Mіldronat (solution for ін'кцій): instructions іf storage. Lykarsky drug Mildronate; Instructions from storage, shown before the injections of Mildronate internally.

Instructions for storing:

Mіldronat - synthetic drug, Scho polypsy energy safety and tissue metabolism

Pharmacological diya

Dіyucha speech Міldronatu will reduce metabolism, spraying accumulated toxins from the clitin, I will tone up the infusion and preservation of clitini from the urge.

As a result of storing Mildronate, the growth of the building of the window is growing and it is quickly seen for them. For the administration of the drug to the authorities, the drug is used for the improvement of blood supply to the brain and for the treatment of destructive problems. heart-vascular system, As well as the promotion of proceedings.

In case of heart failure, Mildronate for instructing the speed of the myocardium, lowering the frequency of attacks of angina pectoris, increasing with a wide tolerance to physical changes.

In case of ischemic cerebral blood circulation disorders Mildronate is used to increase blood circulation in the middle of ischemia, when blood is overgrown.

Also, Mildronate is effective in case of damage to the nervous system in case of abstinence syndrome and in case of pathology of the day-to-day bottom.

Vipusku form

Mіldronat vipuskayut at viglyadі:

Barless prozorogo razchin, in 1 ml of the drug 100 mg diyuchy speech- meldoniy. In ampoules of 5 ml;
Lots of gelatin capsules, which can be used in a crystal powder with a faint odor. For 250 or 500 mg of diyuchy speech in capsules, 10 pieces in blister.

Shown before storing Mіldronatu

Mіldronate indications prior to consumption in complex therapy:

With ischemic ailments of the heart, including myocardial infarction and angina pectoris, as well as with heart failure and dyshormonal cardiomyopathy;
With strokes and cerebrovascular insufficiency.

Mildronate can also be used for:

Decrease in preference;
retinopathy developmental ethology, Including diabetic and hypertonic;
Hemophthalmos and hemorrhages in the context of developmental ethology;
Physical overstrain;
Thrombosis of the central vein of the scent and of the hylok;
Abstinence syndrome in chronic alcoholism, in combination with specific therapy.

How powerful can a drug be? How much can you get involved in? Meldoniy will not be able to power the body, but it will help the cells to help the body. Establishing their own unique mechanism of development, meldonium as a preparation of another lineage, so that as a preparatory therapy to the main one, is used for the treatment of heart disease, psychosocial for the renewal of life

Prototype

It is clear from the instructions of Mildronate that there are contraindications up to 18 years in a child's life, with hypersensitivity to the drug, as well as with an increased intracranial vise, including internal cranial venous pulp.

There was no validation of dosage according to the use of Mildronate during the period of vaginosis and lactation, for which reason the drug is not recommended for use during the period.

Mіldronat zastosovuyut with protection, especially trivial, when stopping the stove or nirok.

Instructions for storing Mildronat

Dose and ways of stopping Mildronate from becoming ill:

With cardialgia, it is possible to develop on aphids of dyshormonal dystrophymyocardium Mildronate take two for 12 days, 250 mg each;
In case of heart-blistering symptoms of Mildronate indications in the warehouse of complex therapy, up to 2 times a day for 0.5-1 g.
In case of chronic damage to cerebral circulation, take 1-2 tablets of Mildronate (500 mg each) for an additional course of 4 to 6 months. Behind the wedding ceremony, you can pass a few times to the river;
In the hospital phase in case of impaired cerebral circulation, Mildronat should be administered intravenously over the instructions for 10 days, 500 mg once a day. If you want to, you can switch to taking Mildronate tablets, 0.5-1 g per doba. The initial course of therapy should be developed up to 6 types;
In case of advanced pink abnormalities, take 1 tablet of Mildronate 250 mg each, up to 4 times a day for two hours. The repeated course can be completed not earlier, not after 2 days.

Athletes are recommended to use Mildronate before training, two to 0.5-1 m per day.

In case of breakdowns, chronic alcoholism, take 4 times a day for 1 tablet of Mildronate (500 mg) for 10 days.

Mіldronate testimony until the end of the first half of the day through the possibility of developing an efficient effect.

Pobichna diya

Behind the guards, Mildronate is a low-toxic drug and not a wicked one for health side effects... Vkray rіdko mozhut vinykati:

snakes arterial vise;
tachycardia;
Dyspeptic symptoms;
Psychomotor zbudzhennya.

Likewise, Mildronate for the advice can get some allergic reactions in the eyes of the vigilante, visipu, pochvoninnya or sverbezh.

There is a trace of care after an hourly intake of antianginal and hypotensive drugs, as well as heart glycosides, and some Mildronate podsylyuє їkh diyu.

With a one-hour intake of mildronate of hypotensive drugs, nifedipin, nitroglycerin, peripheral vasodilators and alpha-adrenergic blockers, it is possible to develop tachycardia and arterial hypertension.

Mіldronate can be taken with anticoagulants and antiplatelet agents, as well as diuretic and antiarrhythmics.

It is especially important for the safety of the drug Mildronate, and it is one of the most important factors, which explains the wider knowledge of the middle and patients. Security Mildronate is confirmed from time to time to hear about security and the results of published clients.

In addition, as Latvia joined the European Union, regulatory authorities became bound by the system and pharmacological monitoring, which is believed for the caution and assessment of the consumption of medications. For monitoring (since March 21, 2006), AT "Grindeks" has received 478 spontaneous calls (occasionally) about products, which revenge meldonium. Potential significant risik for health in qih vipadkah without any statement. There wasn’t any need to worry about the development of fallowing and sounding up to the preparation of the preparation. tribute about bitter appearances But there were no reactions from the side of the athletes.

Umovi zberigannya

Mildronate is available for prescription. Termіn zberіgannya rozchinu for ін'кцій і tablets - 4 rocky.

Presented by the guides to the site - from the survivors of this tag, as well as the thoughts of the lecturers from the victorious Mildronat in their practice. There is a great way to actively give your advice about the drug: it helped or did not help the person to get sick, because it was spared the acceleration and side effects, it might not be declared by the virobnik in the abstract. Analogs of Mildronat with obvious structural analogs. Vikoristannya for the treatment of infarctions and strokes and the improvement of metabolism in tissues of older adults, children, as well as during vaginosis and breastfeeding.

Mildronate is a drug that polyps metabolism. Meldoniy (diaucha speech for the drug Mildronate) is a structural analogue of gama-butyrobetaine, speech, which is found in the skin cells of the human organism.

In the minds of the advised supply of Mildronate, the supply and demand of clients for food, assimilating the accumulation of toxic products in exchange in the cells, taking over from every day; nadaє also tonizuyuchiy infusion. As a result of the second storage, the organisms are built up, the vitamins are built up and the energy reserves are quickly renewed. The directors of the authorities, Mіldronat vikoristovuyut for the development of the destructive heart-vascular system, blood supply to the brain, as well as the development of physical and rosy proceeding.

As a result of a decrease in the concentration of carnitine, it is possible to synthesize gamma-butyrobetaine, which is volodya by vasodilating powers. With a state of ischemic posed myocardium, Mildronate relies on the establishment of a necrotic zone, shortening reabilitation period.

In case of heart failure, the drug increases the rate of myocardium, increased tolerance up to physically assigned, Reducing the frequency of angina attacks.

In case of chronic and chronic ischemic damage to the cerebral blood circulation, the circulation of blood in the middle of the ischemia is reduced, and the blood is overgrown to the corny of ischemic dilyanka.

Effective in case of forehead and dystrophic pathologies of the intramural bottom.

Usuva preparation functional breakdown nervous system, developing on the trivial alcohol intake in people with chronic alcoholism with withdrawal syndrome.

When the drug is taken vseredin, it quickly gets wet from the shlunkovo-intestinal tract. Metabolizes in organisms from the statements of two main metabolites, which are metabolized by nirkas.

in the warehouse of complex therapy for ischemic heart ailments (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy;
in the warehouse of complex therapy of hospitals and chronic damage to cerebral blood circulation (insult and cerebrovascular insufficiency);
reduced coverage;
physical overstrain (including in athletes);
withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism);
hemophthalmus, hemorrhaging in the bloodstream of the developmental etiology;
thrombosis of the central vein of the bloodstream and hylok;
retinopathy of the developmental etiology (diabetic, hypertensive).

Capsules 250 mg і 500 mg

Rozchin for internal, internal and parabulbar and injections (injections in ampoules).

Instructions for suction and dosage regimen

In connection with the mobility of the development of an efficient effect, the preparation is recommended to be taken in the first half of the day.

In case of heart disease in the warehouse of complex therapy, the drug should be used in a dose of 0.5-1 g per dose, the frequency is 1-2. The course of treatment is weeks.

In case of cardialgia on aphids of dyshormonal dystrophymyocardium, Mildronate should be administered in a dose of 250 mg 2 times per dose. Lykuvannya course - 12 days.

In case of impaired cerebral blood flow in the GOST phase, the drug should be used internally (in the case of the general drug form - 500 mg 1 time per supplement for 10 days), then switch to the intravenous drug intake, 0.5-1 g per supplement. A home course of therapy weeks.

