Autoimmune illness with the resulting tissue symptoms. As well as systemic impairment of the resulting fabric

The destruction of the exchange of speeches from the received fabric of Mucopolisaccharidosis Ethiology. Affection of tying due to decongestant anomalies of the exchange, manifests itself in viglyadi "accumulation ailments" and leads to deformities in cyst, cartilage, and other tissues.

Infections of the resulting tissue The main symptoms in cases of illness on the basis of tissue In cases of illness on the basis of ailments, the temperature increases, chills, chills, weakness, dysplasia, fever, swelling, pain

The main symptoms in case of sickness with a good tissue When sick with a good tissue, ailment is caused by an increase in temperature, chills, weakness, stamina, anxiety hanging on skirts, pains in cold weather. Get sick often superfluous

Systemic infestation of the resulting tissue, either, as they call it, the diffusion of the associated tissue - the whole group of ailments, which stimulate systemic damage and ignite the immune systems of the immune system and the process of the immune system. At the same time, there is an overwhelming presence of fibrosis. All the stench may have a strong swelling of symptoms.

List of systemic ailments

Come in:

• dermatomyositis idiopathic;
• recurrent polychondritis
• systemic scleroderma;
• systemic chervona vovchanka;
• recurrent panniculitis;
• rheumatic polymialgia;
• Sjogren's ailment;
• diffuse fasciitis;
• zm_shane ailment with the resultant fabric;
• Behcet's ailment;
• systemic vasculature.

Mіzh usіma cimi ailments are even more spіlny. Skin congestion with the resulting tissue may have a similar pathogenesis and symptoms. It is often possible to report on the photo that there is no indication of ailments to some illnesses from patients with a diagnosis of the group.

Available in fabric. What is it?

In order to be aware of the seriousness of the disease, let's get a good look at it, well, on the other hand, on the basis of the fabric.

Received fabrics - all fabrics and organisms However, they do not refer specifically to the function of any organ, or systems to an organism. At the same time, it is important to reevaluate the role. Wonderful organism as a basis for every organism. All tissues are stored in all tissues of the skin and organs, as well as the cystic skeleton and all types of organisms. The fabrics take up from 60% to 90% of the organisms, therefore, the incidence of the resulting fabrics most often hunts a larger part of the organism, if one of them stinks locally, one organ is eagerly deprived.

The factories to pour on the branch of system ailments with the help of a fabric

Falsely because of the widening of the incidence of the resulting fabric, the classification of the incidence of indifference to undifferentiated incapacitation or systemic. For the development of one and the other type of ailment, the most important factor in flux can be called genetic strength. This is what they call autoimmune disease with good tissue. Ale for the development of any zhvoryuvan zhvoryuvan one factor is not enough.

To the body of an organism, a sick one, they can celebrate their own:

• Rise of infections, which disrupt the normal immune process;
• ruin in hormonal background, Which can manifest itself in the period of menopause or vagina;
• injecting into the organisms of various vipromynuvans and toxic rechovins;
• intolerance of singers drugs;
• advised by the insolation;
• oprominennya photo by exchanges;
• temperature conditions and a lot of them.

At the same time, it’s time for the development of skin ailments in a group of groups to see serious damage to certain immune processes, as a result of which all changes in the body are seen.

foreign signs

In addition, they have a similar development, they have more a lot of spilnyh signs:

• skin of them has a genetic strength, often wiclican by the peculiarities of the chromosomes;
• wrinkles in other fabrics may be similar to rice;
• deyakі symptoms of ailments є zagalny;
• diagnostics of a number of illnesses to pass for a similar scheme;
• most of the symptoms of development of illnesses at the first stage of development do not disappear all of the disease, some of them all appear in a weak form;
• all the damage to the system is lost to the body at once;
• in case of certain laboratory predictions, the indicators of the activity of the ignition process will be even more similar;
• the principle behind the treatment of skin disease is carried out, close to the principles of treatment of the others.

