Ketorol diyu. Ketorol: instruction from the storing
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Ketorol is a strained, non-narcotic antiphilous drug with antiapaline activity and with the other heat-reducing effect. However, the main activity of Ketorol is zealous (zealous). The preparation for the painful analgesic effect is an ideal preparation for the bruising of the patient or the strong pain syndrome, Especially tied with traumatic problems fabricPlease, name and form vipusku
In the Danish hour, Ketorol is released in three Lykarsky forms:- Gel for zovnishny zasosuvannya;
- Tablets for taking all the way;
- Role for internal and internal introduction.
The gel is a one-shot substance with a characteristic odor. Rozchin for ін'єкцій is an insight і bezbarvny, or blіdo-zhovty. Tablets are made in green color, Mayut a round, two-convex shape and engraving at the view of the letter "S" on one of the sides. On razlomі the tablet was bіla or even more bіla, with a one-sided structure.
The gel is dispensed in aluminum tubes with a volume of 30 g, in ampoules with a volume of 1 ml, 10 pieces per pack, and tablets - 20 pieces per pack.
Ketorol - warehouse
Before the warehouse of all lykarsky forms of Ketorol yak, the speech is active to enter ketorolac in the development of concentration. So, in tablets there is 10 mg of ketorolac, in the form of 30 mg in 1 ml, and in gel - 20 mg in 1 g (2%). To the warehouse Ketorol gel
- propylene glycol;
- Dimethylsulfoxim;
- carbomer;
- Sodium methyl parahydroxybenzoate;
- tromethamine;
- Fragrance "Drimon Indi";
- Ethyl alcohol;
- Glycerin.
To the warehouse of Ketorol tablets in the capacity of additional speeches, there are offensive components:
- Cellulose is microcrystalline;
- Cornudzian starch;
- Coloidal silicon dioxide;
- Magnesium stearate;
- Sodium carboxymethylcrochmal (type A);
- hypromelose;
- propylene glycol;
- Oliv greenery.
- Ethyl alcohol;
- Dinatriya is going;
- octoxynol;
- propylene glycol;
- Sodium hydroxide;
- Deionized water.
Ketorol - recipe
Recipe for roschin Ketorol viglyadaRp: Sol. "Ketoroli" 3% - 1 ml
D.t.d.10 amp.
S. Introduce intravenously or intravascularly 1 ml each
Prescription for tablets Ketorol viglyada
Rp: Tab. "Ketoroli" 10 mg
D.t.d. 20 tabletae
S. Take 1 tablet for skin for 8 years.
Recipe for Ketorol Viglyada gel
Rp: Gel "Ketoroli" 2%
D.t.d. in tuba 30 g
S. Apply a call to dilyanki shkiri, in the area of \ u200b \ u200bthe
In all the meaningful recipes for the letters "Rp" there is a form of vipusku (Sol., Tab., Gel) and the name Ketorol in the Latin word in the paws, and in some cases it is commercially available. The other row has the letters "D.t.d." vkazuєtsya, as a part of the drug is guilty of the pharmacist in the pharmacy lyudin, who is presenting the prescription. At the third row of the letter "S." vkazuєtsya already for the people themselves, as it is necessary to take the drug.
Therapeutic for the drug Ketorol
Ketorol has a tense, painful effect, as well as an apparently weak fever-lowering and anti-fiery effect. The drug is administered to a group of non-steroidal anti-fumes (refineries), such as three powers (fever-lowering, anti-inflammatory and anti-inflammatory) in of the risky step... Ketorol has very strong analgesic powers, and the anti-fiery and fever-lowering efficacy is surprisingly weak.Mechanism for the preparation of dressings for the purpose of blocking the robot with a special enzyme - cyclooxygenase ... Danium is an enzyme that converts arachidonic acid in prostaglandins - especially speech, which leads to the development of an ignition reaction, pain syndrome and increased temperature. In such a rank, Ketorol, blocking the robot of cyclooxygenase, pinching prostaglandin viroblation, in addition to the process of forming an ignition reaction and pain, as well as an increase in temperature.
However, Ketorol has a stronger anti-inflammatory effect, but it literally leads to a different plan and an anti-firing and anti-inflammatory effect. To this, the drug will become stagnant in itself in the quality of a zest-sicker.
Ketorol is not є a narcotic analgesic and not a viclikє of such unwelcoming effects:
- Infusion to the central nervous system;
- Driving dichannya;
- Weakening of intestinal peristaltic activity;
- Covering the section;
- Advancing an arterial grip.
Ketorol - showing up to sucking
Ketorol is absolutely the same before the tablets are consumed, and the drug form, which is optimal for the specific skin type, should be advised by the patient, the need for a quick response to the best possible level of professionalism. So, if it is necessary to reject a shvid, zealous efect, it is recommended to vikoristovuvati rozchin Ketorol. In іnshikh vipadki more color than tablets Ketorol. However, the differences can also get stuck in quiet drops, for some reason or other people cannot take pills in the middle (for example, gag reflex, Virazka of the cutter tube abo two-fingered intestines etc.). Otzhe, indicated before the intake for tablets and injections Ketorolє relief of pain syndrome of any localization and stage of turn. This means that pills or injections can be used for dental, headache, menstrual, muscular, swelling, cyst pain, as well as for surgical pains, pains for oncological ailments, etc. Slid of the nobility, Ketorol of the signs of only for kupiruvannya very painful, Ale not for the treatment of chronic pain syndrome.
Shown until sucked in Ketorol gelє such stani:
- Injuries (blows, burning of soft tissues, lingering ligaments, bursitis, tendinitis, synovitis, etc.);
- More injuries;
- Boli in meats and slopes;
- Rheumatic illness (gout, psoriatic arthritis, ankylosing spondylitis).