In case of chronic damage to cerebral blood circulation, the drug should be taken in 0.5-1 g per dose. A home course of therapy weeks. Repeated courses are assigned individually 2-3 times per day.

With pink and physical navanazhennyah priznachayut in the middle of 250 mg 4 times for dob. The course of treatment. If necessary, the therapy should be repeated in 2-3 days.

For chronic alcoholism, the drug is prescribed in a dose of 500 mg 4 times per dose. The course of treatment.

In case of heart disease in the warehouse of complex therapy, the drug should be prescribed in a dose of 0.5-1 g per dobut internally (5-10 ml in a dosage for those with a concentration of 500 mg / 5 ml), the dosage rate is 1-2 times for dobu. The course of treatment is weeks.

In case of impaired cerebral blood flow in the GOSTR phase, the drug should be administered intravenously, 500 mg 1 time, for 10 days, then switch to an internal drug (in the case of the new drug form - 0.5-1 g for dobu). A home course of therapy weeks.

In case of forensic pathology and dystrophic sagging, Mildronate should be injected parabulbarically at 0.5 ml razor for іn'ktsіy with a concentration of 500 mg / 5 ml for 10 days.

In case of pink and physical navanazhennyah priznachayut intravenous in a dose of 500 mg 1 time per add. The course of treatment. If necessary, the therapy should be repeated in 2-3 days.

For chronic alcoholism, the drug should be administered intravenously, 500 mg 2 times per dose. The course of treatment.

tachycardia;
change of arterial grip;
psychomotor zbujennya;
head b_l;
dyspeptic symptoms;
allergic reactions (pochvoninnya shkiri, visipannya abo visip, itchy skin, Swelling);
Significant weakness;
nagging.

pidvischennya of the internal cranial vise (including in case of damaged venous flow, internal cranial puffins);
childish and adult age up to 18 years;
sensitivity to the drug has been adjusted.

Stagnation during vaginosis and breastfeeding

The safety of storing Mildronat in case of vaginosis has not been brought to fruition. Schob uniknuti a spirited unwelcoming infusion on the plate, the drug is not a sign of vaginosti.

It is inadvisable to see the drug in breast milk. If necessary, the consumption of Mildronate in the period of lactation breast year bath pinch.

Patients with chronic liver disease and nirok continue to take care of the trivial drug intake. If necessary, a trivial (ponad misyats) drug intake should be consulted with a Fakhivite.

Bagatorial admission of the gostry to myocardial infarction and not stable angina in cardiological reports it is shown that Mildronate is not a drug of the first row in case of coronary syndrome.

Vikoristannya in pediatrics

For children and adults, up to 18 years of age, the effectiveness and efficiency of Mildronate in capsule form has not been established.

Inflow to the building of keruvati by transport means and mechanisms

A tribute to Mildronat, who is unfriendly to her psychomotor reaction, is dumb.

In case of spinal consumption of Mildronate, antianginal diseases, hypotensive drugs, heart glucosides are used.

Mіldronate can be combined with antianginal drugs, anticoagulants and antiplatelet agents, antiarrhythmic drugs, diuretic, Bronchodilators.

In case of an alcoholic stagnation with mildronate nitroglycerin, nifedipin, alpha-adrenergic blockers, antihypertensive disorders and peripheral vasodilators, there is a possibility of development of a combination of tachycardia, arterial hypertension

Likarsky analogs of the drug Mildronat

Structural analogs for common speech:

3- (2,2,2-trimethylhydrazinium) propionate dihydrate;
Vasomag;
Іdrіnol;
Cardionate;
Medetern;
meldoniy;
Meldoniy-Escom;
Meldonium dihydrate;
Melfor;
Mydolat;
Trimethylhydrazinium propionate dihydrate.

Novina vidredaguvav: admin017, 00:15

ін'єкції Мілдроната

Mіldronate is a drug with metabolic activity, the producers of which are fed with energy-free clitin and tissue. Positive input into the exchange of speech and the elimination of energy deficiency was allowed by the stasis of Mildronat in case of chronic diseases of the heart-vascular, mental, nervous systems. It is also used to treat ophthalmologic pathologies, advanced vitrification, both physical and intellectual.

Є A few forms of vipusku Mіldronatu, skin shedding can be recognized as a severe symptom, I will become ailing or special passages. Zvvychay lykarі priznachayut injections of Mіldronate in vipadkah, if it is necessary to quickly reach the therapeutic effect, if ailments cannot be taken pills. You can go to a fake course of reception, you can continue by switching from ін'єкційної to the oral form of the drug.

Diyuchі speeches

From the instructions for the storage of Mildronate in the warehouse by means of a single speech, either meldonium or trimethylhydrazine propionate dihydrate. For the structure, there is є an analogue of gamma-butyrobetain, which is a presence in all human cells. Mechanism of the development of meldonium polyaga in the blocking of carnitine viroblast, in which case the synthesis of gamma-butyrobetaine is advancing. Winning the enlargement of the brain and more effective blood loss of tissue, especially quiet, as it is in the minds of hypoxia.

The drug captures cellini as an aggressive infusion of products into catabolism and toxins, accelerating agents into the body. With ischemia of tissues and organs (for example, myocardium, brain, organ sores), meldonium changes in blood flow to the cornea of areas with hypoxia. This rank is the anti-ischemic and antihypoxic effect.

In the minds of the guest, there is an unstable blood circulation in the myocardium of Mildronate with a confidence in the formation of a necrotic malaise and a speedy reabilitation period. With angina pectoris, the drug decreases the number of attacks in angina pain, causing the heart wikid. Heads of yomu, to start stimulation of neurons, to see activation of the mucous sphere and physical vitrification. Also, there is a anti-stress action.

Meldoniy will paint over the reabilitation period in patients who have suffered fired up the brain was abnormally damaged by CNS injuries. Vin changes in rupture of rukhiv (paresis), in the improvement of coordination, reduction in the frequency of vegetative manifestations. Vikoristannya to the drug, I will become patients with alcoholic deposits, and I will change to show withdrawal symptoms.

Pharmacokinetics

The maximum plasma concentration of Mildronate for the first time can be reached immediately after parenteral administration. Win quickly grows in tissues and clings to blood plasmas. The bioavailability of the drug becomes 100%.

Uwaga! The drug penetrates chastkovo through the hematoplacental bar, as well as drinking milk in the breast.

Metabolism Mildronate is reported in the furnace

The drug and its metabolism are transformed by means of metabolism. The period for transportation is 3-6 years.

showing

Why should you use Mildronate, if you can get brown? The following pathological conditions are indicated before the preparation is consumed:

cardiovascular pathology: chronic ischemic ailment heart, angina pectoris, myocardial infarction, chronic heart failure;
dyshormonal cardiomyopathy;
vegetative-sudinna dystonia;
chronic damage to blood circulation in the brain;
cerebral stroke;
pathology of peripheral arterial vessels;
an important postoperative period;
bronchial asthma and chronic obstructive illness complex treatment;
enlightenment of the eyes of a child's genesis: hemorrhage in the disease and in the disease, retinopathy (hypertensive and diabetic), thrombosis of the central vein of the bloodstream, disruption of the blood circulation.
chronic alcoholism i withdrawal syndrome among alkozalezhnykh in common with other types of lykuvannya;
the temporality is physical stomatology and overexertion;
low productivity of physical and intellectual practice.

Uwaga! When the organ is affected, the zoru is shown to receive injections of the drug Mildronate only parabulbarno.

at cardiovascular pathologyін'єкції "Мілдронат" a part of the complex therapy of cyx disease and cannot substitute for the continuous treatment with basic drugs

In the middle of showing up to Mildronat, they knew their nisha and sports training with the help of the promotion of vitality, for a quick renewal of important and trivial people to take up sports.

Yak take the drug?

Rozchin Mіldronatu has a concentration of meldonіy 10%. Wine is dispensed in ampoules of 5 ml. Apparently, in 1 ml of retail - 100 mg of meldonium, and one ampoule - 500 mg. The box has 10 ampoules. The drug is priznachayut 1 or 2 times for doba. Rozchin the drug can be administered with decilcom by shlakhs:

internal'yazovo;
internally;
parabulbar (close full-time apple).

Mіldronat vnutrіshnovenno zvychay to inject in a strummene way, so you can more easily solicit a bazhany effect. If there is no need for a safe drug, then it is possible to inject it into a vein infusionally behind an additional drip.

The drug in viglyadі rozchinu need not be removed before the introduction

Rozchin Mildronatu was allowed to use sufficient concentration of acting speech and not vimag of additional breeding. All the ways of the drug delivery to the drug should be taken into account. However, there can be signs of this introduction, for example, on the physiological basis. If Mildronat was still being bred, then the absolute number of dialectical speech will not change, it will change without its concentration, but it can be recognized on the strength of this drug.

