Mesalazin pobichni dei. Mesalazin: help the intestines with severe illness

Trade name: mesalazin

International non-patented name:

Likarska form:

warehouse:

describe: tablets mayzhe white or white with siruvatim vidtink color, round, double-convex form. Insignificant impregnations are allowed.

Pharmacotherapeutic group:

ATX code:[A07EC02]

Pharmacodynamics
Volodya's muscle antiapalis, we will summarize the activity of neutrophilic lipoxygenase and the synthesis of prostaglandins and leukotroins. Mention of migration, degranulation, phagocytosis of neutrophils, as well as secretion of immunoglobulin by lymphocytes. MAU antibacterial diyu is admissible intestinal stickі deyakikh kokіv (manifested in tovstіy intestines).
MA antioxidant effect (for the growth of health it is associated with strong acid radicals and ruinuvati їх). It is good to be tolerated, lowering the risk of relapse with Crohn's ailment, especially in ailments with illnesses and great triviality.

Pharmacokinetics
Closely 30-50% of the taken dose is absorbed, by the head, in the small intestine. Mesalazin is acetylated in the mucous membrane of the intestine, in the liver, in the small step, - enterobacteria, taking M-acetyl-5-aminosalicylic acid. The linkage with blue plasmas is 43%, and that of I-acetyl-5-aminosalicylic acid is 73-83%. Mesalazin and its metabolite do not penetrate through the hematoencephalic bar, penetrate into mother's milk.
Cumulative power in healthy volunteers received the drug in a dose of 1500 mg / day. Kumulyu with chronic nirkova lack(XNN). Mesalazin and its metabolism are metabolized through the body and intestines.

Shown to sucking
Nonspecific swelling colitis, Crohn's ailment (prophylaxis and treatment).

Prototype
Hypersensitivity, blood loss, Virazkov's ailment slunk and two-fingered intestine, hemorrhagic disease, severe nirkov / pechinkov deficiency, lactation period, remaining 2-4 vaginosis, childish vik(Up to 12 years), as well as for children weighing less than 50 kg.

With protection
Viability (I trimester), pechinka and / or abnormal deficiency, deficiency of glucose-6-phosphate dehydrogenase.

Stagnation in vaginosis and lactation
It seems that mesalazine penetrates through the placental bar, however, the drug is not allowed to be evaluated in vaginal women. pobichna diya... Zastosuvannya in vagіtnyh moss, only when cinnamon is transferred to the mother, perevit mozhlivannya to the fetus. Mesalazin is produced with breast milk in a concentration lower than in the blood of a woman, and as a metabolite, acetylmesalazine, is found in a lower or higher concentration. If it is necessary to take the drug during the period of lactation, follow up on the nutritional status thoracic treatment.

How to store that dosi
Tablets of mesalazine prolonged diet are recommended to be taken with a single dose, not roasted, written down, washed down with a great amount of ridini.

Ulcers colitis

stage of sharpening
Children: the dose is taken individually, add 20-30 mg of mesalazine per 1 kg of the patient's weight to be taken to the table.

adaptive therapy
Longer: the dose is taken individually, add 2 g of mesalazine for a dose in the morning.
Children: the dose is taken individually, add 20-30 mg of mesalazine per 1 kg of the patient's weight for a dose to be taken.

KHOROBA CROWN

Stage of sharpening and admitting therapy
Longer: the dose is taken individually, add up to 4 g of mesalazine for dob in decilka.
Children: the dose is taken individually, add 20-30 mg of mesalazine per 1 kg of mass for a dose for a day.

Pobichna diya
On the side of the herbal system: nudota, bluing, burning, diarrhea, decreased appetite, beating in the stomach, increased activity of "pechinka" transaminases, hepatitis, pancreatitis.
Three sides heart-vascular system: heart rate, tachycardia, adjustment or reduction arterial vise, Chest pain, backside.
Three sides nervous system: head bill, Noise in vuhah, zapamorochennya, polyneuropathy, tremor, depression.
On the side of the secular system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome.
Allergic reactions: shkіrny visip, sverbіzh, dermatoses, bronchospasm.
On the side of the blood-forming organs: anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia.
Інші: weakness, parotitis, photosensitivity, vovchak-like syndrome, oligospermia, alopecia, changes in the production of tears.

