Mastocytosis - European recommendations. Mastocytosis - European Recommendations Systemic Mastocytosis in Children

Zakvoryuvannya blood, which is characterized by the establishment of special cells, mastocytosis, is called mastocytosis. Clients of this type of health care not only for children, but for children, and moreover, they may be sick or older.

Podibnі insight є to fill up with ogryadnymi, in conjunction with which ailment is brought to the types of chubby ones. Wines appear right away from the statics, but it is more important to learn from children in the period of the first two years of life. The systemic version of the ailment is susceptible to growing up in older adults, at that time the skin mastocytosis itself becomes overwhelmed by children. The rest is also accepted as the name of the pigment crop.

Due to the nature of the ailments, I see a little bit of forms, skin from which vimag to myself a singing lykuvannya:

Childish type. Typical for children, who did not reach the courtier. I will appear to the great red beaches on the skirts of the child, who will be aware of it in an hour. Transformation into a systemic process type of mastocytosis is not very important and is not particularly safe for a growing organism.
Single vipadok. Characterized by the statement of mastocyti, which is a vignette of the battle. With a great stench, there will be no more zones, called universities. There is no systemic continuation.
Shkіrna form, characteristic of a child in the middle age and old, often grows into a systemic one, however, there is no strong progress in this type. Alle і repeated treatment with such viglyadі mastocytosis does not go away.
The fourth type is a shkirnu form of an accelerated viglyad, which turned into a systemic one with further progress. Take a turn in the battle internal organs.
Mastocytosis is of a systemic type, which will be hostile not only to the outer tissues, but also to the internal organisms. Vimag of strictly lykarsky control and post-life treatment.
Fat cell leukemia, is a malignant form of blood loss. This kind of ailment is caused by a rapid current and disgusting forecasts for a sick person on Maybut.

Mastocytosis, in the presence of the fact that it is insidious or systemic, has its own special signs and appears, and there are also options for treatment or therapy.

Talk about the causes of the ailment without the need for a blind eye;

A broader theory, however, is that chromosomes are lost, as a result of which the transmission of ailments is transformed into a genetic condition.

With shkіrnom mastocytosis suffers in the main shkіrnі pokrivi, unaffected by those who have a reason to cry themselves in the womb of blood. The main symptoms of self easy form a lot of important illnesses at the child's і grown-up є:

stronger pohervoninnya okremikh dilyanok;
sverbіzh shkіri, similar to allergic;
lowering the vice;
attack the hasty sertsebitt, breaking the rhythm;
temperature adjustment, as it appears chaotic and for no apparent reason.

Additional signs indicate about the exit of the histamine from the approved stovburovye clitin. Speaking about the battle, you can see the five main types of the process:

System type signs

diagnostics

The visibility of mastocytosis in the organisms allows further detection of the organs for the presence of infiltration by ogryadny cells. It can be in the fallowness of the body, which can be suspected of being severely ill. At the connection with the cym, we see the most advanced options for diagnostic methods:

Doslidzhennya shkiri. The Darina-Unni test is carried out, in addition to vivchayutsya vivchayutsya urazhennya on the subject of improving ogryadnykh clitin. However, this technique is not for the most part, as the zone, which has become aware of mastocytosis, was aware of whether it was mechanical.
Doslіdzhennya sechі. Here, the first is the appearance of the promotion to the gistamin in the sech. Protest, its growth can occur during ignition and ignition processes.
Differential dosage. Look for a new one in the school without a second for a new one in order to get a good idea of it.
Carrying out molecular analysis of klin cystic brain, Otrimanogo for the help of the point.

Modern medical reports new options laboratory tests, for the help of which it is possible not only to discover mastocytosis, but to find out the reason.

Lіkuvannya shkіrny mastocytosis

Therapies for ailments are employed by those of a higher professional level, such as hematologists and therapists with allergic health problems.

Likuvannya to wear in the main symptomatic straightness, fragments of a single scheme of struggle with similar pathology in a child and an older child is not seen.

The complex of therapeutic visits includes the administration of such drugs:

Leaks for stabilization of cell membranes ("Ketotifen").
Antihistamine group preparations (Suprastin, Tavig).
Alpha-interferoni. However, the positive infusion of certain drugs as long as it is found in the sum.

Predictions of a systemic type of disease are not the best ones, and the risk of their transition to an evil form is already great. The successful result is only a school battle. Falsely from the form of becoming ill, you can wonder if the organization of the people is different, but if you are inactive, you can lead to a very lethal result.

Hanging on the lobes and feet in children

Mastocytosis - what?

Unimportant to those who have shown themselves for the first time, they were described in the other half of the XIX century. Until now, for reasons and mechanisms of this development, there are only hypotheses, such as, in the case of pathological types of dermatology.

Shkіrni forma zhvoryuvannya store 0.1-0.8% in the number of all ailments, with the help of which there are consultative additional help in dermatological dispensaries. The frequency of manifestations in the middle of the population and women is the same. Mastocytosis in the middle of children can first be manifested in infants from 1 month to 1 month (up to 75%), but also in children and in larger groups of older children, and in new children. The statistics indicate the 2nd peak of illness. The first of them - in the period of up to 2 years, which is 55% of the income, the other - 35% of the income in the period of 20-40 years.

Mastocytosis - a whole group of growing diseases, which are accumulated in abnormal growths and accumulated in organs, in some abnormal systems, the organisms of ogryl cells (mastocytes, heparinocytes) due to the visions of them.

Causes of the blame

Oscillations of specific causes of mastocytosis have not been established; The majority of authors respect the systemic diseases of the reticulohistiocytic system.

The admission about the role of genetic officials is based on the presence of even more common types of family illnesses, especially in the middle of identical twins. In cich vipads, the autosomal recessive and autosomal dominant type of recession does not occur due to the increasing frequency of the pathology realization.

The growth of mastocytosis is possible as a result of mutation of spring genes, mimic clit proliferation, enriched with cytokines by the system. Likewise, the transmission of the sound of ailments to the destruction of blood washes. To that, the іnshі author її in the group of wicked ailments of lymphoid and hematopoietic tissues.

For good reason, provoke can be immune factor, tied with the openness of the ogryadny cells of glucoprotein receptors, highly sensitive to immunoglobulin class "E" (IgE). Also, risk factors can be both non-immune factors, such as:

physical - rubbing on the great shkiri for the area;
cold and heat;
contact with water;
otruta bjil and snakes, bite comas, active jellyfish;
alcoholic drinks and drugs;
bacteria and viruses toxins;
food products - siri, smoked meats, specialties, citrus fruits and vegetables;
lіkuvalny drugs - acetylsalicylic acid, anti-firing non-steroidal drugs, Also revenge code, vitamins of group "B", morphine, iodine X-ray contrast agents, medical anesthetics and actions of anesthesia.

pathogenesis

smooth cells

In healthy people, stinks of growth, as a rule, are near blood-bearing and lymphatic vessels, peripheral nerves and epithelial surfaces and presence in all tissues and organs. In a great number of cells, cells are found in the dermis (in the superficial balls), in the silty halls, in the mucous membranes of the lungs, in the mucous membrane and in the organs of etching, in the worms, lymph nodes and in the spleen, in the central nervous systems and in the peripheral systems. In secretory granules of mast cells, accumulation of chemically active biologically active words - histamine, heparin, serotonin, peptidases and others - is accumulated.

Smooth clientele vikonuyut the development of regulatory and service functions and in Danish hour they are used by even more strained clitins immune system, Yaki take part in all ignition processes, especially those associated with immunoglobulins of class "E". The development of a clitin occurs during the interaction of growth of receptors with cytokines and factors in the growth of stovbury clitins in the early stages. Remaining immediately stimulates the growth of melanocytes and the synthesis of melanin, which is responsible for the superfluous pigmentation of the elements in the visipu with mastocytosis.

In the pathomorphological suttu, mastocytosis є the accumulation of ogryadny cells grows in urazhenny tissues. Proliferative mastocytes are healthy and do not have atypical signs. Only in grown-up patients in the middle of the cycle they sometimes develop immature mastocytes, like in children, and in case of visceral forms of sickness, serve as the basis for the formation of an evil process.

Mechanism of development of mastocytosis

The purchase of mast cells in normal minds does not give rise to any spil proliferation in case of fluff, in fibrous tissue, in young granulation and in ignition processes.

When ogryadnye cells are activated by immune (mediated IgE) or non-immune factors, degranulation occurs, i.e. granules from the central part move to peripheral views clitini and go into the back space, de-zvіlnyayut biologically active speech.

Taste of a raptus and a shrewd vivilnenya of the great number of speech and manifestation. Symptoms of mastocytosis are overwhelming, even more importantly, for such vivid biologically active words, such as histamine and heparin.

It is transmitted so that histamine can be vivified without clinical degranulation. Efekti yogo pouring on the body is even more flexible. Vіn sounded great judges, widened thermal arterioli, venules and capilaries, scho wede to increase the court channel and lower arterial vise, Zbіlshu penetration of the stinka of dry vessels, stimulating the secretion shlunk juice in the education of the slunk and so on. Gistamin is also volodya ear, on thrombocytes, as a result of which an overwhelming number of mediator serotonin appears. Tse lead to arterial vise and іnshim vegetative reactions.

Overwhelming heparin dysplasia - decreased laryngeal blood flow, in the case of mastocytosis, hemorrhagic symptoms appear - nasal bleeding, petechia (small punctate hemorrhages) and purpuric osipitis (other hemorrhages).

Unimportant to a good perebig zhvoryuvannya, in small vapadas, it is very well transformed into evil. Inodi malignancy of mastocytosis with a stretch of 2 rocks can lead to a fatal result. Naypekonshim butt є mast cell leukemia. Yak viglyadaє mastocytosis?

Therapy for illness is symptomatic. It is especially significant to find out that there are some negative officials - physical inflow, by-stream chemistry, temperature factors, water inflow, especially hot ones, etc.

It is necessary to have a unique method of storing perahovannyh food with food (drug and diagnostic drugs), bites in comas and so on.

Is it necessary for a mastocytosis to pretrimate children?