In quiet vipadkas, if the shvidka doesn’t consume it, you can breed Mildronat. Tilki with a good mark is more beautiful than vikoristovuvati 0.9% solution of sodium chloride (physiological solution). Zmіshuvannya s іnshih razchinniki can be recognized on the power of the drug, which is not wanted in the region.

Mіldronat aktivuє nerves Take this step not less than 4-6 years before bedtime. In the midst of the loss of sleep at the viglyad, sleeplessness. An additional dose can be taken in one іn'єktsіyu or divided into two doses.

Dose in case of malignant pathologies

The dose of the drug should be stored for a specific illness and taken as a medicine individually:

unstable angina and myocardial infarction. In such cases, it is shown that the drug has been injected internally, so I will become a state-of-the-art person and will be innocently involved. Introduce 5-10 ml of Mildronate strumenevium internally. If there is a lack of tolerance, the whole dose should be administered once, in those drops, it is shown that there are two injections. The triviality of parenteral administration of the drug should be from 1 to 10 days. Nadal you can switch to oral forms of Mildronate and take it with a trivial course of up to 4-6 days.
chronic lack blood circulation. It is necessary to consume 5-10 ml intravenously 1 time per day, or 5 ml of two doses per dose of intramuscular tissue.
Ophthalmologic pathology. In general, Mildronate will be stuck parabulbarly at 0.5 ml per dob (50 mg meldonium) for 10 days.
Stroke to the brain in the hospital phase. To achieve a shvidny effect, the drug should be injected internally, 5 ml per dose for 10 days. It is also possible to inject it internally, 500 mg 1 time per second, stretching 2-3 times.
Chronic lack of cerebral blood flow. In case of any pathology, the drug should be administered either internally or in tablet form. Inject 5 ml intramuscularly 1 time for 14 days. Priyom prodovzhutsya once consumed up to 4 types.
Dyshormonal cardiomyopathy. Zastosovuvati 5-10 ml i.v. in a stream for one іn'єktsіyu for dob or 5 ml i / m 2 times a day. The course should be 14 days, and in case of advanced oral administration, it is recommended to take Mildronate for 2 days.
Chronic alcoholism. Ailments should be treated with Mildronate IV strumenevo, 5 ml, 2 times per dose for the suppression of neurological symptoms. Prodovzhuvati therapy up to one day.
Stomp is increased in the period of high physical and intellectual navantages. The guest need for parenteral reception of Mildronate with such indications it is not possible to lay it down in any way that is more acceptable for the patient, as well as a very smart effect. The drug is taken internally in 1 ampoule 1 or 2 times for dobu. Moisture and internal intake of Mildronat in a similar dosage regimen. The course of treatment is to become up to 2 types. Yaksho is a requirement, which can be repeated in 2-3 more times.

when chronic damage cerebral circulation є deterioration of blood flow or problems with etching, followed by a vibration parenteral route introduced to Mildronat

vzaєmodiya

Mіldronat, in conjunction with the іnshim lykarskiy zasobami, Can be victorious as a bazhan, as well as unsafe reactions to the body. Bagatokh paciєntіv tsіkavit, which can be combined with the use of meldonіy with other preparations. Unambiguously, there can be only a car on the food chain.

Meldoniy advertizing efficiency:

antiplatelet agents;
anticoagulants;
bronchodilator disorders;
antiarrhythmics;
antianginal drugs;
diuretics

If you are assigned to Mildronat, be sure to tell the doctor about taking any medications and about your partner's problems.

The drug is feasible for beta-blockers and heart glucosides. With special protection, follow the use of Mildronat with such drugs:

alpha blockers;
nitrates;
antagonists of calcium channels;
peripheral vasodilators.

The spilny reception of the cichus can lead to a sharp decrease in the arterial grip and tachycardia.

Prototype

It is obvious from the instruction because of the intake of the drug, which is not recognized in such cases:

vagіtnіst;
lactation period;
childish vik up to 12 rock_v;
internal cranial vice
allergy or the manifestation of individual hypersensitivity to meldonium.

Possible events and drug overdose

Name the middle of the patients for the highest degree of tolerance to the drug side reactions on Mildronate:

shkіrnі allergic show in viglyadі visipka, kropiv'yanka, rіdko - angioeurotic nabrya Kvіnke;
dyspepsia;
kolivannya bloody vise;
frequent sertsebitty;
sleeplessness and psychomotor stimulation;
weakness;
Change of blood formula (adjustment of the level of eosinophilia).

special requests

In ailments, such as may serious illness nirok and liver with a lack of functions of cich organs, followed by the control of biochemical indicators of blood. If you need a trivial intake of meldonium, a consultation of a doctor for a short dose of meldon is provided.

Lyudin, who took Mildronate, can be tolerated by transport means and robots with mechanisms, since the drug is not successful in responding to reactions. For patients of a kidnapped vik, I need a therapeutically effective dose.

Zasosuvannya in sports

Building managers Mildronat pidvischuvati to develop fabrics, which can be recommended for advancing tolerance to physical navantages. Wine will reduce the vitality of the myocardium and peripheral muscles. The process of reduction is also a quick and flexible update for Trenuvan.

Until recently, Meldoniy did not take into account doping, but since 2016, the rock was included in the list of drugs that are used in sports by doping

Umovi zberigannya

When the ampoule opens, it doesn’t fit for any circumstances. The refrigerator can not be used at a price. Pislya 20 khilin and more pislya broken the tightness of the ampoule slid vikinuti.

Widgets about Mildronate

The drug is overwhelmingly positive. Dumki likariv on rakhunok Mildronatu descho development.

On the other hand, there are the cures of the therapy with Mildronate, which means the high efficiency of taking the medication in their ailments.

So, as a proof base for the drug Mildronate, every day, it’s possible to get used to the placebo effect.

I took Mildronat for the promotion of legal status during the period of the time spent in the Institute. I can say only good things: the drug is very helpful in completing this and polishing the memory for the material. I could never sleep when I saw myself very badly. Wines for his day nagadu energy engineer, only without side effects.

Valentina, 58 rockiv

Likar made me happy to accept Mildronate for more frequent attacks of angina pectoris. I have trimmed off a little bit internal injections Then I drank the syrup for more than 3 minutes. For a period of time, they attacked the pain, and there were no problems.

Irina, 42 rocky, lykar-cardiologist

Myldronate increases the portability of physical options for patients with the IXC. Wine is kindly infused into self-feeling of ailments of vegetative-sudinous dystonia. On the basis of therapy with the drug, the symptoms regress more often, but the necessary course of treatment is repeated, every hour.

They recognized me as a dribble of Mildronate at once with a panangin, ale the two dribblers, fewer nightmares, a rapidly changing and decreasing grip, and a diarrhea appeared;

Mildronat

The description is current on 03/09/2016

Latin name: Mildronate
ATC code С01ЕВ
Diyucha speech: meldoniy (Meldonium)
Virobnik: AT "Grindeks", Latvia

warehouse

Before the warehouse of one hard gelatin capsule, Mildronate should contain 250 or 500 mg of meldonium in the form of an active ingredient and additional words: Amylum solani (potato crumbs), Calcium dioxidum colloidale (calcium oxide), Silicii dioxydum colloidale

For the preparation of the gelatinous shell, use Gelatinum (gelatin) and Titanium dioxyde (titanium dioxide).

In one mildew solution for the first mildronate, there is 100 mg of meldonium and water for the second component.

In one tablet, Mildronate contains 500 mg of meldonium from viglyadi phosphate and additional components: Mannitum (E 421; manit), Povidonum K-29/32 (povidon K-29/32), Amylum solani (crumbling silicon dioxide), Silicii ), Cellulose microcristalline (microcrystalline cellulose), Magnesium stearate (magnesium stearate).

Vipusku form

The drug Mildronate is dispensed with virobnik in the following forms:

pristinely barless razchin for ін'єкцій;
hard gelatin capsules No. 1 and No. 2, filled with hygroscopic crystalline powder white color... To take revenge in capsules powder of little bends, characteristic smell і liquorice gust (the capsule itself has a neutral gusto);
tablets Mildronate Gx 500 mg (relish the tablets are slightly acidic).

Roschin comes in 5 ml ampoules (500 mg / 5 ml). One carton pack contains: 2 charunk packs with 5 ampoules of Mildronate in the skin and instructions for the preparation.

Capsules are packed in blister, 10 pieces per skin. In one case, there are 4 blisters and instructions for the administration of the drug.

Pharmacological diya

Meldoniy - tse synthetic lykarskiy zasib, scho volodin analogous s γ-butyrobetaine (GBB; speech, but є in between oxytrimethylaminobutyric acid - natural vitamin-like speech, native to group B vitamins).

Zgіdno Vіkіpedіі, meldonіy is characterized by a high rate of reduction of metabolism and energy safety of cinnabar and vicorizing yak:

Mechanism of diya meldoniy viznacha wide range yogo pharmacotherapeutic authorities. Acceptance of the drug with the increase in adherence to normalcy, decrease in the incidence of manifestations of mental, intellectual and physical overwork, active tissue and humoral immunity.