Instructions for storing
Clear rules for storing new forms Ketorol (tablets, roschin and gel) in okremikh pіdrozdіlah, schob, unicut plutanin and structure and information.Ketorol tablets - instructions for use
Tablets slid kovtati tsіlimi, not rozzhovyuchi and not supplemented in other ways, but washed down with a small amount of water. You can drink pills right away from the reception, as a mother's protest on uvaz, but Ketorol will take the pills as soon as possible, until the end of the day. Tablets must be taken occasionally, if necessary, taken off or strong. The dosage of Ketorol for a single dose is 10 mg (1 tablet), and the maximum allowable dobova dose- 40 mg (4 tablets). Tobto, with a stretch, you can take a maximum of 4 tablets of the drug. This means that one pill is taken by a person to stop pain for a few years, when you turn around, and then you need to take a pill to a friend, etc. To relieve pain without consulting a doctor, it is allowed to take Ketorol in tablets for a maximum of 5 days.
If Lyudin has to switch from the intake of Ketorol to the intake of tablets, then the total dose is innocent of 90 mg for people younger than 65 years and 60 mg for those who are older than 65 years. Moreover, in qix doses, the maximum allowable number of tablets is 30 mg (3 tablets).
Injections (ampoules) Ketorol - instructions for use
Razchin for ін'єкцій packings in ampoules і ready-to-use. Roschin should be injected gliboko into the ointment (in the upper third of the quilting, shoulder, sidnitsu and іnshі dіlyanka tіla, de muzyazi go close to the shkіri), having typed the necessary amount into the syringe from the ampoule in front of the syringe. It is not possible to inject Ketorol roschin epidurally or in the middle of the spinal membranes. For the introduction of the internal tension, it is necessary to use a disposable syringe of a small amount - 0.5 - 1 ml. The syringe must be removed from the packaging without prior use of the packaging, and not in advance. For ін'єкції it is necessary to open the ampoule in size, fill up the necessary amount with a syringe, remove it and remove it in the mountain. With your fingers, tap on the surface of the syringe at the right edge of the piston to the head, the bulbs gradually come off and on the sides. Then, for the sake of seeing, it is necessary to lightly press the syringe plunger, so that a speck appeared on the tip of the head. When using a syringe, it is necessary to pull the power in the direction of and spray it with an antiseptic. In the vibrana, the misce is perpendicular to the shkirі to introduce the head (for the whole period of time), when, pushing on the piston, often and accurately introduce the rozchin. After the introduction of the gap, the head is removed from the fabric and wiped off, and wiped again with an antiseptic.
If necessary, Ketorol in ampoules can be added to the droplet and injected at once with the same razches. Ketorol sumy in one bottle with advances and drugs:
- Physiological differences;
- 5% glucose distribution;
- Rozchin Ringer;
- Roschin Ringer-Locke;
- Rozchin Plazmalit;
- Aminophylline Roschin;
- Rozchin lidokainu;
- Rozchin dopamine;
- Rozchin to the insulin of a short human being;
- Rozchin heparin.
For people over 65, as well as suffering from sickness nirok for less than 50 kg of a single dose, the dosage becomes 10-15 mg (0.3-0.5 ml), which can also be injected through the skin 4-6 years, if turn around again. The maximum allowable dose of Ketorol for people over 65 years old, with a weight less than 50 kg and suffering from nirok sickness, become 60 mg (2 ampoules).
The triviality of the continuous consumption of Ketorol without the consultation of the doctor is innocent for 5 days.
Ketorol gel - instructions for use
The gel must be applied to the skin with clean, cute hands. Slid uniquely applied to the preparation on dilyanki shkiri with earhooks, for example, undergrowths, blunts, opikas, etc. It is also necessary to be unique and highly effective in using Ketorol gel in the eyes and on the mucous membranes of the mouth, nose and other organs. I will paint the coffin of the shkirny cover with gel, wipe the hands with a cute and dry wither. The tube is filled with the necessary amount of gel, the gel must be closed carefully. Before applying the gel, it is necessary to vimit warm water from a sweet hand and transfer a dilyanka shkiri, on which Ketorol is dispensed. Let the surface of the skin hang and hang with a towel, letting go of 1 - 2 cm of gel from the tube and spread it with a thin ball along the length of the skin cover, in the area where you can see it. As the area of the poured dilyanka is large, the amount of gel can be recovered. Rub the gel with neat massage rukhs into the shkіra practically until again. On top of the crumbled dilyanka of the shkiri, you can put on a loose bandage (for example, gauze, for example, for a snake bandage, etc.), otherwise, do not curl it up. It is not possible to apply a dressing to the skin covered with Ketorol gel.
The gel can be applied to the shkіra 3-4 times for doba. It is not possible to vikoristovuvati gel more than 4 times a day, and if two steps are applied by applying the preparation on the nape, it is necessary to take it at an interval of at least 4 years. Without consulting a doctor, the gel can be stored for a maximum of 10 days after sleep.
special requests
When vicorian tablets and іn'єktsіy Ketorol are needed, it is necessary to take it, so that it’s pouring into the larynx of blood for 1 - 2 dib. If Lyudin suffers from the loss of blood, then on the smallest amount of Ketorol it is necessary to control at least 1 time per day to control hemostasis indicators (hour of bleeding, PTI, APTCH, TV, fibrinogen, etc.).It is also necessary to remember, because a low volume of circulating blood is too low for a rizik side effects from the side of the nirok.
In young people (over 65 years old), the development of side effects Ketorol is more risky;
If lyudin is suffering, be it a kind of sick nirok, then stretching the whole course of storing it is necessary to control the function of the body, regularly producing a zagalny analysis of the slaughter.
In case of vikorstanny size of Ketorol tablets, there can be an increase in the activity of liver transaminases in the blood (ASAT, ALAT), so the preparation must be taken in case of liver disease due to the preservation of short hens. As soon as the destruction of the robotic liver develops on the aphids of Ketorol, it will inadvertently pinch and turn up to the drug after taking the drug.
Zastosuvannya Ketorol immediately with advancing drugs can provoke severe side effects:
- Valproati - may damage platelet aggregation and development of difficult to stop bleeding;
- Non-depolarizing muscle relaxants (Pipekuronia, pancuronium, Tubocurarin and in.) - a strong development of the bad;
- Antiepileptic drugs (Fenitoin, Carbamazepin and in.) - the frequency of epileptic attacks will be adjusted;
- Antidepressants (Fluoxetine, Tiotiksin, Alprazolam і іn.) - may be hallucinations;
- Pentoxifyline, Cefoperazone, cefotetan, heparin, thrombolytics (drugs that prevent clotting) and anticoagulants (drugs that change blood clots) - reduce the risk of bleeding;
- Ingibitories of angiotensin converting enzyme (Berlipril®, Vazolapril, Enalapril, Captopril і іn.)