So, it is recommended to eat with citrus fruits, eggplants, herbs together with extractive speeches, specialties, smoked meats, some types of syringes and seafood, so that the products are potentially allergenic.

basis drug therapyє antihistamines of another generation (Cetirizine, Fexofenadine and Loratatadin), blocking H1-histamine receptors. Volodyut Tavegil і Fenistil is an indomitable therapeutic effect. Especially often, the last hour is marked by Zaditen, which is a poor membrane-stabilizing and antihistaminal action.

In case of diffuse or systemic forms of congestion, it is recommended to congeal in the middle of glucocorticosteroids, and in case of advanced forms - congestion in vyglyadi ointments and creams or not to be introduced in the middle of the period.

With an extended type of mastocytosis, a good effect on the results of photochemotherapy, the proteon is indicated for the treatment of children up to 12 years old. In case of a malignant illness, cytostatics and alpha-interferon are recognized. Have lіkuvannі children, who suffer from mastocytoma, vikorystuyutsya misce introduction high doses of glucocorticosteroids or surgery.

At the connection with small drops of mastocytosis in the lykarskiy practice yogo diagnostics is often pomilkov, and therapeutic infusion is inadequate.

System type signs

In 60% of vipadkіv it is considered that they are trusting not to get sick, and in 40% they are more aggressive. Indulgence in a large variety of vines is characterized by the statements of a great number of beaches and papular visipans, which are sometimes bluish-horny, and later - brownish storms of vidtinoks.

The size of the visipan is small, and the outline is round. Plyami and papules are manifested by characteristic bagatorazovy attacks, which also mean short-term periods of remission.

Farther on, every patient can appear brown-colored vuzli in size from a pea and navi more. Woozli can get angry with themselves, get ready to finish up solid conglomerates. Especially often, such anger can be seen in the folds of the body.

In a number of vypadkiv, diffusion is established with clear boundaries. In the world of growing and foreign cultures of these in the world, there can be formulated eritroderma.

Before the first manifestations of mastocytosis, it is possible to carry:

When pouring into the hanging of physical podraznikiv (heat, vice, rubbing), the stench puffs up yaskravo-chervona pigmentation, swelling. At the same time, the patient has a build-up of sverbinnya. Characteristic of the reaction of the natives, the visipan, called the phenomenon Darina - Unni.

Shkіrny mastocytosis in the main case only shkіrnі pokrivi. At the same time, the following symptoms are observed:

Pochvoninnya shkiri;

Itchy skin;

Reduces the grip;

Periodically frequent sertsebittya;

Periodically adjusting the temperature of the fire.

Systemic mastocytosis of the enemyє:

Nerve tissue;

Selezinku (won in size);

Cystic brain (normal cells in the cystic marrow are replaced by mast cells, leukemia is formed);

Pechinka (pechinka is growing, narrowing, and there are fibrous universities in them);

Herbal tract (there is diarrhea і virazkovі urazhennya);

Cyst system (osteoporosis (cyst growth) and osteosclerosis ( kistkova fabric substitute with a profit), there are pains in the hand);

Lymphatic universities

In case of this type of ailment, it is defeated by new cells of the internal organs themselves. At the same time, you can see the small ones by the small ones.

As signs of a systemic type of enlightenment, there should be some structural changes in them, such as to produce negative and often non-gated inheritances:

Collapsing with mastocytosis

Serious damage on the side of certain organs, which is susceptible to systemic mastocytosis, can be the cause of a lethal result. The most serious prognosis is with leukemia of stovburovikh clitins.

The folding can be super juicy not only with the most aggressive flow. To navigate in case of malignant mastocytosis may anaphylaxis, neoplasia and angioedema. Gastrointestinal damage is also not included.

Causes of mastocytomy in dogs

The reason for the appearance of mastocytomy in dogs is even more folding and mating with a mutation of the proto-oncogene (the proto-oncogene is the proto-oncogene mutation, which is a mutation that leads to the development of cancer) Kit. The Danish proto-oncogene Kit plays an important role in the hematopoiesis and proliferation of smooth clitins, in which case chickens can develop.

For histological classifications they see:

Highly differentiated chickens (1 step) - are characterized by low metastatic potential (rarely give metastasis from other organs and tissues), low potential for causing recurrence and triviality.
In terms of differentiation of pukhlini (2 steps) - metastatic potential 10 - 22%, average potential for recurrence and triviality of life.
Low-grade poohlini (3 steps) - metastatic potential is more than 80%, consistently recurring and moving from the main disease is more than 65%.

The main path of metastasis of mast cells in dogs is lymphogenous (struma of lymphatic age), as well as hematogenous path (blood flow). For localization of mastocytes 50% of the seizure is on the tulub, on the end of the seizure 25 - 40%, on the head is close to 10%. Also, a mastocytoma can enmity in dogs the mucus membrane of the mouth emptying, worms(Visceral mastocytosis of dogs).

Cutting the mouthwash in mastocytoma in dogs

Symptoms of mastocytomy in dogs

Symptoms of mastocytomy in dogs may be malignant. Most of the time is single (in 95% of vipadkіv) rounding of the statement of shkіri, m'yake, crumbling and maybe not the mother of the outside cover. Highly differentiated mastocytomas, most often, tend to grow, elastic and not viciously unrecognizable in animals, nor in those who have masters. Poorly differentiated mastocytoma in dogs most often has signs of burning, erosion of shkirny coat, bends of sverbіzh. For low differentiation of mastocytomy, the manifestation of Darina's syndrome is characteristic - the emergence of chervonuvaty vuzliks with a rosette of self-puffiness and shkirny cover with her hand.

Diagnosis of mastocytomy in dogs

Diagnosis of mastocytes in dogs is guilty of only high-quality diagnostics by a doctor-oncologist. Vona includes a retreat anamnesis, an examination of the creature, cytology, blood analysis, radiographs and ultrasound dosage, Histological and immunological and hygienic dosages of chickens. Such a collapsible diagnosis of mast cells allows us to make an accurate diagnosis, because of the prediction and development of the optimal treatment scheme for a specific skin type.

Cytological picture of mastocytomy in dogs

A mastocytoma can also lead to the development of paraneoplastic syndrome - a complex of symptoms that develop not from a mediocre development of swelling, but from an early stage of development of biologically active speeches. Earlier, it was lost, so mast cells take revenge from their cytoplasm a great number of mediators ignited. With progressive swelling, or with ruinous clitin, especially with low differentiation of the form of mastocytomy, the given speech goes out and is consumed in the bloodstream, the systemic reactions occur. The most characteristic manifestation of paraneoplastic syndrome with mastocytoma in dogs is the reduction of the intestinal tract, right up to the development of the swelling ailment. Not unmistakably striking mental systems(By the name of rhinitis, bronchitis and bronchopneumonia), leukocytosis and thrombocytopenia occur (a decrease in the number of platelets in the blood, which is not without bleeding).

Treatment of mastocytomy in dogs

The treatment of mastocytomy in dogs is very difficult. It is tied, in the first place, there is a thick-celled chubby, like an already zagaduvali vische, widened widely in rich fabrics and a simple surgical vision is not enough. Naybilsh is often in the presence of a given type of chubby process of vicious blockage with hormonal problems. In the course of the visit, invite to see the change in the size of the chickpea, and the activity that allows you to spend a wide range of information. I have given the formulation as evidence that there is a great number of mediators in the mast cells, and hormonal factors, which can be used during blockages, to induce the activity of the world.

Find out the rules for conducting surgical operations for mastocytoma in dogs. In the first place, it is necessary to enter from the regions of pukhlini, not in one size of education, as in the case of some types of cancer in dogs, but in three sizes of mastocytomy. It allows in the meaning of the world to reduce the risk of establishing relapses. Another rule of the surgery of mast cells is about the histological examination of the regions of the wound, the so-called healthy zone, for the presence of stovburovnyh cells.

In case of unhappiness of the surgical operation for mastocytoma in dogs, the recommended chemotherapy regimens are recommended. Smells include vicorystannya prednizolone, vinblastine, Lomustin and cyclophosphamide. Ci drugs, as if chemotherapy, viroblyayut a systemic effect, appear to be attributed to hemopoiesis, development of anemia and intestinal dislocation.

Krym classic chemotherapy and targeting (in English Target - target) therapy of mastocytes. The change in this type of polygonal reaction in vicorian preparations is to bring the growth of cytin, but also to the receptor - C-Kit, VEGFR and in. About the detection of these receptors in mastocytes with mast cell fluff in dogs can be found out at the presentation of immunogastric development. Yogo to spend on a path until the end of the puddle of writing is seen as well as writing off the material in a different way, for example, taking a stack of fabrics for the help of special systems for analysis. In case of detection of cych receptors in mutated mast cells, special preparations are used to block these cells. Naybilsh vicoristovuvanim є two drugs: masitinib (Masivet®) and toceranib (Palladia®). Varto by no means dan likarski zasobi I have not yet gotten the certification in the Russian Federation and the part of this site.

forecast

The prognosis for mastocytoma in dogs is to lie down without a middle class of chickens, the stage of the process and the type of creature. Likewise, we infuse new data on immuno-stochastic analysis, at the presentation of which there are a lot of mutated cells and the effectiveness of targeted therapy. With highly differentiated mastocytomas, the triviality of life is significant, with equally differentiated puffs, the average triviality of life becomes, in the middle, from 1 to 3 years. With low-grade mast cell puffins, the prognosis of unpleasantness and the term of life of patients does not change 12 months.

Clinical diagnosis of mastocytomy stabilization in a pug

Pug 2,5 roku Lola turned up on a welcome in the class with scargs for the approval of Liva upper lip Before the diagnosis of mastocytoma was diagnosed in a third-party clinic, no treatment was carried out.

Also wonder:

Insulinoma in dogs

Insulinoma in dogs is a malignant pukhlin, which develops from beta-clitin in a puddle. Insulinoma is a metastatic puffin, so it is not just a pidshlunk zalosis that can be avoided.

Lymphoid in dogs

Lіmfomi - evil puffs, scho to feud lymphatic system to the organism of dogs, which is built up from lymphatic universities, united by the system of judges. The likelihood of lymphoid in dogs is great and of a warehouse, approximately 80% of all diseases of the hematopoietic system.

