Instructions on the consumption of clindamycin, analogs, prices. Instructions on the intake of clindamycin from infectious diseases Clindamycin Yaka group

Clindamicin is an antibacterial for a wide antimicrobial spectrum of diy, which can be referred to a group of linkosamides. Stagnate wine with bacterial infections in older adults and children. The drug is not effective in viral pathology.

The name of the antibiotic in Latin language is Clindamycin.

ATC

The code for the ATC (anatomical-therapeutic-chemical classification) of the license is D10AF51. Group - D10AF.

Form a vipusk that warehouse

Likas are carried out in gelatin capsules of 150 mg, in the form of a cream, a bottle for introduction into a pen (Klindatsin) and a bottle in ampoules of 300 mg.

rozchin

Antibiotic vypuskayetsya in a form of clear, barless, or slightly chewing roschinu. The ready-made lines of wine representations at the viglyadi phosphate. The amount of the standard component in 1 ml is 150 mg. Dodatkovy warehouses є dinatriyu edetat, alcohol and water. The drug is placed in ampoules of 2 ml, which are placed in packages with occasional or packs of cardboard.

capsules

Capsules with antibiotic mayut size No. 1, with a body of violet koloru and chervona kryshka. Вміст - bilium powder. Antibiotic in capsules presentations in the form of hydrochloride. Additional components of the preparation є: lactose, talc, magnesium stearate and corn starch. Krishechka to take revenge on titanium dioxide, chinolynovy zhovty and barvnik yaskravo-chervoniy Ponso 4R. Housing revenge gelatin, azurobin and black barvnik. The capsules contain 150 mg of antibiotic.

candles

Antibiotic vikorist vaginal test, Which may be Cylindro-conical shape. Colir - from a white to slightly chewy. Interspersed on late development of suppositories during the day. Active speech in the candles is represented by phosphate in the viglyad. Additional components є napivsynthetic glyceride. 1 suppository contains 100 mg of antibacterial dose.

ointment

Antibiotic is not allowed to be used in the form of ointment, but not in the form of ointment; vaginal cream white color. Additional components of liquids є: sodium benzoate, castor oil, polyethylene oxide and propylene glycol. The cream is allowed in aluminum tubes. One dose (5 g) contains 100 mg of antibiotic.

Pharmacological diya

Daniy antibiotic diyut on bagatokh microorganism. It is an effective bacterium, as it is fought and not fought for Gram. Liki nada bacteriostatic effect, i.e. Mechanism of antibacterial action of dressing for the destruction of the problem.

To the liking of sensitive staphylococci (at T. Ch. Epidermal), streptococci, enterococci, peptococci, peptostreptococci, botulism, bacterioids, microplasmi, ureaplasmi, bacilli and anaerobic bacteria. Danish drug for its therapeutic activity make lincomycin.

Pharmacokinetics

When the liquor is wetted into the drain and the intestines are discharged quickly and in general communication. Acceptance of good absorption (moisture absorption). Liks without pratsi eat and go to fabrics. The antibiotic can be found in the brain in a small amount.

Most of the leaks are found in the blood after 1 year (when the capsules are implanted), after 1 year (when introduced into the midnight ointment) in children, and after 3 years - in adults. The most effective antibiotic is consumed in the bloodstream when it is introduced into a vein. The medication in drug concentration has been in the blood for 8-12 years. In the tissues of the liver, the drug is metabolized. Liki vivoditsya nirkami with a slit and intestines with feces.

Shown to sucking

Infections, for which a drug may be prescribed, є:

1. Infections of ENT organs (inflammation of the pharynx, larynx, vuha, nasal sinuses, lesions, bronchial tubes, abscesses), respiratory pathologies.
2. Scarlet fever.
3. Diphtheria.
4. Sickness of sechostatic organs (uterine infection, vulvovaginitis, colpitis, salpingoophoritis, chlamydiasis).
5. Staphyloderma, pyoderma, abscesses, peritonitis.
6. Septicemia (infection of blood without infection of internal organs).
7. Gn_yne fired cyst tissue (osteomyelitis).
8. Bacterial endocarditis (inflamed inner membrane of the heart with lesions of the valves)

Likki can be recognized as a prophylactic method for injuries and lesions of the intestine. At the same time, the transfer is seen as internal or internal ones.

Prototype

In the instructions for prescribing such a counter-indication until the end of the list:

• myasthenia (weakness of myaziv);
• allergy to drugs based on clindamycin and lincomycin;
• asthma;
• virazkov form of colitis (inflamed intestine);
• vagіtnіst (in 2 and 3 trimesters without sucking cream);
• lactation period;
• вік up to 3 rockіv (for the price range);
• up to 8 rocky or vaga baby less than 25 kg (for capsules).

It is necessary to take care of people who are lithuanians and people with nircovy and pechinka pathology.

yak accept

Children over 15 years of age and older than 15 years of age are recommended to take 1 capsule with an interval of 6 years. In important cases, the dose may be increased. Ін'єкції requires two doses per day (2 times 300 mg). In case of illnesses older than 3 years, the dose should be 15-25 mg / kg / day.

In case of liver dysfunction and nirok, as well as in times of great intervals (8 or more years), the dosage adjustment is not required.

Taking the drug for sugar diabetes

at reddish diabetics antibiotic is stagnant in the form of oral administration, as well as in a viglyad for intravaginal administration and retail. In case of addiction, it is recommended to control the amount of sugar in the blood.

Pobichna diya

The most frequent smell of werewolves and knowledges when deprived of lіkuvannya.

Shlunkovo-intestinal tract

If you are stuck with Clindamycin you can:

• dyspepsia (deterioration of etching in viglyadi diareya, nudota);
• Signs zapalennya stravohodu (difficulty kovtannya, stove, b_l);
• zhovtushn_st shkіri;
• disagreement normal indicators liver enzymes;
• adjusting the concentration of liver enzymes in the blood;
• adjusting the concentration of bilirubin in the blood;
• intestinal dysbiosis.

In some cases, pseudomembranous colitis develops in ailments.

organ blood

On the side of the blood and organs of the blood-forming organism there are such changes:

• fall of the level of leukocytes;
• decrease in neutrophils;
• agranulocytosis;
• for platelets.

On the side of the heart-vascular system

When the drug is taken into the vein, it can become jammed, reduce the grip, collapse and weakness.

On the side of the kistkovo-meat system

The emergence of a deterioration in the transmission of impulses from nerves to muses.

allergies

Possible offensive types of allergic reactions:

• kropiv'yanka (sverblyachі hanging from viglyadі pukhirіv on small dіlyanka tіla);
• maculopapular visip;
• dermatitis;
• eosinophilia (growth of eosinophilia in the blood);
• anaphylaxis (shock, quirk of Kvinke).

special requests

The development of pseudomembranous colitis has an effective ion exchange resin. It is necessary to pin the drug with an antibiotic. If necessary, a drug based on metronidazole and infusion therapy should be carried out.

In the instructions from the stasis it is stipulated that it is not possible for Klindamycin to receive an appointment:

• vikoristovuvati medications, which can cause intestinal peristalsis;
• live alcohol;
• vikoristovuvati іnshі vaginalnі koshti (for cream and whiskey).

