not roasted, washed down with a sufficient amount of water, right from the reception.

The recommended dose is 1 tab. / Sut. It is recommended to titrate the dosage of the three components. In a specific skin condition, it is necessary to control the titration by adjusting the dosage of individual components in order to reduce the risk of developing hypotension and other side effects.

In the presence of clinical conditions, it is possible to see the direct transition from monotherapy to the combination of a drug with a fixed dose in patients who lack control during monotherapy with valsartan or hydrochlorothyroidism.

If necessary, for the control of the arterial vise, the dose can be increased by 1-2 doses up to the maximum additional dose of 320 mg to valsartan and 25 mg to hydrochlorothiazide.

The antihypertensive effect can be reached in 2 lengths. In most patients, the maximum antihypertensive effect can be reached for 4 years. However, for children there can be 4-8 years of life. Certainly, it is secured when titrating a dose.

Have patients with nircovy lack of lung and pomirny (GFR> 30 ml / hv / 1.73 m 2) Correction of a dose is not required. contraindication drug for patients with nirkovy lack of a severe step (GFR<30 мл/мин/1.73 м 2) i anurієyu through the presence of hydrochlorothiazide at the warehouse.

<60 мл/мин/1.73 м 2).

Immediately stasis of valsartan with aliskiren was suggested in patients with diabetic diabetes.

Have patients with mild and moderately impaired liver function without cholestasis the dose of valsartan is innocent of 80 mg. There is no need for a change in the dose of hydrochlorothiazide in patients with lungs and with reduced liver function. contraindication drug patients with severely impaired liver function, bilious liver cirrhosis and cholestasis, Oskіlki revenge valsartan.

To the patients of the kidnapped vik Do not use a dose of Co-Valsartan.

Pobichna diya

Lower pererakhovanі pobіchnі efekti, for whichever bully there is a powerful connection from the intake of valsartan in combination with hydrochlorothiazide.

Classification of the frequency and development of side effects:

• even more often (≥1 / 10);
• often (≥1 / 100, ale<1/10);
• infrequently (≥1 / 1000, ale<1/100);
• ridko (≥1 / 10,000, ale<1/1000), очень редко (<1/10 000).

In case of stagnation of the combination of valsartan and hydrochlorothiazide, there may be adverse effects.

On the side of the exchange of words: infrequently - dehydration.

On the side of the nervous system: infrequently - paresthesia;

On the side of the organ zoru: infrequently - unclearness.

infrequently - noise from wuhah.

infrequently - hypotension.

infrequently - cough;

even more rarely - diarrhea.

frequency of non-homeopathy - impaired function of nirok.

infrequently - b_l at myaz;

Injection on the results of laboratory and instrumental dosages: the frequency of miscarriage - adjustment of the concentration of sech acid, creatine and bilirubin in syrovatics, hypocalypse, hyponatriamia, adduction of nitrogen in the blood, neutropenia.

Інші: infrequently - stomatomy

Negative occurrences, earlier in the presence of skin s components, may be misplaced in the presence of Co-valsartan, as the stench has not been detected in clinical reports.

valsartan

The onset of undesirable manifestations were indicated during monotherapy with valsartan, directly as a causal linkage with this drug.

the frequency of non-homeopathy is a decrease in the concentration of hemoglobin and hematocrit, thrombocytopenia.

Allergic reactions: the frequency of miscarriage - hypersensitivity reactions, including syrovatkovu ailment, angioedema.

On the side of the exchange of words: the frequency of miscarriage - increased concentration of calories in the blood, hyponatriamia.

On the side of the organs in hearing and labyrinthine damage: infrequently - vertigo.

On the side of the heart-vascular system: the frequency of nevidoma - vasculitis.

On the side of the herbal system: infrequently - beating in the stomach;

On the side of the secular system: the frequency of miscarriage is a nirkova lack.

frequency of abnormalities - visip, sverbіzh shkіri.

Hydrochlorothiazide

The onset of undesirable manifestations were indicated during monotherapy with hydrochlorothiazide, directly from a causal link with this drug.

On the side of the hematopoietic system: Ridko - thrombocytopenia (inodi with purpura);

Allergic reactions: often - kropiv'yanka;

On the side of the exchange of words: even more often - hypocalypse, adjusting the concentration of lipids in the blood (which is important when the drug is consumed in high doses);

Psychic derailment: Ridko - depression, sleep disorder.

On the side of the nervous system: rіdko - head bіl, zamorochennya, paresthesia.

On the side of the organ zoru: rіdko - ruinous zoru;

On the side of the heart-vascular system: often - orthostatic hypotension;

On the side of the mental system: even more rarely - respiratory distress syndrome with pneumonitis and bulging of lesions.

On the side of the herbal system: often - decreased appetite, nudota, blues;

On the side of the secular system: the frequency of non-domination is the deterioration of the function of nirok, the state standard of nirkov's lack.

On the side of the statuary organs and milky cocks: often - erectile dysfunction.

On the side of the kistkovo-meat system: the frequency of abnormalities is myazov spasms.

On the side of shkіri and іdshkіrnyh fabrics: often - visip;

Інші: the frequency of abnormalities - increased temperature, asthenia.

Prototype

• severe damage to the function of the liver;
• bilarial cirrhosis of the liver and cholestasis;
• nirkova lack of an important step (GFR<30 мл/мин/1.73 м 2);
• anurya;
• refractory hipocalemia, hiponatria, hypercalcemia and symptomatic hiperuricaemia;
• overnight stagnation of antagonists of receptors in angiotensin II, including valsartan, or angiotensin ACE with aliskiren in patients with diabetic diabetics or a lack of interim / important stage (SKF<60 мл/мин/1.73м 2);
• vagіtnіst;
• lactation period;
• childish and adult age up to 18 years (safety and efficiency of storage is not established);
• sensitivity is adjusted to valsartan, hydrochlorothiazide, sulfonamides, or to any other component of the drug.

Stagnation during vaginosis and breastfeeding

availability

Zastosuvannya drug Co-Valsartan is contraindicated in vaginosis.

valsartan

Stasis of antagonists of receptors in angiotensin II is not recommended in the first trimester of vaginosity and is not recommended in the II and III trimesters of vaginosity.