Overdose
A single dose of less than 150 mg / kg is an overdose of a mild severity level, 150-300 mg / kg is an amount less than 150 mg / kg, and more than 300 mg / kg is an overdose.
Symptoms: mild i average gravity- symptoms of "salicilism" (nudota, blues, noises in the ears, ruined zoru, fouling, severe headache, zagalne nezduzhannya, Likhomanka - a prognostic sign of rotting in grown-ups). Important - hyperventilation of the lungs of central genesis, respiratory alkalosis, metabolic acidosis, Integrity of symptoms, drowsiness, collapse, suddenness, anuria, bleeding. A collection of central hyperventilation of the legends is brought to a dichy alkalosis - zadishka, poison, cyanosis, cold sticky pite; Due to the strengthening of the intoxication of the build-up, there is a parallel reaction and the growth of phosphorylate oxide, which leads to respiratory acidosis.
In case of chronic overdose concentration, it is accumulated in plasma, rottenly at the level of severity of intoxication. The greatest risk of development of chronic toxicity is indicated in particular in the case of a sick person with a prolonged dose of dib, more than 100 mg / kg / day. At children and children of a kidnapped vik cob signs salicylicism is not dependent on it, for that it is quite periodically to start the concentration of salicylates in the blood: 70 mg% of salicylic acid is indicative of something else or an important scent; vishche 100 mg% - about the most important, prognostically unpleasant. In case of a mediocre severity, a hospitalization is required for 24 years.
Lіkuvannya: provocation of blues, recognition active vugilla continuous control over the acid-base storage of blood (KOS) and electrolytic balance; in the fallowness I will change the words - the introduction of sodium hydrocarbonate, the range of sodium citrate or sodium lactate. Allocation of reserve water supply to the mesalazine for the alkalization of the slaughter. Serving is shown in case of іvnі salicylates in food 40 mg% and to get in / in infused sodium hydrocarbonate (88 meq in 1 liter of 5% glucose range, in the amount of 10-15 ml / year / kg); The renewal of the volume of circulating blood (BCC) and the induction of dyuresis is reached by the introduction of sodium hydrocarbonate in the same doses and diluted, which is repeated 2-3 times. A little bit of care is taken in young people with ailments, in those who have an intensive infusion of children, it can lead to a lot of legends. It is not recommended to use acetazolamide for alkalinization of the slaughter toxic diyu salicylate). Hemodialysis of indications in case of salicylate levels of more than 100-130 mg%, in ailments with chronic rejection - 40 mg% and lower in case of manifestation (refractory acidosis, progressive death of stun, lack of lesion of the central nervous system, gain). With a lot of legends - piece ventilation Legen (SHVL) sumyushyu, yak zbagachena sour.

vzaєmodiya
Hypoglycemic effect of old sulfonylate, ulcerogenicity of glucocorticosteroids, toxicity of methotrexate. Weaken the activity of furosemide, spironolactone, sulfanilamides, rifampicin. Anti-coagulant therapy. Improved efficiency of uricosuric drug use (blockers of tubular secretion). Dedicated to the absorption of cyanocobalamin.

special requests
Regularly carrying out the postal analysis of blood (before the ear, half an hour, and also during the process) and control over the function of the image of the blood. Ailments, such as "common acetylators", may change the risk of development of side effects. You can also try to make sure that you have a lot of smudges and tears in orange-colored colors, and you can also use a lot of contact lines.
If I miss a drug, I missed a dose and then take it at any hour or at the same time with the next dose.
If a few doses have been missed, then, if you do not pinch it, you will turn to drink. If you are susceptible to development, the syndrome of hostile intolerance to mesalazine should be skasuvati.
Patients have a unique experience of caring for a car, as well as a visitor to the robustness of the increased concentration of respect and responsiveness.

Vipusku form
Prolonged tablets of 500 mg. For 10 or 15 tablets in a contoured charunk package of polyvinylchloride and aluminum foil, aluminum hand lacquered.
For 1, 3, 5, 6, 9 or 10 blisters, 10 tablets each, or 2, 4 or 6 blisters, 15 tablets at a time from the instructions and put into a carton box.

Term of attachment
3 rock.
Do not fix the term for endowment.

Umovi zberigannya
List B. In a dry, stolen light at a temperature of 25 ° C. Zberigati out of the reach of children.

Mind that term zberigannya
For the recipe.

Virobnik / organization of acceptance of claims
ZAT "Canonpharm production", Russia.
Addresses: 141100, m Shchelkovo, Moskovska oblast, st. Zarichna, 105

Clinical-pharmacological group

Pharmacological diya

Protisapalny with a significant localization in the intestine. Mesalazin (5-aminosalicylic acid) induces the activity of neutrophilic lipoxygenase and the synthesis of metabolites in arachidonic acid (prostaglandins and leukotric acids), which are fired by mediators. Galmune migration, degranulation, phagocytosis of neutrophils, as well as secretion of immunoglobulin by lymphocytes. Mesalazin is an antioxidant power, which is associated with strong acidic radicals.

Pharmacokinetics

When I receive mesalazine in the middle of the distal view small intestine and in the intestine. The linkage with the blood plasma becomes 43%. Metabolizes in the mucous membrane of the intestine and in the liver with N-acetyl-5-ASA. T1 / 2 warehouseє 0.5-2 hours. Mesalazin is transported from the section, even in acetylated form.

sundown

In the middle, fill in 400-800 mg 3 times / dob with a stretch of 8-12 times.

likarska vzaєmodiya

With a one-hour consumption of mesalazine with azathioprine, mercaptopurine, the toxicity of azathioprine and mercaptopurine increases; with warfarin - descriptions of the changes in the effectiveness of warfarin.