Histiocytoma in dogs

Histiocytoma of the shkiri dogs is a good shkiri sudino-connective tissue pukhlin. Approved by the clines of Langerhans, in the norm - by the residents of the shkіri and mucous membranes.

Osteosarcoma in dogs

Osteosarcoma is a malignant pukhlin, scho winy in the cysts, which can lead to direct atypical osteogenesis (the formation of cyst tissue).

So also gastritis, and why should it develop?

Zakvoryuvannya, when dogs ignite the mucous membrane of the shlunk, call it gastritis. A little bit of ailment forms:

viklikaniyami Helicobacter (I first see the information, because of the ailment go to the state standard and chronic form);
eosinophilic (eosinophils accumulate in mucous membranes, how to vibrate words, scho rusinuyut pre-colonic fabrics);
atrophic (chronic form, when there is a change in the size of shlunkovykh zalozov, groaning of slime, reducing the amount of shlunkovy juice);
gostry (buvah and self-reliant, and second-hand illnesses);
chronic (contraction without symptoms, or occasionally trapelling zagostrennya).

The reasons for the development of ailments can be reduced.

With an atrophic form, the mucous membrane of the shlunka grows thin, the function of shlunkovye zaloz decreases. Until such a form, a strong foxter and a retriever. The reason for this is autoimmune processes.

The chronic form develops through a continuous infusion of factors, which can lead to gastritis: helminthi, lyki, trivial growth of an uncomfortable rye (especially dry food of low quality).

Gastritis is often a secondary illness. Wine grows on the smallest serous ailments of the central nervous system, nirok i n.

Important! When ignited without a proper addiction, erosions take place on the muck, which step by step move into the twists.

Dog gastritis: symptoms and diagnosis

Symptoms of gastritis of different species may appear one in one, but they all have a cheap sleep - the ailment of the creature suffers from blues. It is necessary to correct vitlumace and signs of such an unacceptable illness, such as gastritis in a dog: the symptoms of the skin form are suggestive of distant.

Viklicanii with Helicobacter bacteria

In dogs, which suffer from the form of ailments, they are susceptible to chronic blues. The veterinarian is diagnosed with a biopsy of mucous and gastroscopy. Using a microscope, take an hour of tissue procedure. Ailments appear in case of bacteriological pre-sludge secretion or bluetongue.

eosinophilic

Creatures from the cymbals suffer from dairy and periodic vomiting. Ailments of the dog consume the vagina, sometimes increasing the peripheral lymph nodes. In the course of diagnostics, they diagnose ailments of the intestinal tract and are infected with helminths, conduct a biopsy of the mucus.

atrophic

Ailments of the dog suffer dwarf, before sparing the blues. The creatures do not grow normally, they eat the meat, they consume the vagu, they melt, they grow hungry, the appetite grows overwhelming (the creatures receive unreal objects). Inodi ailment against symptoms without symptoms.

Another feature of this form is that the ailment may not manifest itself, if the dog gnaws at dry food, or when the lumpy meat is fed, the creature develops diarrhea (it should be introduced through a decrease in the decay of the slurry juice).

In the course of diagnostics, conduct a biopsy of mucous and reveal atrophy of shlunkovy zoloz. The results of blood and blood loss often fall in between the norms.

The head symptom of such a form is bloating, it is easy to provoke the palpation of the slunk. The dog is old, nasty, it’s bad, it’s bad for me (with some blues). The mucus is strongly affected, and streaks of blood appear in the blues and calories. Shlunkov's bleeding is easy to see through the bloody feces. Diagnostics includes a parkan of cut and blood (develop indicators in the boundaries of norms, altogether prevent leukocytosis).

Uwaga! When the watery blooms move, the acid-water balance breaks down through the blotches. Vyavlyayut GOST form for the help of the endoscope and biopsies.

chronic

With a regular increase in the acidity of the slurry, the ditch is periodically ditched with undisturbed gut and streaks of blood, and constipation can also be prevented. There are obvious signs of gastritis in dogs. With a decrease in acidity, diarrhea is often consumed. Ailing creatures are rotten.

In the course of diagnostics, the veterinarian should conduct an x-ray for the detection of the young aliens... It is obligatory to control gastroscopy and biopsies. Indicators of blood and slaughter grow in the norm, and even in some cases, anemia can develop.

Treatment of gastritis in dogs

The methodology includes: the usunenia of pershoprichini, the knowledge of the fiery muck, the sign of the child. In case of diarrhea and bloating, it is obligatory to carry out prophylaxis of inflammation.

Likuvannya gastritis in dogs lie in the form of ailments, as the cause of the diagnosis.

Gastritis, bacterial infection Helicobacter, elimination of antibacterial diseases (call a combination of amoxicillin and trichopolum).

Important! One hour, with the medications, the veterinarian will indicate the intake of the drugs, which will seize the mucus from the day: De-nol and in.

The eosinophilic form is treated with corticosteroids (prednisolone) in combination with azathioprine. Precisely the dosage of the sign of the veterinary medicine is given to look around and diagnostics.

In case of atrophic gastritis, the veterinarian signs the intake of Metoclopramide and Erythromycin (the stench causes the activity of the slunk). One of the indications for taking antibiotics.

The chronic form is not without sharpening. In case of frequent bloating, the dog does not fit for 1-2 days, for which it should be transferred to a sparing rice day. In case of annealing, an internal infusion is shown, according to the Ringer's range. physiological... The veterinarian has diagnosed the symptoms, carry out diagnostics and the results indicate the use of drugs: Prednizolone, Metoclopramide, Misoprostol and I.

Uwaga! It is not possible to fix the problem without prior diagnostics, so as in all cases, you can tell the creature. Whether the drugs are indicative of only a veterinary drug for a clinical checkup and the results of treatment.

Prevention and prevention for a dog with gastritis

Prevention of gastritis includes the treatment of children. The dog is allowed to walk in small portions, often in singing years. It is recommended to take dry food from the race and go to natural food(Vinatok - veterinary children for creatures with sensitive poisoning). So

General rules for children's food:

zmenshuvati zvychainy dobovy obsyag yzhi by 20-30%;
їzhu gotuvati for a couple, wipe;
the number of years is up to 5-6 times a day, depending on the normal mode of the year.

Get to know visually the symptoms, signs and methods of treating gastritis in vihovants on the video below:

What kind of mastocytoma?

Pukhlin is diagnosed in 25% of cases due to characteristic new products of the school and pediatric cells. Might viglyad superficial forms with a vilny ruch, or with a pediatric dermal growth, the dermis can move over a mastocytoma.

on cob stage won іmіtu іmіtіn іs іn wiglyadі papules, vuzlіv, kіrochok, etc. appraisal. When staging a diagnosis, carry out a differentiation from the primary and secondary schools of thought. In 15% of cases of a mastocytoma, it is "hovayetsya" under the sight of a pediatric lipoma.

Fact! Accurately diagnostics of mastocytes in dogs is unfortunate, since cytological and histological dosages have not been performed. As soon as the veterinarian gives a quick glance at the new solution, his competence can be put on the list.

Most often, the mastocytoma is single, but in important cases, multifocal growths are detected. In case of invasive mastocytosis, there is recurrent lymphadenopathy, which forms when metastasized in pre-colonic tissue. With systemic lesions, splenomegaly and hepatomegaly are known.

It is not common for dogs with mastocytoma to be counted for a specific diffuse filling through those that have large cells that are critical of biologically active (vasoactive) speech. Nabreak і firing process is formed near the primary swelling or in the area of known metastases. On the way, hematomas and erythemi are formed on the basis of production.

breed intelligence

Fat-cell pukhlin with the same frequency grows up in bitches and dogs, “love” old dogs, from 9 years. However, there is no guarantee that a mastocytoma does not appear at a vikhovants until a kidnapped vik.

Significantly with caution, signs of ailments are more common in such breeds of dogs:

Boxer, bulldog, pіtbulter'єr.
Bigl, Shar Pei, English seter.
Boston Ter'єr, Labrador Retrieve.

It is noteworthy that in short-haired and wire-haired breeds of mastocytoma, they develop more often, they can be easily tied through UV-exchanges.

Mastocytoma: vidi and form

Fat cell fluff in dogs is classified for key symptoms, Histological structure (class 3).

Highly differentiated pukhlin 1 class follow the additional operation and exchange therapy. Mobility oduzhannya with a lot of significant vitality, lower with a new establishment of the 3rd class. When diagnosing, the veterinarian will give a mitotic index, with which it is possible to develop a prognosis for mastocytosis. In case of index 5, the prognosis is very poor.

For key symptoms, they develop:

solitary or lonely education. The stench grows all over the place, you don't faint;
single mastocytoma with metastases in pre-colonic tissues and lymph nodes;
a lot of (diffuse) chickens from the accumulations in the pathological process of lymph nodes and a great number of growths;
mast cell leukemia.

Symptoms of mast cells develop, lie in the localization of the puffiness, the level of malignancy.

Fact! Veterinary doctors call mastocytes "great іmіtator". Not a single one strictly sanctioned form of education, yaka could serve as a "stencil" for ailments.

Vona buvaє yak is single, surrounded by healthy tissues, as well as in a viglyadі strong growth, who were angry with tissues of fluff. Fillings and ignition processes are formed around them.

Why grow ailments

dumb exact reasons, Yaki lie in the basis of the development of mastocytomy. You can get away to a group of children, be it from home wives, if you want to be sickly brachycephalic dogs for 8-9 years.

Transmission, which causes mastocytomy to be scared in the diy of factors of the new middle of the virus, bacterial or fungal nature. Ale tse the pretense of niyak was not realized, it is not possible for me to be admitted.

Independently of all, veterinarians are single-stage in one - the development of cancer of the shkiri with a mutation of the proto-oncogene gene. Take care of the fate of the blood, proliferation of mast cells. The whole fact is confirmed by the fact that the newly established form is formed from stovburovye clitins.

Named viglyad mastocytomy

"Іmіtator" - this is how one evils can characterize the fat-cell pukhlin. You may experience a lot of symptoms similar to those with ailments. Mastocytoma can "pretend" to allergic shkіrnoy reactions.