Epidemiological data showed an increase in the risk of teratogenic infusion in case of stagnation of ACE in the first trimester of vaginosis. A similar risik can also be found in patients receiving antagonists of receptors in angiotensin II (including valsartan). Patients who are planning a stay should, if necessary, identify an alternative antihypertensive treatment, as it is possible to establish a safety profile for staying in case of vaginosis.

With the onset of vaginosis, taking antagonists of receptors in angiotensin II (including the drug Co-Valsartan), it is necessary to pinch it badly and, if necessary, indicate an antihypertensive therapy.

As a result of antagonizing angiotensin II receptors in the II and III trimesters of vaginosity, hypertrophic fetotoxicity (decreased function of low blood pressure, lack of water, occlusion of the skull ossification) and neonatal toxicity (nirkoval toxicity)

If the woman took antagonism of receptors to angiotensin II in the II and III trimesters of vaginosity, then ultrasound monitoring of the fetal skull function is required. Newborns, mothers who have taken antagonism of receptors in angiotensin II, are guilty of being overused for a quick visual connection with a powerful arterial potential.

Hydrochlorothiazide

Dosvid zasosuvannya hydrochlorothiazide with vaginosis, especially in the first trimester, intercourse. Danі, otrimanі in experimental doslіdzhennya on creatures, deficiencies. Hydrochlorothiazide penetrates through the placental bar. Investigations into the mechanism of pharmacological action of hydrochlorothiazide in case of stasis in the II and III trimesters of vaginosity may impair the placental perfusion and development in the fetus of a neonatal thrombosis.

lactation period

The gift of valsartan's potency in the period of the day of the day is in the chest. Hydrochlorothiazide is seen in breast milk. It is not recommended to use Ko-Valsartan during the lactation period. The patient should be transferred to an alternative therapy for drug use with a good health profile for breastfeeding, especially if the baby is new or premature.

Stagnation in case of deterioration of the function of the liver

In patients with mild and moderately impaired liver function without cholestasis, the dose of valsartan is innocent of 80 mg.

There is no need for a change in the dose of hydrochlorothiazide in patients with lungs and with reduced liver function.

The drug contraindicates patients with severely impaired liver function, bilious liver cirrhosis and cholestasis, oskilki revenge valsartan.

Zasosuvannya in case of destructive functions of nirok

In patients with a nircovy lack of lung and average (GFR> 30 ml / hv / 1.73 m 2), a dose correction is not required.

Drug contraindications for patients with severe disability (GFR<30 мл/мин/1.73 м 2) и анурией из-за наличия в составе гидрохлоротиазида.

Immediate consumption of valsartan with aliskiren is contraindicated in patients with a nircovy lack of a peaceful / important stage (GFR<60 мл/мин/1.73 м 2).

special requests

Change to the balance of electricity

It is not recommended to immediately prescribe valsartan with preparations of calories, substitutes for salts, or to avenge calories, calyzbergyuchimidiuretics or other drugs, which may increase the concentration of calories in the blood (for example, heparin). It is recommended to control the concentration of calories in the blood.

I have experienced problems with the development of hypocalypses for the hour of treatment with thiazide diuretics. It is recommended to control the food instead of the blood in the blood.

Treatment with thiazide nimidiuretics is often associated with diagnoses of hyponatremia and hypochloremic alkalosis. Thiazidium, including hydrochlorothiazide, can be used to produce magnesium from the cross-section, which can lead to the development of hypomagnesemia. Tiazidi reduce the amount of calcium from the cross section, which can lead to the development of hypercalcium. Periodic monitoring of the concentration of electrolytes in the blood is recommended.

Patients with a deficiency in the organism of sodium and / or a decrease in the BCC

In patients with a severe degree of sodium deficiency and / or a decrease in BCC, for example, diuretics can be dispensed at high doses, in some cases, if the cob is treated with Co-Valsartan, hypotension may be symptomatic. Before the ear of the drink, it is necessary to carry out a correction instead of sodium in the body and / or a volume of circulating blood.

Patients with severe heart deficiency and those with small statures, who are supervised by the activation of the RAAS

In patients with severe heart deficiency, in some of the functions, there may be some deficiencies in the activity of the RAAS, the treatment of ACE inhibitors may be the cause of oliguria and / or progressive azotemia, and in the case of severe hospitality / Evaluation of patients due to heart failure or postinfarction will be guilty of including an evaluation of the function of nirok. Zastosuvannya drug in patients with severe heart failure was not injected. This cannot be vicious, but galmuvannya RAAS with the drug Co-Valsartan can also be used to reduce the function of nirok. It is not recommended to use Ko-Valsartan at this group of patients in connection with the tsim.

Stenosis of the nirkovo artery

Co-Valsartan is not a sign of stasis for the treatment of arterial hypertension in patients with single or double stenosis of nirkoval arteries and for stenosis of artery hypertension, for which there is more blood concentration.

Primary hyperaldosteronism

Patients with primary hyperaldosteronism are not recommended to take the drug Co-Valsartan, the oskilka of the renin-angiotensin system is not active.

Aortic abdominal valve stenosis, obstructive hypertrophic cardiomyopathy

In case of stagnation of other vasodilators, special care is taken when the drug Co-Valsartan is prescribed for patients with aortic or mitral stenosis or hypertrophic obstructive cardiomyopathy.

Damaged function of nirok

In patients with impaired functions of nirok (CC> 30 ml / hv), a dose correction to the drug is not required. It is recommended to periodically monitor the concentration of calories, creatine and sech acid in patients with impaired functions of nirok, who take Co-Valsartan.

One hour consumption of the drug Co-Valsartan with aliskiren is contraindicated in patients with nircum deficiency (GFR<60 мл/мин/1.73 м 2).

transplantation nirok

In the last hour of the day, there was a report about the safety of the Co-Valsartan drug in patients who had recently undergone an operation for a nirka transplant.

Damaged function of the stove

In patients with mild and moderately impaired liver function without cholestasis, Co-Valsartan has gone down to safety. The reason for the protection of the patients with the damaged functions of the stove, or the progressive form of the stove, some minor hypovolemia and electrical imbalance can provoke the development of the stove.