In patients who suffer from heart failure, they increase the strength of the heart muscle faster, lower the frequency of heart attacks (attacks of angina pectoris), and also increase the tolerance of the body to physical fitness.

at gostrich ushkojennyah myocardium of stagnation of meldonium is supportive of the establishment of necrotic zones, the rapidity of the period of reabilitation, normalization of blood circulation in the middle of the ischemic ear and overgrowth of blood for the mantle of ischemicization.

In minds pіdvischenih navantazhen meldonіy spriyaє vіdnovlennyu balance mіzh transport CHIN in klіtini i require klіtin in nyoma, pereshkodzhaє skupchennyu in klіtinah produktіv klіtinnogo obmіnu i toxic rechovin, zahischaє klіtini i klіtinnі structuring od poshkodzhen, zabezpechuє Shvidky kompensatsіyu organіzmom Yogo energetichnih rezervіv i pіdtrimku naybіlsh visokіy shvidkostі exchange processes.

Tonification of the central nervous system, meldonium effectively assimilates the deterioration of the functional state of the somatic and autonomic (autonomic) nervous system, including the deterioration, which supervises the abstinence syndrome in patients with chronic alcoholic guardianship.

In addition, the speech is infused beneficially on the camp of dystrophic changes in the stenosis, which allows it to be used for the treatment of vascular and dystrophic pathologies of the intramural bottom.

Pharmacodynamics and pharmacokinetics

The activity of the drug is aimed at driving the enzymatic activity of γ-butyrobetainghydroxylase, which is the inhibiting enzyme in the lanceol reaction to the synthesis of L-carnitine.

Meldonium with a decrease in the concentration of vital carnitine, the transfer of fatty acids through the cell membrane to a lancet, which increases accumulation in the cells of active forms of non-oxidized fatty acids, which are taken away by acidic acids.

In the ischemic tissues, the balance between the transport of sour and of the blood cells, the loss of transport of adenosine triphosphate, activates one hour from the cycle of glycolysis, which is prevented without additional acidic life.

The result of a decrease in the concentration of carnitine є the synthesis of the vasodilator γ-butyrobetaine is increased.

When I take the tablets Mildronate per os, it’s possible to get wet in the herbal tract. The drug is characterized by a high rate of bioavailability. Stop becoming approximately 78%.

The concentration of meldonium in the blood plasma reaches its maximum values in a year or two after receiving. In the body, meldonium is metabolized to non-toxic products - glucose, succinate, 3-hydroxypropionic acid.

Vivedennya of metabolism is healthy. The period of occurrence (T 1/2) in the presence of the particularities of a particular organism and the dose taken can be from three to six years.

The drug in the ін'єкційної form is characterized by 100% bioavailability. The concentration of meldonium in the blood plasma reaches its maximum values immediately after the introduction of the drug. The period of occurrence (T 1/2) in the presence of the particularities of a particular organism and the dose taken can be from three to six years.

The result of the metabolization of meldonium is the establishment of non-toxic metabolites (glucose, succinate, 3-hydroxypropionic acid), which can be transferred to the body by means of nirkas.

Shown before consumption of Mildronate: what type of tablets Mildronate, what type of injections

All drug formulations are indicated for the treatment of older patients.

Shown before storing Mildronat (for all lykarsky forms drug):

ІХС (at the same time using other methods of treatment and methods of treatment);
ailments of the peripheral arteries;
reduced coverage;
discirculatory encephalopathy;
physical perevantazhennya (including in sports);
pislyaoperats_yny period (for accelerating renewal to the body);
heart failure in chronic form;
cardialgia ( more views in Lviv part breast cancer), Surrounded by dyshormonal myocardial disease;
bronchial asthma;
COPD;
alcohol abstinence (as additional to specific therapy);
insult.

Dodatkov is indicated before the injection of the drug:

bleeding into the empty space of the bedrock (hemophthalmus);
krovoviliv in the s_tchastu shell of the eye;
thrombosis and occlusion of the central vein of the bloodstream or hylok;
retinopathy of a small nature is walking (for example, hemorrhagic or diabetic).

Stagnation of Mildronat in sports

Mildronate is characterized by a wider range of tolerance to physical (both dynamic and static) and is not only capable of smart, healthy ears and alike.

The drug is even cinnamon for athletes to grow up to their authorities to improve the health of the heart, and to reduce the quality of the heart and reduce the effectiveness of sports training at once.

Against all the dissimilar Duma Mildronat does not vikoristvuyutsya in favor for the sake of growing myazovoi masi... Yogo zavdannya in sports and in bodybuilding zokrem descho іnsha: Mildronate for athletes testimony is a professional one, as well as overreaching (including heart muscle) and overtraining.

In addition, it will help to improve the efficiency of the client's products in the fall and accelerate the renewal of energy resources in the client, Mildronate will reduce the metabolism to the client's growth and accelerate the renewal of the energy resources of the athletes. Moreover, they stay away from the security forces, as well as from the physical ones to the fluidity and / or the vitality of the organism.

I think that the use of Mildronat in sports can provoke fatty liver hepatosis. However, it is out of the question.

Myldronate does not allow fatty acids to penetrate into the middle of the cell, and in such a way, the accumulated fat in the liver is transferred. In addition, the vitriol organism, which burns down to a large extent, is larger than the amount of vitriolic syruvina, which is yakraz and є fat, the molecule of adenosine triphosphate is violated on the skin (tobto on the energy supply).

Meldoniy did not belong to the class of dopings until 1 June 2016, which allowed it to be used absolutely legally in all kinds of sports.

However, the introduction of the fence for the implantation of the cattle by the Anti-Doping Agency (WADA) on the ear of 2016 is low in athletes, in the main from Russia and the country of the large SND, bully vicriti in the implantation given to the drug... Mіldronat also became the subject of a magnificent scandal, since Marya Sharapova on the 7th of March 2016 saw the implantation of this supplement.

Mildronate: contraindicated until the end of the day

Prototype indications before assigned to Mildronate (for all forms of the drug release):

individual sensitivity to meldonium, whether it be with additional components in the drug;
internal cranial hypertension, in which case it is encumbered with internal cranial puffs and damaged venous flow.

Pobichna diya

Pobichna diya, Amused by the acceptance of Mildronat, they are often found. As a rule, the stench swirls around the viglyad:

allergic reactions (pochvoninnya, visipan on shkіrі, sverbіnnya and nabryaku);
dyspeptic symptoms, which appear in vidryzhkoyu, attacks of boredom, blues, stoves, seeks to re-equip the slurry to see an insignificant portion of the age;
takhіkardії;
pidvischennya zbujennya;
Decrease of indicators of arterial vise.

Instructions for storing Mildronat

It is not often possible to develop food "Is it possible to introduce Mildronate internally?" or "Is it possible to inject an internal preparation?"

In the instructions for medical administration, it is indicated that the drug is in the form of internal use, and capsules and tablets are used for oral administration.

Likarski form for oral administration should be taken in whole viglyad, not roasted, not supplemented and not hung in the place of capsules.

Mіldronat I / O introduction is carried out in a ready-made viglyadі. Mіldronate internally with the introduction of okremo from the other drug preparations, dispensing water dispute sodium chloride is not required (protein in a number of types is not required).

With the introduction of a solution to the communication, it can be used to tease and provoke local ill-feeling and allergic reactions of the muscular character. For many reasons, Mildronate should be administered at a vein.

Injections to Mildronat: instructions from the start

Indicated before the injections of Mildronate were injected: unstable (progressive) angina pectoris, myocardial infarction, abnormalities of the daytime fundus and impaired blood circulation in the brain.

paciєntam s coronary syndrome the drug is injected into the vein of strumenevo in a dose equal to mg, once a day. For the therapy, take pills or capsules.

Patients with forensic pathologies of the intramural bottom of the face should be injected retrobulbarly (for the intramural apple) or subconjunctively (for the first time the shell of the intramural apple) 0.5 ml each for 10 days.

Patients with impaired cerebral blood circulation in the state of rozchin should be injected at the vein once per dose at a dose of 500 mg. The triviality of the therapeutic course - 10 days. Farther lykuvannya is carried out with vikoristannya lykarsky forms for oral administration.

Patients with impaired cerebral blood circulation in chronic forms are shown to be administered internally to Mildronat one or three times per dose, equal to 500 mg (optimally - to the dose). The triviality of the therapeutic course becomes 2 to 3 types.

Mildronat tablets: instructions for use

For patients with diseases of the heart-vascular system, tablets and capsules Mildronate are indicated in a specific therapy. The drug will take a pomg for doba. The entire dose can be taken at once, so it is divided into two doses.

As a rule, the course of treatment is trivial from 4 to 6 months.

In case of cardialgia, dyshormonal myocardialopathy, Mildronate should be taken once a day for one tablet of 500 mg or 2 tablets of 250 mg.

For patients with impaired cerebral blood circulation, for the weakened gostrich porushen, it is shown that the drug is consumed in a dose equal to mg per dose. Accept її for one reception, or for two receptions.

Patients with impaired cerebral blood flow in chronic forms are recommended to take 500 mg of Mildronate per dose.