Yakbi fahivtsi accurately identified the right reasons, which are launched in the body spadkovo get sick with the resulting fabrics, then the diagnosis would become easier. With the whole stench, we could accurately establish the necessary methods, such as prevention of illness and prevention of ailments. It’s not just that there’s been any progress in the whole region. Everything that can be said about the factor of the newest middle age, including about viruses, how the stench can get rid of the ailments that have passed through to the whole in the primed form, and also become the genetics of the genetics in the organisms.

lykuvannya

Classification of ailments behind the form її її її їіkannya is seen as it is, as in the bagatokh іnshih types:

• easy form;
• important form;
• period of prophylaxis.

Zakvoryuvannya spoluchnoi fabrics, scho dіє systematically, mayzhe zmushu zmushuє zastosovuvati active lykuvannya, Whenever there are days of corticosteroids great razmіrіv... If ailments pass in a great calm channel, then the need for a great doze of the day. In such cases, small portions of corticosteroids can be supplemented with anti-pyretic drugs.

It is not very effective to use corticosteroids, it should be carried out in parallel with the use of cytostatics. In such a combination, the most frequent galvanization of the development of cells is carried out, as they carry out pardon reactions to the cells of the vlasnogo organism.

Likuvannya ailments in important forms to be seen cheaply. Vono vimagaє the dilution of the immunocomplexes, as they became pratsyuvati incorrectly, for which the plasmapheresis technique is used. To prevent the formation of new groups of incorrect immunoactive cells, a number of procedures are carried out to optimize lymphatic universities.

The schob lіkuvannya passed successfully, some zusil lіkar is lacking. It’s a lot of fakhivts to say that to relieve any ailments you need more 2 basic words. First of all, the positive attitude of the patient and the yogh bazhannya oduzhati is guilty of being present. More than once, I thought about it, so Vera in her power helped people to vibrate in the face of horrible situations. On the other hand, it is necessary to be trained in family and in the middle of friends. We are important in the region є the peace of our loved ones, the price of giving people strength. First of all in the photo, do not marvel at the ailment, we are happy, but we can see that we love it, we see the new life in all manifestations.

Timely diagnostics of the disease in the cob yogi stage allows to carry out the treatment and prophylaxis of procedures with the greatest efficiency. There is a special respect for all the patients, if there are some minor symptoms, it may be that the problems have come to pass. Especially the report is guilty of diagnostics for every hour of robots with individuals, in some of whom are symptoms of particular sensitivity to a part of the products of food and drug preparations, allergies, bronchial asthma... Before a group of patients, there are also patients, relatives of whom have already turned up for help and undergo treatment, having developed the symptoms of diffuse ailments. How much damage is found, remembered in the extravagant analysis blood, a lot of people are also consumed in a group, behind which they stand to lead the saw with caution. I don’t forget about individuals, the symptoms of which can be attributed to the presence of a disease in the presence of a gloomy tissue.

Friends, today we will talk with you about the change of illusion. Chuli about taka?

Sinonymi: Overlap syndrome, overlap syndrome, Sharp syndrome.

What is it? Zmіshany zhvoryuvannya spoluchnoї fabrics (SZST)- tse free syndrome, in which there are signs of young people with a complete fabric (analogy with a ball of thread). There may be a risk of development, dermatomyositis, and also a frequent suppression ("dry syndrome").

Near the SZST, there were a lot of ideas and theories. It’s natural to eat: but it’s also self-inflicted, because it’s an atypical form, which is also a kind of sickness from a good tissue (for example, vovchaka, scleroderma, etc.).

In the Danish hour, SZST is brought up to independent illnesses with the resultant fabric, if only one debut like the SZST becomes ill-fated for the year in the type of ailments from the resulting fabric. Do not swindle the SZST with undifferentiated illnesses with the resulting fabric.

wideness definitely not at home, imovirno, not more than 2-3% of the bulk of all the illnesses of the resulting fabric. Ailments are overwhelming for young women (the peak of illness is 20-30 years).