Angioneurotic swelling in anamnesis

I had a problem with the development of angioedema, incl. the larynx and the vocal slit, which can lead to the obstruction of the dysfunctional nobles and / or the bulge of the face, lips, pharynx and / or the language of the patients who have taken valsartan. Deyakі s cich patients in mali in anamnesis of the development of an anioneurotic embryo in the reception of other drugs, incl. іngіbіtorіv APF. In case of development of an anneurotic swelling, the patients should be inadvertently pinned with the drug Co-Valsartan, the drug should not be reassigned.

Systemic chervona vovchanka

Occasionally, thiazide diuretics are sharpened or active to manifest systemic heart disease.

Інші metabolic damage

Thiazides, including hydrochlorothiazide, can cause changes in tolerance to glucose and increase the concentration of cholesterol, triglycerides and sech acid in syrovate. Patients with diabetes can know the correct dosage of insulin or oral hypoglycemic problems.

Thiazidi can reduce the intake of calcium from the cross section and reduce the time and slightly increase the concentration of calcium. Hyperparathyroidism can be seen as a symptom of hyperparathyroidism. It is recommended to prescribe the treatment with thiazidnymiduretics prior to the test to assess the function of the parathyroid glands.

photosensitivity

Prolongation of thiazide diuretics can provoke the development of photosensitivity reactions. When developing a photosensitivity reaction, it is recommended to pinch the drug with Co-Valsartan. If there is a need for repeated storage of diuretics, it is recommended to seize them from sleepy exchanges and UV treatment.

ruinous

There is a slight precariousness in patients with hypersensitivity to the other antagonists of angiotensin II receptors. Hypersensitivity reactions to hydrochlorothiazide are the most widespread in patients with allergic or asthma.

Gostra zakritokutova glaucoma

Hydrochlorothiazide, being an absent sulfonamide, can lead to an idiosyncratic reaction in patients with state of the art transient and severe glaucoma. Symptoms of cichliks include an unsuitable decrease in gorodism, or beating in the eyes, as they occur for a long time from decile years to deciduous tendencies when a cob is consumed by the drug. With the onset of the gostril disease, zakrytokutovaya glaucoma can lead to a loss.

When these symptoms appear in taking the drug, it is necessary to pinch. As the internal grip becomes uncontrollable, it can be known not to be conservative or surgical. Prior to factors in the development of severe glaucoma, there may be reports of allergy to sulfonamides or penicilin in history.

Subway blockade of RAAS

Hypotensiveness, obscurity, insult, hypercalcemia and deterioration of the function of nirok (including the gostra nirkova deficiency) were indicated in individuals with a sensitivity to sensitivity, especially when combined with a combination of many It is not recommended to block the RAAS in case of a linkage with cymosis in case of one-hour detection of aliskiren with angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists (including with valsartan).

Prototypically shown to be immediately consumed by the drug Co-Valsartan with aliskirene in patients with diabetic diabetics or a deficiency of the secondary / important stage (GFR<60 мл/мин/1.73 м 2).

Inflow to the building of keruvati by transport means and mechanisms

The appraisal of the Co-Valsartan preparation for the health of the keruvati was not carried out by car and machinery with mechanisms. In case of keruvanny by motor transport, or robots with mechanisms, it is possible to get rid of it because of weakness.

Overdose

symptoms: overdosing with valsartan can cause hypotension, yak, in its own right, can lead to loss of symptoms, circulatory collapse and / or shock. In case of an overdose of hydrochlorothiazide, there is a potential development of boredom, drowsiness, hypovolemia, impairment of the balance of electrolytes, which leads to cardiac arrhythmias and muscle spasms.

lykuvannya: therapeutic come to lie down due to the age of the overdose dose, as well as the type of the severity of the symptoms, with a first visit to stabilize the heart-vascular system. In case of an overdose in the fallowness every hour, if you have gone to the taken preparation, please go in and turn on the stimulation of the blues, the slurry was poured and / or the sign of the active worm. In case of hypotension when the patient is in a horizontal position, it is not easy to prevent the water-salt balance from being restored by introducing an ultra-tonic salt solution. Valsartan is not vivod for additional hemodialysis through the microscope connection with blood plasmas, however, for the administration of the organism to hydrochlorothiazide hemodialysis is effective.

lykarska vzaєmodiya

Valsartan / hydrochlorothiazide

lіtіy: I have seen about the werewolf the increase in the concentration of lithium and the increased toxicity in the case of a one-hour stagnation with ACE inhibitors and thiazidnymiduretics. Prior to one-hour consumption of valsartan and preparations in the course of a period of intercourse, it is not recommended to combine these preparations. If a one-hour reception of a given preparation is necessary, it is recommended to carry out a retinal control of the synovial concentration of the lithium.

Іnshі antihypertensive drugs: Co-Valsartan can be used for other antihypertensive drugs (guanethidine, methyldopa, vasodilators, angibitorium ACE, beta-adrenoblockers, blockers of calcium channels).

Sympathomimetics (adrenaline, norepinephrine): the possibility of a weakening of therapeutic indications for sympathomimetics.

Refinery, incl. selective ingibitori COX-2, acetylsalicylic acid (more than 3 g / dobut) and іnshі non-selective refineries: with an one-hour sign of a weakening of antihypertensive activity, as well as an increase in the risk of a decrease in the function of low blood pressure and an increase in plasma concentration of calories. If there is a need for such a combination, it will be necessary to ensure adequate hydration of patients and control of the function of the ear.

Vzaєmodia, which is a winy with a drug with some active components, can be winy and a winy with a drug.

valsartan

Subsidiary blockade of RAAS by angiotensin II receptor antagonists, ACE inhibitors or aliskiren: Following the protection of the antagonism of receptors in angiotensin II, including valsartan, one hour with other drugs, but blocking the RAAS - tobto with the angiotensin II angiotensin, or with aliskiren.

The prototype has been shown that the antagonism of receptors in angiotensin II, including valsartan, or angiotensin II angiotensin antagonists, or angiotensin II angiotensin antagonists, or angiotensin II angiotensin antagonists, or angiotensin II angiotensin antagonists with aliskiren in patients with diabetic diabetics, or a lack of secondary<60 мл/мин/1.73 м 2).