The triviality of the exchange rate varies from 4 to 6 years. For the decisions of the doctor, the patient may be assigned to carry out repeated courses of treatment (as a rule, two or three times per ric).

For patients with pathologies of peripheral arteries, the drug should be taken twice a day, 500 mg. The recommended dose is in case of advancing intellectual and physical adjustments to organisms (including athletes) mg, as they are divided into two doses.

The triviality of the exchange rate becomes from 10 to 14 days. If necessary, repeat the course, showing two or three times the interval.

During the period before training, Mildronate athletes are recommended to take two per day in a dose equal to mg. The triviality of the course during the preparatory period should be taken from two to three times, during the period of holding the course of the course, the triviality varies from 10 to 14 days.

For alcoholic abstinence patients who suffer from chronic alcoholism, Mildronat slid take a chotiri dose of 500 mg per day. The triviality of the course is from 7 to 10 days.

The maximum allowable additional dose is a dose of 2000 milligrams.

Overdose

The overdose of boules was fixed. The drug Mildronate is characterized as being of low toxicity and does not provoke side effects, which could damage the health of the patient.

vzaєmodiya

It is allowed to combine Mildronate with antianginal, antiarrhythmic, anticoagulant, antiaggregant and diuretic drugs, heart glucosides, bronchodilators and other drugs. Drugs.

Mіldronate power potential for nitroglycerin, β-adrenergic blockers; nifedepina and other problems, which may cause coronary artery disease; antihypertensive drugs, as well as zasob_v, for which it is straightened on the expansion of peripheral sudins.

Through the powerful development of the world tachycardia and the decrease in the indicators of the arterial grip of stasis, the food is re-insured in the combination with the mildronate followed by the protection.

Mind the sale

Mіldronate should be ranked up to the category of prescription drugs.

Umovi zberigannya

Mіldronat sberіgati in dry mix. Take care of all children. The optimal temperature regime is not more than 25 ° C.

Term of attachment

special requests

I will look at those, where the drug can provoke a stimulating effect, it is recommended to use it in the first half of the dose.

The tribute to the health of Mildronat is changing the speed of the response and the investment in traffic control on the road.

The drug is used to protect people with liver pathologies and / or abnormalities.

Dosvid of the diagnosis of patients with myocardial infarction and unstable angina showing that Mildronate is not active as a first-line drug in ACS.

analogues of Mildronat

The price of analogs in the drug will be repaired at 170 Russian rubles.

Riboxin or Mildronate - is it more beautiful?

Riboxin is a naturally occurring substance, which is also found in human organisms.

Being an alternative to adenosine triphosphate, it increases the energy balance of the heart muscle, improves the coronary blood circulation, reduces the rate of inheritance in the intraoperative ischemic lesion.

I am positively pouring into the processes of exchange in the heart, increasing the strength of the heart sooner and stimulating more and more relaxation in the diastol, so that in my heart it is necessary to produce the indicators of VOK (shock volume of blood) to grow.

Mіldronat needs more help, but he himself doesn’t get involved in the processes of synthesizing these words. At the same time, the drug regulates the activity and biosynthesis of enzymes, which take part in the biological energy, and in such a way normalizes the exchange of words.

Visnovok is as follows: Mildronate is a drug that is directly linked to the correction of the processes of exchange of speech, Riboxin takes part in biochemical reactions and by way of metabolic infusion.

For rejection of the cleansed effect, it is necessary to inject Riboxin in quantities that can be adjusted to the organism. And oskіlki Riboksin vikoristovaetsya organism in іnіh reactions, wіn is consumed in even great quantities.

Mildronate, navpaki, itself does not turn out to be in exchange reactions, it takes longer for an hour, and the organism needs it is much less than Riboksin.

To that, I will paint Mildronate with organism Riboksin. In such a rank, overnight stasis of cich preparations will potentiate one or more.

Cardionat or Mildronat - is it more beautiful?

Cardionate and Mildronate are synonymous with drugs. Oh, the basis of the warehouse is one thing, and the very same speech, the insult will be caused by the analogous mechanism of the activity.

The difference is that only in the form of 250 mg capsules and in the form of 500 mg / 5 ml capsules for the form of Mildronate Cardionate.

Appreciate to Mildronat children

Oscillations for this year's day There is a lot of money about the safety of storing Mildronate in pediatric practice, the drug is not suitable for children.

Consistency with alcohol

Active speech Mіldronat vivoditsya from the body for 12 years, now, at the end of the hour, the drug is in vigorous mode with the lowest active speech in the region is low, or it is called vіdsutnіy.

In general, alcohol for the hour of drinking Mildronat is not overpowering; However, if the drug is stagnant for the treatment of heart-and-heart disease, or in case of impaired blood circulation in the brain, the patient is still recommended to be brought back to alcohol.

It is linked with those who take the drug in the presence of alcohol, it is possible to re-cross all the positive results that have gone far into the treatment of ill health.

Taking Mildronat with alcohol can be provoked:

The filth of madness Mildronat with alcohol is accumulated by the growth of the rhizic of the growing family, the acceleration and development of the recurrence of the ailment. There are several reasons for the entire period of drinking with the drug alcohol.

Stagnation of Mildronate during vaginosis and during lactation

The safety deposit for Mіldronatu for the treatment of vagіtny women has not been brought. Shcheb viklyuchiti the power of this unpleasant infusion on the development of the fetus, the drug is not used for vaginosity.

It has not been established which meldonium can be seen in the milk of a year-old woman. To that, if the mother is shown the treatment of Mildronate, for the entire period of therapy, it is necessary to fix the breast.

Bezbarvna Ridin's insight.

warehouse

1 ampoule (5 ml) to replace:

active speech- 0.5 g of meldonium dihydrate;

additional speech: water for ін'єкцій up to 5 ml.

classification code

Інші zasobi for a lіkuvannya sickness of the heart.

ATX code: С01ЕВ22

Pharmacological authorities

Pharmacodynamics

Meldonium is an alternate to carnitine, a structural analogue of gamma-butyrobetaine (GBB), in which one atom is substituted for a nitrogen atom.

Meldonium, reversibly attracting gamma-butyrobetaingidroxylase, reduces the biosynthesis of carnitin and translocation of fatty acids from lanceolate fatty acids through the shells of clitin, such a class of assets of the unoxidized fatty acid accumulated in the acidic acid. This is the rank of the ear for cell membranes.

With a change in the concentration of carnitine in the brain of ischemia, β-oxidation of fatty acids is suppressed and the vitality of acidity in cells is optimized, the oxidation of glucose is stimulated and the transport of ATP is refreshed to the bone. By the day, klitin get sick live rhymes and we will sour, and also optimize the victoriousness of the cich speech.

In its own circle, with an increase in biosynthesis, opposite to carnitine, GBB, NO-synthetase is activated, as a result of which rheological power of the blood grows, and the peripheral opyr of sudin changes.

With a change in the concentration of meldonium, the biosynthesis of carnitin will be

The number of fatty acids gradually increases.

Coronary heart ailment (stable angina pectoris) Analyzes of clinical data on the rate of stagnation of meldonium of stable angina pectoris in combination with antianginal diseases, showing that the drug reduces the frequency and intensity of attacks of angina pectoris, as well as the disease The drug manifests an antiarrhythmic effect in ailments with coronary ailment heart (CHS) і heart extrasystoles, less infusion sposter in patients with supraventricular extrasystoles. The drug has the ability to change the condition of living in a calm state, which is an effective criterion for antianginal therapy of CHD.

Meldonium is pleasantly infused into atherosclerotic processes in the coronary and peripheral vessels, changing the level of cholesterol in the syrovate and atherogenic index.

Chronic heart failure

In most of the number of clinical preliminaries, the role of the drug in the elimination of chronic heart failure in the result of CHD was analyzed and the health of the patient was determined to be tolerant to physical training, as well as due to

Efficiency in cerebral blood flow impairment and neurological ailments

Delivered, scho meldoniy є efficiently complex treatment of gostrich and chronic damage to cerebral blood circulation (ischemic stroke, chronic lack of cerebral blood circulation). Meldonium normalizing tone and appearance of capillaries and arterioles in the brain.

Injected meldonium into the process of rehabilitation in patients with damaged neurological character (for the transfer of blood-bearing brain damage, brain surgery, trauma, transferred clichus encephalitis). As a result of the reconsideration of the therapeutic activity of the drug, it was seen that the dose was more positive for the physical vitality and the renewal of the functional activity in the period of use.

It was established that the drug will dye the convalescent quality of life, before the drug will reduce the mental impairment of the patient.

Meldoniy positively infused into the regression of the deterioration of the functions of the nervous system in patients with neurological deficiency during the period of life.

Pharmacokinetics

Pharmacokinetics was introduced in healthy individuals with ingestion of meldonium internally and orally.

soaktuvannya

For internal administration of bagatoraz doses, the maximum concentration of meldonium in blood plasma (Cmax) reached 25.50 ± 3.63 μg / ml.