Stagnation in vaginosis and lactation

In the first trimester of vaginosti stasosuvannya can only be shown after suvorim. As long as it allows the individual to get overwhelmed, then in the remaining 2-4 days of vaginosity, when the mesalazine is taken, it should be pinched.

If necessary, during the period of lactation, follow up on the nutritional status of breastfeeding, in conjunction with the availability of sufficient clinical information about the availability of mesalazine from the category of patients.

Pobichna diya

On the side of the herbal system: diarrhea, nudity, blues, stoves, abdominal pain, loss of appetite, dryness in rot, stomatitis, increased activity of liver enzymes.

On the side of the central nervous system and peripheral nervous system: headache, depression, zamorochennya, sleep disturbance, paresthesia, tremor, noise in the ears.

Allergic reactions: shkirny visip, sverbіzh, eritema.

On the side of the heart-vascular system: appearance of the heart, tachycardia, arterial hypertension abo hypotension, bіl behind the sternum, zadishka.

On the side of the secular system: proteinuria, hematuria, crystalluria, oliguria, anuria.

On the side of the hematopoietic system: anemia, leukopenia, agranulocytosis, thrombocytopenia; hypoprothrombinemia.

Іnshi: alopecia, a change in the production of a sleazy birth.

showing

NVK, Crohn's ailment (prophylaxis and treatment of hot spots).

Prototype

Blood poisoning, deviations in the function of the liver and / or abnormal, swelling ailments of the slunk, or two-fingered intestines in the phase of hardening, discoloration of the larynx of blood, a child's up to 2 births, salvaging up to 2 deaths.

special requests

I am protected from stasis in case of liver disease and nirok, lack of glucose-6-phosphate dehydrogenase, allergic diseases and mental illness before them. Before the ear of blood, and then after the first 3 months of testing, we will monitor the picture of peripheral blood, liver function, and also determine the concentration of blood and creatine in the blood. In ailments, such as "common acetylators", the development of secondary effects is promoted.

Stagnation in children younger than 2 years is possible only at the same time as the cinnamon of therapy is changing the potential risk for a child.

Preparations for revealing mesalazine (MESALAZINE)

Mesakol: instructions from the reception and advice

Latin name: Mesalazine
PBX code A07EC02
Diyucha speech:
Virobnik: Canonpharm Production,
Russia and in.
Umova vidpustki from the pharmacy: For the recipe
Price: from 350 to 700 rubles.

"Mesalazin" is a drug with an anti-firing effect. At this time, it’s uncomfortable to get it in the pharmacies of the country, there are no analogues of "mesalazine" with an identical dialectical speech.

Shown to sucking

"Mesalazin" must go away to reach the high spectrum of ailments: Crohn's ailments and inferior colitis. Zakvoryuvannya can perebuvati in stadiyah be-some type, "Mesalazin" is stagnant to all.

warehouse

One tablet "mesalazine" to revenge:

• Active ingredient: 500 mg mesalazine
• The other components: copovidone, silicon dioxide, sodium alginate, magnesium stearate, calcium hydrophosphate dihydrate, cellulose.

Likuvalny power

The infusion of lykarsky zasob on organism is essentially a prototype, localized here in the intestines, in the epicenter. "Mesalazin" building:

• Induce synthesis and activity of mediators of ignition - metabolites of arachidonic acid and neutrophilic lipoxygenase
• Galmuvati degranulation, migration, phagocytosis and before taking the secretion of immunoglobulin
• Zv'yazuvatisya with strong acidic radicals (the river has antioxidant yakosti).

If Lyudin takes a pill of this drug, mesalazine is released from the shell into the small intestine, and then the work is done. Vivoditsya all obsyag "mesalazin" with a section.

Average price from 350 to 700 rubles.

Vipusku form

The drug can be installed in a carton box. All the middle of them are in the middle of the package, so you can put 15 tablets in each. There are 2, 4, 6 and 10 packs in total.

Tablets - white-siruvate, practical white color Moreover, on their surfaces there may be some impregnations. The shape of the tablets is double-convex, round.

How to secure

"Mesalazin" looks like two ailments - Crohn's ailments and red colitis; The lower dose is administered, as it is most often given to the patients, but he is guilty of the personal norm of the drug for the singing patient.

With Crohn's ailment

In case of aggravated sickness and in the course of additional therapy:

• Dosage: up to approx. 4 g of liquor in dobu, divided into a few drops
• Children: most often - 20-30 mg per skin kg of vaginal per day, divided for a couple of times.

With swelling colitis

When caught in a stinging place:

• Dosage: most often - up to 4 g of liquor per day, distributed on a number of occasions
• Children: vividly - 20-30 mg per skin kg of vagi per day, divided for a couple of doses.

When applied therapy:

• Doroslі: close to 2 g of liquor in dobu, divided into a dough of priyomіv
• Children: most often - 20-30 mg per dermal kg of vagi per day, divided into a few doses.