The first fact that I will put on the chubby is the adoption of a soft, crumbling segment on the screen. When you call it out, the wool grows or grows up.

The behavior of mastocytomy can be characterized by the word - inability to transmit!

Mastocytoma in 1 stage of growth in general, not turbulence. Likuvannya at the tsiy stage gives good results, but the breeders do not cheat with their relatives, they don’t go wild before the veterinarian.

At the last, 3 stages, the complex of symptoms is great, to be observed:

stronger sverbinnya. Vikhovanets literally in the shelter razchіsuє mіsce pukhlini;
erosions and flames are formed on skiri;
Near mastocytomy, there is a strong swelling and heart failure.

When a bacteriological infection is received, the schoolboy starts to suppress. In most cases, mast cell fluff is superfluous and ailments. The bend of the slunk is developed through active robotic receptors in the histamine. Symptoms - bloody, blood in the feces.

Fact! Syndrome of Darina vinikє in case of intensive rooting of chickens and children near her. Pidhoplyuyutsya chervony vuzliki. Tse is a direct sign of mastocytomy 3 steps.

systemic mastocytosis

It is a dissemination of ogryadny cells from internal organisms. Клінічні signs to lie down as an organ of exercises and as a result of a mediator's development.

signs:

feed from feed;
weakness is strong;
visnazhennya;
diarrhea;
blues.

Symptoms are typical for some internal ailments, so it is necessary to correctly diagnose. Spleno-hepatomegaly, lymphodenopathy, vipoti in the heart and legacy systems with the mass of ogryadnye cells and penetration into the cystic brain.

The prognosis for systemic mastocytosis of unpleasantness. Chemotherapy is not more effective. A dog's life is not more than 3 months.

diagnostics

You can accurately diagnose ailments in the minds of the veterinary clinic. Wickedness of standard and specific tests: anamnesis, examination, histological and cytological information, ultrasound, X-ray, analysis of blood and blood.

Histological characteristics:

Pukhlini 1 class, highly differentiated with a low chance of expanded metastases in the organization. With the occasional visible relapse, it is not a fault.
Pomirna (class 2) differentiation is characterized by a metastasis in 20% of cases. Relapse does not happen, for the statistics deprive three of the Vikhovanets survives to the age of the elder.
Mastocytomy 3 class or low differentiation, characterized by a high risk of developing metastases. Part of recurrence and death of the dog.

Mast cell pukhlina (cancer) metastasis along the lymph ducts, ale neridki and broadened along the circulatory system. Know the mastocytomy on the paws, tulub, and on the shoulder and head. In the case of even more severe ailments, I will burst empty and slime in my mouth. According to the results of diagnostics, the car is indicative of the liking and the blame for the forecasted prognosis of the disease.

Illness therapy and prognosis

Likuvalny path is foldable, to pass through the stage of stages, to accumulate in the form of mastocytomy and the appearance of metastases. Conduct chemotherapy, surgical operation, Promenade therapy in children. Seeing the pudding obov'yazkovo with the volume of buried healthy tissues, as well as allowing the localization of mastocytomy. Chemotherapy should be carried out for 6 or more months.

The dog is constantly sent to the veterinarian-oncologist for the operation. In case of recurrence of drug manipulation, it should be repeated. In case of unproductive behavior, feed on euthanasia is considered.

Special features:

The chat shows a sign hormonal drugs(Prednizolone, 2mg \ kg \ add.). Pukhlin is up to 3 cm in diameter, there are a lot of ailments. With lonely, ale great mastocytomas, Prednizolon is required for kupiruvannya ignition processes in soft, peri-tumor tissues. When the chemotherapy is introduced, the glucocorticoid is predominantly recognized, as it’s possible to give the sickness more time, but the ailment itself isn’t forgiving.
The hanging of the chubby is correct in the case of "manual" localization and in the case of the possibility of a large flooding (not less than 2-3 cm) of healthy tissues. With mastocytomas at 3 stages, and with visualization without great flooding, a relapse occurs.
Appointment of antihistamines during the operation is necessary for the prevention of allergic reactions (anaphylactic shock) through the massive development of BAR.
The exchange therapy should be performed only on small mastocytomas, or before the operation (SOD 50іGy). At the 3rd stage of development, the effect is low, alopecia, and the fluff cannot be found (SOD dose 40-55 igor).
Systemic chemotherapy should be performed with multiple mastocytomas, metastases in the lymph nodes, and with ill-feeling. Vikoristovuyut: Wincristin, Winblastin, Lomustin, Cyclophosphamide, Diskorubistin tosho.

There is no accurate prognosis on the development of mastocytomy at any stage. Explain the price of the unwillingness to predict the behavior of the new solution. Veterinary medications for lichen allow for the best option for overcoming ailments and an effect from a disease.

Mastocytosis (mast cell leukemia)- systemic morphology, morphological substratum for massive infiltration of children, organisms and tissues with large cells (mast cells, mast cells, tissue basophils). Zahvoryuvannya rіdkіsne, the frequency does not lie in the statі. You want to develop by stretching the first two rocks of the life of a child (75% of the population) and in half of the years it is possible to mimically allow it until puberty. Systemic mastocytosis is often sick in adults.

Diagnosis of ailments Mastocytosis (mast cell leukemia)

Ethiology and pathogenesis of mastocytosis unavailable. In some cases, it is transmitted in an autosomal dominant way, if in a large number of cases of ailment there is no family history.

Perebig ailments Mastocytosis (mast cell leukemia)

Histological picture of all forms of mastocytosis manifest themselves as infiltrates, which are stocked as the head rank of stovbrovykh clitins. Metachromasis of fatty clitin granules occurs in the presence of toluidine, methylene blue, as well as naphthol-AS-D-chloroacetate esterazy (Leder method), farbuval cytoplasmic granules of fatty clitins in fervone coli. With maculopapular and tele-angiectatic types, mastocytosis of ogryadnaya clitinus grows head-on in the upper third of the dermis along the capillaries. The nuclei of ogryadnye clitines are more often spindle-shaped, more round or oval. At the connection with this, there can be small cells in the presence of small cells and on the cells, filled with hematoxylin and eosin, and their nuclei can inflate the nuclei of fibroblasts or pericytes, for the establishment correct diagnosis Requirements for special procurement. With many universities, or plaques, as well as with great solitary universities, ogryadny cells make great purchases of the type of chickens, infiltrating the whole dermis and fat cells. If the large cells lie in the grocery stores, their nuclei are more cubic, lower the spindle-like cells, may eosinophilic cytoplasm and good growth between the cells. Tse nadaє їm to finish the characteristic viglyad, so the diagnosis can be made without a special farbuvannya. In case of diffuse (erithrodermic) type, at the upper part of the dermis, there is a tendency to develop thinner-like infiltrates from stovbury cells with rounded or oval nuclei and clearly surrounded by cytoplasm. With all types of mastocytosis (teleangiectatic for some reason), eosinophils can develop in the middle of large cells. An increase in the number of eosinophilic and lateral granules of fatty clitins in the biopsy taken after rubbing into the cavity, to indicate the development of granules from stovburykh clitins. The nature of the bulbs with subepidermal mastocytosis; However, at the connection with the regeneration of the epidermis in the delivery of the bulbs, the bulbs can be localized internally. Puzir often takes revenge on smooth cells, as well as eosinophils. Pigmentation of elements in mastocytosis was accompanied by an increase in the number of melanin in the cells of the basal ball epidermis, and later - in the appearance of melanophages of the upper part of the dermis. In case of systemic mastocytosis, paratrabecular inflammation of fatty cells in the cystic marrow, diffuse infiltration of red spleen pulp, periportal infiltration in liver cells The purchase of fat cells is spostering in the hearts, nirks, mucous membranes of the intestinal tract.

Symptoms of ailments Mastocytosis (mast cell leukemia)

see 4 formy mastocytosis:

shkіrny mastocytosis childish abo early childish vik When there is a shkіrnі vognischa in puberty, systemic changes, as a rule, are seen, and progress with the development of a systemic form is infused in the edge.
shkіrny mastocytosis fatigue and grown-ups with frequent systemic disorders, which often lead to systemic disorders, ale stench, as a rule, does not progress. Spontaneous regression in older adults, on the view of children, not descriptions. The first form is progressing, passing into systemic mastocytosis with progressive lesions of internal organs;
systemic mastocytosis;
malignant mastocytosis(Fat cell leukemia) - even worse form, characterized by the appearance of cytological malignant fat cells in the organs and tissues of the tissues, especially in the cysts and peripheral blood, with a quick lethal result; bezvychay not supervised by shkіrny manifestations.

More than half of the ailments mastocytosis Skargi obmezhuyutsya urazhennyam shkіri. Closely 1/3 of the children skarish on sverbіzh, attack the arterial grip, paroxysmal tachycardia, fall arterial grip, periodically temperature, etc. Symptoms of obesity degranulation of fat cells and are susceptible to advanced forms of mastocytosis of the skin or internal organs.

with mastopitosis I see five types of small stripes (moreover, the first two of them are spontaneous, both in the elderly, and in the grown-ups).

Maculopapular type of mastocytosis, Performances in dozens or hundreds of other red-brown hyperactive beaches and papules, as the grating (Darina-Unni test) swells an urticarial character, most frequent.

Multiple vuzluvate type of mastocytosis performances by multiple napivkulyastiyh universities of horny, chervony or zhovtoy koloru, 0.5-1 cm in diameter with a smooth surface, some vuzli get angry in plaques, the phenomenon of Dar'i-Unni bends is weak, especially in older adults.

Great solitary node type, Abo mastocytomy, is manifested in a knot with a diameter of 2-5 cm. May be smooth or wrinkled, like an orange pick, a surface and a gum consistency. The education is organized up to 3-4 universities. Vuzli viklyuyut in nemovlyat, bowls in the area of shii, tuluba, beforeplich. Darina-Unni's test is positive. Traumatization should be carried out to form bulbs on the surface of the vuz, pustules or bulbs, and also until the appearance of bulbs. Mastocytomy sinister regress spontaneously, with a great stench it sinks and smoothes. In a number of vipads of universities, they are associated with hanging, characteristic of the maculopapular type of mastocytosis.