With trivial vicorian Clindamycin, as well as Erythromycin, there is a risk of activization of other fungi and development of candidiasis.

Consistency with alcohol

Influencing the building with keruvati mechanisms

The antibiotic does not suffer from damaged and rudimentary problems, so it does not pour into the control of the mechanisms and the water of the car.

clindamicin for children

If children are recognized, they should be wrung out. Capsules cannot be up to 8 rocky, and up to 3 rocky.

Stagnation during vaginosis and during lactation

Likewise in the form of the size and size of the capsules, it is shown before the hour of wine. Vaginal cream can be vikoristovuvati only after suvorim are shown, as long as there is cinnamon in the form of perevischu potential Skoda for the fetus. In the first 3 months of marriage, they do not recognize candles, because during the whole period, life is laid down in an important organization of the child.

Stagnation of Clindamicin in the form of a cream before the hour of lactation and the year of breastfeeding is possible with the urahuvannya of the mossy rhizik.

Stuck in the kidnapped vice

The drug for in-and-out and oral administration in a kidnapped person needs special protection.

Overdose

how to change I will add a dose drug, then more neobzhanikh effects... Overdoses against pain in the abdomen, fever and other symptoms. Hemodialis (blood purification) is generally ineffective. We are sick to recognize symptomatic problems. Antidote vidsutniy. Overdosing with leaks in the form of a cream, or the candle is spontaneous in the edge.

Interaction with other drugs

Danish drug pidsilyuє therapeutic effect of the onset of dreams:

• aminoglikosidiv (Streptomycin, Gentamicin);
• old rifamycin (Rifampicin);
• muscle relaxant.

Buried overnight stasis antibiotics with Ampicilin, magnesia, obsolete barbituric acid and calcium gluconate. Antagonists of Clindamicin є erithromicin і Chloramphenicol.

Liki nasty go to the antidiarrheal diseases, preparations of vitamins of group B and phenytoin. If in parallel to vicoristovuvati narcotic analgesics, then you can get rid of the dichotomy.

analogs

Analogs of liquor in viglyadi cream є Dalatsin, Klindes and Klindatsin. All stench is indicated for gynecological pathology. Gels are released for the most recent supply of Klindatop, Klenzit-S and Klindovit. The stench is indispensable when complex treatment vugrovoy visipka(Acne).

Є also cream Klindatsin B prolonged. It is recognized that it includes to its warehouse antifungal speech butoconazole nitrate, which broadens the spectrum antimicrobial activity... An analogue of Klindamitsin in the form of є Zerkalin. Wine cleans up the skin of vugri and prischiv, as well as the drug Adapalene.

Umovi vidpustki from the pharmacy

Liky are allowed to follow the recipe for likar.

Price for Clindamicin

Capsules cost 170 rubles, and the price of the price based on antibiotics is 600 rubles. Cream kostu vіd 350 rubles

Take care of the drug Clindamicin

It can be stored in a darkened light at temperatures of +15 ... + 25ºC. Misce zberigannya antibiotics maє buti is not available for children. Likas are included in the list B. Suppositories are saved with quiet minds, while others are dry. When taking a cream, the temperature is not to blame for a 20ºC change. Clindamycin-based gel (Clindatop) cannot be frozen and stored in the refrigerator.

Antibiotics for rosacea: Doxycycline, Metrogyl, Trichopolum, Clindamicin, Hyoxysone, Zinerit

Azithromicin, Yunidox, Vilprafen, Clindamicin, Ornidazole, Terzhinan, Clion D with gardnerellosis

1 ml solution for inking with clindamicine in viglyad with clindamicin phosphate - 150 mg

additional speeches: Benzyl alcohol, sodium edetat, sodium hydroxide, hydrochloric acid, water for ін'єкцій.

Form vipusku

solutions for ін'єкцій.

pharmacological group"Type =" checkbox ">

pharmacological group

antibacterials for systemic storage. Macrolide and linkosamide. ATC code J01FF01.

Pharmacological authorities"Type =" checkbox ">

Pharmacological authorities

Pharmacological. Antibiotic of the group of linkosamides. The active drug, clindamicin, is a napivsynthetic antibiotic, which is synthesized from lincomycin by means of replacing 7- (R) hydroxyl groups with 7 (S) -chlorine. Porushu internal synthesis of bile.

Clindamicin is a wide range of diets, it can be bactericidal or bacteriostatic, which can be found in microorganism sensitivity and antibiotic concentration.

Klindamitsin dyn on such forms of microorganisms:

aerobic gram-positive coca: Staphylococcus aureus, Staphylococcus epidermidis(Pieces that produce and do not produce penicylinase). When conducted in vitro the rapid development of stiffness to clindamicin in some staphylococcus strains, resistant to erithromycin; Streptococcus spp.(with a blame Enterococcus faecalis) Streptococcus pneumoniae;

anaerobic gram-negative bacteria: Bacteroides species(Including the group B. fragilis i group B. melaninogenicus), Fusobacterium specie;

anaerobic gram-positive bacteria, but do not argue: Propionibacterium spp .; Eubacterium spp .; Actinornyces spp .;

anaerobic and microaerophilic gram-positive coca: Peptococcus spp .; Peptostreptococcus spp .; Microaerophilic streptococci; Clostridium spp.(Clostridia show a greater resistance to clindamicin, less anaerobics) more species of Clostridium, zokrem C1ostridium perfringens, Sensitive to clindamicin, ale deyaki vidi, for example C.sporogenesі C.terium, Often stiykі to dії clіndamіtsinu. At the connection with the cym, it is necessary to test for sensitivity.

Development of organisms: Chlamydia trachomatis; Toxoplasma gondii; Plasmodium falciparumі Pneumocystis carinii(In addition to primahin) Gardnerella vaginalis; Mobiluncus mulieris, Mobiluncus curtisii; Mycoplasma hominis.

To Clindamicin-resistant:

aerobic gram-negative bacteria: Streptococcus faecalis ; Nocardia species; Neisseria meningitidis; penіtsіlіnresіstentnіkh shtami Staphylococcus aureus; shtami Haemophilus influenzae.

Pharmacokinetics. For intravenous injection of 600 mg of clindamicin phosphate, the maximum concentration in the blood (9mkg / ml) is reached after 1 - 3:00 from the moment of injection. For internal infusion of 300 mg with a pull of 10 quilins or 600 mg with a pull of 20 quilins, the maximum concentration is 7 μg / ml and 10 μg / ml, apparently, it can be reached at the end of the introduction of the drug. A steady dose of the drug in the body is reached after the third dose.

40 - 90% of the injected drug is called into the body with bottles. Clindamicine easily penetrates into tissues and organisms. The concentration of Clindamicin in the cyst tissue reaches approximately 40% (20 - 75%) of the concentration of the drug in the blood. In maternal milk, the concentration of the drug becomes 50 - 100% in synovial blood, in synovial rydin - 50%, in sputum - 30 - 75%, in peritoneal ridge - 50%, in fetal blood - 40%, in pus - 30% and in pleural ridin - 50 - 90% concentration in syrovatz blood. Clindamicin does not penetrate into spinal cord, Navіt in the times of menіngіtu.