Cause... Allowing for a genetic role in the connection with the appearance of the native species of the SZST.

Klinichna picture.

Show ailments even more versatile and dynamic. In the debut, ailments often experience symptoms of systemic scleroderma, such as: Raynaud's syndrome, swelling of the hands or fingers, flying pains in the slopes, fever, lymphadenopathy, early childhood - typical for those who are in school. Zgodom is a sign of battle internal organs Such is the hypotonia of the stravohode and the foldability of the cowl, the reduction of the leg, the heart, the nervous system, nirok, myaziv, etc.

The most common symptoms of SSTD (on the decline):

• Arthritis or pain in the slopes
  
• Raynaud's syndrome
  
• hypotonia stravohodu
  
• lung striking
  
• a set of brushes
  
• myositis
  
• lymphadenopathy
  
• Picking shkiri yak at STD
  
• Dissection of serous membranes (pleurisy, pericardium)
  
• nirok battle
  
• Disruption of the nervous system
  
• Sjogren's syndrome

swamps : Unstable and mild polyarthritis, mild pains in the slopes. You can wonder if it’s like a loaf (great, great), the process of kudi is more good, not in case of rheumatoid arthritis, for example.

Raynaud's syndrome- one of the most early and strong manifestations.

Nabryak fingers and kisti th - a soft, pillow-like crease of the brushes. Often susceptible to sleep with Raynaud's syndrome.

m'yazi: From mild and minor pains in the muscles to an important lesion in case of dermatomyositis.

stravohid: Easy to bake, ruinous kovtannya.

serous barnacles i: pericarditis, pleurisy.

lungs: Zadishka, p_vischennya vise in the legendary artery.

shkira: Exercise is even more versatile and variable: pigmentation, discoid vovchak, type "blizzard", diffuse hair loss, damage to the eyes near the eyes (Gottron's symptom) and in.

nirki: In the case of proteinuria, hematuria (the appearance of blood and blood cells in the section), the importance of nephritis is developing rapidly.

Nervous system: Polyneuropathy, Meningit, Migren.

diagnostics.

The laboratory diagnostics of SZST is of great importance. May be: anemia, leukopenia, earlier - thrombocytopenia, advanced SHOE, rheumatoid factor, circulating immune complexes (CVC), ASAT, CPK, LDH.

Specific laboratory marker of SZST antibodies to nuclear ribonucleoprotein (RNP), appear in 80-100% of vipads. When ANF is detected, the type of light (granular, part) is indicated.

Diagnosis is based on symptoms and manifestations of RNP.

lykuvannya.

The main therapy is hormones in low doses, depending on the activity key manifestations... The triviality of therapies from decile month to decile rocky. Also, cytostatics can be vicious, non-steroidal anti-pyretic drugs, symptomatic treatment.

Unimportant to those who are SZST є "make up serious sickness, Yak SSD, VKV, dermatomyositis, etc., the prognosis is more beautiful, less in patients with typical incapacitation with the resulting tissue.

Zmіshany zhvoryuvannya spoluchnoї fabrics (SZST)- free clinical immunological syndrome of systemic lesions of the resulting tissue fiery character, Will appear on the basis of data on the symptoms of SDS, polymyositis (dermatomyositis), VKV, antibodies to nuclear ribonucleoprotein (RNP) in high titers; the prognosis is more friendly, less ailment, a sign that a syndrome is developing.