Stagnation in vaginosis and breast enlargement
Tablets and solutions for the injections of Ketorol are contraindicated until they are consumed by a stretch of all vaginosity and the period of breastfeeding. Vagіtni women are guilty of vibrating іnshі painless drugs, allowed to be consumed, such as, for example, Ibuprofen, Nurofen, No-shpa and іnshі. As soon as the mother accepts Ketorol, then for the entire period of the journey, translate the child into a piece of vigoduvannya.Gel Ketorol can be stored for additional care by stretching the first and other trimesters of vaginosity, tobto, up to 27 months of gestation inclusive. The protection of the field in the retailer prophylaxis of potent vapadic consumption of the drug is in the middle, for example, to lick the gel, which is sloshing on the lips because of the fact that they rubbed the lack of immediacy of the application with their hands, etc.
In the third trimester of vaginosti, tobto from 28 months to flatness, Ketorol gel can not be stashed, there is only too much to provoke a resuscitation or an accelerated flatness.
Ketorol for toothache
With a toothache, Ketorol is excellent and effective drug stopping inappropriate views shvidko and nadovgo. The drug can be taken before the visit to the dentist, as well as after the procedure, if it is possible for a day or so before the tissue has not healed.If Ketorol is stagnant to stop a toothache before seeing a dentist, then it’s not possible to take the drug for more than 5 days, but it’s not possible to take the drug until it’s not enough, it’s necessary to find out if there’s a problem. Moreover, it’s worthwhile to try to buy it with Ketorol, and it’s worth bringing the clinical situation to the end, and there, it’s only necessary to pick a tooth, you might know it.
With a toothache, Ketorol is optimally taken in tablets, the fragments are given a form to complete effectively and are handy in one hour. Take 1 tablet for pain relief. Another tablet can be taken not earlier, not after 4 years. If after 4 years it was more or less early, then taking the offensive Ketorol tablet is required until the moment the pain syndrome appears. With a stretch, you can take a maximum of 4 tablets to relieve a toothache.
Ketorol for children
Gel Ketorol cannot be used for children younger than 12 years, and tablets and solutions for those who are younger than 15 years. In such a rank, Vikoristovuvati Ketorol among children in be-yako lykarskiy form not possible.Pick-up on Ketorol for children of dressings with thymus, which the drug can be used for malukov important delayed, such as nephritis (inflamed nirok), depression, hearing impairment, allergic reactions, etc.
Therefore, for children, it is necessary to choose the most sensitive drugs, so that they are more mild in children with Ketorol for a low risk of developing important side effects, such as, for example, such as, for example, such
Pobіchnі efekti drug Ketorol
Possible efficacy of tablets and the size for inn'ktsіy, however, ale the smell is often seen as such in the Ketorol gel. The entire list of side effects of tablets and the size of Ketorol is shown in the table.| organ system | Tablet efficacy and dosage Ketorol |
| Shlunkovo-intestinal tract | Boli in the shlunk |
| carry | |
| stomatitis | |
| flatulence | |
| constipation | |
| blues | |
| Seeing the slurry | |
| nudota | |
| Erosion and vyrazki organs in the shlunkovo-intestinal tract with mossy perforation or bleeding | |
| Zhovtyanitsya in a case of stagnation of zhovchi | |
| hepatitis | |
| Hepatomegaly (improvement of liver tumors) | |
| pancreatitis | |
| Human Anatomy Models | gostra nirkova lack |
| Pain across | |
| Hematuria (shelter at the slaughter) | |
| Azotemia (adjustment of excess nitrogen in blood) | |
| hemolytic uremic syndrome(Includes hemolytic anemia, nirkova deficiency, thrombocytopenia, purpura | |
| often sechovipuskannya | |
| Decrease or decrease in number of sechs | |
| nephritis | |
| bulges | |
| Dichny system | bronchospasm |
| dyspnoe | |
| rinit | |
| swelling of the larynx | |
| Central nervous system | Head bill |
| dirty | |
| sleepiness | |
| asepticmenіngіt | |
| hyperactivity | |
| Change the mood | |
| unrepentant | |
| hallucinations | |
| depression | |
| psychosis | |
| hearing loss | |
| Dzvin u wuhah | |
| unclearness | |
| Sertsevo-Sudinna system | admission arterial vise |
| Nabryak of Legends | |
Refinery, which is less pyrolizine-carboxylic acid.
Preparation: KETOROL®
Speech is active for the drug:
ketorolac
Koduvannya ATS M01AB15
KFG: Refinery with a flexible analgesic process
Registration number: П №015823 / 01
Restructuring date: 07/08/04
Vlasnik reg. certificate: DR. REDDY`S LABORATORIES LTD. (India)
Vipusku Ketorol form, preparation packing and warehouse.
Tablets, with a green sheath, round, two-bulged, with the letter "S" on one side; on evil - the core of a white or mayzhe white color.
1 tab.
ketorolac tromethamine
10 mg
Additional words: microcrystalline cellulose, lactose, corn starch, magnesium stearate, silica coloide oxide, sodium crochmalglycollate, hypromelose, propylene glycol, titanium green olives.
10 pieces. - blister (2) - packs of cardboard.
Rozchin for ін'єкцій
1 ml
ketorolac tromethamine
30 mg
Additional words: sodium chloride, ethanol, disodium edetate, octoxynol, propylene glycol, sodium hydroxide, water d / i.
1 ml - dark side ampoules (10) - blister.
DESCRIPTION OF ACTIVE SPEECH.
All information is provided only for knowledge of the drug;
Pharmacological diya Ketorol
Refinery, which is less pyrolizine-carboxylic acid. I can turn a zealous action, I can also have an anti-fiery and an inner heat-negative action. Mechanism of dressing due to the attribution of COX activity - the main enzyme in the metabolism of arachidonic acid, which is an alternative to prostaglandins, which play a leading role in pathogenesis of inflammation, pain and fever.
Pharmacokinetics for the drug.