Diffuse (eritrodermic) type of mastocytosis be ready to be repaired in an early child. It is characterized by great itching in the light-brown іnfіltratsії, in the groin depressions and between the berry folds. The lights may have an irregular shape, clear boundaries, solid (up to woody) consistency, on their surfaces it is easy to find bends, trellises, exorcisms. Progression of the pathological process can lead to erythroderma. With a lot of shkіrnі pokrivi swelled doughy, abbreviated consistency, color іх varіyuє from rye-chervony from zhovto-burr to dark brown. The Darina-Unni test is positive, and moreover, it is easy to traumatize it, it can lead to the appearance of bulbs, often supervised by an intense sverblyachkoy. When perevazhanni in the classic picture of bulbs, talk about bulloses mastocytosis. After getting ill, step by step, to progress into systemic mastocytosis, it rarely occurs, death is unheard of as a result of histamine shock.

Teleangiectatic type of mastocytosis(Type of stiff plyamistoy teleangiectasis) - a rare form of mastocytosis, it is very important in older adults, the head rank in females. Appear with the broadening of the brownish-red beaches of the young outlines, which are made up of the best teleangiectasias. roztasvanih on pigment aphids. It is evident that there is little strength before the appearance of chubby in the mice rubbing or spontaneously. Bowls of breasts and pictures. Characteristic sverb_zh. In a number of vipadkiv there is a reduction in cysts and virazkov ailment.

systemic mastocytosis characterized by lesions of internal organs in the presence of schkinny mastocytosis, but without it, they develop the same often in men and women. Sposter in 10% of ailments with small manifestations of mastocytosis. At the same time, in a large number of vypadkіv, the training of the school is pereduyut signs of the systemic process. Shkiri changes in systemic mastocytosis are represented by maculopapular, multiple vuzluvati or diffuse (erithrodermic) types.

In the process of mastocytosis You can get started whether you are an organization or a system. Naybilsh often - kistki, pechinka, spleenka, lymphatic universities, shlunkovo-intestinal tract, Central nervous system. 20-30% of ailments with mastocytosis may develop cysts, which, in case of radiological pre-developmental diagnosis, appear as osteoporosis and osteosclerosis. Osteolytic changes are accompanied by pain syndrome. Closely 1/4 of the number of cysts are mastocytomas, protest infrequently in children. Uterine liver disease is manifested by mild symptoms of mast cell infiltrates and fibrosis with hepatomegaly and diffuse mastocytosis.

systemic mastocytosis over the course of the day, you can be good and bad. To malignant mastocytosis, mast cell leukemia, mast cell sarcoma, variants of systemic mastocytosis, association with lymphomas, solid new diseases, or malignant blood clots are carried.

Diagnostics Mastocytosis (mast cell leukemia)

Mast cell leukemia is manifested by basophilia, neutrophilia with significant destruction of the nucleus, hepato-and splenomegaly, minor hyperplasia of lymph nodes. At the cyst-cerebral punctate, there are blast stem-drill clitins.

Diagnosis of mastocytosis of shkiri stand at the office classic paintings, positive test Darin-Unni, the growth of ogryadnye clines in the midst of lesions. days).

In the diagnosis of mastocytosis vikoristovuyt viznachennya gistamіnu in sechі (gіstamіnurіya), however, this rіven also grows with ignited, allergic ailments, as well as in healthy individuals (for example, in athletes). For the prevention of systemic mastocytosis, carry out the appointment of the head metabolism of histamine - 1-methyl-4-imidazoleacetic acid, which changes the core due to the activity of mast cell proliferation and rapidly grows in case of a form of mastitis.

It is carried out with pigment nevi, freckles, lenti-ginosis, such as mastocytosis, to manifest the positive phenomenon of Darina-Unni. Papulogenicity and vuzluvatie elements of mastocytosis occur as xanthomas, dematofibroma, histiocytosis X, nevoxantoendotheliomy on the basis of histological reports. On the basis of likarskoy toxidermia, with mastocytosis of the daytime ulcers, there is an incidence of discomfort. For bites, comas, epidermoid bladder neoplasms, differential diagnosis should be carried out at the submission of clinical data and the results of pre-treatment on histamines. Mastocytosis smoothly vіdrіzniti od vrodzhenoї poykіlodermіі Rotmunda Thomson autosomal retsesivnogo zahvoryuvannya, klіnіchno proyavlyaєtsya in Pershi Rocky Zhyttia i harakterizuєtsya eritematozny plyamami, zmіnyuyutsya sіtchastoї gіperpіgmentatsієyu, atrofієyu i TV angіektazi on shkіrі oblichchya, shiї, rіdshe - on kіntsіvkah. On the basis of mastocytosis, it means low growth, microcephaly, dystrophy of teeth, hair and nіgtyv, cataract, rosum appearance. Teleangіektatіcheskaya form of mastocytosis vіdrіznyaєtsya od atrophic sudinnoї poykіlodermіі Yakobі, yak harakterizuєtsya oseredkovoї gіper- i hypopigmentation, teleangіoektazіyami i atrofієyu shkіri, generalіzovanim character Process, nayavnіstyu plyamisto-papuloznі visipan, skhilnih to zlittya, of utvorennyam great vognisch urazhennya de mozhliva prisutnіst zagalnih simptomіv (Attacking "Flushing", beating the sverbezh, tachycardia, etc.) or the level of internal organs. Pigmentous purple and lychenoid angodermatitis of Guzhero-Blum, on the form of mastocytosis, hostile to people in the middle age and are characterized by blistering diseases in the areas of papules, hemorrhagic papules lower kintzivok And also the negative phenomenon of Darina-Unni.

Differential diagnosis of mastocytosis It can also be carried out from sickness, which is supervised to increase the number of ogryadny cells in histological preparations. Mast cell proliferation may occur in the middle of reactive mastocytoplasia, hemangioma, dermatophibroma, lymphoid, lymphogranulomatosis and other conditions. An important feature of the histological diagnosis of mastocytosis is those in the "old" in the "old" mastocytosis of the ogryadnі clіtini can be found in a small number. The diagnosis of mastocytomy can be established with certainty according to the histological picture, which has a non-toxic structure. In those cases, the diagnosis will be established at the presentation of the histological prescriptive donations from the clinical donations.

Likuvannya ailments Mastocytosis (mast cell leukemia)

lykuvannya mastocytosis insufficiently effective. Isolated mastocytomas are seen surgical. For the elimination of mastocytosis, cyproheptadine chlorohydrate (Peractin) at 16 mg / day, H2-blocker histamine, ingibitorium serotonin. drugs that galvanize degranulation of mast cells (damaging and in.), cytostatics (prospidin, spirobromin), PUVA-therapy. When itching and "flushes", take antihistamines drugs. In bullosa forms, corticosteroid hormones are used.

Prevention of ailments Mastocytosis (mast cell leukemia)

prevention of mastocytosis polyaga in zapobіgannі injected into the organism of activators in the degranulation of ogryadnykh clitins, such as chills, injecting cold, heat, trauma, insolation, drugs (especially morphine-opium group of alkaloids and acetylsalic acid)

Before you get rid of any symptoms you have Mastocytosis (mast cell leukemia)

Sho take Mastocytosis (mast cell leukemia)

Provokuє Mastocytosis (mast cell leukemia)

Ethiology and pathogenesis of mastocytosis unavailable. In some cases, it is transmitted in an autosomal dominant way, if in a large number of cases of ailment there is no family history.

Pathogenesis (how to see?) For an hour with mastocytosis (mast cell leukemia)

Histological picture of all forms of mastocytosis manifest themselves as infiltrates, which are stocked as the head rank of stovbrovykh clitins. Metachromasis of fatty clitin granules occurs in the presence of toluidine, methylene blue, as well as naphthol-AS-D-chloroacetate esterazy (Leder method), farbuval cytoplasmic granules of fatty clitins in fervone coli. With maculopapular and tele-angiectatic types, mastocytosis of ogryadnaya clitinus grows head-on in the upper third of the dermis along the capillaries. The nuclei of ogryadnye clitines are more often spindle-shaped, more round or oval. At the connection with this, there can be small cells in the presence of small cells and on the cells filled with hematoxylin and eosin, their nuclei will inflate the nuclei of fibroblasts or pericytes, for the establishment of the correct preparation With many universities, or plaques, as well as with great solitary universities, ogryadny cells make great purchases of the type of chickens, infiltrating the whole dermis and fat cells. If the large cells lie in the grocery stores, their nuclei are more cubic, lower the spindle-like cells, may eosinophilic cytoplasm and good growth between the cells. Tse nadaє їm to finish the characteristic viglyad, so the diagnosis can be made without a special farbuvannya. In case of diffuse (erithrodermic) type, at the upper part of the dermis, there is a tendency to develop thinner-like infiltrates from stovbury cells with rounded or oval nuclei and clearly surrounded by cytoplasm. With all types of mastocytosis (teleangiectatic for some reason), eosinophils can develop in the middle of large cells. An increase in the number of eosinophilic and lateral granules of fatty clitins in the biopsy taken after rubbing into the cavity, to indicate the development of granules from stovburykh clitins. The nature of the bulbs with subepidermal mastocytosis; However, at the connection with the regeneration of the epidermis in the delivery of the bulbs, the bulbs can be localized internally. Puzir often takes revenge on smooth cells, as well as eosinophils. Pigmentation of elements in mastocytosis was accompanied by an increase in the number of melanin in the cells of the basal ball epidermis, and later - in the appearance of melanophages of the upper part of the dermis. In case of systemic mastocytosis, paratrabecular inflammation of fatty cells in the cystic marrow, diffuse infiltration of red spleen pulp, periportal infiltration in liver cells The purchase of fat cells is spostering in the hearts, nirks, mucous membranes of the intestinal tract.