With vaginosis and breast cancer

Dіyucha talkin to the drug - mesalazine - to penetrate through the placental bar'єr, even now they didn’t get any assessments of all admissible inheritances of the disease. So, in any case, you can get rid of the drug with vaginim if you have extraordinary circumstances, if the cinnamon will be better than the predicted Skoda for the not yet popular child. Krym, I'll start drinking pills on the ninth month of pregnancy.

"Mesalazin" can also penetrate into breast milk;

Prototype

Check the counter-indications before taking the mesalazine tablets:

• ailments of blood
• Virazkov's ailment of two-fingered intestine abo slunk
• Nirkova, pechinkova lack
• hemorrhagic diagnosis
• hypersensitivity
• Vіk sickly until 12 rockіv
• Waga up to 50 kg.

Zapobizhnі come in

Well, it’s necessary to work out before the ear of the course of treatment and flow of new food in three months of conversion and control of the level of blood, creatine, blood storage. It is also necessary to work zagalny analiz sich.

Before an hour of treatment, it is necessary to follow the patient's camp, and in the event of symptoms of hypersensitivity, or allergies, it is necessary to pinch the drug intake. It is necessary for the nobility, as soon as one can easily develop hypersensitivity syndrome from intestinal inflammation in important forms.

Patients, who are "common acetylators", see symptoms of side effects in most, not all of them.

Perekhresnі lіkarskі vzaєmodії

Tablets "Mesalazin" vzaєmodіyut:

• Methotrescate - zagostuyut toxicity
• With furosemide, spironolactone, sulfanilamide, rifampicin - decrease the activity
• With anticoagulants - drink more
• With the legacy sulfonyls - paint hypocritical infusion
• With blockers of tubular serkretsіі
• With cyanocobalamin - with galvanic absorption.

Vicious Effects

With implantation of tablets, there are no signs of symptoms, symptoms, illnesses, and axis of deactivation from them.:

• Hypersensitivity and allergic reactions: itching, viscera on the shkiri, spasm of the bronchus, erythema
• Organism of the intestinal tract: nudota, bloating, furnace, flatulence, diarrhea, hepatitis, parotitis, pancreatitis
• Hematopoietic system: hardening of heart rate, tachycardia, collapse of arterial vise, backwardness, anemia, leukopenia, agranulocytosis, thrombocytopenia
• Nervous system: headache, trouble with sleep, depression, paresthesia, sudom, tremor
• Sechostate system: proteinuria, hematuria, crystalluria, oliguria, anuria, nephrotic syndrome, oligospermia.

In some cases, the patients suffered from a fever, alopecia, a similar syndrome, photosensitivity. There is also a decrease in the number of products in the slack age and increase in the amount of methemoglobin.

Overdose

When the dose is overdose taken with "mesalazine", overdose is often consumed. Її signs є:

• weakness
• sleepiness
• nudota
• blues
• Gastralgia.

In order to eliminate the symptoms and prevent them from delaying, a special treatment should be carried out: a couple of patients are rinsed with a slurry, and then a medicine is indicated to carry out and symptomatic therapy.

Mind that term zberigannya

analogs

Dr. Falk Pharma GmbH, Nimechchina
Price from 1200 to 7400 rubles.

The drug "Salofalk" makes the very same speech, yak and "Mesalazin". "Salofalk" can be used in tablets, in granules, in candles, in suspensions.

Tablets "Salofalk" are light-colored, and for an hour they are brown-colored. And the granules "Salofalku" are very good for light and medium-heavy colitis and produce remission.

plus

• Possibility for the help of granules lіkuvati sharpen colіt and pіdtrimuvati yogo remіssііyu
• The ability to give children three rockies.

minusi

• Big price
• A large number of side effects.

Krka, Slovenia
Price from 250 to 440 rubles.

The drug "Sulfasalazine" in yakostі diyuchy speech It is necessary to use sulfasalazine only in the form of tablets.

plus

• Possibility of storing children from 6 years
• lіkuvannya arthritis
• trivial effect

minusi

• More evidence
• Trivale lykuvannya.

Ferring, Dania
Price from 3000 to 9700 rubles

"Pentasa" is just one analogue of "mesalazine", which is volodya analogous to the speech. The big plus is that you can give children two rockets. It is also used in the form of tablets, candles, suspensions and granules.

plus

• You can give children two rocks
• Free forms of vipusku: tablets, granules, fillets, suspension

minusi

• Before side effects Allergic dermatosis, myocarditis and in.
• The price is higher.

mesalazinє a drug of basic therapy for virazovaya colitis, easy form Crohn's ailments of deyakikh localizations, as well as a number of others ailments.

For a chemistry structure mesalazine є 5-aminosalicylic acid (5-ASA), Shcho Volodya Mistsev Protisapalnu Diyu. The drug is injected into the synthesis of pro-fired prostaglandins and leukotrines, which promotes migration, degranulation and phagocytosis of neutrophils, reducing the rate ignition processes... Mesalazin is capable of antioxidant activity for linking molecules with free radicals.