When taken, it is absorbed in the middle from the shlunkovo-intestinal tract. Cmax in blood plasma can be reached in 40-50 minutes after receiving intramuscular injection, as well as after intramuscular injection. Acceptance does not flow into absorption. The connection with the plasma beads to become more than 99%.
T1 / 2 - 4-6 hours when receiving an intramuscular injection, as well as when an intramuscular injection.
More than 90% of the dose is taken from the cross-section, in the uninterrupted view - 60%; resta - through the intestines.
For children with impaired functions, the speed of life is reduced, T1 / 2 is reduced.
Shown to zasosuvannya:
For a short-hour purchase of those severe pain interesting genesis.
Dose and method of sucking the drug.
Doslim in case of receiving vseredin - 10 mg of skin for 4-6 years, in times of need - 20 mg 3-4 times / dob.
With an intramuscular injection, a single dose is 10-30 mg, the interval between injections is 4-6 hours. The maximum triviality of intake is 2 dB.
The maximum dose: when taking vseredin or intramuscularly administered - 90 mg / dobu; for patients with body weight up to 50 kg, with impaired functions of nirok, as well as for individuals over 65 years old - 60 mg / add.
Pobichna diya Ketorol:
Three sides heart-vascular system Ridko - bradycardia, symptoms of arterial grip, heartache, obscurity.
On the side of the herbal system: excessive boredom, abdominal pain, diarrhea; Ridko - constipation, flatulence, suspicion of re-alignment of the intestinal tract, bloating, dryness in the mouth, spraga, stomatitis, gastritis, erosive-deflation of the intestinal tract, impaired liver function.
On the side of the central nervous system and peripheral nervous system May I be awake, head b_l, Drowsiness; Ridko - paresthesia, depression, euphoria, ruined sleep, ruined, snort of savory visions, ruined zoru, ruined ruined.
Three sides mental systems Ridko - deranged dikhannya, attack the breath.
On the side of the secular system: rarely - often secular, oliguria, polyuria, proteinuria, hematuria, azotemia, state of the art nirkova deficiency.
On the side of the laryngeal system: rarely - nasal bleeding, anemia, eosinophilia, thrombocytopenia, bleeding from surgical wounds.
On the side of the exchange of words: mozhlvo beefy potovidlennya, nabryaki; Ridko - oliguria, adduction of the level of creatine and / or anything in the blood plasma, hypocalypse, hyponatrium.
Allergic reactions: you can itchy skin, Hemorrhagic visip; in single cases - exfoliative dermatitis, kropivyanka, Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic shock, bronchospasm, Quinke's bulge, malgia.
Inshі: you can be a feverish woman.
Mistsevі reactions: bіl u mісtsі ін'єкції.
Prototype indications before the preparation:
Erosive-disruption of the intestinal tract in the phase of hypertension, the appearance of any increase in the amount of hemorrhage and / or craniocerebral hemorrhage, impairment of hemorrhage in the anamnesis, the diagnosis of hemorrhage in the acute function of nirok (concentration of creatine in plasma at 50 mg / l), risk of development of nirk deficiency in case of hypovolemia and dehydration; "Aspirinova triada", bronchial asthma, nasal emptying, polypyridine nasal inflammation, anamnesis of malnourishment, prophylactic soreness before the operation and every hour of the operation, children and adolescents up to 16 lacquers, vaginal ...
Stagnation in vaginosis and lactation.
Prototypes of indications for vaginosis, for an hour during pregnancy and in the period of lactation (breastfeeding).
Ketorolac is a contraindication for storing in quality for premedication, for premedication, for anesthesia and for pain in obstetric practice, some of the more triviality of the first period. In addition, ketorolac can reduce the rate of the uterus and blood circulation of the fetus.
Special orders for storing Ketorol.
To protect stagnation in patients with impaired liver function and nirok, chronic heart failure, arterial hypertension, in patients with erosive-inferior intestinal tract disorders of the intestinal tract and intestinal tract
Slid with the protection of zastosovuvati ketorolac in during the operational period in vipads, if special hemostasis is required (including for resection of anterior mucosa, tonsillectomy, in cosmetic surgery), as well as in ailments of an old age, this may be the period of the disease. In the highest category of ailments, it is recommended to use ketorolac in doses that are in the lower inter-therapeutic range. With the appearance of symptoms of liver disease, shkirnoy visipka, eosinophilia ketorolac slid skasuvati. Ketorolac is not an indication for chronic pain syndrome.
Inflow to the building of keruvati by transport means and mechanisms
Even during the period of being treated with ketorolac, there is drowsiness, sleepiness, sleeplessness, or depression, you need to take special care for an hour to take up potentially unsafe types of activity, so that you can respect your feelings.
Vzaєmodia Ketorol with other preparations.
With a one-hour consumption of ketorolac from the other refineries, the development of additive side effects is possible; with pentoxifyline, anticoagulants (including heparin at low doses) - it is possible to reduce the risk of bleeding; s Angibitors ACE- you can improve the development of more functional functions; with probenecid - to increase the concentration of ketorolac in plasma during the period of the first time; with preparations of lithium - a decrease in the level of lithium clearance and an increase in the concentration in plasma; with furosemid - a decrease in the yogh sechoginnu diyu.
In case of consumption of ketoralac, the demand for consumption of opioid analgesics decreases with the use of antibiotics.
Ketorol (Ketorol)warehouse
Ketorol tabletsInactive speeches: lactose, microcrystalline cellulose, magnesium stearate, coloidal silica, corn starch, hypromelose, sodium crochmalglycollate, titanium dioxide, propylene glycol - green olives, barrels.
Ketorol-roschin for ін'єкцій
Active speech: trometaminu ketorolac.
Inactive speech: ethanol, sodium chloride, octoxynol, disodium edetate, sodium hydroxide, propylene glycol, water for injections.