The period for which Clindamycin is to become is 1.5 - 3.5 years. In ailments with grievous derailments of a nirkovo or pechinkovoi function, the period of time for a dedication. With the obviousness of easy, abo average gravity the form of a zhvoryuvannya nirok is not necessary. Clindamicine may be metabolized more frequently.

10 - 20% vivoditsya s organism nirkami in microbiologically active form, 4% - in feces. Reshta is produced from the body in the form of biologically inactive products in exchange, head rank, food and feces.

showing

Lіkuvannya іnfektsіy, caused by sensitive to new anaerobic bacteria or strains of gram-positive aerobic microorganisms:

• Infections of the upper dikhalnyh nobles, Including: tonsillitis, pharyngitis, sinusitis, inflammation of the middle air and scarlet fever;
• empty company infections, such as periodontal abscess and periodontitis;
• toxoplasmosis encephalitis in ailments on SNID. The effectiveness of clindamycin in patients with perimethamine in patients with intolerance to standard therapy has been reported
• Infections of the lower types of dichally nobles, including: bronchitis, pneumonia, pleurisy and abscesses;
• Infectious diseases black empty, Including: peritonitis and abscesses of black emptying (in the case of antibiotics, as they do in gram-negative aerobic bacteria)
• Pneumocystis pneumonia in ailments on SNID. In ailments with intolerance to those who are resistant to standard therapy, Clindamicin can be used in combination with primaquin;
• septicemia and endocarditis;
• Infectious diseases of microorganisms and small tissues, including: diseases of diseases, boils, celulite, impetigo, abscesses, infections of wounds, specific infections of tissue
• Infectious disease of cysts and loams, including: osteomyelitis and septic arthritis
• clindamycin indications for the treatment of gynecological infections, including anti-inflammatory diseases, cervicitis, infections of the cuff, tube abscesses and ulcers, salpingitis and inflammation of the organs Infections of uterine cervix, wiklikan Chlamydia trachomatis ;

How to store that dosi

Dose and how to get the drug to lie down because of the severity of the disease, I will become ailing and sensitiveness of the infectious disease to the prescribed drug.

Internal and internal introduction.

Dozi Klindamitsin for grown-ups.

When explicit Infectious diseases black empty igniter get sick pelvic organs in females, as well as in case of their accelerated or severe infections, it is essential to prescribe 2400 - 2700 mg of clindamycin for dobu, dispensed for 2, 3 or 4 times the dose. In mild forms of infection and in the presence of a more sensitive child before therapy likuvalny effect Reach і at the sign of lower doses of the drug - 1200 - 1800 mg per day, divided by 3 - 4 doses of the same.

The dose of the drug was successfully consumed, and the dose was 4800 mg per day. It is not recommended to sign a single dose of more than 600 mg internal and external.

Dozi Klindamitsin for children from 1 month.

20 - 40 mg per kg of body weight per day, divided into 3 - 4 equal doses.

new population:

Novonarogenim Clindamicin is prescribed in doses of 15 - 20 mg per kg of body weight per day, divided into 3 - 4 doses of the same. For small premature babies, a sufficient dosage may be needed: 10 - 15 mg per kg of mass per day.

Licuvannya of igneous diseases of the pelvic organs and infection of the cervix, vicious Chlamydia trachomatis.

Inflamed pelvic organs - stationary 900 mg clindamicin dermal 8:00 + internal antibiotic, active gram-negative aerobic diseases (for example, 2.0 mg / kg gentamicin 3 by such means 1.5 mg / kg skin 8:00 for a patient with normal function of the skin). Prodovzhuvati the introduction of the drug for at least 4 days and then take 48 years for the polish to become the patient. Nadal prodovzhuvati take in the middle of Clindamicin in a dose of 450 mg of skin 6:00 until the end of the 10-14-day cycle of therapy.

Toxoplasmosis encephalitis in ailments on SNID.

Clindamicin intravenously in a dose of 600 - 1200 mg of skin at 6:00 for 2 times, sometimes 300 - 600 mg of skin at 6:00.

Call a course of treatment to become 8 - 10 tendencies. The dose of perimethamine should be 25 - 75 mg orally every 8 - 10 hours. Folic acid 10 - 20 mg / dob is guilty when high doses of perimethamine are consumed.

Pneumocystis pneumonia in patients with SNIDom.

Clindamicine intravenously 600 - 900 mg of skin 8.00 for 21 days and primaquine 15 - 30 mg orally once a day for 21 days.

Dispensing and liquidity of infusion.

The concentration of Clindamicin in the solution for infusions is not to blame for the change of 18 mg / ml, but Shvidk_st introduced is not guilty of replacing 30 mg per quilin.

It is not recommended to inject a dose of 1200 mg about 1:00 infusion.

Pobichna diya

• Herbal tract: abdominal beating, nudity, bloating and penetration, pseudomembranous colitis.
• Reactions of sensitiveness: maculopapular visp, kropivy of generalization, core-like visip of the lung and middle stage of turn. With clindamycin bouly, we tied one at a time in the form of multiforme erythemi, which nagadu Stevens-Johnson syndrome. Bulo describes the decile of anaphylactoid reactions.
• Pechinka: zhovtyanitsa destructed function of the pechinka.
• Shkіra and mucous membranes: sverbіzh, vaginitis, rarely - eksfolіative and vesiculobulous dermatitis.
• Hematopoiesis: neutropenia, leukopenia and eosinophilia of the past character, as well as agranulocytosis and thrombocytopenia.
• Heart-vascular system: when the drug was injected quickly, there were signs of heart disease, as well as development of hypotension.
• Miscellaneous manifestations: when the drug is injected, it may be possible to prevent the occurrence of such manifestations, such as miscellaneous malignancies, whether or not abscesses are confirmed in the case of the drug administered, and sometimes there is a diagnosis of thrombophlebitis. The incidence of such diseases changes when the drug is injected into and in the first place prior to the use of post-internal catheters.

Prototype

Assignment to Clindamycin is contraindicated, we are sick with an increased sensitivity to Clindamycin or Lincomycin. Mіasthenіya.

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Overdose.

symptoms: with parenteral introduction of high doses of the drug (especially in the case of a rapid introduction), the development of collapse is possible, the deterioration of the disorder. lykuvannya symptomatic.

specialties

It has been shown that an early indication of Clindamycin in the second with an emergent antibiotic, even for gram-negative bacteria (for example, from a group of aminoglycosides), successfully propels intestinal development of abscess in the village For those who were uncontrolled until afterwards, de vikorisovyvayut monotherapy doses, give the opportunity to allow, for Clindamycin, which is stagnant parenterally at a dose of 20 mg / kg / day for at least 5 days, good alternative hinin abo amodiahin for the treatment of multi-resistant Plasmodium falciparum.

Lіkuvannya drug can be supervised by the development of pseudomembranous colitis.

When the drug is prescribed, we have an illness, in those who have a history of illness herbal tract, Especially colitis, Clindamicin needs to be taken for protection.

Clindamicin is not intended to be used for treatment of meningitis, because the drug does not penetrate through the hematoencephalic bar.

If the process is carried out for a trivial hour, then at all times it is necessary to stitch up the function of the stove and nirok.