The drug is taken internally (orally) in the form of tablets, MMX tablets or granules; The antiapaline effect of mesalazine is more muscular (on the mucous membrane of the intestine), which is important for the concentration of the drug, as there is a contact with the intestinal wall, and part of the contact. The concentration of the drug in the blood is minimal and does not add to its effectiveness.

Dіyucha speech in all the drugs is the same, but mesalazine in the intestinal lumen is more vivid. Tse to lay down in the form of a vypusku lіkіv, yogo shell and structure.

Below is a characteristic of the main mesalazine, registered in Russian Federation.

Brief characteristics of the drug in mesalazine

The firm of the company "Doctor Falk Pharma GmbH" (Nimechchina). Russia has views in the form of tablets, granules, rectal pins, rectal suspensions and pigs.

a. Salofalk tablets

Salofalk tablets Protect with an intestinal corrosive membrane from Eudragita L, which will prevent pH-control from being given to mesalazine. The shell cannot be shlunk juice... Ale, podralyuchi in the intestine, pH ≥6.0, vona ruinut, and even the drug appears in the intestinal lumen. In the final form of the club intestine, 15-30% of the drug is injected, in the intestine - 60-75%.

The preparation of mesalazine from the Salofalk tablets is repaired in the thermal end of the club intestine after 110-170 gallins of the received drug, and after 4-5 years the dispensing is completed in the lowest rim gut... Do not infuse mesalazine with mid-pH changes through the intake of other preparations, or even implantation.

Close to 10% of mesalazine will get wet into the bloodstream, it will be quickly transformed into an inactive form and transferred to the body by nirkas.

Salofalk tablets are presented in doses of 250 mg and 500 mg. Accept їх вранці, in the day and in the evenings 1 year before. The tablets are not roasted, washed down with a generous amount of ridini.

b. Granules "Salofalk"

Granules "Salofalk"- a two-component lykarska form, which, on the basis of a single pH-control, does not allow mesalazine to be vivified with a trivial visualization lykarskoy speech from the core based on the original polymeric matrix. Intestinal congestion shell will preserve the pH-deposit of an active substance (at acidity values ​​≥6.0) of an active substance, so that it can be repaired in the thermal area of ​​the club intestine and more easily in the lower intestine. The loss of diyuchoy speech to the club intestine is minimal. The polymeric matrix core will provide a trivial, uninterrupted vision of the active substance on the entire protrusion of the intestine, right up to the rectum.

There is a large number of granules (3 g of "Salofalk" to place close to 3500 granules) will provide an equal and effective increase in active substance, great area surface, sberigє effectively navit at diarrhea.

The drug reaches the ileocecal viddil in about 3 years, and the viscid viddil of the intestine - after 4 years (shvidsche, not when taking Salofalk tablets). Approximately 80% of the taken oral dose reaches the sigmoid and rectum. The amount of the drug, which is consumed in the house and is seen in the cross section at the viglyadі metabolite, is less, less when the tablets "Salofalk" are victorious.

Form vipusku and method of storing

Granules "Salofalk" are presented in doses of 500 mg and 1000 mg. Granules go to the tongue and are not rosy, they are washed down with a great amount of ridini. Assigned a dose of "Salofalk" in granules, you need to take it once for doba, right from the reception.

v. Rectal pina (aerosol) "Salofalk"

Rectal pina (aerosol) "Salofalk"- lykarska a form for rectal stasis, which allows to preserve the optimal contact of the tongue with the surface of the mucous membrane of the intestine. It is highly effective in case of active red colitis with localization in the rectum, as well as in case of widespread malignant colitis in the warehouse of combined therapy. With the introduction of pini through the rectum, mesalazine is administered without preferential treatment to the mucous membrane of the intestinal tract. Favors of a high adhesive quality of food "Salofalk", the drug can "stick" to the mucous membrane, which will prevent a trivial contact of mesalazine with the ignited intestine. And the triviality of contact (exposure) increases the effectiveness of the drug.

Pina "Salofalk" is put into an aerosol spray, where 14 aplications of the preparation 1 g each, a set of 14 disposable soft applicators for introduction into the rectum. It is recommended to administer the drug before bedtime (when intestinal emptying), however, in case of frequent low defecation, an elusive drug may indicate an hour.

Vityag with instructions for storing rectal pini "Salofalk":

• At the moment of introduction, the drug is guilty of buty room temperature (20-25 ° C)
• Place the applicator on the balloon head
• Strushuvati Balon, lasting 20 seconds
• At the first vikorystanna vidalyti zachisny tongue from the front of the dozing head
• Turn the cup, turn the cup, turn it into a round viriz on the outside wheel, and turn it on the same line with the nozzle
• Introduce the applicator into the rectum of the yakomog glibshe. Nikrasche when tsyomu put your foot on the stile or stool. In order to introduce the first part of the dose to the preparation, push it on the small cup until it stops and as much as possible. Give another part of the dose of the drug to another, once it is pressed onto the small cup and as much as possible. Play for 10-15 seconds, sometimes it is necessary to use the appliance from the rectum
• Writing the introduction of pini, seeing the applicator and vikinuti yogo, packed in a plastic bag. For a new cutaneous introduction of a dose of the drug, a slid vikoristovuvati noviy
• Pislya shake hands. Sprobuvati do not empty the intestines until the onset of the wound.

m Rectal suspension "Salofalk" (microclism)

Rectal suspension "Salofalk"(Mikroklizma)- ready suspension in a bottle with disposable applicators. The drug reaches the livogo (splenic) kuta of the intestine. In children, the drug is accessible to the transverse rim and to navigate the viscid intestine. When mesalazine is consumed in microclisms, the drug is low in absorption (absorption).