SZST was described by G. G. Sharp i sp_vavt. yak free "syndrome of small rheumatic ailments." It’s not important for those in the coming rocky, it’s known about the problems of the first time in the winter lands, the day of the SZST still doesn’t open, since it doesn’t feel unambiguous - the self-sufficient price of nosological fabrics are different from the same varied

Scho provokuє / The reasons for the Zmіshany ailment with the resultant fabric:

In the development of ailments, they play the role of a free deterioration of immunity, which manifests itself in trivial strong changes in antibodies to RNP, hypergammaglobuli of germs, hypocomplements and circulating immunity. Deposits of TgG, IgM and complement appear in the walls of the blood-bearing vessels of the mucous membranes, glomeruli of the nirka and dermoe-dermal stick of the dermis, and the deposits of TgG, IgM and complement appear in the tissues of the blood-bearing mucus, the glomeruli of the nirka and the dermal tissue of the dermis. Installed changes in immunoregulatory functions of Tlimphotsi. Particularly in the pathogenesis of SZST є development of proliferative processes in the internal and middle shells of the great Sudins with a history of legacy hypertension and the first manifestations of the disease.

Symptoms of Zmіshany ailment with the resulting fabric:

It is indicated in the name of SZST, the class of ailments is caused by such signs of SJS, as Raynaud's syndrome, swelling of the hands and hypochondria to the traumatic pathway, as well as symptoms of polymyositis and VKV in the presence of polyarticular diseases and recurrent symptoms

Raynaud's syndrome- one s best frequent signs... Zokrema, behind our materials, Raynaud's sydrome of all the ailments with the development of the SZST. Raynaud's syndrome is not only partial, ale uneasy and early signs of ailments, proteases on the form of SSV are against myaxia, not often by the type of two-phase, but the development of ischemic necrosis or sometimes in the margin.

Raynaud's syndrome with SZST, as a rule, is superfluous with swollen hands right up to the development of "sausage-like" forms of the fingers, and it is practically impossible to end with induration and atrophy of sclerosus with severe initial contractures (sclerodectomy).

Svoєrіdnoyu myazova symptoms- v classy paintings ailments relieve pain and muscle weakness in the proximal muscles of the corticals with fast polygons for the infusion of medium doses of corticosteroids therapy. The change of meat enzymes (creatine phosphokinase, aldolase) grows smartly and quickly normalizes in response to hormone therapy. Occasionally, it is characteristic of dermatomyositis that there is a reduction of the skin over the knuckles of the fingers, heliotropic preparation of the wall, teleangiectasis along the edge of the nail bed.

Svoєrіdna suglobova symptomatology... The involvement in the pathological process of locks is made possible practically in all ailments, the head rank among those who suffer from polyarthralgia, and in 2/3 of those who suffer from polyarthritis (non-germless, as a rule, they do not get sick), who want to get sick brushes. It is characteristic of the formation in the process of great slopes in the order of the damage in other slopes of the brushes, as in the case of VKV. The appearance is described of the type of knowledge from the RA of the erosive destruction of the worms in the nodules of the hands. Similar snorts were spoken by the ailments and in our institute.

hypocrisy to stravohod It is due to the efforts not only of X-ray dosages, but of the manometric ones, to protect the collapse of the airway at the edge of such a step, as in the case of STS.

Dissection of the serous membranes Sposter not so often, as with VKV, prote at SSTC, bilateral vip pleurisy and pericarditis are described. Significantly more often attributed to the involvement in the pathological process of the lungs (ventilation damage, decreased life of the body, and in the case of X-ray dosage, strengthening and deformity of the lung malinka). At the same hour, the symptoms of Legenev's symptoms in those with ailments can be seen as the main role, manifesting themselves as an overgrowth and / or symptomatology of Legeny hypertension.

The specialty of the SZST nirok battle(According to the literature, in 10-15% of the ailments), but in quiet ailments, in those who appear to have some kind of protein, hematuria or morphological changes in biopsy of nirok, call it a good interruption. Viklyuchno rarely sposter the development of nephrotic syndrome. For example, according to the data of the clinic, the level of nirok is equal to 2 out of 21 patients with SZST.

So it is itself rarely diagnosed with cerebrovascular disease, polyneuropathy, which is a part of the sign in the class of SZST, is not severely affected.