Symptoms of mastocytosis (mast cell leukemia)

see 4 formy mastocytosis:

shkіrny mastocytosis a childish or an early childish age, with any kind of shkіrnі vognischa in puberty, systemic changes, as a rule, are seen, and progressing with the development of a systemic form insisted in the edge rarely.
shkіrny mastocytosis fatigue and grown-ups with frequent systemic disorders, which often lead to systemic disorders, ale stench, as a rule, does not progress. Spontaneous regression in older adults, on the view of children, not descriptions. The first form is progressing, passing into systemic mastocytosis with progressive lesions of internal organs;
systemic mastocytosis;
malignant mastocytosis(Fat cell leukemia) - even worse form, characterized by the appearance of cytological malignant fat cells in the organs and tissues of the tissues, especially in the cysts and peripheral blood, with a quick lethal result; bezvychay not supervised by shkіrny manifestations.

More than half of the ailments mastocytosis Skargi obmezhuyutsya urazhennyam shkіri. Closely 1/3 of the children skarish on sverbіzh, attack the heart condition, paroxysmal tachycardia, fall arterial pressure, periodically increase the temperature of the body and so on. Symptoms of obesity degranulation of fat cells and are susceptible to advanced forms of mastocytosis of the skin or internal organs.

with mastopitosis I see five types of small stripes (moreover, the first two of them are spontaneous, both in the elderly, and in the grown-ups).

Multiple vuzluvate type of mastocytosis performances by numerous napivkulyastiynyh vuzovymi vuzovy, red absent color, with a diameter of 0.5-1 cm from a smooth surface, some vuzli get angry in plaques, the phenomenon of Dar'ya-Unni turns weak, especially in grown-ups.

In the process of mastocytosis You can get started whether you are an organization or a system. Naybilsh often - cysts, pechynka, spleen, lymphatic universities, shlunkovo-intestinal tract, central nervous system. 20-30% of ailments with mastocytosis may develop cysts, which, in case of radiological pre-developmental diagnosis, appear as osteoporosis and osteosclerosis. Osteolytic changes are accompanied by pain syndrome. Closely 1/4 of the number of cysts are mastocytomas, protest infrequently in children. Uterine liver disease is manifested by mild symptoms of mast cell infiltrates and fibrosis with hepatomegaly and diffuse mastocytosis.

Diagnosis of mastocytosis (mast cell leukemia)

Diagnosis of mastocytosis of shkiri to get up at the presentation of a key picture, a positive test of Darina-Unny, for the growth of large cells in the midst of a lesion. granules of ogryadnykh klin, - 2-3 days).

It is carried out with pigment nevi, freckles, lenti-ginosis, such as mastocytosis, to manifest the positive phenomenon of Darina-Unni. Papulogenous and vuzluvaty elements of mastocytosis occur as xanthomas, dematofibroma, histiocytosis X, nevoxantoendotheliomy on the basis of histological reports. On the basis of likarskoy toxidermia, with mastocytosis of the daytime ulcers, there is an incidence of discomfort. For bites, comas, epidermic puscular neoplasms, differential diagnosis should be carried out at the end of clinical data and the results of pre-treatment on histamines. Mastocytosis smoothly vіdrіzniti od vrodzhenoї poykіlodermіі Rotmunda Thomson autosomal retsesivnogo zahvoryuvannya, klіnіchno proyavlyaєtsya in Pershi Rocky Zhyttia i harakterizuєtsya eritematozny plyamami, zmіnyuyutsya sіtchastoї gіperpіgmentatsієyu, atrofієyu i TV angіektazi on shkіrі oblichchya, shiї, rіdshe - on kіntsіvkah. On the basis of mastocytosis, it means low growth, microcephaly, dystrophy of teeth, hair and nigths, cataract, rosum appearance. Teleangіektatіcheskaya form of mastocytosis vіdrіznyaєtsya od atrophic sudinnoї poykіlodermіі Yakobі, yak harakterizuєtsya oseredkovoї gіper- i hypopigmentation, teleangіoektazіyami i atrofієyu shkіri, generalіzovanim character Process, nayavnіstyu plyamisto-papuloznі visipan, skhilnih to zlittya, of utvorennyam great vognisch urazhennya de mozhliva prisutnіst zagalnih simptomіv (Attacking "Flushing", making it stronger, tachycardia, etc.) or the level of internal organs. Pigmentous purpuric and lychenoid angiodermatitis of Guzhero-Blum, on the basis of the phenomenon of mastocytosis, hostile to people in the middle age and are characterized by rapid symptoms of papules, hemorrhagic papules

Lіkuvannya mastocytosis (mast cell leukemia)

Prevention of mastocytosis (mast cell leukemia)

Mastocytosis, albeit a pigment-like crocus, can be carried out to the end of the child and leave no more kindly to those who are ill. Again, there can be no one with the same image as a cholovik, or a woman. Most often they learn among children, less among older adults - in about 75% of cases. Bagato hto rogue ailment with cropping or vvazhayut one of the forms. Tsia dumka є pardon. The links between the congestions are practically niyakoi. Zbig in the name can be varied in type. Єdine - chronic kropivyanka in some cases, it is possible to provoke the development of mastocytosis. About інші causes of ailments, as well as its specifics, symptoms and treatment, read in the tsy statty.

Video - Mastocytosis: severity of disease and more disease

the essence of mastocytosis

Mastocytosis є circulatory system... It is characteristic of a new establishment, mass multiplication and accumulation in the body of special cells. They are still called mast cells, or ogryadny cells, which play an important role in the functional system, being an unimportant part. Tse yes, Medkom provided allowances, so the pigment sprinkling can pose a lot of problems with immunity. Accumulated in living tissues, percolating through the skin and internal organisms, mastocytes provoke the development of symptoms characteristic of this disease.

Forms of pigment plant

There are two main forms of mastocytosis: screen and systemic. Stink may cause symptoms, cause a diagnosis, as well as prognosis for treatment.

Mastocytosis in children, as a rule, is shkirnim. develop into early vіtsі... The main group is children up to two rocks (it is not easy to diagnose in newborns). Pathological processes are getting rid of the curvature. The exercise of internal organs cannot be spared at all.

Tips for the transition of this form into a larger folding system one by one. Most of the children forget about ailments before the age of sickness, and most often they are more likely to experience ailments. Inodi shkirna form adapt to older adults. Ailment in such diseases does not become apparent, or does not progress. Krim shkiri to collect internal organizations.

Mastocytosis in adults, as well as in children from 13-14 years of age, develop a systemic form. When they are urazhayutsya, the head rank of the fabric of the internal organs. Epidermis in some cases may become a bit too specific. Systemic mastocytosis protested against becoming self-defeating and not becoming self-conscious. The ailment vvazhaєtsya chronic.

In the most unfriendly cases, pathology goes into a malignant form, as a mast cell is called leukemia. Tse is a very aggressive type of cancer with an unpleasant prognosis. Vilіkuvati yogo is extremely important.

Tipi uzhen shkіri with mastocytosis

In case of mastocytosis of the shkіrnoy form (and in some systemic form), five types of lesions of the epidermis develop.

Solitary. The enemy is a child of a child. It is characterized by the appearance of single new-foundations on the back of hands, shia or tuluba. For some vypadki vuzlikov buvaє kilka - maximum, chotiri. The stench is similar to gum on the dot. When mechanic pockenny is covered with bulbs. The surface of the vuzliks is smooth, or even zmorshkuvat. Diameter can reach 50 mm. In a large number of vipadkiv cones, the child knows the raptor, too much writing to themselves wrinkled "failures" on the skirts.
Vuzlovy. On the shkiri there is a large number of smooth (shorter than humpbacked) cones with a vascular shape with a diameter of up to one centimeter. Ushchilnennya buvayut zhovtuvaty, horny or worms. In children, children are encouraged to develop deciduous universities, as a result of which plaques are established.
Maculopapular. Epidermis to be curious about the lack of dark chicks or vuzliks of small sizes. Chervono-brownish illuminate the shape. When it is mechanically pockmarked, it’s like a pigmenty croppery woman, and it’s a bit too big.
Erіtrodermіchesky. Educate on shkіrі may be a yellow-brown color and a strong consistency. Oh, they are big, the land is unsettled, and the cordons are clearly okresleni. Most of the higher education institutions are located in the area of sidnichny folds. Stink the sick person strong worm, And I will react to the detection of trilogy and twist. One day the battle of the school becomes critical and the knowledge of chervonuvatiy vidtinok.
Teleangiectatic. Most of the enemies are older women. It is characterized by the statements on the shkirі beaches of the red-brown color. The main places of dislocation: breasts and pictures. The shape and size of the beach can be small. The result of rubbing a flock of fluff. The urazheni dilyanka does not often itch. In some cases, the pathological process spreads to the cysts.

cause sickness

The causes of pigmentous kropyvnytsi (mastocytosis) are still unclear. A simple version of the decline of the mind. On її cinnamon to bring those who often have mastocytosis among relatives. Ale from іnshy side, in about 50 hundreds of vypadkіv gennoi schilosti not to be found.

The science is very important, so the pigment of the crop can be either immune or NOT immune in nature. Zahvoryuvannya, which is referred to a different type, often evolves in the face of incessant factors:

excess ultraviolet;
rubbing;
overcooling chi overcooling;
nerve spasm, stress;
zmіna klіmatu;
reception of drug products;
the hedgehog is unhealthy;
toxins;
chronic kropivyanka.

symptomatic picture

In case of shkіrny mastocytosis і systemic, the picture is symptomatic. The first form is characterized by:

coverage of universities and beaches, descriptions of the region;
hypotomy;
temperature jumps;
accelerated sertsebitty, vinikє periodically.

Symptoms of systemic mastocytosis є:

improvement of liver and spleen;
I have pain in the cysts;
firing and soreness of lymph nodes;
virazkov_ urazhennya organs in the shlunkovo-intestinal tract;
diarrhea.

diagnostics

Deyakі people, having appeared on themselves on their nests bumps і voldyrіnki, take them for showing sprinkling women and become magical and self-absorbed. The diagnosis of stench is actually put on the photo from the Internet, and the preparations are known there. For example, to bathe widely advertised films of the "Transfer Factor" brand, as it is efficiently effective in case of severe sprinkling, but in case of a pigment acceptance of falsehoods, do not expect it.