Pharmacological diya
Ketorol is a non-steroidal anti-fiery one with an extremely sensitive effect. Dіyucha rechovina drug - ketorolac (ketorolac trometamіnu). Ketorolac can help me with a fever-lowering power, an anti-fiery effect and an analgesic effect. Ketorolac is important in peripheral tissues of viclikov nevibirkovu suppressed the activity of cyclooxygenase enzymes of 1 and 2 types, as a result of which the prevention of prostaglandin formation is prevented. Prostaglandins play an important role in the emergence of pain, reactions of inflammation and the mechanism of thermoregulation. Due to the chemical structure of Ketorol's speech, it is racemic sum of z + R- and -S- enantiomers, moreover, the antibiotic drug is zoomed with the same -S-enantiomers. Ketorol does not infuse into the receptor until opioid, it does not drive the mental center, it doesn’t have a volatile and antidepressant effect, and it doesn’t get sick. The powerless effect of Ketorol for strength can be correlated with morphine and more overturning non-steroidal anti-fiery groups. An ear of analgesic activity is sent from the inner tongue introduction, or it will be repaired in 0.5 and 1 year, as appropriate. The maximum analgesic effect is observed in 1-2 years.Shown to sucking
For the elimination of pain syndromes, wicked as a cause, with a strong or middle stage of turnaround (including oncological pathology and pain in the period of operative involvement).How to secure
Ketorol tabletsDesigned to be accepted in the middle. Falling down from the stage of turn and severity of pain should be taken once or repeatedly in a dose of 10 mg (the maximum allowable dose is 4 tablets per dose - 40 mg). The triviality of the 1st course of treatment is not more than 5 days.
Ketorol for internal injection
Individually, take the least effective dose in order to stay in the therapeutic form of the patient and the intensity of the pain syndrome. While it is necessary, it is possible in parallel to indicate a change in the dose of analgesics in the opioid series.
In patients up to 65 years old, it is necessary to use 10-30 mg of the drug in a single dose or repeatedly (skin 4-6 years) at 10-30 mg. Patients over 65 years of age, and in case of impaired nerve functions, Ketorol is prescribed internally one-time 10-15 mg, or again 10-15 mg of skin for 4-6 years in the presence of the degree of severity of pain syndrome.
The maximum allowable dose for patients up to 65 years is 90 mg / add. In case of impaired nirkovy functions, or at 65 times the maximum allowable dose is 60 mg / dob. The course of therapy is not more than 5 days.
Moving from internal to internal storage
On the day of the transition, the dose of Ketorol for the reception in the middle is not to blame for the transfer of 30 mg. Dobova total dose of tablets and the difference in the transition from the internal injection to the reception is not more than 90 mg / dose for patients 65 years and less, for patients with damaged functions - 60/65 mg / day.
Pobichna diya
Gradation of side effects: more than 3% - parts, 1-3% - less parts; less than 1% - рідкісні.On the side of the secular system: bile across the body without any abnormalities and / or hematuria, gostra nirkova deficiency, uremic hemolytic syndrome (nircovascular deficiency, thrombocytopenia, hemolytic anemia, purpura) often sechovipuskannya, Jade (ridko).
On the side of the herbal system: diarrhea and bile near the shlunk, especially in sick people, 65 years of age, as in history they suffered from erosive-sickly illnesses shlunkovo-intestinal tract(Often); flatulence, the appearance of a replenishing of the shlunk, constipation, stomatitis, blues (often mensh); erosive-viral lesion of the intestinal tract, including bleeding (hepatitis or spasm in the epigastric disease, abdominal blisters, blues for the type of "caviar", perforation, melena, nudity) zhovtyanitsya, hepatomegaly (ridko).
On the side of the central nervous system: headache, drowsiness, spoiled (often); depression, hallucinations, psychosis, dysfunction in wuhah, loss of hearing, loss of hearing (including impaired health), hyperactivity (unconsciousness, change in mood), aseptic changes in mood (severe headache) ) - Ridko.
On the side of the dyshal system: laryngeal obstruction (difficulty in dysfunction, zadishka), dyspnea or bronchospasm, rhinitis (ridko).
Allergic reactions: anaphylactic reactions or anaphylaxis (shkirny visip, sverbіzh shkіri, sverbіzh shkіri, kropivyanka, dyspnoea abnormally, periorbital problems, fatigue breast cancer) - Ridko.
On the side of the laryngeal system: nasal bleeding, bleeding from an operative wound, bleeding from the intestine (rarely).
On the side of the blood-forming organs: eosinophilia, anemia, leukopenia (ridko).
Reactions from the side of the shkiri: purpura and visipania on the shkiri, including maculopapular visip (mensh often); kropivyanka, exfoliative dermatitis (hot for no chills, peeling or crushing of shkiri, dermatitis, soreness and / for chills infantile migdalin), Lyell's syndrome, Stevens-Johnson syndrome (ridko).
On the side of the heart-vascular system: small advices arterial vise (less often); a load of legends, a loss of svidomostі (rіdko).
Miscellaneous reactions when introduced into the language: more or less printing in the message (less often).
Інші: nabrya gomіlok, individuals, ankles, steps, fingers, pidvischennya masi tila (often); overwhelming piety (mensh often); feverish woman, nabryak movi, (ridko).
Prototype
Aspirinova triada;angioedema;
bronchospasm;
sensitivity to trometamin ketorolac and / or any of the others in the group of refineries has been adjusted;
Hypovolemia is undoubtedly the cause of development;
erosive-virazkovі zagvoryuvannya herbal system at the phase zagostrennya;
hypocoagulation (including hemophilia types);
dehydration;
peptides;
hemorrhagic insult (pre-examination or confirmation);
combination with the largest refineries;
nirkova і / abo pechinkova lack (also plasma creatine is more than 50 mg / l);
destruction of blood-forming;
hemorrhagic diagnosis;
vagіtnіst, canopy, lactation;
high risik development of bleeding (including pislyaoperatsіynі);
up to 16 rocky.
availability
Ketorol is contraindicated for vaginal women. If it is necessary to prescribe the drug before the hour of lactation, breast year bath to pinch for an hour.lykarska vzaєmodiya
Combination of paracetamol and Ketorol with toxic toxicity injected onto nirk tissue, with methotrexate - inducing nephro- and hepatotoxicity.One hour appointment of ketorolac with calcium preparations, glucocorticosteroids, acetylsalicylic acid, Non-steroidal anti-pyretic drugs from other groups, corticotropin and ethanol can provoke the establishment of a pathway in the mucosa of the intestinal tract, which will block the development of the intestinal bleeding.