Form vipusku and method of storing

Mikroklizmi "Salofalk" is dispensed in doses of 2 g / 30 ml and 4 g / 60 ml. Mikroklіzmi lessehy obsyagu go to the patients, who are important to take great obsyagi suspension. The whole amount of microcrystals is injected into the rectum at the very least (well, when the intestines are emptying), however, with frequent low defecations, an elusive drug may indicate the last hour.

Rectal suppositories "Salofalk"

Rectal suppositories "Salofalk"- suppositories, intended for introduction into the rectum. Stagnate for the highest concentration of mesalazine in the whole intestine.

Form vipusku and method of storing

Rectal candles "Salofalk" are dispensed in doses of 250 mg, 500 mg and 1000 mg (the dose is not registered in Russia). The candles are injected into the rectum 1-2 times for additional use for the sign of the drug (bazhano for intestinal emptying). It is advisable to recommend the introduction of a curettage at low, protest in the presence of the indicated frequency and the introduction, in addition to other muscular forms of therapy, as well as in case of low defecation, an elusive drug may indicate a last hour.

Small sizes of granules (close to 1 mm), so that they can pass without a cross-cut through the slurry, can be taken right from the receiving end.

2. "Pentasa"

Vyrobnitsvo company "Ferring" (Dania). Presented in the Russian Federation for tablets, granules and a slug.

a. Pentasa tablets

Pentasa tablets pokriti intestinal corrosive sheath. It should be taken to fall on microgranules, including ethyl cellulose. Microgranules are used to form a self-sustaining formulation for the drug. Tse will provide a therapeutic effect on all limbs from two to twenty fingers to the rectum, regardless of pH. Microgranules reach the two-fingered intestine for a year or so after taking a pill, right after taking it. An hour for the preparation to pass through the small intestine in the middle becomes 3-4 years. Closely 30-50% of the taken dose is absorbed in the small intestine.

Form vipusku and method of storing

Pentasa tablets are dispensed in doses of 500 mg. It is recommended to take a drink, not rozzhoyuchi in 2-3 priyomi. The tablet can be divided into a sprinkle of parts or it can be broken by the water, so it will be easier to get through.

b. Granules "Pentasa"

Granules "Pentasa"- microgranules, including ethyl cellulose. Diyut yak self-form to the drug with confidence in vivilnennym, which will preserve the therapeutic effect on all limbs from two to twenty-fingered to the rectum, just in the form of pH. Microgranules reach twelve-fingered intestines for a year, right out of the way. An hour for the preparation to pass through the small intestine in the middle 3-4 years.

Form vipusku and method of storing

Granules "Pentasa" are dispensed in doses of 1000 mg and 2000 mg. Granules are recommended to be taken in food, not roasted. Instead of one sachet of visipati per MOV and drink water or juice.

v. Rectal suppositories "Pentasa"

Rectal suppositories "Pentasa"- suppositories, intended for introduction into the rectum. Stagnate for the highest concentration of mesalazine in the whole intestine.

Form vipusku and method of storing

Rectal plugs "Pentasa" are dispensed in doses of 1000 mg. The names are similar to dovgasti tablets. The candles are injected into the rectum 1-2 times for additional reasons for the signs of the drug, but also for the emptying of the intestines. It is advisable to recommend the introduction of a curettage at low, protest in the presence of the indicated frequency and the introduction, in addition to the other forms of therapy, as well as in case of frequent low defecations, a lingering drug may indicate the last hour.

The drug can be soaked with water for easier administration.

3. "Mezavant"

The firm of Johnson & Johnson (USA). Representations in the Russian Federation for the view of MMX tablets. Tablets MMX "Mezavant" have a core, so they can avenge mesalazine in a rich component matrix. The nucleus is isolated from copolymers of methacrylic acid and types A and B. Mesalazin can be seen in the intestines of only a child at an increased pH> 7. After the scintigraphy it was shown that 1.2 hours of a single dose was taken by a healthy heart. viddili slunkovo-intestinal tract. Traces of 14C-labeled mesalazine appeared on the entire prosthetic gut. The recession of the tablet and the increase in the amount of mesalazine was observed after approximately 17.4 years. For a single-use drug taken by healthy volunteers in a dose of 2.4 or 4.8 g for 14 days, the absorption of mesalazine became 21-22% of the dose taken.

Form vipusku and method of storing

Tablets MMX "Mezavant" are dispensed in doses of 1.2 g (1200 mg). The entire recommended dose is taken 1 time per day every hour. Tablets can not be dispensed or rozzhovuvati, їkh slіd kovtati tsіlimi.