Such behavior є in the edge of the life-threatening health. With the presence of anxious signs, it is necessary to turn up to the drug and go through the rigging. When diagnosing ailments, you should be recognized for an analysis of blood, which will show the presence or appearance of ogryadnye clines; carried out chromosomal pre-screening, as well as biopsies of shkiri. X-ray and MRI cysts are often used in pre-existing methods. In order to determine the level of damage to organs in the case of an internal form of pathology, ultrasound examination of the liver, spleen, etc. should be performed. In the obov'yazkovy order, the slaughter is reached.

Likuvannya and prophylaxis

The treatment of mastocytosis is carried out to the competence of therapists and hematologists. The therapy is complex. As a rule, drugs are used to reduce the amount of serotonin, to inhibit the anti-firing and anti-allergic effect. Also, better for everything, you get to take cytostatics and corticosteroids.

Vil_kuvati p_gmentnu kropiv'yanka (especially of the system type) is even foldable. In bagatokh vipadkah, the therapy is only symptomatic; In addition to this, the patients are assigned immunomodulators of the "Transfer Factor" type, or else. Inodі is brought to the operative engagement, for the help of which a new solution is seen.

For people who suffer from mastocytosis, do not be advised not to be ill with sleepy baths, saunas, hot springs and solariums. Tse can be negatively recognized on the body of the organism. Individuals who may have a decline in mental capacity should be especially respectfully put to their health.

Tim, whoever is suffering from a horrible sprinkling woman should be, in any way, not to allow the transition to chronic form... The first axis here is even more relevant to the drug "Transfer Factor". There are no natural ingredients in these warehouses, the stench passed through the classy viprobation and well recommended for themselves when drinking sprinklers. Besides, "Transfer Factor" is one of the best effective participation in the plan for improvement of immunity.

Since it was already a sign of malnutrition, shkirny mastocytosis in children, as a rule, pass before the age of adolescence. Ale daddy, showing up at the baby with characteristic plums, often fall into panika. vidomy childish lykar Evgen Komarovskiy cries out to you, don’t be bothered, and don’t take care of yourself. The child is absolutely necessary to show the doctor, how to recognize adequate therapy. Nabagato girshe, on Komarovsky's dummy, yakscho maє mіsce zvychayna kropiv'yanka, scho I will block Kvinke with a lot. Tsey stan is not safe for life. On the personal site of the doctor, the message to the forum was assigned to mastocytosis;

Otzhe, pigmentna kropivyanka is a pathology, as in some cases it can be absolutely safe and self-sustaining, and in some cases it is quite a way to reduce the quality of life and help provoke oncology.

To maximally preserve yourself from negative inheritances, do not engage in self-abuse, take Transfer Factor anyway. It is important to put an accurate diagnosis and correct the sign of a competent fakhivtsya. Todi can be promoted to the most agreeable prognosis and the desire is not to get more treatment, then to a predominant remission of mastocytosis.

Video - Kropiv'yanka yak vilykuvatisya

Myeloproliferative illness, which is characterized by the manifestation of an overworldly number of normal, active stovbrovykh cells. Call the stench to take revenge in the school, ale innocent systemically hostile to the organization. Often it is diagnosed through a few rocks from the ear of the ear, and sometimes it can lead to fatal inheritances.

Mastocytosis is trapped in any person: they are not sick of people who have been kidnapped. Symptoms of mastocytosis are diagnosed, if pharmacological or physical agents are involved in the degranulation of fat cells from histamine, prostaglandin, leukotroin and other mediators. A number of episodic attacks are manifested in a hyperemesis, and in extreme cases - a collapse, which can become a threat to life.

Classification and Epidemiology

The increase in the number of ogryadnykh cells in the shkiri buva:

generalization (diffuse mastocytosis);
accumulation of ogryadny clitins in numerous mid-midseeds (urticaria pigmentosa and persistent telangiectasia macularis eruptiva perstans)
single accumulation of ogryadnykh clitins (solitary mastocytoma).

The increase in the number of ogryadny cells in the cyst, the intestinal tract, the liver, the selenium, the central nervous system, the heart, or the blood, grows deeper, the lower the level of the disease.

The frequency of a common pathology becomes one per 1000-8000 new patients in a dermatological clinic. Mastocytosis is hostile to representatives of all races, people and women who are ill with the same frequency. The peak of illness falls on the first ric of life and early dynasty, and the other peak - in the middle age. You can be good, with minimal transient symptomatology, as it is possible that a sick person doesn’t get sick. medical aid, Abo become a threat to the life of the sick.

shkіrny mastocytosis

On the shkіrny mastocytosis seizure 90% of cases of mastocytosis, which are not associated with hematologic diseases. A part of the type of shkіrnogo mastocytosis - pigment kropivyanka, yak trawling approximately in 2/3 of patients with a lot of pathology. Sickness can be manifested in the nation, in the first month of life, or in any occasion of the nation. Approximately a third of the patients are characterized by visibility for the first time in an older age.

Zhovtuvato-brown or red-brown maculi, typical for pigment grass, sometimes appear on tulubes and quickly expand symmetrically to the central right-hand side. Dolony, feet, exposing the scalp and letting you get clean. Elementi visipu can be a small size і nagaduvati vesnianki or transform into papules, vuzliki or plaques. Much better exercise. For a series of physical pals (heat, cold, or vice), a sprinkler is localized (Darier's symptom). The process of physical development is often called generalization or localized sensation, dermographism, localized system and generalized hypothesis. Bulbashki, bully (rarely with local hemorrhage) and superficial erosions develop only in children under 2 years old. I do not have a diagnosis of superinfection, the scar is very rare.

In patients with a great number of ogryadnye clines, there is a bump in the stomach, nudot, bloating and diarrhea, the severity of which can cause malabsorption. Also mastocytosis can be supressed with headache, arterial hypotension, which can lead to malnutrition, hemorrhagic disease, shlunk ailment and psychological changes, such as concentration and deterioration.

If a pigment sprinkler is repaired before the first child, or in an early child, in 50% of the patients, the child can change to puberty. In the latter, the meaning is not polyphenia, visiparity, and the frequency and severity of symptoms change. On the vidminu of a child's affliction, a pigmenty croppery woman, who has rested in a grown-up child, is taken care of by stretching out the child's life.

Mastocytosis in children photo: pigmentna kropiv'yanka

solitary mastocytoma

Solitary mastocytomas are often seen in newborns and children, and not among older ones. The stench of the grown-ups is a bit harsh, so old people get used to tramping in the early period of life. Vuzol will give you a big size (3-4 cm), often winnies on kintzivka, Darier's symptom is positive. The number of ogryadnye clines is insignificant, systemic symptoms are infrequent. Secondary mastocytomas also occur infrequently; If the stench is on, then you will not be zazviche, less than 2 months later you will see the first hit.

Mastocytoma

A common form of shkirny mastocytosis in children, as it is more important to develop in children less than 3 years. Pislya the folk of the child's shkira can be seen as normal, ale shvidko's generalizations of sweating, scho a lemon crust. Often there are bully and puffy, important systemic symptoms. As a rule, insisting spontaneously, I want to avenge the risk of persistence and development of systemic symptomatology in order to achieve puberty.

Persistent plyamista volcanic teleangiectasia

Ridkisne zvoryuvannya, as diagnostics mainly in adults. This is what I will call the illusion of images, that the form of mastocytosis does not supervise overthrowing. Elementi visipu of a lesser size, lower in case of pigment grass.

Persistent plyamista volcanic teleangiectasia

systemic mastocytosis

According to the criteria of the WHO, for the establishment of the diagnosis of systemic mastocytosis, the manifestation of one great or three small criteria is required:

great criterion:

multifocal infiltration of ogryadny cells in the cystic marrow and / or any other organs (crim shkiri)

Small criteria:

cob zagalny rivn tryptasis perevistiє 20 ng / ml
> 25% ogryadnye cells in the aspirate of the cystic brain or tissue biopsy with atypical fusiform shape of the cells;
Expression CD 25 or CD 2 on ogryadny cells of the cystic marrow, blood or other tissues;
detection of mutation to codon 816 c-kit in blood, cystic marrow and other uterine tissues.

Systemic mastocytosis can be supravodzhuvatisya urazhennya shkіri, but do not expect. Systemic damage can overwhelm the development of the pigment sprinkling (85% of patients suffer from systemic mastocytosis), and more often it is caused by the visipus. On the other hand, the frequency of systemic growth of growth, reaching 15-30% of older patients with small manifestations

You may show systemic mastocytosis:

anemia and coagulopathy
a frequent symptom on the side of the intestinal tract is a beating in the abdomen, diarrhea, nausea and bloating are not so common
symptoms of reflux esophagitis
sverbіzh and hіperemya shkіri
anaphylactic reactions.

Before an hour of physical improvement, you can see the following signs:

show anemia (for example, blіdіst)
hepatomegaly (27%)
splenomegaly (37%)
lymphadenopathy (21%)
kropivyanka (41%)
osteolysis and pathological fractures (rare)

Patients with systemic discomforts often skary on short-term sleepers of a spastic woman, hyperaemia, sickness, heartache, pain, trouble, rhinorrhea, boring, bloating, spastic and sickly sick people Often buvay gastritis, esophagitis and Virazkov's ailment shlunk. Call me to attack the period of lethargy.

Often, asymptomatic hepatosplenomegaly and lymphadenopathy are indicated. Pislya shkiri cystic brain є another part of the target organ, and its infiltration by mast cells can be observed in cysts, anemia and pathological fractures. The dissection of the cysts can also be manifested by osteosclerosis and osteoporosis.

establishment of diagnosis

Diagnosis of mastocytosis is important, especially in patients, in whom there is a lack of characteristic signs and symptoms of Darier. In addition, many people are not aware of their illnesses and cannot suspect a diagnosis. If you are susceptible to mastocytosis, the test results can lead to negative technical problems.

Criteria for establishing the diagnosis of mastocytosis:

histological examination of the level of education (in case of manifestation);
histological confirmation of systemic lesion with hematological pathology or without it;
biochemical markers of activity of stovbrovykh clitin.