The availability of the bull is improved for individuals with severe deficiencies of Cmax, which is flat due to the curve "hour-concentration" (AUC) and for example, for patients with liver cysts With an internal intake of AUC, a single dose or repeated administration of doses of meldonium occurs. The results are indicative of the accumulation of meldonium in the blood plasma.

rospodil

Meldonium rapidly expands in the tissues from the bloodstream. Plasma trickles grow in fallowness every hour after the dose is consumed. Meldonium and its metabolism often add to the placental bar. There was no post-production of meldonium in the mother's milk.

metabolism

Meldonium is metabolized by the head rank in the oven.

vivedennya

In vivedennі meldonіy and th yogo metabolites, the role of vіdіgraє nirkov ekskretsіya is significant. for a one-time internal storage meldonium in doses of 250 mg, 500 mg and 1000 mg for the period of early vivenia, meldonium becomes 5.56-6.55 years, and for the period of early veneration, it becomes 15.34 years.

Special groups of patients

lіtnі paciєnti

The dose of meldonium has been changed to children with a deteriorated liver function, or for those who have increased accessibility.

Patients with damaged functions of nirok

Patients with a weakened health of nirok, in which there is a decrease in metabolism and excretion, followed by a change in the dose of meldonium. Icnu interaction of nirkovy reabsorption of meldonium of any metabolites (for example, 3-hydroxymeldonia) and carnitine, as a result of which the nyrcovy clearence of carnitine is reduced. During the day, direct injection of meldonium, GBB and combination of meldonium / GBB on the renin-angiotensin-aldosterone system.

Patients with damaged functions of the stove

Patients with liver dysfunctions, in which there is a decrease in metabolism and recovery, followed by a change in the dose of meldonium. Changes in the indicators of liver efficiency in people after the intake of doses, should be 400-800 mg, without spostering. It is not possible to take into account the possibility of infiltrating fat in the liver.

Shown for zasosuvannya

Stasis in complex therapy in the onset of symptoms:

Ailment heart i circulatory system- stable angina pectoris, chronic heart failure (NYHA I-Ш functional class), cardiomyopathy, functional damage to the heart and the circulatory system; state and chronic ischemic damage to cerebral blood circulation; reduced patronage, physical and psychomotional re-entanglement; during the period of time, there is a history of cerebrovascular damage, head trauma and encephalitis.

How to save and add

Internal. In connection with a powerful stimulating effect, it is recommended to stay in the first half of the day. Zastosuvannya to the drug is not given a special preparation before the introduction.

At the warehouse of complex therapy, inject 0.5-1.0 g of meldonium (5-10 ml of the size for internal introduction) per day internally, the entire dose is taken at once, or for 2 days and 10-14 days, with a further transition to the reception in the middle. The primary course of education is to become 4-6 years old. The course of treatment can be repeated 2-3 times a day.

lіtnі paciєnti

Litnim patients with damaged liver function and / or a low dose of meldonium sludge change.

Patients with damaged activities nirok

Oskilki the drug is administered to the body through nirki, to patients with impaired strength from the lung to the middle degree of severity after consuming a lower dose of meldonium.

Patients with damaged activitiespechinki

Patients with liver dysfunctions from light to medium severity should receive a lower dose of meldonium.

children

There is a lack of information about the safety and efficiency of the intake of meldonium in children and children under 18 years of age, so the intake of the drug for children and children is not indicated.

Pobichna diya

Nadal re-insured secondary activities classified according to groups of systems and organs and frequencies of MedDRA: often (> 1/100 to 1/10 000 before

On the side of the immune system

Often: allergic reactions *.

Ridko: sensitivity to sensitivity, allergic dermatitis, crotchitis, angioedema, anaphylactic reaction.

On the side of the psycho

Ridko: ruin, feeling fear, obsessive thoughts, Ruined sleep.

On the side of the nervous system

Often: head b_l *.

Ridko: paresthesia, tremor, hipesthesia, noise in the ears, vertigo, zamorochennya, ruptured walking, antero-prone stump, loss of svidomosty.

On the side of the heart

Ridko: arrhythmia, heart rate, tachycardia / sinus tachycardia, fibrillation of the atrium, discomfort in the breasts / pain in the breasts.

On the side of the sudin

Ridko: increased / decreased blood pressure, hypertensive crisis, hyperaemia, bladder of shkiri.

Three sides mental systems, Breast plate and middle

Ridko: burning in the throat, cough, indigestion, apnea.

On the side of the shlunkovo-intestinal tract

Often: dyspepsia *.

Ridko: dysgeusia (metalevium in roti), loss of appetite, bloating positive, nausea, bloating, accumulation of gas, diarrhea, abdominal pain.

On the side of shkіri and іdshkіrnyh fabrics

Ridko: visceral, zagalny / macular / papulovispatic, sverb_zh.

Three sides skeletal-tissue system and support systems

Ridko: pain in the back, muscle weakness, muscle spasms.

On the side of the nirok and sevividnoy system

Ridko: pollakiuria.

Major breakdowns and reactions in the introduction

Ridko: weakness, tremulousness, asthenia, nagryak, nagryak, nigryak, feeling hot, seeing cold, cold food.

doslіdzhennya

Ridko: viewing in electrocardiogram (EKG), accelerated robotic heart, eosinophilia *.

* Vicious activities, which were spostered in uncontrolled classrooms.

I also had problems with pain in the epigastric and migraine.

In the event of occurrence of alternate side reactions, as well as in the event of occurrence of a secondary reaction, which is not described by the instruction, it is necessary to return to the license.

Prototype

Sensitivity is increased to meldonium digidrate. Pidvischennya of the internal cranial vise (with damaged venous flow, internal cranial puffs). Severe nirkov і / abo pechinka lack (there are not enough tributes about the security of storing). Vigilance and year of breastfeeding. Childish vіk up to 18 years old

Overdose

Not a lot of information about the overdose of meldonium. The drug is low-toxic and does not wickle harmful side effects.

symptoms: in times of reduced arterial grip, there may be headaches, zamorochennya, tachycardia, weakness.

lykuvannya symptomatic. In case of severe overdose, it is necessary to control the function of the liver and nirok. Hemodialis is not a small value in connection with the ringing of the meldonium with the bottles.

Zapobizhnі come in

Patients with chronic liver disease and / or nirok should be protected when the drug is consumed (necessary control of liver function and / or abnormalities).

Bagatorial dosage to the diagnosis of myocardial infarction and unstable angina in cardiologic diseases shows that meldonium is not the first drug in the list of patients with coronary syndrome.

Vigor and breastfeeding years

For assessing the infusion of meldonium on the vagina, the development of the embryo and the fruit, the canopy and the pislyapologic development of the pre-development on the deficiencies. Potential risik for people with disabilities. The drug is in the period of contraindications.

It’s impossible to see the drug from the mother’s milk of the people. It is not possible to vklyuchiti risik for neonatal / nemovlyat, that before the hour of the birth of a breastfeeding child, the preparation is not possible.

Inflow to the building of keruvati by transport means and service personnel by means of mechanics

There is no tribute about the inflow of keruvati to the building by transport means and service mechanics.

Vzaєmodia with іnshy lіkarskiy zasob

The drug can be taken together with nitrates of prolonged action and other antianginal drugs for the treatment of stable angina pectoris, along with heart glucosides and diuretic methods for the treatment of heart failure.

Meldonium can be combined with anticoagulants, antiplatelet agents, antiarrhythmic agents, and drugs that use microcirculation.

You can also use drugs to take revenge on glitceroltrinitrate, nifedipin, beta-adrenergic blockers, and other hypotensive and peripheral vasodilators.

In patients with chronic heart failure, who take one hour to reduce symptoms of meldonium and lizinopril, a positive action of combined therapy (vasodilatation of the head arteries, peripheral disease)

In case of stagnation of meldonium in a combination of orotic acid for the use of orotic acid, for the treatment of ischemia / reperfusion, it promotes the addition of pharmacological action.

As a result of one hour Sorbifer and meldonium in patients with anemia, viciklikanovy deficiency, polystyrene storage of fatty acids in red blood cells.

Meldoniy dopomagaє usunuti pathological changes heart, viclican with azidothymidine (AZT), and mediately injected on the reaction of oxide stress, viclican with AZT, which can lead to dysfunction of mitochondria. Stagnation of meldonium in combination with AZT or other drugs for treating the syndrome of swollen immune deficiency (SNID) positively influx into SNID therapy. An overdose of meldonium may be capable of cardiotoxicity, cyclican with cyclophosphamide.

Mind that term zberigannya

Take it at a temperature of 25 ° C. Do not freeze it.

Zberigati out of reach for children.

Termіn zberіgannya - 4 rock.

Date coriguvannya text: leaf fall 2017 r

Diyuchі speeches

Uwaga! when advised physical activity Mildronate supplements help to reduce the need for tissue and tissue organism in a simple manner without the need for an average delivery.

Meldonium dyed the reabilitation period in patients who had suffered a loss of life, ignited brain damage, or due to CNS injuries. Vin changes in rupture of rukhiv (paresis), in the improvement of coordination, reduction in the frequency of vegetative manifestations. Vikoristannya to the drug, I will become patients with alcoholic deposits, and I will change to show withdrawal symptoms.