As a result of drug administration, there can be an activation of the flora, the yak is not sensitive to the drug, especially to the other flora.

Clindamicin should not be injected into an unbroken eye, as well as a unique fast (bolus) injection of the drug. Infusion must be carried out at least 10 - 60 quilins.

Clindamicin is necessary to show that we are sick, we are sick to the point of allergic reactions.

Clindamicine can induce neurological conductivity.

The safety of storage for vaginosti has not been established, so it can only be used for life.

I was aware of the appearance of Clindamicin in breast milk at a concentration of 0.7 to 3.8 μg / ml. given to the drug for pinning the year to the chest.

Vzaєmodia with іnshy lіkarskiy zasob

Isnu antagonism between clindamicin and erithromicin. Clindamicine deyakoyu the world є neuromuscular blockages and can increase the number of neuromuscular blockers in the body, so the drug needs to be prescribed for the protection of ailments, as to get rid of muscle relaxants.

Z clindamycin is nonsense: ampicilin, phenytoin sodium, barbiturati, aminophilin, calcium gluconate and magnesium sulfate.

Clindamicine is physically and chemically summarized, if it is available in 5% glucose on water and sodium chloride, sodium chloride for antibiotics, which can be vicorized in standard concentrations: ammonium sulfate naphthame, cefamate ceftizoxime sodium, gentamicin sulfate, Netromycin sulfate, pperacylin and tobramicin.

The consistency and stability of Clindamicin's insanity with the other drugs will be found in the concentration of the other minds.

Umovi zberigannya

take at a temperature of 25 ° C, inaccessible to children, stolen from the light. Term of attachment - 2 rock.

wash away

for the recipe.

package

1 bottle of 2 ml in a carton pack for 1 ml.

Virobnik

TOV "Pharmaceutical company" Zdorov'ya ".

Clindamicin is classified as a synthetic antibiotic from a group of lincozamines. The drug is susceptible to bacteriostatic and antiprotozoal effects.

With high concentrations of the drug, the drug is effective against bactericidal bacteria on pathogenic microorganisms.

The main reason for the drug is clindamicine, the strength of the ribosomal subunit of bacteria and the inhibition of the processes of the synthesis of bacterial cells, which leads to the destruction of the growth and multiplication of bacteria.

The drug is a sign for the fight against bacterial infections, so it is an antibiotic. For a given lykarskoy form, a single antibiotic-linkosamide in viglyad salt (phosphate) is used. Drinking on the slime, it’s awake, it’s not easy, so there’s an insignificant systemic effect, splinters in small amounts get wet into the bloodstream. In order to find out non-essential inheritances, the preparation of suppositories is required only for the signs of the drug and, in advance, to learn about the analysis to the preparation.

Likarsky's warehouse

A variety of capsules and vaginal suppositories - clindamicine from a group of antibiotics.

It is nap_vsynthetic, older than natural, which has changed its pharmaceutical characteristics. Active and suspiciously gram-positive pathogenic microflora and non-sportive anaerobes:

• Staphylococcus aureus and Staphylococcus epidermidis;
• Streptococcus spp. (Krim Streptococcus faecalis);
• Pneumococcus spp .;
• Bacteroides spp .;
• Fusobacterium spp .;
• Propionibacterium spp .;
• Actinomyces spp .;
• Peptococcus spp .;
• Clostridia spp .;
• Plasmodium falciparum;

In the therapy of vaginosis, the antibiotic activity of schodo gardnerel, Mobiluncus spp., Mycoplasmi, Bacteroides spp. Is especially significant. and peptostreptococcus. At the same time, Clindamicin is ineffective in vulvovaginitis, viclikanich trichomonads, trash, gonococci, fungi, other and herpes virus.

Form vipusku

To the renewal dedicated to Volodya the Moldavian pharmaceutical company "Pharmaprim" Lykarska form for muscular intravaginal congestion to replace 100 mg of dialectical speech and form-making additions to ingredinti - napivsynthetic glitserida. The carton pack has 3 suppositories of white color in a contour package.

Photo of the packaging of Klindamicin ® in capsules of 150 mg

Antibiotic clindamycin ® should not only be used for muscular administration, so tablets or capsules of 150 mg for oral administration are also dispensed. infusion problems... The basic alternative form for intravaginal vicarystanny is 2% gel, which is injected into the first place with the help of the applicator.

Recipe Clindamicin ® Latin

A list of over-the-counter anti-microbial drugs and the strength is on the ear of the smallest rock, go in advance for a drink without a prescription. At the same time, buying in the pharmacy is practically all antibiotics in the form of a lykarsky sign. The form is guilty of revealing the necessary information about the patient, as well as confirmation of the certificate and special seal of the fax. The very notation of the viglead is approximately like this:

Rp .: Suppositorium cum Clindamycini 0.1

S. t. d. No. 10

S. Introduce 1 suppository for doba before bedtime.

Shown and counter-shown

Candles are recognized by a gynecologist for vaginosis (non-infectious processes in the first place), sensitive to antibiotics microflora -, and others.

There are only two prototypes for the drug in this drug form: individual intolerance to the components and the first 3 months of vaginosity. In addition, it is recommended to use antibiotic therapy for the period of antibiotic therapy.

For the largest forms of vipusku - tablets and retail - the range of indications is quite extensive. This includes infectious diseases, hypochondriacs, cysts and soft tissues, pelvic organs, gravelly emptying, as well as generalized bacterial inflammation (sepsis, septicemia, and іnshі).

Systemic forms of antibiotics are not recognized in case of individual intolerance to an antibiotic, as well as in case of an anamnesis of antibiotic diarrhea or pseudomembranous colitis.

Clindamitsn in viglyad lotions and gels stagnate in vigorous viscous.

Dosing and dosing mode

Suppositories Klindamicin ® for gardnerellosis and other types of vaginosis are recognized for the scheme "1 test for doba for nothing". It is easy to knock the stench out of the package (it is necessary to overdrive along the contour). Introduce in the first place as much as possible, bazhano in the proper lying position, without the middle before going into bed. Expect the triviality of the course of antibiotic therapy does not change 5 dB, but for the svidchennyy you can be improved until the end.

In case of systemic infections in older adults, capsules become vicious - in the middle of 600-1800 mg for dobu, distributed for three chotiri priyomi.

at streptococcal infections priznachayut on 300 mg dvіchі for dob not less than ten days.

In case of chlamydian cervicitis, it is necessary to take 1800 mg per dose for 10-14 days.

Children older than six years should be given 8-25 mg per kilogram for doba, dispensed for 3-4 doses.

In case of malaria, consume 20 mg per kg for dobu for 5-7 days.

In case of pneumocystis pneumonia in patients with VIL, consume 300-450 mg of skin for 6 years for 21 days (in the warehouse of complex therapy).

Pobіchnі efekti i lіkarska vzaєmodіya

When there is an increase in sensitivity to any of the components in suppositories, the body's reaction is not expected to occur in the region. Possibility of inflammation of the mucous cervical canal or pichvi, vulvitis, superinfection in the form of candidiasis. With regard to the reduction of active speech into the bloodstream, in some cases, systemic reactions in the presence of mild forms of allergy (), changes in the form of elements of the bloodstream, pseudomembranous reactions are indicated.