At the same time, the drug can be used to reduce the efficiency of lithium and methotrexate and to increase the toxicity of both recovins.
Immediate consumption of indirect anticoagulants, thrombolytics, heparin, cefoperazone, antiplatelet agents, pentoxiphilin and cefotetan increased the risk of bleeding.
Ketorol lowering the level of hypotensive patients diuretic, Oskіlki wiklikє the change in the establishment of prostaglandins in nirkas.
Probenecid reduces the amount of growth and plasma cleansing of Ketorol, which is increased instead of in the blood and increases the period when given to ketorolac tromethamine.
The use of methotrexate and ketorolac can be reduced to a prescription at low doses of methotrexate (when it is necessary to control the plasma concentration of methotrexate).
On the wetting of ketorolac, tromethamine is not infused with antacids.
Ketorol zbіlshuє vmіst in blood plasma nіfedipіnu and verapamіlu.
At one hour with Ketorol, the hypoglycemic dose of oral hypoglycemic drugs is consumed and the insulin is taken, as soon as the patient is asked to select the dose. When the drug is prescribed, lykarskiy zasobami, Nephrotoxic drugs (including gold-mixed preparations) increase the risk of nephrotoxicity.
Likarskі zasobi, Iakіchuyut tubular secretion, change the clearance of trometamіin ketorolac and increase thіѕ concentration in syrovatі blood.
When the drug is given with analgesics of the opioid series, a decrease in the dosage of the remains is possible.
It is essential to produce sodium valproate and Ketorol to break down platelet aggregation.
Pharmaceutically, trometamina ketorolac is insane with preparations of lithium and roschin tramadol.
It doesn’t go to the trouble of getting rid of Ketorol in one syringe with promethazine, morphine sulfate and hydroxyzine, a bit of stench to enter into a chemical siege.
Roschin for ін'єкцій Ketorol sumіsny with 5% solution of glucose, physiological solution of sodium chloride, plasmalite, solution of Ringer-lactate and solution of Ringer, as well as infusions, Included are lidocaine hydrochloride, dopamine hydrochloride, aminophilin, heparin natrієva sil and the human insulin of a short story.
Overdose
Possible signs of an overdose of Ketorol: nudity, abdominal pain, bloating, peptic changes or erosive damage to the intestinal tract, metabolic acidosis, Damage to the function of nirok.Likuvannya: washing the slurry with the existing signs of adsorbent preparations, symptomatic lykuvannya... Chi is not vivod in meaning world by means of digital methods.
Vipusku form
Ketorol tablets: round, in a shell of green color, with the symbol "S" on 1 side, two-convex, place 10 mg of ketorolac tromethamin. Evil is a bily or mayzhe bily. The package contains 20 pieces (10 pieces in a leather blister).Ketorol - rozchin for ін'єкцій in ampoules from the dark side, place 1 ml of Ketorol (30 mg of ketorolac tromethamin). Blister has 10 ampoules.
Umovi zberigannya
We will take for the list of B. the place for the capture is guilty of being dry and we will steal all of the light. Temperature - no more than 25 ° C. Term of accessibility - 3 rocky. Seize access to children. Prescription release from pharmacies.dodatkovo
It is not recommended to prescribe Ketorol as a component for premedication, antiphlogistic in obstetric practice and during anesthesia through significant risk of bleeding. Chi is not an indication in the therapy of chronic pain syndrome.inflow diyuchy speech Ketorol on platelet aggregation is stimulated to last for 1-2 dib.
For patients with impaired blood circulation, ketorolac should be prescribed at the time when continuous monitoring of platelet counts is carried out - it is especially important if necessary hemostasis is necessary (during the operative period).
Consider protection for cholecystitis, bronchial asthma, arterial hypertension, Chronic heart failure, impaired function of nasal tissue (with serovate creatinine less than 50 mg / l), active hepatitis, cholestasis, systemic cervonia, sepsis, polyphysyndromic growths in the nasopharyngeal and malignant membranes
Rizik the development of side-by-side action from the side of the secular system and to advance in case of hypovolemia.
Ketorol, if necessary, can be used in combination with opioid group analgesics.
Ketorol is not recommended to take one hour with paracetamol for 5 days.
When Ketorol is consumed, significant number of patients develop pobichna diya on the side of the central nervous system (for example, drowsiness, headache, zamorochennya), that is more beautiful than a unique view of the kind of performance, as well as quick reactions and increased respect (robot with mechanisms of vehicles, water).
Information about the drug has been given in the absence of knowledge and is not guilty of being vicoristan as a matter of responsibility before self-abuse. Only a drug can take a decision about the prescription of the drug, as well as the importance of the dosage and the methods of its administration.
Refinery with a turn of analgesic action
Diyucha rechovina
Form vipusku, warehouse and packaging
Tablets, including a plastic sheath green color, round, double-convex, with the letter "S" embossed on one boat; view of the transverse view - a shell of a green color and a core of a white or even a white color.
Additional words: microcrystalline cellulose - 121 mg, lactose - 15 mg, corn starch - 20 mg, coloidal silicon dioxide - 4 mg, magnesium stearate - 2 mg, sodium carboxymethylcrochmal (type A) - 15 mg.
Warehouse for ply casing: hypromelose - 2.6 mg, propylene glycol - 0.97 mg, titanium dioxide - 0.33 mg, olive green (chinolynovy zhovty - 78%, diamantium blakitniy barvnik - 22%) - 0.1 mg.
10 pieces. - blister (2) - packs of cardboard.
Pharmacological diya
NPZP, it has a strong analgesic effect, it can be used as an antiheat and in addition to the fever-lowering effect. Mechanism of dressing with non-selective adjustment of COX activity (COX-1 and COX-2), which catalyzes the establishment of prostaglandins with arachidonic acid, as it plays an important role in the pathogenesis of pain, pain. Ketorolac is a racemic sum of [-] S- and [+] R-enantiomers, with a zeboluvial effect zumovlen [-] S-form. For the strength of the analgesic effect, it is possible to change it, meaningfully overturning the NPZP.
The drug is not injected onto the opioid receptor, it doesn’t drive the reaction, it doesn’t get sick, it doesn’t have a sedative and anxiolytic effect.