Calcium-containing diuretics, preparations of calories and substitutes for salts, for revealing calories: as soon as valsartan is immediately consumed with the drug, which is infused into the concentration of calories in the blood, it is recognized as necessary, it is recommended to control the concentration of calories in the blood.

Transporters for transporters: In vitro data show that valsartan is a substrate for transporter proteins OATP1B1 / OATP1B3 and MRP2. Immediate storage of the transporter bins OATP1B1 / OATP1B3 (rifampin, cyclosporin) or the efflux transporter protein MRP2 (ritonavir) can reduce the systemic expression. Especially zapobizhni come in guilty to live on the cob, or in the school of social therapy with meanings of likars.

іnshі: classically significant interactions with such drugs as cimetidine, warfarin, furosemide, digoxin, atenolol, indomethacin, hydrochlorothiazide, amlodipin and glibenclamid have not been detected.

Hydrochlorothiazide

Preparations that are injected into the concentration of calories in the blood: hypokaline effect of a diuretic can be observed in case of one-hour intake of other kaliyuretichesky diuretics, corticosteroids, persistent, ACTH, amphotericin B, carbenoxolone, peniciline G, salicylic acid;

Preparations for wicking heart arrhythmias: through the development of the hypocalypse, followed by the prevention of care when the drug is consumed for one hour, then the heart arrhythmias of the type "fever" (torsade de pointes), such as antiarrhythmic in the class IA and III, are antiarrhythmic.

Preparations that are injected into the concentration of sodium in the blood: hyponatric effect of diuretics can occur with an one-hour stagnation with deyakim lykarskiy diseases, such as antidepressant, antipsychotic and antiepileptic diseases. It is recommended to take care of the triviality in case of trivial zasosuvanny tsikh lykarskih zasobіv.

Heart glucoside: hypocalypse and hypomagnesemia, onset of thiazide diuretics, development of heart arrhythmias in case of cardiac glucosides.

Calcium salt and vitamin D: Stagnation of hydrochlorothiazide, including hydrochlorothiazide, with vitamin D, or calcium salts, can lead to an increase in the concentration of calcium in the development of hypercalcic urolithiasis

Protidiabetic patients (oral hypoglycemic patients and insulin): thiazide diuretics can cause tolerance to glucose. With the intake of thiazide diuretics, there may be a need for a regulated dose of anti-diabetic patients. If you start to take care when you are stuck with metformin, then you can develop lactic acidosis as a result of the development of a functional deficiency in the presence of hydrochlorothiazide.

Beta-blockers and diazoxide: overnight storage of thiazide diuretics, incl. hydrochlorothiazide, with beta-blockers, you can improve hyperglycemia. Thiazide can cause hyperglycemic effect of diazoxide.

Likarski for gout treatment (probenecid, sulfinpyrazone and alopurinol): There may be a need for a regulated dosage of drugs for the treatment of gout through the adjustment of the syvate concentration of sech acid and in the presence of hydrochlorothiazide. If necessary, take a dose of probenecid or sulfinpyrazone. One hour consumption of thiazide diuretics, including hydrochlorothiazide, can increase the frequency of development of hypersensitivity reactions to alopurinol.

Antiholinergichnі zasobi and іnshi lіkarski zasobi, which inject on the motility of the slunk-intestinal tract: anticholinergic diseases (atropin, biperiden) may increase the availability of thiazide diuretics, obviously, due to the decrease in the motility of the intestinal tract and the decrease in the reduction of the fluid loss. Prokinetics, such as cisapride, navpaki, can change the bioavailability of thiazide diuretics.

amantadine: thiazide diuretics can improve the development of non-essential effects of amantadine.

Ion exchange resins: When hydrochlorothiazide is moistened, it will burn in the presence of colestiramine and colestipol. It is recommended to take hydrochlorothiazide 4 years before or after 4-6 years after receiving ion exchange resins.

Cytotoxic effects: hydrochlorothiazide can reduce the level of cytotoxic drugs (cyclophosphamide, methotrexate) and the potential for microsuppressive effects.

Non-depolarizing muscle relaxant (tubocurarine): hydrochlorothiazid according to curare.

cyclosporine: with a one-hour consumption of cyclosporine, the development of hyperuricemia and an accelerated type of gout develop.

Ethanol, barbіturati and narcotic drugs: The connection of thiazide diuretics with the help of spines, which will help to increase the hypotensive effect, can increase the development of orthostatic hypotension.

methyldopa: I have seen about the development of hemolytic anemia on the basis of an hourly intake of hydrochlorothiazide and methyldopi.

Contacts for beast

ACADEMFARM State enterprise, representative office, (Republic of Bilorus)

• 14 - blister (2) - packs of cardboard. 14 - blister (6) - packs of cardboard. 28 tabs per pack 28 tabs per pack tab., Pokr. plivkovyu sheath, 80 mg :, 30 tabs Tablets, in plivkovyu sheaths 160 mg, 30 tablets per pack. pack of 84 tablets

Description of licarsky form

• Tablets, in the plunge shell of the erysipelas colora, round, double-shaped, two balls are visible on the evil - the nucleus of the white or even white colora and the pluvka shell of the tablet, in the plavkovaya shell of the double-erysipelas, one side, one side ; two balls are visible on the evil - the nucleus of the white or even the white colora і plіvkovy shell Tablets, in the plavkovy shell of the Tablets, in the velvety shell of the orange-brown colora, dovgasti, dyadopucle; on the evil of a white color with an orange-brown edge. Tablets, vkriti plavkovyu shell of erysipelas, dovgasti, dvukopukli; on the evil of the white color with the horny edge.