4. "Mesakol"

Wirobnytstvo company "SanFarma" (India). Performances in the Russian Federation for tablets. Tablets "Mesacol" are coated with intestinal corrosive membranes from Eudragita-L and Eudragita-S, which can be dispensed at pH> 7. The main part of mesalazine (60-79%) is found in the intestine.

Form vipusku and method of storing

Tablets "Mesakol" are dispensed in a dose of 400 mg. The recommended dose for the drug should be 2-3 times. Take the pills until you go, not rozzhovyuchi.

5. "Asakol"

Tillots Pharma company (Switzerland). Performances in the Russian Federation for tablets. Tablets "Asakol" are coated with intestinal corrosive shell from Eudragita-S. The preparation should be restored in the intestine at pH> 7.

Form vipusku and method of storing

Tablets "Asakol" are dispensed in doses of 400 mg and 800 mg. The dose is recommended for the drug to be taken in 2-3 doses. Take the pills until they go, not rozzhovyuchi.

6. "Kansalazin"

Virobnystvo ZAT "Canonpharm Production" (Russia). Performances in the Russian Federation for tablets. The results of the further bioequivalence of the drug Kansalazin, the original drug mesalazine (produced by the Danish company "Ferring AS"), was again confirmed by the dynamics of the intestinal concentration in the origin of mesalazine in the origin of the origin. In such a rank, the virobnik rozglyadaє tablets "Kansalazin" is a drug, which is the same effect, as well as tablets "Pentasa".

Form vipusku and method of storing

Tablets "Kansalazin" are dispensed in doses of 500 mg. The dose is recommended for the drug to be taken in 2-3 times. Tablets are recommended to be taken, not roasted.

Shown for zasosuvannya mesalazin

Bagato paciєntіv with wavy colitis and ailment Crohn's znayomі z cym lykarskiy zasob with different commercial names (Salofalk, Pentasa, Mezavant, Mesakol, Asakol, etc.).

Most often drugs are recognized when fiery ills intestines (IBD), perch, with curly colitis.

Mesalazin and Vibrant Colitis

Zgіdno Russian and European recommendations 2017 rock mesalazine is a drug for basic therapy for colitis, whether localization. Clinical preliminaries have shown that all commercial forms of mesalazine are equally effective in the treatment of varicose colitis.

What is the difference? Why should some patients be assisted by mesalazine granules with pH to fallen vivials, others - tablets to vivilnennyy drug, and deyakim vzagal not growing more beautiful?

Insanely, in the form of drugs є. Have razdіlі z in-house characteristics with mesalazine to complete the reports by the mechanisms of vivilnennya diyuchoy speech from tablets and granules. In the case of vivilnennya and pryvnomirny rozpodil preparation for the intestine infused acidity (that is, the pH itself) into the intestine. In some drops, mesalazine can not be stored in pH, but it can be stored for an hour through the intestine. In pathological countries, the pH value can vary greatly and change according to the norms. So, as a result of the results of one dosage (on an adjacent group of healthy individuals), the pH value did not reach 7 ni in one type of slurry-intestinal tract in 25% of cases. In 90% of the cases (well, not all of the participants before) had a pH value of 6. but it is less effective, it is less effective.
If the pH-independent mesalazine (Pentasa, Kanasalazin) is victorious, then I think that I do not want to pay more attention to the preparation, but it means that there is no need for the future. In a number of vipadkіv such a value can be reduced to a higher dosage of the drug.

The dose of mesalazine- Another reason for the success and failure in the treatment of IBD. The lack of a dose of the drug leads to a disgusting result on therapy.

It is important to correctly assess the localization of the intestinal lesions. Same won (proctitis, free-form abnormalities / total inflated colitis) amalgamated with vibrating lykarskoy form mesalazine (tablets, granules, pina, microcrystals or suppositories). So, for example, suppositories can be a vicorian in the therapy of the first line in case of acute colitis with lesions of the rectum.

Nareshty, mesalazin pounding pressure on ochikuvannya positive effect through the temple activity of ailment. In general, take some drugs (including hormonal drugs and immunosuppressants).

Pidsumovuchi vischevikladena, you can create a visnovok:

Good knowledge of the mechanism of drugs and capabilities of children lykarsky forms Allowing the gastroenterologist-doctor to admit for the patient an individual treatment scheme.

Mesalazin and Crohn's ailment

Kilka sliv about Crohn's ailment and the effectiveness of mesalazine in the drug industry. Until 2016, if the update of the European Consensus on the diagnosis of Crohn's disease (3rd view) was published, mesalazine was recommended for easy formation of the disease of the small intestine (Crohn's colitis). The first vypadk was recommended to use high doses of mesalazine (3-4 g per dobu) with a pH-fallow system of vivilnennya, the other - mesalazine with a pH-independent system of vivilnennya ("Pentasa") at a dose of 4 g per dobu. By publishing a consensus in the strategy for the policy of taking the boule, the changes were introduced. The price was connected to the Russian recommendations, linked to the diagnosis and treatment of Crohn's ailments. Mesalazin is less effective in terms of placebo. Protest, the classic practice of showing, for the children with a slight interruption, getting sick with mesalazine dope, right up to the start of the slime.