If the recipient is in the middle of the zealotomy, it will develop in 1 year.
Pharmacokinetics
soaktuvannya
When you take it all the way, ketorolac is good and quickly get wet from the shlunkovo-intestinal tract. Bioavailability of ketorolac becomes 80-100%, C max for oral administration in a dose of 10 mg - 0.82-1.46 μg / ml, T max - 10-78 min. Bagata with fats will lower the C max to the drug in the blood and will take it for a year.
rospodil
The connection with bricks becomes 99%, V d - 0.15-0.33 l / kg. The hour of reaching C ss when taking a dose of 10 mg 4 times / add becomes 24 years, C ss - 0.39-0.79 μg / ml.
To be seen in breast milk: when taking ketorolac at a dose of 10 mg C max in breast milk, it can be reached after 2 years, or when the first dose is taken from the warehouse, 7.3 ng / ml, after 2 years, after taking another dose of ketorolac (when consumed), add 4 times / 7.9 ng / l.
metabolism
More than 50% of the administered dose is metabolized in the form of pharmacologically inactive metabolites. The head metabolites are glucuronide and p-hydroxyketorolac.
vivedennya
Vivoditsya mainly nirkami - 91%, through the intestines - 6%, glucuronidis vivoditsya from the slit. Chi does not get through to hemodialysis.
T 1/2 for children normal function nirok in the middle - 5.3 hours (2.4-9 hours for oral administration in a dose of 10 mg). When taken orally in a dose of 10 mg, the zagalny clearence becomes 0.025 l / h / kg.
Pharmacokinetics in special groups of patients
T 1/2 grows up in children of a kidnapped vik and short children in young ones.
Damaged stove function does not flow into T 1/2.
In patients with nirkovy lack of Vd drug can be reduced 2 times, and Vd th R-enantiomer - by 20%. In patients with impaired function of nirkov at a concentration of creatine in plasma of 19-50 mg / l (168-442 μmol / l) T 1/2 becomes 10.3-10.8 h, with a turn of nircovy deficiency - more than 13.6 h. at a concentration of creatine in plasma of 19-50 mg / l), the zagalny clearence becomes 0.016 l / h / kg.
showing
Severe and moderate pain syndrome:
- injuries;
- toothbrush;
- pain in the mental and operational period;
— cancer;
- b_l at m'yaz;
- arthralgia;
- neuralgia, radiculitis;
- vivihi, stretching;
- rheumatic illnesses.
Meanings for symptomatic therapy, Changing the intensity of pain and burning up at the time of getting sick, not pouring into the progress of getting sick.
Prototype
- ovne abo nadnannya bronchial asthma, Recurrent polyposis of the nose, abo nasal sinuses and intolerance and other non-steroidal anti-fatigue diseases (including in the anamnesis);
- erosive and vivid snakes of the mucous membrane of the slunk and two-fingered intestine;
- active shlunkovo-intestinal bleeding;
- cerebrovascular or bleeding;
— fired up intestines (Crohn's ailment, swelling colitis) at zagostrenny phase;
- loss of blood circulation, incl. hemophilia;
- heart failure is decompensated;
- pechinka lack of pecuniary disease;
- nirkova deficiency (QC<30 мл/мин), прогрессирующие заболевания почек;
- approved by hypercalis;
- period of time for coronary artery bypass surgery;
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- vagіtnіst, the period of the canopy;
- period of lactation (breastfeeding);
- childish and adult age up to 16 years;
- sensitivity to ketorolac is increased.
Z protection: sensitivity has been increased to those of the non-steroidal anti-fiery fires; bronchial asthma; IXC; lack of heart; quilting; arterial hypertension; cerebrovascular disease; pathological dyslipidemia / hyperlipidemia; deterioration of the function of nirok (CC 30-60 ml / min); Diabetes mellitus; cholestasis; active hepatitis; sepsis; VKV; zakvoryuvannya peripheral arteries; kurnnya; one-hour reception with non-steroidal anti-fiery fires; virazkovі urazhennya shlunkovo-intestinal tract in anamnesis; ominous alcohol; important somatic illnesses; suppression of therapy with advancing drugs - anticoagulants (for example, warfarin), antiaggreganti (for example, acetylsalicylic acid, clopidogrel), oral corticosteroids (for example, prednisolone), selective ingibitori of vortex cytoplasm, serramiloxidin patients of the kidnapped vik (over 65 years old).
sundown
Take all the way in a single dose of 10 mg.
at severe pain syndrome the drug should be taken repeatedly at 10 mg up to 4 times / add in the presence of the degree of pain swelling. The maximum dose is 40 mg. Slide zastosovuvati the minimum effective dose. When you are in the middle, the triviality of the course is not to blame for 5 days.
During the transition from parenteral administration of the drug to the first dose, the total dose of both lykarsky forms on the day of transfer is not guilty of changing 90 mg for Patients from 16 to 65 years i 60 mg - for patients over 65 years old for s damage to the function of nirok... With a single dose of the drug in tablets on the day of the transition, it is not guilty to change 30 mg.
Pobichna diya
The value of the frequency of side effects: often (1-10%), inodi (0.1-1%), rarely (0.01-0.1%), even rarely (less than 0.01%), including occasional episodes.
On the side of the herbal system: often (especially in patients with kidney disease over 65 years old, who have a history of erosive-intestinal tract damage) - more in the shlunku, diarrhea; Inodi - stomatitis, flatulence, constipation, bloating, the appearance of a re-leveling of the slunk; Ridko - boredom, erosive-disturbance of the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, spasm; ), cholestatic zhovtyanitsya, hepatitis, hepatomegaly, gostry pancreatitis.
On the side of the secular system: Ridko - gostra nirkova deficiency, bile at the crossroads with or without hemorrhage and / or azotemia, hemolytic-uremic syndrome (hemolytic anemia, nirkova deficiency, thrombocytopenia, purpura), often, adenitis ...
Chuttya on the side of the organs: Ridko - a decrease in hearing, dzvin in wuhah, deadened zoru (including unclearness of a good spirits).
On the side of the mental system: Ridko - bronchospasm, sluggishness, rhinitis, laryngeal swelling.