Pharmacological diya

Pharmacokinetics

Special mind

warehouse

• 1 tab. valsartan 160 mg hydrochlorothiazide 12.5 mg; additional words: lactose monohydrate - 100.5 mg, croscarmellose sodium - 21 mg, silicon dioxide coloidal anhydrous - 2.25 mg, magnesium stearate - 3.75 mg. 1 tab. valsartan 80 mg hydrochlorothiazide 12.5 mg; additional words: lactose monohydrate - 44 mg, croscarmellose sodium - 10.5 mg, silicon dioxide coloidal anhydrous - 1.125 mg, magnesium stearate - 1.875 mg. valsartan 160 mg; additional words: microcrystalline cellulose 90.2 mg, croscarmellose sodium 5.5 mg, coloidal silicon dioxide 2.7 mg, magnesium stearate 1.6 mg. Warehouse of plive shell: Opadrai Rozheviy 6 mg, including Polyvinyl alcohol 2.4 mg, macrogol-3350 - 1.463 mg, barvnik zaliza chervonium oxide - 0.024 mg, barvnik zaliza zhovtiy oxide - 0.013 mg, talc 0.888 mg, titanium dioxide 1.2 ... valsartan 160 mg; additional words: salting (sum of cellulose microcrystalline 98% and silica coloidal dioxide 2%) - 67 mg, sorbitol - 18.5 mg, destab magnesium carbonate 90 (sum of magnesium carbonate 90%, crumb 1% pregelatin) corn starch with pregelatinization - 6 mg, povidone K25 - 15 mg, sodium stearyl fumarate - 8 mg, sodium lauryl sulfate - 2 mg, crospovidone (type A) - 26 mg, silica coloide anhydrous dioxide - 4 mg. Warehouse of plush shell: opadray® OY-L-28900 (sum of lactose monohydrate 36%, hypromelozy 2910 - 28%, titanium dioxide 26% and macrogol 10%) - 6 mg, barvnik zaliza zhovtiy oxide - 0.4 mg, barvnik zaliza oxide brown - 0.1 mg. Valsartan 160mg; Additional substances: MCC, silica coloidal dioxide, sorbitol, corn starch, povidone, sodium stearyl fumarate, sodium lauryl sulfate valsartan 80 mg; additional words: microcrystalline cellulose 90.2 mg, croscarmellose sodium 5.5 mg, coloidal silicon dioxide 2.7 mg, magnesium stearate 1.6 mg. Warehouse of plive shell: Opadrai Rozheviy 6 mg, including Polyvinyl alcohol 2.4 mg, macrogol-3350 - 1.463 mg, barvnik zaliza chervonium oxide - 0.024 mg, barvnik zaliza zhovtiy oxide - 0.013 mg, talc 0.888 mg, titanium dioxide 1.2 ... Valsartan 80mg; Additional substances: MCC, silicon dioxide coloide, sorbitol, corn starch, povidone, sodium stearyl fumarate, sodium lauryl sulfate

Valsartan is shown before being sucked

• - arterial hypertension; - Chronic heart failure (II-IV functional class for NYHA classification) in ailments who accept standard therapy, incl. diuretics, heart glucosides, as well as ACE inhibitors or beta-blockers (not overnight) (the intake of skin drugs with reinsured drugs is not obligatory); - for the improvement of the visibility of patients with a state of myocardial infarction and for a period of a postponed myocardial infarction, an accelerated defect due to an abnormal or systolic dysfunction in the presence of stable symptoms

valsartan contraindicated

• - severe damage to the function of the liver, bilious cirrhosis and cholestasis; - up to 18 rockets; - availability; - period of lactation (breastfeeding); - lactose intolerance, lactase deficiency or a syndrome, glucose-galactose malabsorption; - sensitivity to the components of the preparation has been adjusted. With protection: with bilateral stenosis of nirkovy arteries; stenosis of the artery of a single nirka; when children are old enough to eat kitchen salt; when camps, supravodzhuyutsya decrease in the volume of circulating blood (including diarrhea and bloating); in ailments with a nirkovy lack of a difficult step (KK

valsartan dosage

• 160 mg 160 mg + 12.5 mg 80 mg 80 mg + 12.5 mg

Valsartan pobichnі dії

• The values ​​of the lower side effects of the guidance in the case of the upcoming gradations of the frequencies, up to the classification of the all-round organization of health protection: even more often (? 1/10); often (? 1/100,