Mesalazin can also be recognized in chronic colitis of an unclear or unspecified pacing, exchange (radioactive) colitis, diverticular ailment of the intestine, etc.

Potential efficacy in sucking mesalazine

The victorious effects of mesalazine should be submitted to the report in the official instructions before the drug, the protein in the whole drug is tolerated well at high doses and with trivial intake (in 93-98% of patients).

Allergic reactions of a non-secret type (filling of soft fabrics, filling of Kvinke, anaphylaxis) when mesalazine is taken, it amounts to 0.07 to 0.1% of the concentration.

Rizik allergic reactions in general improve in patients with bronchial asthma.

The drug is toxic for the liver, slurry soil cystic brain... Likarskoe urazhennya stove and clinically insignificant change in stove tests (adjustment of ALT and / abo AST) with the intake of mesalazine is developed in 2.6-4% of the test. Toxic pancreatitis (inflamed pancreatitis) is more significant - less than 1% of vapors.

Mesalazin, vagina and breast cancer

In the article “Nutrition and reports about IBD,” we looked at the problem of conception, vaginosity and flatness in case of Crohn's malignant colitis and ailment.

Tsi diagnosi - zovsim not virok, patients with IBD can vagitniti and narodzhuvati. At the same hour, the patient may require further intake of mesalazine for an hour of vaginosity.

Injection of mesalazine for conception

Danikh about the infusion of mesalazine on the health of people before conception (for example, for example, from sulfasalazine) is dumb.

Mesalazin, vagina and breast cancer

Mesalazin in the form of tablets or granules penetrates into breast milk (approximately 0.1% of the dose taken to the drug, the metabolite of mesalazine N-acetyl-5-aminosalicylic acid - in a higher concentration). Wine also penetrates through the placental bar, and the concentration of speech in the tissues of the fetus is significantly lower than when it is consumed in therapeutic doses in older people. Until recently, the creatures did not show an unpleasant development of mesalazin for vaginal growth, development of the embryo / fetus, canopy and postnatal development of offspring.

Mesalazin in candles, aerosols and suspensions can also soak into the blood and penetrate through the placental bar and in breast milk. Ale on the basis of the intake of tablets and granules of such mesalazine is significantly less.

Inflamed VZK and vagіtnіst. Chi є Skoda for mother and child? A statistical analysis of 2000 vaginities (1300 with swollen colitis, 700 with Crohn's ailment) showed that 83% of females with Crohn's ailment and 85% with swollen colitis had normal circulation. The frequency of development of wad in children was 1% - yak and in children of healthy fathers. However, recent reports showed that mothers with active IBD in the phase of aggravated disease showed better indicators. Moreover, women from aggravated diseases have a lower vagueness of vagueness, and children do not have a lot of vagueness with a nationality and a lesser value of points on the Apgar scale.

The activity from IBD in the remission phase is not very much recognized as an abnormal one, at that time it is an increased risk of anomalous vaginosity. It is necessary to continue the treatment until the hour of the visit.

Brothers do not take mesalazine for an hour of vaginosti? First of all, it is important to know why mesalazine is vicarious for IBD. Mesalazin is a drug for the prevention and treatment of remission in case of acute colitis. It seems like it’s to let the vagina woman become more alert, or to increase the risk of lighting up for an hour of vagineness, as it’s conceived during the period of remission.

The pre-treatment on the creatures and the care of people did not show teratogenic mesalazine for the fruit, so the drug is not victorious, but it’s about development. This recommendation of the European Consensus on reproduction and vaginosity in IBD (2015 ric) should be made before the vicarystanny does not tied mesalazine with with a high rizik neobzhanikh effects, Likki may be vicious during vaginosis, as well as during breastfeeding in a dose not exceeding 3 g per dob (for tablets and granules). Vinatok - "Mesakol" and "Asakol" preparations, as in its obolontsi take revenge dibutyl phthalate (injected into the sectional system fruit in the twins). At the sound of a potent injection of dibutyl phthalate on a lot of people, "Mesakol" and "Asakol" are taken up to reception.

So, for example, in the instructions to tablets and granules "Salofalk" in the first trimester of vagineness, the drug is more likely to be indicated. In the II and III trimesters, "Salofalk" has begun to develop only if the potential for the therapy for the mother will change the moss for the fetus. "Salofalk" in the form of granules can be stored in the period of breastfeeding, as a potential effect of this for the mother, it is possible to transfer the energetic risik of the unpleasant child to the child. As soon as a newborn has a breastfeeding, diarrhea appears, and it is necessary to pinch the breast.

Therefore, a greater amount of mesalazine (including Asakol and Mesacol) is permissible for treatment in the period of vaginosity and breast administration, the protease and form of the drug is used as a drug.

Author of the article

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