Among the out-of-the-way clinical manifestations of ailments, it means a rising degree of turn hot reaction and lymphadenopathy(In 14 to 21 patients) and earlier splenomegaly and hepatomegaly.

Sjogren's syndrome does not develop often in case of SZST, which is also a good interruption, as in case of VKV.

Diagnostics of Zmіshany ailment with the resulting fabric:

• laboratory data

General laboratory data for nonspecific SZST. Approximately in half of the ailments in the active phase of the ailment, it means less hypochromic anemia and a tendency to leukopenia, in all of them - accelerated SHOE. However serological data The appearance of a dose is characteristic for ailments of the development of antinuclear factor (ANF) with mottling type of immunofluorescence.

In ailments, SZST appears in a high titer of antibodies to nuclear ribonucleoproteins (RNP) - one of the various nuclear antigens, sensitive to the infusion of ribonuclease and trypsin. Yak viyavilosya, the same antibodies to the RNP and to the other nuclear antigens, which are available in the range of nuclear antigens, add to the nuclear type of immunofluorescence. According to the day and the serological peculiarities, the order is due to the values ​​\ u200b \ u200bof the clinical indications of the classics nosological forms and served as a guide for seeing the syndrome of SZST.

In addition, it is often referred to as gipsrhammaglobulus, not rarely overwhelming, as well as the Russian Federation. At the same time, SZST is especially characterized by the strength and the swelling of the chickens, independent of the amount of activity of the pathological process. At the same hour, in the active phase of the ailment, circulating immune complexes and mild hypocomplementa are not so rare.

Lіkuvannya Zmіshany zmіshanyu svoryuvannya sluchnoї fabrics:

Characterized by the temporal efficiency of GCS to navit in medium and small doses on a daily basis from the SSD.

Oscillations in the rest of the rock are indicated by the tendency to the development of nephropathy and legacy hypertension, ailments with cimi key signs require an hour in large doses of corticosteroids and cytostatic drugs.

The prognosis of ailments in general is quite serious, the problem of death is described, but it is very important when nirkova lack for the legacy of hypertension.

Until some of the likars go to death, if you have Zmishana getting sick with the good fabric:

rheumatologist

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You? It is imperative to go further to the camp of your health as a whole. People get too little respect symptoms in illness and do not understand that ailments can be life-threatening. Є a lot of ailments, as a few things do not manifest themselves in our body, or in the bag to appear, but, unfortunately, it’s already nice. Skin congestion has its own singing signs, characteristic signs of manifestation - so called symptoms of ailments... The symptom score is the first croc in the diagnosis of illness in general. For the whole, it is simply necessary to develop the passes the rigging at the lykar, It’s not just a terrible ailment, but a healthy spirit in everybody’s body in general.

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Іnshi incapacitation from the group Khvorobi kistkovo-m'yazovoy system and the resulting fabrics:

Autoimmune ailment - the tse of a fallacy of tying up the broken functions of the immune system of people, which repairs the power of the people, like aliens, and pozhkozhuvati їkh. Someone who is sick is called systemic, as a rule, the whole system can be used, or the whole body can be found.

At our hour we often talk about new infections, which pose a threat to all people. Tse, pershu chergu, SNID, as well as SARS ( atypical pneumonia), Bird flu and virus infections. As a result of the history, there are a lot of insecure viruses and bacteria in the distance, and why for a reason to stimulate the immune system (vaccination).

Mechanism of recognition of the processes has not yet been revealed. Fakhіvtsі can’t be intelligent, which is linked to the negative reaction of the immune system to the tissues. Provokuvat zbi in the body can be injured, stress, hypothermia, infection, etc.