Pharmacokinetics

Uwaga! The drug penetrates chastkovo through the hematoplacental bar, as well as drinking milk in the breast.

Metabolism Mildronate is reported in the furnace

The drug and its metabolism are transformed by means of metabolism. The period for transportation is 3-6 years.

showing

Why should you use Mildronate, if you can get brown? The following pathological conditions are indicated before the preparation is consumed:

cardiovascular pathology: chronic ischemic heart disease, angina pectoris, myocardial infarction, chronic heart failure;
vegetative-sudinna dystonia;
chronic damage to blood circulation in the brain;
cerebral stroke;
pathology of peripheral arterial vessels;
an important postoperative period;
bronchial asthma and chronic obstructive disease is a component of complex treatment;
enlightenment of the eyes of a child's genesis: hemorrhage in the disease and in the disease, retinopathy (hypertensive and diabetic), thrombosis of the central vein of the bloodstream, disruption of the blood circulation.
chronic alcoholism and abstinence syndrome in alkozalezhnykh in some other types of alcoholism;
the temporality is physical stomatology and overexertion;
low productivity of physical and intellectual practice.

Uwaga! When the organ is affected, the zoru is shown to receive injections of the drug Mildronate only parabulbarno.

In case of heart-vascular pathology, "Mildronat" is a part of the complex therapy of cyx disease and cannot replace the continuous treatment with basic drugs

In the middle of showing up to Mildronat, they knew their nisha and sports training with the help of the promotion of vitality, for a quick renewal of important and trivial people to take up sports.

Yak take the drug?

internal'yazovo;
internally;
parabulbarno (close to intramural apple).

The drug in viglyadі rozchinu need not be removed before the introduction

Mіldronate vnutrіshnyom'yazovo introduced, if there are no gostrich stanіv. Such way of introduction of indications for chronic heart-vascular and cerebrovascular diseases.

Mildronate is an active nerve agent, so take it not less than 4-6 years before bedtime. In the midst of the loss of sleep at the viglyad, sleeplessness. An additional dose can be taken in one іn'єktsіyu or divided into two doses.

Dose in case of malignant pathologies

The dose of the drug should be stored for a specific illness and taken as a medicine individually:

Unstable angina and myocardial infarction. In such cases, it is shown that the drug has been injected internally, so I will become a state-of-the-art person and will be innocently involved. Introduce 5-10 ml of Mildronate strumenevium internally. If there is a lack of tolerance, the whole dose should be administered once, in those drops, it is shown that there are two injections. The triviality of parenteral administration of the drug should be from 1 to 10 days. Nadal you can switch to oral forms of Mildronate and take it with a trivial course of up to 4-6 days.
Chronic lack of blood circulation. It is necessary to consume 5-10 ml intravenously 1 time per day, or 5 ml of two doses per dose of intramuscular tissue.
Ophthalmologic pathology. In general, Mildronate will be stuck parabulbarly at 0.5 ml per dob (50 mg meldonium) for 10 days.
Stroke to the brain in the hospital phase. To achieve a shvidny effect, the drug should be injected internally, 5 ml per dose for 10 days. It is also possible to inject it internally, 500 mg 1 time per second, stretching 2-3 times.
Chronic lack of cerebral blood flow. In case of any pathology, the drug should be administered either internally or in tablet form. Inject 5 ml intramuscularly 1 time for 14 days. Priyom prodovzhutsya once consumed up to 4 types.
Dyshormonal cardiomyopathy. Zastosovuvati 5-10 ml i.v. in a stream for one іn'єktsіyu for dob or 5 ml i / m 2 times a day. The course should be 14 days, and in case of advanced oral administration, it is recommended to take Mildronate for 2 days.
Chronic alcoholism. Ailments should be treated with Mildronate IV strumenevo, 5 ml, 2 times per dose for the suppression of neurological symptoms. Prodovzhuvati therapy up to one day.
Stomp is increased in the period of high physical and intellectual navantages. The guest need for parenteral reception of Mildronate with such indications it is not possible to lay it down in any way that is more acceptable for the patient, as well as a very smart effect. The drug is taken internally in 1 ampoule 1 or 2 times for dobu. Moisture and internal intake of Mildronat in a similar dosage regimen. The course of treatment is to become up to 2 types. Yaksho is a requirement, which can be repeated in 2-3 more times.

Even in case of chronic impaired cerebral blood flow є impaired blood circulation or problems with etching, followed by a vibration parenteral route introduced to Mildronat

vzaєmodiya

Mіldronat, in conjunction with іnshih lіkarskiye zasob, can be victorious as bazhanі, and also not safe reactions to organism. Bagatokh paciєntіv tsіkavit, which can be combined with the use of meldonіy with other preparations. Unambiguously, there can be only a car on the food chain.

Meldoniy advertizing efficiency:

antiplatelet agents;
anticoagulants;
bronchodilator disorders;
antiarrhythmics;
antianginal drugs;
diuretics

If you are assigned to Mildronat, be sure to tell the doctor about taking any medications and about your partner's problems.

The drug is feasible for beta-blockers and heart glucosides. With special protection, follow the use of Mildronat with such drugs:

alpha blockers;
nitrates;
antagonists of calcium channels;
peripheral vasodilators.

The spilny reception of the cichus can lead to a sharp decrease in the arterial grip and tachycardia.

Prototype

It is obvious from the instruction because of the intake of the drug, which is not recognized in such cases:

vagіtnіst;
lactation period;
childish up to 12 years;
internal cranial vice
allergy or the manifestation of individual hypersensitivity to meldonium.

Dovidka! At the connection with the visibility of the monitored dosages of meldonium, it is not recommended during the period of the child's admission, for lactation. However, in practice, it can be victorious in case of vaginosis with impaired fetal-placental blood flow.

Possible events and drug overdose

Name the middle of the patients for the highest degree of tolerance to the drug, but in some cases there are some side reactions to Mildronate:

shkіrnі allergic show in viglyadі visipka, kropiv'yanka, rіdko - angioeurotic nabrya Kvіnke;
dyspepsia;
kolivannya bloody vise;
frequent sertsebitty;
sleeplessness and psychomotor stimulation;
weakness;
Change of blood formula (adjustment of the level of eosinophilia).

Recorded vipads overdosing with Mildronate was not implied. With a strong change in the recommended doses, a decrease in the arterial grip, weakness, zamorochennya, headache can be increased. Therapy for signs of overdose is symptomatic.

special requests

In ailments, who may be seriously ill with a liver and a lack of functions of their organs, there is a consequent control of biochemical indicators of blood. If you need a trivial intake of meldonium, a consultation of a doctor for a short dose of meldon is provided.

Zasosuvannya in sports

Until recently, Meldoniy did not take into account doping, but since 2016, the rock was included in the list of drugs that are used in sports by doping

Umovi zberigannya

When the ampoule opens, it doesn’t fit for any circumstances. The refrigerator can not be used at a price. Pislya 20 khilin and more pislya broken the tightness of the ampoule slid vikinuti.

Instructions

Trade name

MILDRONAT®

International non-patented name

meldoniy

Lykarska form

Roschin for ін'єкцій 0.5 g / 5 ml, 5 ml

warehouse

1 ampoule (5 ml) to revenge:

active speech- meldonium dihydrate 500 mg,

additional speech - water for ін'єкцій.

to describe

Prozora bezbarvna ridina

Pharmacotherapeutic group

Іnshі preparations for the treatment of sickness of the heart. Meldoniy.

ATC code C01EB22

Pharmacological authorities

Pharmacokinetics

soaktuvannya

For the internal introduction of bagatoraz doses of meldonium, the maximum concentration (Cmax) reached 25.50 ± 3.63 μg / ml.

The availability of the bull for increased in individuals with severe deficiencies Cmax, area for the graph of changes in concentration per hour (AUC) and for the period of delivery (t1 / 2), in patients with severe diseases. In case of internal consumption, AUC for a single and repeated introduction of doses of meldonium grows. The results are indicative of the accumulation of meldonium in the blood plasma.

rospodil

Meldonium rapidly expands in the tissues from the bloodstream; I have a lot of affinities to the fabric of my heart. The link with the plasmas will grow in fallowness every hour after the dose is collected. Meldonium and its metabolism often add to the placental bar. There was no post-production of meldonium in the mother's milk.

metabolism

Meldonium is metabolized in the oven.

vivedennya

In the vivedenny meldonium and its metabolites, the role of the form of nirkov excretion is significant. For a one-time internal intake of 250 mg, 500 mg and 1000 mg doses of meldonium for the period of early vivenia of meldonium become 5.56-6.55 years, and for the period of vivenium - 15.34 years.

Special groups of patients

Patients of the kidnapped vik

The dose of meldonium has been changed to children with a deteriorated liver function, or for those who have increased accessibility.