The presence of all three criteria in the skin patient is not necessarily obvious.

biopsia

As a result of the diagnosis, a biopsy is necessary to confirm the diagnosis, some of Darier's symptom is NOT pathognomonic. For muscular anesthesia, it is necessary to inject an anesthetic without adrenaline into the biopsy area (but not necessarily into the biopsy area). The management of traumas or adrenaline adrenaline can reduce the degranulation of fat cells, as a result of which the identification can be accelerated. Oskilki for an additional farbuvannya microdrug by extravagant barvniks, you can not find overworldly varieties of ogryadnye clines, you need to use special barvniks: toluidinovy blue, Romanovskiy-Gimza.

In liver biopsy, abnormally cystic marrow in patients with systemic mastocytosis, there is often an overwhelming number of ogryadny cells.

Laboratory indicators

Systemic mastocytosis is characterized by the onset of changes in laboratory parameters:

hypocholesterolemia (10-20% of patients, imovirno, in case of heparin)
at systemic —
- thrombocytopenia, eosinophilia (12-25% of patients),
- the adjustment of the level of potassium phosphatase and liver enzymes.

There are no characteristic elements of a visipu, followed by a viscous bully biopsy (if obvious).

In ailments, it is often the case of circulating biochemical mediators, especially if a large number of stovburovye clitins are activated before an hour is attacked. If I want to diagnose mastocytosis in children, I would like to develop a small number of biochemically diagnosed blood and blood cells, one of the most sensitive ones, the development of tryptase in blood plasma.

The second indicators of fatty cell degranulation: chronic Disease of the histamine and metabolism - N-methylgistamine in the blood and blood, the presence of chronic metabolic disease in the blood 2 and a partial thromboplastin hour podovzheniya, not immediately sent to attack. Diagnostic value of heparin level in non-viscous blood. For patients with a school form, testing is not necessary.

diagnostic algorithm

In the tables below, there is a diagnostic algorithm for older patients who are older for mastocytosis. Nervous mastocytosis in children Zvidsi іnsha obsozhennya, bіopsy shkіri, is not required. With the presence of systemic symptomatology, as well as becoming ill with a 5-week diagnosis, the diagnosis of the condition of children is also as old as they are.

Diagnostic algorithm for older patients with adolescence for mastocytosis

Even in an older person, a cystic brain biopsy is indicated for the diagnosis of primary hematologic disease, especially in patients with a kidney disease with systemic symptoms, lymphadenopathy and hepatospyulosis. Slide the scintigraphy of the cysts with technetium for the assessment of the cysts' range, so that they do not interfere with the other pathology of the cysts. For diagnostics, cyst densitometry is indicated. Vvazhayut, how osteoporosis in patients with mastocytosis we will advise prostaglandin D 2 і heparin.

Endoscopy of the slunk-intestinal tract is indicated for patients with symptoms of upper urinary tract herbal tract, Resistant to lіkuvannya. For the diagnosis of systemic mastocytosis without affecting the children, patients are shown a biopsy of the cystic brain and biochemical test. The risk of manifestation of common malignant approval in older patients with mastocytosis occurs in the range of 2% in patients who may only be diagnosed with spinal disease, up to 70% in symptomatic patients with mastitis. The role of periodic dispensary examination has not been clearly established, the protec- zagalny analiz blood.

lykuvannya mastocytosis

Patients with symptomatic mastocytosis are guilty of the nobility about their provocative factors and their uniqueness. Zokrema, followed by a rise in the uniqueness of overwhelming temperatures, alcohol and singing medications.

Meta of pharmacological treatment of mastocytosis in the stabilization of cell membranes for the reduction of the severity of attacks and blocking of mediators. Some of the advances to treatment include surgical isolation of smooth cells, topical corticosteroids, and psoralen with ultraviolet type A (PUVA) for the reduction of pigmentation of multiple cells. There is no specific way of getting sick, I want children to reach the classroom.

H1 і H2 - blockers

For the reduction of sverbezh, erythemi, bull and kropivyanka, the antagonism of histamine H 1 receptors is indicated: hydroxyzine, doxepin and chlorfeniramin. It is also possible to designate non-sedative antihistamines. Titrate the dose until the optimal regime is reached. Dyspepsia of non-viral etiology, such as trapping during mastocytosis, often associated with infusion of H 1 blockers.

H 2 blockers zasosovyut for lowering the acidity of slunk juice, yak is often superficially violated in patients with systemic mastocytosis. Not all mast cells may have an H 1 receptor, so H 2 blockers can also reduce symptoms.

For the additional intake of cromolyn sodium in a dose of 200 mg 4 times a day orally, it is possible to change the abdominal pain and diarrhea. If I want to get cromolyn in the intestines, I’m bridged, it was brought that the drug changes the bile in the cysts and heads, instantly reducing the cognitive health and lightening the symptoms. Polіpshennya will become ill, I can come only through the spine of the sickness. For the knowledge of intestinal rings, anticholinergic drugs can be indicated.

In case of an anaphylactic reaction, H 1 - і H 2 blockers have been identified. Patients with mastocytosis are guilty of wearing a medical bracelet in order to get sick and a syringe, to give adrenaline a boost. Anaphylactic shock is not helpful in shock associated with mastocytosis, as well as in anaphylactic shock. It is often necessary to inject adrenaline, antihistamines, vasopressors and carry out infusion therapy.

Stasis of aspirin in mastocytosis

For the knowledge of the hypothesis, related to the adolescents of prostaglandins before an hour of attack, consider aspirin, the protest against the power of aspirin and the other non-steroidal anti-pyretic diseases of the disease. To that, aspirin treatment is indicated for patients with heart-vascular collapse, in which prophylactic signs of H 1 - and H 2 blockers are ineffective. Therapy is repaired in the minds of the hospital in low doses. Before the cob of therapy with aspirin, the patient is guilty of eliminating antihistamines.

PUVA therapy

Prolonged PUVA therapy has a cosmetic effect on the improvement of the symptoms and time of the symptoms. The efficacy of potent corticosteroids in the form of topical application is either transient in the element of the visipus, or the persistence of corticosteroids is shown in solitary mastocytoma. Systemic administration of corticosteroids may be indicated for severe interruption of the formation of mastocytosis, malabsorption or ascites on aphids of systemic mastocytosis.

Shkіrny mastocytosis in adults - key vipadok

Bagato patients with mastocytosis may have a trivial anamnesis with chronic symptomatology, and sometimes they manifest themselves as raptus sharpening. Between the ear of symptoms and the establishment of the correct diagnosis, take place in the middle of 10 years. From the induced lower clinical vypadku slid, it is easy to miss the diagnosis of mastocytosis in adults.

A 53-child patient turned up to the dentist with a dental abscess, and was diagnosed with penicillin. Before going to the dentist's office, Vona took two pills of penicillin. The trip went to the parking and the power in the car, standing for a long hour on the sun. Vona drove to her mother's house with a stretch of 5 chilines. The patient has lost her mind, but now it’s been boring and won’t see for herself, " nibi passed in the tunnel". Immediately after coming to the mother, she wasted a little bit of testimony. Mati winked at the brigade of the medical aid.

The team of doctors saw the child with a high degree of discomfort, profuse sweating, with a whistle, she did not react to the teasers. The systolic vice becomes 80 mm Hg. Art. For infusion, oxygen therapy, adrenaline and medical anti-shock pants (MAST) were administered.

At the time of arrival at the admission of unavailable help, the disease was in evidence. The vice became 52 mm Hg. Art. The sickness said that if she had lost her witness to her mother’s house, she didn’t have a problem, I was in pain or felt a grip in her breasts. The EKG revealed diffuse changes in the ST segment, characteristic of ischemia of the myocardium. Dopamine infusion, methylprednisolone, cimetidine, diphenhydramine and metoclopramide were also administered. Introduced two doses of adrenaline. The arterial vise is reduced to 90/50 mm Hg. Art. On the second EHC I will show positive dynamics. The patient Bula was hospitalized at the stage of intensive therapy for the treatment of arterial vise and myocardial infarction.

Over the course of the year, the patient guessed about some kind of epizod in the loss of testimony to the fact that she would like that vipadok not to be tied with a penicillin. Today, as a result of a series of attacks, before the hour of some illness, the patient may have lost her testimony, she was hospitalized, and later written without a singing diagnosis. Vona saw about the hang, she trimmed for 7-8 rockets, and when the heat flowed in for an hour of emotional stress, she repaired the occasional hyperemia. The patient did not take any likings and not a small amount of lykar allergy, she previously took penicillin without problems.

At the time of arrival at the visit to intensive therapy, the patient's grip was 90/55 mm Hg. Art.; won іnfused infusion dopamine sіshvidkіstu 5 mcg / hv. Pulse sklav 94 / hv; dikhannya frequency - 14 / hv; no fever and distress syndrome.

With a dilated heart and legends, no pathology has been revealed. When palpation of the abdomen - hepatosplenomegaly during the day. On shkіrі Bula there is a macular visipa, more elements in the form of a yellow-brown and orange-horny color, boules appear on children, tulips and stegnae (photo of mastocytosis below). When streaking the pigmented shkiri wines, the symptom of Darier (eritema and pukhiri) is shown. The laboratory indices are normal, with the exception of calories at the level of 2.8 mmol / l.

Mastocytosis of a photo: show a shkirni in a patient from a guided clinic vipadku (livoruch). Elementi visipu with the increase (right-handed).

Before the onset of the wound, step by step skasuvati dopamine, myocardial infarction, ichemic changes on the EKG passed. The results of the EchoKG і navantazhuvalnogo test for talієm boules in between the norms. The pathologist described the result of the histological pre-examination of the biopsy of the child in the area of the viscera easier to burn, Ale after informing about the rate of clinical diagnosis in the diagnosis according to Gimza-Romanovskiy and with such a rank, confirming the diagnosis of mastocytosis.

Early diagnosis at the time of the whiskey from the license: shkіrny mastocytosis... Hvory buv signs of cimetidine, loratidine, the patient was forced to use a pen for adrenaline, alcohol, penicillin, aspirin and superfluous spices.

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