Clindamicin ® in lycarsky form of suppositories is inappropriate with other drugs for muscular treatment of vaginosis, as well as with lincomycin (in the remaining form of vinicum, resistance is overridden). In case of a spinal congestion with rifampicin, it has a therapeutic effect. Antibiotics erythromycin and ampicilin may not be vicious, as it is with aminophylline, barbiturates, magnesium sulfate, old diphenylhydantoin and calcium gluconate.

Clindamicin ® for vaginosity and lactation

The whole antibiotic navit in case of muscular congestion to get wet from the surface of the mucous membranes and consumed in the bloodstream (about 5% of the backbone amount). It is characterized by good penetrating health, including through the placental bar. To that, at the stage of active development of the fetus in the first trimester, it will become more active, and in the beginning of the month it will only be indicated for serious indications. Years old women bazhano in the period of lіkuvannya for an hour vigodovuvannya pinch, and milk ztsіjuvati.

Capsules with vaginosti stasis only for life shown.

Consistency with alcohol

About those who are anti-microbial preparations of systemic diy (tablets, injections) are insane with ethanol, I know practically everything. Nebezpeka of this kind is tied to shkіdlivim flow on the chitin pechinki, as they know the gifts of the chemical spoluca, as well as with the alcoholic drinks. Remaining factor overshkodzhaє the establishment of the required concentration lykarsky zasobu in blood, antibiotic therapy results to zero.

And why can you drink antibiotics with alcohol? Do not marvel at those who do not get wet into the bloodstream into the bloodstream in this way and do not pour into internal organizations... On the right, in the fact that alcoholic beverages significantly reduce the effectiveness of antibacterial therapy, it increases the risk of progressing ill health.

Analogs of Klindamitsin ®

On the basis of the given antibiotic-linkozamidy, a decilka of species is released vaginal suppositoriesі gelіv pіd іnshim trade names... In pharmacies, it is possible to add such deputy to the origin of the latest virobniks in the price range from 400 to 650 rubles:

• Dalacin ® (Pfizer ®, USA) - also 3 candles, 100 mg of diyuchy speech or 2% gel with applicators;
• Klindatsin ® (Akrikhin ®, RF) - a new analogue of a candle behind a warehouse and in the form of a release;
• Klindatsin prolonged ® (from the current pharmaceutical company) - 2% cream.

You can also be substituted for anti-microbial support for the intra-travaginal storage of other groups. Instead of trying to get a recommendation from a gynecologist and for a bacterial culture, it will definitely allow you to identify the cause of vaginosis.

Analogues of Clindamitsin ® in tablets are preparations for oral implantation, which are systemically injected on infections. The antibiotic is used in the form of antibiotics under the trade names Dalatsin (capsules of 150 and 300 mg each), Klindatsin ® and Klindafer ®, as well as Klіmіtsin ® capsules. In addition, on the basis of practical speech, one hundred and one ointments and products of Zerkalin ® are issued for a new period of time, effective against high visibility.

Clindamicin ® or Dalatsin ®, which is more beautiful?

As soon as one can judge about the chemical structure and effectiveness of both drugs, the difference between them is dumb. The offense of the stench is dispensed in lykarskiy forms of intravaginal candles, so take 100 mg of one and the same antibiotics, but of the same form-making ingredinti - solid fat. Rіznitsya polyag lishe at partostі, and the American analogue here sacrifices the Moldovan original, oskіlki kostu dear.

structural formula

Russian name

Latin name of the speech Clindamitsin

cheery name

Methyl-7-chloro-6,7,8-trideoxy-6 - ([(4R) -1-methyl-4-propiv-L-strait] amino) -1-thio-L-threo-alpha-D-galactooctopyranoside (in viglyadі hydrochloride, phosphate or palmitate hydrochloride)

Clindamicin is a synthetic antibiotic of the group of lincosamides, which can be used for lincomycin when the 7 (R) -hydroxyl group is substituted for 7 (S) -chlorine.

In medical practice, it is necessary to consume hydrochloride, palmitate, hydrochloride and phosphate.

Clindamicin hydrochloride is developed in water, pyridine, ethanol, dimethylformamide.

Clindamicinum palmitate hydrochloride developed at water.

Clindamicine phosphate in water.

pharmacology

Link with the 50S ribosomal subunit of microbial cells and drive the synthesis of sensitive microorganisms. Vyavlyak bacteriostatic effect, in high concentrations and in visibly highly sensitive microorganisms can show a bactericidal effect. For the mechanism of microorganism and antimicrobial spectrum, it is close to flincomycin (most of the types of microorganisms are 2-10 times active).

When taking in the middle of clindamycin, hydrochloride is fast and good to get out of the intestinal tract (more brightly, less lincomycin), bioavailability - 90%, one-hour reception and hope for absorption, not winter. Linking with bricks - 92-94%. Easily penetrates into biological life, organ and tissue, organism, incl. mydalini, myazovu i kistkovu fabric(Approximately 40% of the concentration in the blood), bronchi, lesions, pleura, pleural ridina (50-90%), gut ducts, appendix, fallopian tubes, anterior mucus, synovialnuridin (50%), mucus (30-75% ), seeing wounds. It is disgusting to pass through the hematoencephalic bar (when the cerebral membranes are inflamed, the penetration of the GEB moves). Obsyag rozpodilu in older adults - approximately 0.66 l / kg, in children - 0.86 l / kg. Shvidko pass through the placenta, appear in the blood of the fetus (40%), penetrate into the breast milk (50-100%).

Clindamicin palmitate and clindamicin phosphate are inactive; stench quickly gidrolizuyutsya in the body to active clindamycin.

C max in syrovattsi blood with oral administration is reached after 0.75-1 years, with intramuscular injection - after 3 years (older) or 1 hour (children), with intravenous infusion - until the end of the injection. Metabolize in the liver from the statements of active (N-dimethylclindamicin and clindamicinsulfoxide) and inactive metabolites. It is produced by a stretch of 4 dB from a section (10%) and through the intestine (3.6%) in vigilads of active faction, and solids - in viglia of inactive metabolites. T 1/2 at normal function nirok in adults to become 2.4-3 years old, in infants and older children - 2.5-3 hours, in premature newborns - 6.3-8.6 years. At the thermal stage nirkova lack for in case of severely impaired function of the liver, the vivenny of clindamycin is reliant on (T 1/2 in older adults - 3-5 hours). Chi is not cumulativeє.

With intravaginal intake of 100 mg of clindamicine phosphate in viglyad 2% vaginal cream 1 time for another 7 days in 5 females with bacterial vaginosis, systemic absorption became approximately 5% (in the range of 2-8%) of the administered dose. The value of C max on the first day is approximately 13 ng / ml (from 3 to 34 ng / ml), on the next day - on the middle 16 ng / ml (from 7 to 26 ng / ml); T max - approx. 16 years (in the range of 8-24 hours) for consumption. In case of bagatorazovy intravaginal stasis, the systemic cumulation of the bullet is almost negligible. T 1/2 with systemic wetness - 1.5-2.6 years.