  lykarska vzaєmodiya

  Zagalnі lіkarskі vzaєmodії for valsartan i gіdrohlortіazidu Lіkarskі zasobi, spіlnogo zastosuvannya of yakimi slіd Unikat preparations lіtіyu When odnochasnomu zastosuvannі preparatіv lіtіyu of іngіbіtorami ACE ARA II i tіazidіv Povіdomlyalosya about timchasove pіdvischennya vmіstu lіtіyu in sirovattsі krovі i pov'yazane of CIM posilennya proyavіv toxicity. The risk of toxic manifestations, associated with drug intake in lithium, can be reduced for a period of time in case of a one-hour consumption with a drug oskilki nyrcovial clearence of the drug in lithuania, decrease in the duration of the disease. At the connection with the cym, it is recommended to carry out retaliatory control in the place of lithium in syrovattsi blood. Likarski zasobi, dormitory for the need for care Hypotensive drugs You can manage the antihypertensive effect in case of alcohol consumption with dysfunction. reduce arterial vise (ingibitori ACE, beta-adrenoblockers, blockers of large calcium channels, guanethidine, methyldopa, vasodilators, direct ingibitori reninu, ARA II). Fresh aminos Potentially weakened by fresh aminous (norepinephrine, adrenaline), as it does not require a spillover. Non-steroidal anti-pyretic drugs (NPZP), including selective anti-inflammatory cyclooxygenase-2 (COX-2) The problem of hypovolemia can lead to the development of a hostile deficiency. Likarski vzaєmodії for valsartan lіkarski zasobi, spіlnіpіnіkіvіtіvіnіyu vіkіmi uniqueness, Immediately congestion of antagonists of receptors in angiotensin II withіnіy drugs, which is injected on RAAS, It is necessary to control the indicators of arterial pressure, the function of nirok, as well as the change of electrolytes by blood plasma when the drug is prescribed with other drugs, which is injected onto the RAAS. Immediate consumption of kalyzberіgayuchih diuretics, biologically active additives, scho to revenge kalіy; kaliyvmіsnykh deputy soli; of the largest lykarskih problems, who move instead of calories in syrovat blood (for example, heparin), in order to avoid foreign visits (including frequent visits instead of calories in syrovattsi blood). Non-steroidal anti-pyretic drugs (NPZP) When valsartan is consumed, one hour with non-steroidal anti-pyretic drugs (including selective inhibitors COX-2), it is possible to change the antihypertensive action. Suddenly, the ARA II і NPZP, especially in patients with impaired functions of nirok and / or hypovolemia (including on the basis of diuretic therapy), can lead to the development of hospitality nirkova disadvantages. If there is a need for a special consumption of valsartan and oil refineries, before the cob of treatment, it is necessary to assess the function of water and electrolyte deterioration. Bilki-carriers According to the results of in vitro follow-up on liver cultures, valsartan is a substrate for bile carriers OATP1B1 and MRP2. Immediate detection of valsartan with the inhibitors of the transporter OATP1B1 (rifampicin, cyclosporin) and with the inhibitor of the transporter MRP2 (ritonavir) can reduce the systemic expression of valsartan AUC (Cmax). Visibility of lyceum interaction Not seen as clinically significant interaction with valsartan monotherapy on the background of onset drugs: cimetidine, warfarin, furosemid, digolorticin, atenolamide Likarski vzaєmodії for hydrochlorothiazide Litiy With an one-hour stagnation with ACE inhibitors and diuretics, it was caused by changes in the circulating plasma concentration lithium and the third toxic day. The administration of one-hour administration of hydrochlorothiazide with valsartan and lithium preparations was not carried out. However, in case of a one-hour intake of hydrochlorothiazide and drugs, it is recommended to control the concentration of lithium in the blood. Інші hypotensive drugs, diuretics, antihypertensive effect of antihypertensive drugs; Curative muscle relaxants Tiazidi, including hydrochlorothiazide, potential for non-depolarizing muscle relaxants. Lіkarskі preparations scho vplivayut on vmіst kalіyu in krovі Rizik gіpokalієmії, sprichinenoї dіuretikami, Mauger posilyuvatisya at odnochasnomu zastosuvannі glyukokortikosteroїdіv (GCS), adrenocorticotropic hormone (ACTH), amphotericin, carbenoxolone, penіtsilіnu, atsetilsalіtsilovoї acid abo її pohіdnih i antiaritmіchnih preparatіv. Lykarsky drugs, which are injected into the place of sodium in the blood Hyponatremic effect, viklicaniy with diuretics, can be used with an one-hour consumption of antidepressants, antipsychotic, protisudominal drugs, etc. Slide after preservation with trivial alcohol intake of hydrochlorothiazide at the same time with vishchevkazanny drugs. Hypoglycemic diuretics can change tolerance to glucose, in conjunction with which there may be a need for regulated doses of insulin and hypoglycemic substances for receiving in the middle. Heart glucosides Hypokalemia and hypomagnesemia (non-essential efficacy of thiazide diuretics) can cause heart rhythm disturbances in patients who recognize the heart of glucosides. Oil refinery plant One hour oil refinery plant filling and hydrochlorothiazide can lead to a decrease in diuretic and antihypertensive effects of the rest. The problem of hypovolemia can provoke the development of a hostile deficiency. N і m-cholinoblokatory N і m-cholinoblokatory (including atropin, biperiden) can increase the availability of hydrochlorothiazide, which is associated with the reduction of peristalsis of the intestinal tract and the intestinal tract Apparently, motility stimulants of the intestinal tract (cisapride) can reduce the bioavailability of hydrochlorothiazide. Anion exchange of resin When wet with hydrochlorothiazide is destroyed in the presence of colestiramine and colestipol. Hydrochlorothiazide should be taken either 4 years before or after 4-6 years after receiving an acceptable amount of time. Vitamin D and calcium salts One hour intake of hydrochlorothiazide with vitamin D or calcium preparations can lead to hypercalcium. Cyclosporine With a one-hour consumption of hydrochlorothiazide and cyclosporine, the development of hyperuricemia and hypertension of gout is increased. Methyldopa Occasionally developed hemolytic anemia with a one-hour sign of hydrochlorothiazide and methyldopi. Fresh aminium Hydrochlorothiazide can reduce the organism's response to the introduction of fresh aminiv (norepinephrine). The clever meaning of the relationship is insignificant; Інші types of interaction One hour consumption of thiazide diuretics, including hydrochlorothiazides, can lead to an increase in the frequency of hypersensitivity reactions to alopurinol: an increase in the risk of antihypertensive disorders; Potential for the hyperglycemic effect of diazoxide, lead to a change in the administration of drugs with cytotoxic drugs (for example, cyclophosphamide, methotrexate), the potential for microsuppressive drugs. Ethanol, barbiturates and narcotic drugs The consumption of hydrochlorothiazide can lead to the development of orthostatic hypotension.

Pharmacological diya

Antihypertensive zasib. Є specific antagonist of angiotensin II receptors. The most vibrant antagonistic action on the AT 1 receptor, as the result of the implementation of the effects of angiotensin II.

During the blockade of AT 1 receptors, the plasma concentration of angiotensin II increases, which can stimulate the unblocked AT 2 receptor. Not volodya agonistic activity of AT 1 receptors. The ratio of valsartan to AT 1 receptors is approximately 20,000 times in food, down to AT 2 receptors.

Chi will not drive ACE. Chi does not interfere with and does not block the receptor of other hormones, or even channels, which may be more important for the regulation of the functions of the heart-vascular system. Do not infuse the level of zagalny cholesterol, triglycerides, glucose and secular acid into the blood plasma.

An ear of antihypertensive action of valsartan when consumed in a single dose in a single dose is promoted to last for 2 years after receiving, the maximum effect is reached for 4-6 years.

Pharmacokinetics

When valsartan is taken in the middle, it is rapidly absorbed from the intestinal tract, the feet are characterized by individual symptoms. The absolute availability in the middle becomes 23%. The pharmacokinetic curve of valsartan has a multiexponential character (T 1/2 in α-phase< 1 ч и T 1/2 в β-фазе - около 9 ч), кинетика линейная.

With the exchange rate change, pharmacokinetic parameters were not recognized.

With the intake of valsartan from the young, the AUC decreases by 48%, with approximately 8 years later, the intake of the concentration of valsartan in the plasma is the same in the patients who took it in the heart. The change in AUC does not supervise clinically significant changes in the therapeutic effect.

When taking valsartan 1 time / day, the cumulation is not significant. Concentration of valsartan in blood plasma of women and choloviks of boules is the same.

The linkage with blood plasmas, especially with albumin, becomes 94-97%. V d in an equally important stand to become close to 17 liters.