Patients with damaged activities nirok

Patients with a weakened health of nirok, for those who have increased accessibility, then change the dose. Іnu interaction of nirkovy reabsorption of meldonium any of its metabolites (for example, 3-hydroxymeldonіya) and carnitine, as a result of which the nyrcovy clearence of carnitine is reduced. During the day, direct injection of meldonium, gamma butyrobetaine (GBB) and combination of meldonium / GBB on the renin-angiotensin-aldosterone system.

Patients with broken furnaces

Patients with liver dysfunctions, those with increased accessibility, then change the dose of meldonium. Changes in the indicators of liver efficiency in people after the intake of doses, should be 400-800 mg, without spostering. It is not possible to turn on the possibility of infiltrating fat in the liver.

pediatric population

There is a lack of information about the safety and efficiency of the storage of meldonium in children and children up to 18 years of age, so the storage of meldonium in the whole group of patients is proved to be.

Pharmacodynamics

Meldonium is a structural analogue of the alternator of gamma butyrobetaine (GBB) carnitine, in which one of the carbon atoms is substituted for the nitrogen atom. In the minds of the increased supply of meldonium, the supply and demand of food and drink, assimilation of the accumulated toxic products in the exchange in the cells, taking over from the food; nadaє also tonizuyuchiy infusion. As a result of the second storage, the organisms are built up, the vitamins are built up and the energy reserves are quickly renewed. The breeders of the powers of the meldonium are stagnant for the destruction of the destructive heart-vascular system, the blood supply to the brain, as well as for the development of the physical and rosum-like cerebralism. As a result of a decrease in the concentration of carnitine, it is possible to synthesize GBB, which is volodymy by vasodilating powers. In the case of a state-of-the-art ischemic myocardium meldonium, it is possible to establish a necrotic zone, shortening the rehabilitation period. In case of heart failure, the rate of myocardium increases, tolerance to physical pressure decreases, and the frequency of attacks of angina pectoris decreases. In case of chronic and chronic ischemic damage to the cerebral blood circulation, the circulation of blood in the middle of the ischemia is reduced, and the blood is overgrown to the corny of ischemic dilyanka. In case of damage of a neurological nature (for damage to cerebral blood flow, surgery on the brain, head injuries, previous clichus encephalitis) positively influences the process of renewal of physical and intellectual functions in the period of weariness.

Shown to sucking

In complex therapy in the onset of symptoms:

sickness of the heart and the vascular system: stable angina pectoris, chronic heart failure (NYHA I-III functional class), cardiomyopathy, functional impairment of the heart and vascular system;

state and chronic ischemic damage to cerebral blood circulation;

decreased performance, physical and psycho-social overstrain;

during the period of time, due to cerebrovascular damage, head injuries and encephalitis.

How to store that dosi

Internal. Zastosuvannya to the drug is not given a special preparation before the introduction.

In conjunction with a powerful stimulating effect, the drug is recommended to be taken in the first half of the day.

Heart failure and impairment of cerebral blood circulation

At the warehouse of complex therapy, 500 mg-1000 mg per day internally (5-10 ml of the size for 0.5 g / 5 ml), take the whole dose at once, or for 2 doses. Maximum dobova dose become 1000 mg.

Decreased attendance, overwork and period of overwork

500 mg (5 ml) per day intravenously. The maximum dose is 500 mg.

The triviality of the course is 4-6 years.

The course can be repeated 2-3 times per pik.

lіtnі paciєnti

Lіtnіm patients іf sick liver аn / or a small dose of meldonіy slіd change.

Patients with damaged activities nirok

Oskilki the drug is administered to the body through nirki, to patients with impaired strength from the lung to the middle degree of severity after consuming a lower dose of meldonium.

Patients with broken furnaces

Patients with liver dysfunctions from light to medium severity should receive a lower dose of meldonium.

pediatric population

Pobichna diya

often

Allergic reactions (sensitiveness, allergic dermatitis, crotchis, angioedema, anaphylactic reaction)

Headache

Dyspepsia (feeling of severity, sickness, reassignment, pain and discomfort in the episode, nudota)

ridko

Ruined, feeling the fear, obsessive thoughts, ruined by sleep

Paresthesia, tremor, hipesthesia, noise in the ears, vertigo, zamorochennya, disordered walking, antero-prostate stump, loss of svidomosty

Tachycardia / sinus tachycardia, atrial fibrillation, arrhythmia, chest discomfort / chest pain

Arterial vise colony, hypertensive crisis, hyperaemia, bladder malformations

Sore throat, cough, sickness, apnea

Dysgeusia (metalevium in roti), loss of appetite, nudota, bloating, accumulation of gas, diarrhea, abdominal pain

Visipannya (headache / macular / papulogenous), sverb_zh

Pain in the back, muscle weakness, muscle spasms

pollakіurіya

Galna weakly, tremor, asthenia, zagalniy Vodka, Nigacious damping, Vіdchuttya Zha, Vіdchuttya cold, cold

Vidhilennya in the electrocardiogram (EKG), accelerated robotic heart, eosinophilia

Prototype

Increased sensitivity to meldonium digidrate

Important pechinkova i / abo nirkova lack, bizarre on the day of the day

Viability and period of lactation, through the availability of data on clinical reports from the consumption of the drug in the whole period

Childish up to 18 years old, eager for the daytime of the day

lykarska vzaєmodiya

Meldonium can be taken together with nitrates of prolonged action and other antianginal drugs for the treatment of stable angina pectoris, along with heart glucosides and diuretic methods for the treatment of heart deficiencies.

Meldonium can be combined with anticoagulants, antiplatelet agents, antiarrhythmic agents, and drugs that use microcirculation.

Meldonium can be used with other drugs, which can be used to replace glitceroltrinitrate, nifedipin, beta-blockers, other hypotensive diseases and peripheral vasodilators.

In case of stagnation of meldonium in a combination of orotic acid for the use of orotic acid, for the treatment of ischemia / reperfusion, it promotes the addition of pharmacological action.

As a result of one hour Sorbifer and meldonium in patients with anemia, viclikanovye deficiency, polystyrene storage of fatty acids in erythrocytes.

Meldonium supplementation helps to suspect pathological changes of the heart, viclican azidothymidine (AZT), and mediated infusion on the reaction of oxide stress, viclican AZT, which leads to dysfunction of mitochondria. Stagnation of meldonium in combination with AZT or other drugs for treating the syndrome of swollen immune deficiency (SNID) positively influx into SNID therapy.

In the test, lose the ravnovagi reflex, viclikan ethanol, meldonium change the triviality of sleep. At the hour of the court, pentylenetetrazole was victorious, it was established that the proto-domy meldonium was turned. At his side, when stasis before therapy with meldonium alpha2-adrenergic blocker, yohimbine at a dose of 2 mg / kg and ingibitor synthase to nitric oxide (SOA) N- (G) -nitro-L-arginine at a dose of 10 mg / kg meldoniy.

An overdose of meldonium may be capable of cardiotoxicity, with cyclophosphamide.

Deficiency of carnitine, which is established in case of intake of D-carnitine (pharmacologically inactive isomeria) -meldonia, may be able to increase cardiotoxicity, viclican with iphosphamide.

Meldonium can be used in cases of cardiotoxicity, viclican indinavir, neurotoxicity, viclican efavirenz.

special requests

Patients with chronic liver disease and nirok in case of trivial stagnation, then they see their care (next to monitor the functions of the liver and / or nyrok).

Special features of the infusion of a lykarsky drug on the health of keruvatiby means of transport or potentially unsafe mechanisms

There is no tribute about the inflow of keruvati onto the building by means of transport or potentially not safe mechanisms.

Overdose

The effects of overdose are not very toxic, the drug is low-toxic and not safe for the health of the patient.

In case of low blood pressure, there may be headaches, zapamorochennya, tachycardia, weakness. Likuvannya is symptomatic.

In case of severe overdose, it is necessary to control the function of the liver and nirok.

At the connection with the vyrazhennym zyuzuvannyam drug with bricks, hemodialysis is not small value.

Form vipusku i packaging

For 5 ml in an ampoule from a barless storage, I hydrolytic class with a line at a point.

For 5 ampoules, put in a contour charunk packaging from polyvinylchloride water.

For 2 or 4 contoured charunk packs at once with instructions for medical storage by sovereign and Russian movs put into a box of cardboard.

Umovi zberigannya

Take at a temperature of 25 ° C.

Chi do not freeze!

Zberigati out of reach for children!

Termіn zberіgannya

Do not fix the message for the end of the term of accessibility indicated on the package.

Mind that term zberigannya

For the recipe

Vlasnik of restoration

AT "Grindeks". Vul. Krustpils, 53, Riga, LV-1057, Latvia

Virobnik

Addresses of the organization, which are accepted on the territory of the Republic of Kazakhstan, claims for the quality of the product (goods):

Representative office of AT "Grindeks"

050010, metro Almati, Dostyk ave, rig st. Bogenbai Batira, 34a / 87a, office No. 1

t./f. 291-88-77, 291-13-84

ate. mail: [Email protected]

Attached files

817660521477976824_en.doc	85 kb
505048371477977981_kz.doc	91 kb