When clindamicine phosphate is consumed vaginally in viglyadi suppositories at a dose of 100 mg once a day for 3 days, approximately 30% (6-70%) of the administered dose will soak into the systemic circulation, at which the average value of AUC becomes 3.2 μg / year 0.42-11 μg / year / ml). C max is reached after about 5 hours (1-10 years) after the introduction of the vaginal suppository.

When vigorous in viglyadі gel for the lasting suction of clindamicine phosphate is rapidly hydrolyzed by phosphatase in the ducts sebaceous vines from the statements of clindamycin. The gel can be moistened in droplets to make a systemic effect.

Before clindamycin is sensitive in vitro such microorganisms: aerobic coca, including Staphylococcus aureus, Staphylococcus epidermidis, incl. shtami that do not virobly and do not vibrate penicylinase ( in vitro according to the rate of development of stability to clindamicin in some staphylococcus strains resistant to erithromycin), Streptococcus spp.(with a blame Streptococcus faecalis); Pneumococcus spp .; anaerobic gram-negative bacilli, including Bacteroides spp... (Including group B. fragilis i group B. melaninogenicus), Fusobacterium spp .; anaerobic gram-positive bacilli, which do not settle disputes, including Propionibacterium spp., Eubacterium spp., Actinomyces spp.; anaerobic and microaerophilic gram-positive coca, including Peptococcus spp., Peptostreptococcus spp., Microaerophilic Streptococcus spp., Clostridia spp.(Clostridia show a greater resistance to clindamicin, less anaerobics). more Clostridium perfringens sensitive to clindamicin, ale іnshі vidi, for example C. sporogenesі C. tertium, often try to clindamycin, so it is necessary to carry out tests for sensitivity.

In high doses, the dosage is per day. (Plasmodium falciparum).

It has been shown that there is a cross-resistance between clindamicin and lincomicin and antagonism between clindamicin and erithromicin.

In the minds in vitro clindamycin is active in a relatively large number of strains of such microorganisms, which cause bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp., Mycoplasma hominis, Bacteroides spp., Peptostreptococcus spp. Clindamicine for intravaginal congestion is ineffective for the treatment of vulvovaginitis Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans or a virus Herpes simplex.

Acne anti-acne in case of zastosuvanny, ymovirno, it is explained by the fact that clindamicine is changing the concentration of essential fatty acids on shkiri and attracting proliferation Propionibacterium acnes- anaerobe, which appears in sebaceous lobes and follicles. The sensitivity of all preselected strains is shown P. acnes to clindamicin in vitro(MIC 0.4 μg / ml).

Carcinogenicity, mutagenicity, infusion on fertility

Trivial dosages of clindamycin have not been carried out on animals using the assessment of the potential carcinogenicity of clindamycin. No mutagenic activity was detected in Eims' and micronucleus tests on pike. Unfavorable infusion on fertility and health before mating in shchura, when clindamicin was treated at doses up to 300 mg / kg / dob (approximately 1.6 times the MRDC per mg / m 2), did not sputter.

Viability. In pre-reproductions on animals (schuri, mish) with intracranial doses of clindamycin up to 600 mg / kg / dob (in 3.2 and 1.6 times as MRDC in a pererakhunka on mg / m 2 as an indication) or s / c in doses up to 250 mg / kg / dobu (in 1.3 and 0.7 times the MRDC in a pererakhunku per mg / m 2 as a matter of fact) no teratogenic effect was detected. In one case, there was a gorge in the sky on the mishas in the fruit (the result was not taken into account in the experiments on the mishworms and on the mish lines).

Stagnation of speech by Clindamicin

For systemic consumption: bacterial infections, Viklican with sensitive microorganisms: infections of ENT organs (including pharyngitis, tonsillitis, sinusitis, otitis media), Infectious organs of the disease (bronchitis, pneumonia, including aspiration, abscesses of the lungs, pleural effusion, fibrosing alveolitis), Infections of cysts and loam (osteomyelitis, arthritis) including vugri, furunculi, celulitis, impetigo, panaritus, infection of wounds, abscesses, erysipelas), septicemia (the first for all anaerobic), infection of pelvic organs and internal abscesses of the so-called LZ actively schodo gramnegativnihaerobnih mіkroorganіzmіv) gіnekologіchnі zahvoryuvannya (including endometrium, adnexitis, abscess fallopієvih pipe i yaєchnikіv, salpіngіt, pelvіoperitonіt) іnfektsії porozhnini company (including perіodontalny abscess) Toksoplazmovy entsefalіt, tropіchna malyarіya ( viclicana Plasmodium falciparum), Resistant to chloroquin (in addition to chloroquin); Pneumocystis pneumonia Pneumocystis carinii), Sepsis, bacterial endocarditis, scarlet fever, diphtheria.

For intravaginal stasis: vaginosis, giving sensitive to clindamicin microorganisms.

For a callous filling (gel): vugrovy visip.

Prototype

Hypersensitivity (including to flincomycin), history of regional enteritis, swelling colitis or antibiotic colitis.

Obmezheniya to zasuvannya

Miastenia (possibly damaged nerve-muscle transmission), rotational damage to the liver function і / abo nirok, thoracic vіk (up to 1 mіs), for gel - up to 12 years (safety and efficiency).

Stagnation during vaginosis and breastfeeding

With vaginosity, it is possible, as well as cleansing, the effect of therapy is changing the potential for the fetus (adequate and strictly controlled dosages were not carried out in vaginal women, clindamines pass through the placenta and can concentrate in the liver of an unborn fetus, however. As a result, it was established, reducing the number of BV consumption of such uncomfortable herds of vaginosity, such as the early ripening of fruit husks, the earliest ear of canopy, or the early development.

Take care when stagnating in the period thoracic treatment(Inadvertently, clindamycin penetrates into the breast milk for the lasting and intravaginal intake, but does not appear in the breast milk for oral or parenteral administration).

Pobіchnі diї speeches Clіndamіcin

System Effects:

Ridko - the breakdown of the nerve-myazovoi conduction.

On the side of the cardiovascular system and blood (blood formation, hemostasis): transient neutropenia (leukopenia) and eosinophilia, agranulocytosis, thrombocytopenia; with a quick intravenous injection - heart-vascular deficiency (collapse, heart zupinka), arterial hypotension.

On the side of the organs in the intestinal tract: bile in the abdomen, pseudomembranous colitis, esophagitis, nudota, bloating, diarrhea, dysbacteriosis, zhovtyanitsya, impaired liver function, hyperbilirubinemia; at high doses intravenously introduced - inappropriate abometalevium in roti.

Allergic reactions: generalized korepodobny visip of the lung and the middle stage of the turn, maculopapular visp, kropiv'yanka, sverb_zh; Ridko - exfoliative and vesiculobulous dermatitis, multiforme erythema, toxic epidermal necrolysis; in some cases - anaphylactic reactions.

Інші: Ridko - azotemia, oliguria and / or proteinemia, polyarthritis, development of superinfections; reactions in the injection - ailment, soreness, abscess (with intramuscular injection), thrombophlebitis (with intravenous injection).