Plasma cleansing for valsartan in the warehouse is close to 2 l / h. Vivoditsya with feces - 70% and from the cross-section - 30%, which is important in an uninterrupted viglyad.

In case of bilious cirrhosis or obstruction of the galls of the AUC, valsartan is reduced by about 2 times.

showing

Likuvannya arterial hypertension.

Treatment of chronic heart failure (II-IV functional class for NYHA classification) in patients who accept traditional therapy with diuretics, digitalis drugs, and also with ACP adrenergic blockers and beta-blockers.

dosage regimen

Take vseredin in a dose of 80 mg 1 time / day or 40 mg 2 times / dob, every day. If there is an adequate effect, the dose can be increased step by step.

Dobov dose is maximal become 320 mg in 2 priyomi.

Pobichna diya

On the side of the heart-vascular system: arterial hypotension, postural hypothermia, postural hypotension.

On the side of the central nervous system: zapamorochennya, head b_l.

On the side of the herbal system: diarrhea, nudota, adjustment of the level to bilirubin.

On the side of the secular system: Ridko - the deterioration of the function of nirok, the adjustment of the level of creatine and nitrogen of the sechovine (especially with chronic heart failure).

On the side of the exchange of words: hyperkalієmiya.

On the side of the hematopoietic system: neutropenia, decrease in hemoglobin and hematocrit.

Allergic reactions: Ridko - angioneurotic nagryak, visip, sverbіzh, syrovatkov's fever, vasculitis.

Інші: stomachache, lateral weakness, cough, pharyngitis, increased risk of development of viral infections.

Prototype

Sensitivity, sensitivity is adjusted to valsartan.

Stagnation during vaginosis and breastfeeding

Valsartan is contraindicated until it is consumed with vaginosis.

It is impossible to see valsartan in breast milk in humans. Prolongation during the period of lactation (breastfeeding) is not recommended.

V experimental studies it is shown that valsartan is seen in breast milk in shchuriv.

Zasosuvannya in children

lykarska vzaєmodiya

With a one-hour consumption of diuretics in high doses, the development of arterial hypotension is strong.

With a one-hour consumption of high-calorie-containing diuretics, heparin, biologically active additives, or substitution of salts, it is possible to waste calories, high-potency development of hypercritical substances.

With a one-hour consumption of endometacin, the antihypertensive effect of valsartan can be changed.

With a one-hour consumption of carbonate, the descriptions of the development of the toxicity of the lithium are described.

Zasosuvannya in case of destructive functions of nirok

In addition to the ingibuvannya system of renin in sickly patients, it is possible to change the function of nirok.

special requests

With hyponatriasis and / or a decrease in the amount of circulating blood, as well as during the therapy with high doses of diuretics in rare valsartan drops, hypotension can be affected. Before the cob of drinking, it is necessary to carry out a correction of the water-salt exchange.

In patients with renovascular hypertension, who developed suddenly as a result of stenosis of the nirkovo artery, during the period of their development they regularly monitored the level of serum and creatine in syrovatics. Dani about the safety of the provision of patients with CC less than 10 ml / min per day.

With a special protection you will be stuck with the children with the ruined prodigality of the female nobles.

In addition to the ingibuvannya system of renin in sickly patients, it is possible to change the function of nirok. In case of stagnation of angiotensin ACE and antagonism of angiotensin receptors in patients with chronic heart deficiency, severe overwhelming spontaneous oliguria and / or an increase in the development of the disease

Safety and efficiency of valsartan consumption in children has not been established.

Inflow to the building of keruvati by transport means and mechanisms

Valsartan is a drug that reduces the arterial vise (tobto pills to viroblyayut antihypertensive effect). The class of hypertensive medications includes non-lactic drugs, including valsartan itself, which is the most advanced: it is readily available from published honey. statistics, the evidence base for the drug includes over 140 thousand patients.

Valsartan buv by himself sold lekami from a high vise in the period from 2008 to 2010 rock. Sales statistics are not only for the Russian Federation, but for the whole world. One of the reasons for the popularity of the drug is the low price of valsartan.

The dosage is based on the effectiveness of the drug. The middle one is recommended - valsartan 80 mg per dose at a time, or 40 mg dvichі per day. Even the result is not spared, the dose is gradually increased. Extreme boundary - 320 mg / dobu, rozbitі for 2 priyomi.

If you want to check it out:

• Efect will be nastane in 2 years after that moment, when you took the drug;
• I'll do it for a few days;
• Stabilize AT after 3 months after a cob to the rate of improvement;
• The maximum efficiency is promoted after 4 months after a cob course.

When taken, the tablets should be poured out, but not rozzhovuvati. It is necessary to wash it down with a great amount of water.

Provided terms are clear, more accurate forecasts are needed, and specific tributes are needed.

On someone, valsartan should be given a greater strength (this means that it is necessary to lower it), on someone it should be weaker (in the whole dose of the dose you will get an extra dose, if you want to reach the effect yourself.

In case of implicitly varying efficacy of the drug, it is necessary to give a higher dose (it is indicated) or to add diuretics to the course of treatment (in case of vikorstanny it is necessary to constantly be careful with the doctor and the test is often given).

Valsartan: showing up to sucking

Likki valsartan is indicated in case of heart failure and chronic low arterial vise (dal - AT). The drug can be vicoristovuvati for myocardial infarction.

In his group (Sartan) there are only one pill, which cannot be negatively inserted into the body and life of the body during an infarction.

Tablets valsartan vicoristoyut ti, who drank foxglove, beta-blockers or ingibitori.

Form vipusku

Valsartan is dispensed in tablets of 40, 80 and 160 mg. Rizna is not only the price of packages, but the first filling for the preparation:

• At 40 mg in the amount of additional storage facilities, croscaramellose sodium, cellulose of the microcrystalline type, magnesium stearate and barvnik (wine nonshkidliviy) are produced;
• Valsartan 80 і 160 includes up to the warehouse, except for the rewind, another additional element - aerosil.

Tablets are not the only form of release. Valsartan in granules, powders and capsules is available in the pharmacy. The drug is on sale only for a prescription, if you want to change it through an Internet pharmacy.