Diagnostics and diseases of systemic ailments can be done by such doctors as a therapist, immunologist, rheumatologist and іnshі fakhіvtsі.

put on

To those who are sick from the group є rheumatoid arthritis. However, the ailment is not the most common autoimmune pathology. An autoimmune lesion of the thyroid gland often occurs - diffuse toxic goiter(Basedova's ailment) і Troidіt Hashimoto. Autoimmune mechanism also develops diabet Type I, systemic chervonia vovchak and rossyaniy sclerosis.

Autoimmune nature can be caused by not only ailments, but ale and deyaki syndromes. A typical butt є chlamidioz is a sickness, which is subject to trash, and transmitted by a state path. With a lot of sickness, there can be such titles as Reiter's syndrome, for which it is characteristic of the eyes, loops and sechostatic organs. Do not show a direct infusion of a microbe, but cause autoimmune reactions.

cause

In the process of maturation of the immune system, the main hour of what is brought in the period from the people to 13-15 years, lymphocytes - cells of the immune system - to go through the "navchannya" in the thymus and lymphatic universities... At the same time, a skin clone of a clone nabuva of healthy development of foreign bolsters, who are struggling with small infections in the future.

A part of lymphocytes is learned to develop the cells of one's own body as aliens. In normi, such lymphocytes are strictly controlled by the immune system and serve, in order to ensure that they know their own organisms. However, for some people, control over the cybercriminals is lost, their activity grows and starts the process of destroying normal cells - developing autoimmune illnesses.

cause autoimmune disease vivcheni lacks, altogether lacking views allow the distribution of callі internal.

The main reasons are Infectious diseases abo physical injection, For example, ultraviolet viprominuvannya abo radioacia. In case of urezhenny singing tissue of human organism, the stench changes the power of molecules in such a rank, that the immune system is spryming and alien. Pislya "attack" on the exercise organ immune system wiklikє chronically firedі, apparently, farther away from cotton fabrics.

іnshy the most important reasonє development of cross-border immunity. Also, if an infectious person appears "similar" to a vlast cell - as a result, the immune system is immediately hostile as a microbe, as well as a cell (one explanation is Reiter's syndrome in chlamydiasis).

Internal causes are, in the first place, genetic mutations, which are transmitted during recessions.

Some mutations can change the antigenic structure of the singing organ, or tissues that infest lymphocytes are known as "svoih" - such autoimmune diseases are called organ-specific... Too, in the fall, the ailment itself will be transmitted (among the older generation, there will be one or more organisms).

These mutations can destroy the balance of the immune system, disrupting the control of autoaggressive lymphocytes. Todi lyudin, with the infusion of stimulating factors, can get organ-specific autoimmune illnesses, so get a lot of systems and organisms.

Likuvannya. promising methods

Treatment of autoimmune (systemic) illnesses of polyagons in the reception of anti-inflammatory drugs and drugs that are likely to be taken immune system(The stench is even more toxic and similar to the spraying therapy to the point of infection).

Surely, they are not going to the cause of the disease, but not to the organ, but to the whole organism. At the same time, we should try to develop fundamentally new methods, which will be done locally for a few days.

Poshuk new drugs against autoimmune ailments somewhere behind the three main routes.

Gene therapy is one of the most promising methods, which can replace the defective gene. However, before practical sucking gene therapy is far away, but mutations, which lead to a specific illness, do not occur in all cases.

If the reason is the loss of control over the cells of the immune system, then the presenters simply substitute for new ones, before they have given a lot of immunosuppressive therapy. This technique has already shown good results in the treatment of systemic heart disease and rosy sclerosis Protect to the point of being uncomfortable, but we can’t help it, but it’s infallible for the body to stifle the “old” immunity.

Mabut, who used to be available to become techniques, which do not understand the cause of the ailment, but precisely clean up and show it. Tse, in the first place, preparations on the basis of antibodies. The smell of building blocks the attack of the tissues of the immune system.

In the first way, it is the sign of speech, which takes part in the fine regulation of the immune process. Tobto, it's not about the speech, how to adjust the immune system as a whole, but about the analogs of natural regulators, which only work on the same kind of clitin.