With intravaginal stasis:

cream

Approximately 4% of the patients were treated with a cream in conjunction with the indications of side reactions.

cervicitis / vaginitis (symptomatic, 16%; Candida albicans, 11%; Trichomonas vaginalis, 1%), vulvovaginosis (6%), vulvovaginitis, vulvovaginitis menstrual cycle, Bіl at pіkhvi, seeing from pіkhvi, uterine bleeding, Dysuria, Infections of secular nobles, abnormal canopy, endometriosis, glucosuria, proteinuria.

Three sides nervous system and organs chuttya: zapamorochennya, head b_l, vertigo.

System headings: fungal infections, bacterial infections, igniter, infections of the upper branches, generalizations, bins, bins in the back.

On the side of the organs in the intestinal tract: baking, nudota, bloating, diarrhea / constipation, dyspepsia, flatulence, unpleasant odor from the company, beating in the abdomen, beating in the lower abdomen, cramps in the abdomen.

Інші: monitoring of results in microbiological analyzes of norms, candidiasis, twisting relish, nasal bleeding, hyperthyroidism, visip, kropivyanka.

suppositories vaginal

On the side of the cross-sectional system: subdivision of the mucous membrane of the vulva і pіchvi, bіl in pіchvi, vaginal candidiasis, vaginal infections, disruption of the menstrual cycle, vision of pіchvi, dysuria, pyelonephritis.

System headings: fungal infections, fever, generalization bl, head bl, bl at the bots.

On the side of the organs in the intestinal tract: diarrhea, nudity, bloating, abdominal pain, cramps in the abdomen.

On the side of the curved curves: itchy skin, Visip, bіl і sverbіzh at mісці introduction.

In case of zastosuvanny (gel)

Dryness and subtlety of shkiri (in the place of application), contact dermatitis, seeing in the eyes; foliculitis, with gram-negative flora; promotion of products of sebaceous salmon. With systemic moistening, it is possible to lead to the development of systemic side effects, incl. damage to the functions of the intestinal tract (bile in the abdomen, mild diarrhea); in small vipads - pseudomembranous colitis.

vzaєmodiya

Inappropriate with the differences, but the complex of vitamins of group B, aminoglycosides, ampicilin, phenytoin, barbiturates, aminophilin, calcium gluconate and magnesium sulfate.

In vitro indications of antagonism of clindamycin with erithromycin, as well as with chloramphenicol; Oskіlki Daniy The effect can be clinically significant, as the LZ does not go overnight.

Oscillations of clindamicin will interfere with the nerve-muscle transmission and may be more stimulating to the muscle relaxants of the peripheral movement, with an immediate immobilization of the care and lead for the sickness of the retreat. With a one-hour consumption of opioid (narcotic) analgesics, it is possible to improve the strength of the reduction, right up to apnea. One hour the sign of antidiarrheal LZ, which reduces the motility of the slunk-intestinal tract, reduces the development of pseudomembranous colitis.

Overdose

symptoms: to improve the turn of the side effects.

lykuvannya: symptomatic and susceptible. Chi does not occur for additional hemodialysis and peritoneal dialysis.

introduction

in the middle, in / m abo iv drip, zovnishno, vaginally.

Zapobіzhny come in speeches Klіndamіtsin

With the development of hypersensitivity reactions to clindamicin treatment, it is necessary to fix it and (if necessary) carry out a specific therapy.

Antibacterial drugs bring normal intestinal flora, so that clostridia can grow more easily. Symptoms of pseudomembranous colitis of the risky step gravity, right up to clutter up the life, Sposterіgalsya in case of stagnation of practically all antibacterial diseases, including clindamіcin.

Brought toxins, how to produce Clostridium difficile,є the main cause of colitis, tied with antibiotic therapy. Diarrhea, colitis, symptoms of pseudomembranous colitis may appear on the same type of clindamycin, so after 2-3 months after the onset of the disease. Pseudomembranous colitis is manifested by diarrhea, leukocytosis, fever, abdominal pain feces blood and slime). In addition, in all cases, the development of the diagnosis of antibacterial drugs should be followed by the possibility of this diagnosis. For setting the diagnosis of pseudomembranous colitis in light vials, it is shown during the period antibacterial drug, Effective shodo Clostridium difficile(For example, indicate vancomycin or metronidazole).

Slid pam'yatati lykarsky forms systemic effects can be manifested. With a callous congestion of clindamicin, pseudomembranous colitis develops in small vapors, but with an intravaginal congestion of vitamins, they are not of connotation.

Patients over 60 years of age have antibiotic-associative colitis and diarrhea (wiklican Clostridium difficile) They are more often and may be more important (following the pace of patients and the frequency of style, the diarrhea did not develop).

In case of stagnation of clindamicin, there is a superfluous growth of insensitive microorganisms, especially other fungi. At the end of the day, the diagnosis of superinfectious diseases has been observed in the course of the previous visits to the fallen lands due to the clinical situation.

When indicated at high doses, it is necessary to control the concentration of clindamicin in plasma. As long as it is carried out for a trivial period of an hour, then it is necessary to regularly carry out additional functions of the stove and nirok.

Before the appointment of vaginal suppositories or vaginal cream for additional reasons laboratory methods guilty buty Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans, virus Herpes simplex, Often viklikayut vulvovaginit.

bedroom property vaginal suppositories and vaginal cream with other drugs for intravaginal administration are not recommended. Before the hour of therapy, the children should not enter into the state of the art. Do not go to the same vicoristovuvati virobi for intravaginal introduction (for example, tamponi). For an hour of therapy, it is not recommended to use condoms for vaginal anti-inflammatory diaphragms, since the components that enter the cream warehouse, or suppositories, may change the effect of latex and rubber virobes.

In case of zvnіshny zasosuvannі in viglyadі gel, it is only necessary to use the gel on the mucous membrane of the eyes and the empty company. Pislya applied to the gel on the screen, then wimit hands. In case of vipadkovom contact with sensitive surfaces (eyes, sad on the skiri, mucous membranes), the area is clearly given with cold water.

It is not recommended to vikoritovuvaty gel for zvnіshny zasosuvannya immediately іt sludge, but to wick the peeling and scorching shkіri (including resorcinol, salicylic acid spirtovmіsnі koshty), with cute or disinfective tricks, to take revenge on abrasive speech - a powerful cumulative drastic or hanging effect and overwhelmingly teasing shkіri.

It takes an hour to take care of it for an hour to take care of it for an hour, and it’s working for transport workers and people, the profession of which is tied to the increased concentration of respect (it can be screwed up).

Vzamodії with іnshih dyuchy speeches

knitted news

trade name

Preparations instead of Klindamitsin are taken to the group of leaks. a wide range recognition. Daniy antibiotic is dispensed in offensive forms - Clindamicin cream, gel, capsules, suppositories, tablets and ampoules for injections. head component are active as a matter of fact without bacteria. Ce Streptococcus spp, Bacteroidesspp, Propionibacterium spp., Corynebacterium diphtheria і інші.

The spectrum of antibiotics is similar to lincomicin.

Clindamicin - fortune:

• ailments infectious disease... Tse of incapacitation of ENT organs and ecclesiastical nobles;
• diphtheria, scarlet fever, osteomyelitis;
• bacterial endocarditis, septicemia;
• infectious ailments of the state of the sphere, soft fabrics;
• ailments of the shk_rny mantle;
• Infections of worms and a company.