Zberіgaєtsya zіb 3 rocky. Writing the end of the term of prescription, it is categorically impossible to accept it.

Self-determination of a liking (self-abuse) can lead to unsuitable results - from a failure to recognize any positive effect before it can be considered a fatal result.

Prototype

Prototype is shown to valsartan minimum. The head emphasis is to be afraid of sensitivity (allergy) to the components of the taste and the manifestation of the vagueness (+ period of lactation).

Inadvertently, valsartan is infused into a child's body, so it is not recommended to use it for up to 18 years, if the drug in small doses may be indicative. The effectiveness of the implantation of the drug in children has not been established either, so there is no reason to be sensitive to those who are not healthy for a child's body. The cordon is 18 years old.

If you take care of the liquids carefully?

Chi is not є contraindicated for valsartan, ale vimagayut reticently caution of the lykar of the onset of ill health / vidhilennya:

• Deficiency of sodium in the blood;
• Decrease in blood circulation rate;
• Be-like the ruin of the nirk arteries;
• Dysfunction (dysfunction from norms) nirok;
• Insufficiently effective oven robot;
• Problems with zhovchivіdnymi streams;
• Cirrosis of the pink type and the stage of development.

Cooperation with інshih lіkami and products

As soon as you accept the AAS Ingibitories, be ready before the next day or so.

And with vikorystanny іngіbіtorіv type of ACE, patients with heart-vascular lack of chronic character were not very often rejected by GOST Nirkov lack, dysfunction of nirok and alteration of the permissible level of nitrogen in the blood. In the end, it rarely led to unsatisfactory conditions, including a lethal result.

availability

The drug valsartan is not susceptible to vaginitis. Before one hour of bathing, breastfeed only in extreme drops.

Clinical viprobuvannya did not bring the fact of seeing valsartan at once with breast milk, but they did it experimentally until they saw the drug at once with milk (if they wanted to put it on bee-eaters, but they didn’t want to see it for a year)

Vicious Effects

Beast to respect: side effects with valsartan manifest themselves rarely. Call the course of treatment not to get a headache.

In the main negativnye efekti viklikanі nedotrimannym graphy accept tablets (or іншої form vipusku), which signifies a drug, or reassignment dosuvannya.

One side effect is manifested when valsartan is used with other leaks without prior use of a drug.

How fast can you check?

• After lowering the grip;
• Reducing the grip when trying to get up;
• Permanently dirty;
• Zamorochennya when changing the position of the body (stand up, turn over, etc.);
• nudota;
• diarrhea;
• Visokiy rivn bilirubinu;
• A high level of nitrogen and creatine (especially with heart failure);
• Destruction of the function of nirok (ridko);
• Peresichennya kalієm;
• Low level of hematocrit and / or hemoglobin;
• Neutropenic fever (lack of neutrophils in the blood);
• Vasculitis (ridko);
• Visip i / abo sverbіzh (rіdko);
• Syrovatkova ailment (ridko);
• Nabryak Kvinke (ridko);
• cough;
• Shvidka vtomlyuvanstvo;
• pharyngitis;
• Significant weakness;
• Decrease in immunity (as inheritance - adduction of the risk of health problems in infection).

Decrease in AT varto ochіkuvati in one of 3 vipadkіv:

1. Overpopulated organism by natrієm;
2. Perebir with diuretics, which can be stored in a warehouse with sodium;
3. Zboi in blood circulation (change to the flow).

A decrease in AT in qih vipadkah can be easily rotated. The first help in the given situation is the correction of water-salt exchange.

If the hypertension of the disease is damaged by robots (so that the renovascular hypertension), then we will take care of it: it is necessary to take care of creatine and sevine levels. Yaksho nirkova function (CC) is less, less than 10 ml / hv, more vidrimatisya vidyattya valsartan. Tse is tied from the days of the day about the ailments, as they lived on when the filthy robot nirok got used to it. You will need to protect the walls from those who have the trouble of keeping the flow of women.

To the waters and to the people who can help me with the development of mechanisms, before an hour the course is going to take a step towards the main activity, some of the drug can be reduced to respect, the memory can be reduced, and injected into the visibility of your reaction.

Overdose

Dignity of honor, for overdosing with valsartan, all day long.

Imovirno, the effect of being overpopulated with the drug will be offensive:

• Stronger to lower the grip;
• Zapamorochennya when trying to get up.

Persha dopoga in tsyom vipadku:

• Lead the sick person in a horizontal position;
• Introduce a patient salt solution, and update the required balance.

Valsartan does not come from the body by a natural path (tobto slaughter, feces, pit, etc.), the splinters of it are called to the bottles. Tom should be called in for an overdose.

Also, in case of overdose, a change in the heart rhythm can be promoted - tachycardia or bradycardia. If given, additional help is needed for a sick person, symptoms, valsartan fragments, as it is already meant, the body does not vivodit.

Likuvannya valsartan in combination with other drugs

In case of a history of infarction, at once with valsartan, it is necessary to prescribe captopril (it is possible to reduce the risk of rapid heart disease, as it can be caused by an infarction).

Often valsartan vikoristovuyut in zyaztsi with amlodipinu (the active component), which is avenged in such drugs, yak vamloset, Exforzh.

In a complex of liki ide todi, if a sick person has a diagnosis of heart failure in a chronic form. With an advanced arterial vise and post-infarction stage, valsartan will start to take root as an independent drug.

Price for valsartan in pharmacies

You can buy valsartan at the pharmacy. Prices vary from country to region, if it is possible to set the middle between the drugs:

• Valsartan 40 mg (tablets) - about 130 rubles;
• Valsartan 80 mg (tablets) - 220 rubles;
• Packing of 160 mg - in the region of 350 rubles.

valsartan analogs

Nayblich analogs - valsacor, valsatran Valz, valsatran Zeniva, valsatran sandoz (plus), sandoz, valsartan n, dovan, valsartan plus, valsartan nan and іnshі. The drugs are considered to be stock (both in the sense of the word, and in the general sense).

According to the level of salesability and the characteristic of analogs of valsartan, the most popular navs (for the index of Vishkovsky):

1. Valsakor;
2. Dovan.

It is not possible to change the liquor on its own, some of the preparation can be used for mothers without the need for the original valsartan.