Zastosuєmo і yak prophylaxis in case of early injuries, intracranial abscesses, peritonitis, vaginosis.

Likuvalny power

Dіyucha speech Clіndamіtsinu hydrochloride quickly soaks into the intestines. However, everybody is able to cope with it, as if it were victorious one hour at a time. At the blood, it is maximally concentrated in about 1 year with vicious tablet form.

Diya with an internal or internal introduction appears on the way more quickly - as soon as it is manipulated.

Therapeutic concentration of the drug is 8 years old, metabolic processes are in the liver, the metabolism is approved. Outside the life of the body through intestinal tractі stove - 4 add. The details of the instructions for storing Klindamitsin in different forms are displayed.

cream

Vaginal cream Clindamicin is used in gynecology for treatment of vaginosis. The head component of the moth is clindamycin phosphate. Zhovto-cream colora ointment with a slightly swirling specific smell.

Vipuskayutsya in tubes of 20 g and 40 g. Vikoristovuyutsya before bedtime, no more than 7 days sleep.

Prototype indication and sub-series

If there is a problem with the sevidular system in vigiladi candidiasis, or it is razdratuvannya. Ridkisny vypadki show bleeding, endometriosis and dysuria.

Significantly show:

• fungal disease;
• bacterial infections;
• bile at the back;
• visualization in the results of analyzes;
• allergic reactions.

You can have problems with the intestinal tract in the viglyadi diarea and tedium. The children of the kids have a tampering or shkirnі sverblyachі visipannya.

Side effects do not appear more than 10% of patients.

Instructions of the cream to Clindamicin to revenge only one contraindication - sensitivity is adjusted to the kind of speech or to lincomicin.

Overdose

About these types of drops, it is not uncommon, it is more important to remember that the drug is vicorized only vaginally.

lykarska vzaєmodiya

On the current day of the insanity of Clindamicin with other drugs, he was not spasmodic.

special requests

Persh nіzh vikoristovuvati cream Klіndamіcin, you need to go through a number of doslіdzhen. It is not possible to allow the appearance of microorganisms, for which the drug cannot cope with: Clindamicine can increase the growth of microorganisms, most often of other similar fungi.

It is not installed, but antibiotic is infused into the concentration of respect, that is not the case for driving and driving by car.

If you go through a lіkuvannya, you can not enter into іntimnі contacts, vikorisovuvati tampons or douches.

gel

Basically, it is shown before the gel is filled - in the form of visibility and prischі. Zasib is a one-sided warehouse in a white color with a slight specific smell. The active ingredient is clindamycin phosphate. This form of Clindamycin is dispensed, 150 mg in tubes.

Vikoristovuєtsya only calls and locally - applied on the visipannya. Fallowing ailments, it may be close to 1 month. Apply the gel once a day.

Liki perfectly block the growth of bacteria; Applied growth of bacteria strains Propionibacterium acnes. In some cases, the drug was used to reduce the amount of fatty acids from 14% to 2%.

Prototype

1. Clindamicine in gel cannot be vicarious in case of hypersensitivity to active speech.
2. It is not allowed for children who are living and living, and also for children who have not reached 12 years of age.
3. The gel is not recommended for atopia or for inflated colitis, regional enteritis.

Pobichna diya

Possibility of baking and sverbіzh, dryness of skins and hulling. In some cases, there is a carry-over of the slunk-intestinal tract. Through the frequent manifestation of the diarea of ​​the vicorian gel with clindamicin, it is recommended to immediately start the therapy.

Yak vikoristovuvati drug

It is not possible to vikoristovuvati gel in any way, except for the calling. To be applied with a thin ball on the dish of the shkiri.

Likewise it wasted in the eyes, or on the lips, it was safe to snatch.

zberigannya

You can freeze it, take it at a temperature of + 25 ° C.

capsules

Clindamicine capsules can be used to treat ailments, including peritonitis, stomatitis and infectious myositis. Effective with ENT-congestion, bursitis, problems with the sectostatic system in choloviks, ignition processes pelvic organs with unspecified pacing.

90% of the drug is absorbed in the intestinal tract. If you start taking in small doses, then the absorption will be on the skin.

Capsules can be found in the middle of grown-ups and children, older than 15 years. Prescribe in capsules (150 mg) 4 times per dob for the registered ones. At an important dose, the dose can be increased up to 300 mg-450 mg.

Prototype

It is a good idea to instruct Clindamycin in capsules, contraindicated for admission to the vagina and years of breastfeeding. Active speech through the placenta enters circulatory system baby and great naughty.

Do not use the drug because of hypersensitivity to active speech and in case of obvious problems with nerves and liver.

Pobichna diya

It is not possible to take the capsule in case of zhovtyanitsi, esophagitis, illnesses of nirok and liver. Detection of thrombophlebitis, hypotonia, allergies is also contraindicated.

Vzaєmodia with інshih likami

Clindamicin is insane with the leaks of the ampicilin group, as well as with the vitamins of group B, aminophylline, magnesium sulfate, barbiturates.

pills

Tablets Klindamitsin vikoristovytsya with infections of black emptying, skin cover, loam, soft tissue.

Obov'yazkova vimoga before taking pills - dry mice.

suppositories

With clindamicinum suppositories are in gynecology. May I be happy or else I will biliy kolir without dissemination. Vipuskayutsya in a cylindrical form. Vikoristovytsya with bacterial vaginosis.

Prototype

The drug Clindamicin in the viglyadi svitchet is not vicious in case of vaginosity and individual intolerance.

sundown

Vaginal candles Clindamicin stasis no more than 7 days after 1 piece. It is recommended to carry out the procedure at night. The candle is sounded from the shell, and it is better to insert it into the shell.

Pobichna diya

With singing conditions, the sows can wicklikati vaginit or razdratuvannya vulva. Ridko develop the appearance of neutropenia or leukopenia. If there is an allergy, then it will manifest itself in the viglyadi papular viscous or spinyworms with sverblyachkoy.

Overdose

Due to the low level of absorption, the overdose is low.

Vzaєmodia with Likami

Clindamicin is a healthy dietary supplement for other drugs, including gentamicin, streptomycin, aminoglikosidi.

special requests

Zastosuvannya sv_chok v_pravdano vipravdano, as cinnamon vіd yogo vykorystannya vishche riziku for the fetus. Those are the very same time for women.

ampoules

Internally or internally, the introduction is recommended in vipads, where the ailment has taken a folding shape. As a rule, we will grow internally to inject Clindamicin 2 times per dose, not changing the dose of 300 mg. Under any circumstances, a single dose is innocent but 600 mg.

For children in ін'єкції rocking with rosrahunka: not more than 25 mg per 1 kg of vagi baby. The dose is divided into two or more doses. In extreme cases, it can be increased to 40 mg.

As long as the patient has a lot of problems with nirok or pechinki, then it is necessary to introduce a breakdown about 8 years.

Uwaga! In case of internal іn'єktsіah, they should be raised and introduced only in dots.

General indications for all forms of the drug

In any case, it is impossible to vikoristovuvati Clindamicin with bronchial asthmaі swollen colitis, malignancies і in case of some rare genetic illnesses. Tse glucose-galactose malabsorption, lack of lactose in the body, galactose intolerance.