On the side of the nervous system: often - headache, zamorochennya, drowsiness; Ridko - aseptic meningitis (hot, strong headache, sudomy, rigidity of the spine and / or back), hyperactivity (mood change, restlessness), hallucinations, depression, psychosis.
On the side of the heart-vascular system: inodі - advancing the arterial vise; Ridko - a bunch of legends, obscurity.
On the side of the hematopoietic system: rarely - anemia, eosinophilia, leukopenia.
On the side of hemostasis: Ridko - bleeding from the operative wound, nosebleeds, rectal bleeding.
On the side of the curved curves: inodi - shkirny visip (including maculo-papular visip), purpura; Ridko - exfoliative dermatitis (hot with a chill or without, dermatitis, depletion or peeling of shkiri, swelling and / or ailment of infantile migdalin), sprinkling of Lyceum, Stevens-Johnson syndrome, syndrome.
Allergic reactions: ridko - anaphylaxis and anaphylactic reactions (changes to the colorah of the convicts, shkirnі visipannya, kropivyanka, sverbіzh shkiri, tachypne abnormal, dysplasia, perirbital, severe
Інші: often - embarrassment (incriminating, homily, kistochok, fingers, step, shifting mastilla); Inodi - adjusted for food; Ridko - nagryak movi, feverish woman.
Overdose
symptoms: abdominal pain, nausea, blues, erosive-vyrazkovy lesion of the slunk-intestinal tract, impaired function of nirok, metabolic acidosis.
lykuvannya: the production of the slurry, the introduction of adsorbents () and the implementation of symptomatic therapy (the development of vital functions to the body). Chi does not live in abundance in the world for additional dialogue.
lykarska vzaєmodiya
One hour consumption of ketorolac with acetylsalicylic acid or other non-steroidal anti-pyretic drugs, calcium preparations, GCS, ethanol, corticotropin can lead to viral lesions of the intestinal tract and hemorrhage-intestinal mucosa.
With a one-hour stagnation with other nephrotoxic drugs (including gold preparations), the development of nephrotoxicity rises. An immediate indication of paracetamol leads to nephrotoxicity, hepato- and nephrotoxicity. The use of ketorolac and methotrexate can only be used in low doses (control of the concentration of the drug in blood plasma).
Probenecid changes the plasma cleansing and Vd of ketorolac, increasing the concentration in the blood plasma and increasing T 1/2. On aphids the consumption of ketorolac is more likely to change the clearing of methotrexate and lithium and to improve the toxicity of the cich rechovin.
Immediately marked with indirect anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefotetan and pentoxiphilin cause bleeding disorders.
Decrease the effect of hypotensive and diuretic drugs (decrease in the synthesis of prostaglandins in nirkahs).
When combined with opioid analgesics, doses of the remaining can be reduced.
Do not pour antacids into the mixture while wetting ketorolac.
Ketorolac for oral hypoglycemic drugs (dosage correction is required).
One hour a sign of destruction of platelet aggregation. Increased concentration in blood plasma of verapamil and nifedipin.
Drugs that block tubular secretion, reduce the clearance of ketorolac and increase its concentration in blood plasma.
special requests
Ketorol maє dvі lykarskі forma (tablets, including plavkovoy shell, and roschin for i / v and i / m introduction). Vibir to the method of the introduction of the drug to lie down at the stage of the turn of the pain syndrome that will become the patient.
Rizik the development of lykarskih accelerated when taking the drug in the middle of the growth when increasing the term for more than 5 days and the increased oral dose of the drug is more than 40 mg / dob.
Do not take the drug overnight with other oil refineries. With a one-hour stagnation with the other oil refineries, there may be an increase in birth, decompensation of the heart, and an increase in the arterial grip. The infusion for platelet aggregation will creep in 24-48 hours.
For patients with damaged laryngeal blood, the drug is used only for continuous control of the number of platelets, which is especially important for patients with operative ailments, if the retinal control of hemostasis is required.
The drug can change the power of thrombocytes, but does not replace the prophylactic action of acetylsalicylic acid in case of heart disease.
To reduce the risk of development of NPZP-gastropathy, antacid drugs, misoprostol, omeprazole are used.
Inflow to the building of keruvati by transport means and mechanisms
During the period of life, it is necessary to take care of the safety of water vehicles and those who are busy with the other potentially unsafe types of activity, so that an increased concentration of respect and high-profile reaction is required.
Vigor and lactation
Prototype is shown for the drug to be consumed in case of vaginosity, before the hour of flatness; in the period of lactation (breastfeeding).
Zastosuvannya in the child age of students over 65 years old. With a single dose of the drug in tablets on the day of the transition, it is not guilty to change 30 mg.
Mind that term zberigannya
The drug is available for a prescription.
Mind that term zberigannya
The drug should be taken out of the reach of children, dry, stolen from light at a temperature of 25 ° C. Term of affinity - 3 rocks.
Trade name: Ketorol ®
International non-patented name:
ketorolac.
Lykarska form
tablets, including a plaster shell.
warehouse
Skin tablet, injected with a shell, revenge:
Speech is active: ketorolac tromethamine (ketorolac trometamol) - 10 mg;
Additional speeches: cellulose microcrystalline 121 mg, lactose 15 mg, corn starch 20 mg, coloidal silicon dioxide 4 mg, magnesium stearate 2 mg, sodium carboxymethyl crochmal (type A) 15 mg;
pokritta: hypromelose 2.6 mg, propylene glycol 0.97 mg, titanium dioxide 0.33 mg, green olive (chinolynovy zhovtiy 78%, barvnik diamond blakitniy 22%) 0.1 mg.
to describe
Round two-shaped tablets, with a green sheath, on one embossing plate is marked with letter "S". View on the transverse view: a shell of a green color and a core of a white or even a white color.
Pharmacotherapeutic group:
non-steroidal anti-inflammatory drug.
PBX code M01AV15
Pharmacological authorities
Pharmacodynamics
Non-steroidal anti-pyretic drug (NPZP), has a strong analgesic effect, but is less anti-pyretic and less fever-lowering. Mechanism of dressing with non-selective attribution of cyclooxygenase (COX) activity - COX-1 and COX-2, which catalyzes the establishment of prostaglandins from arachidonic acid, which plays an important role in pathogenicity. Ketorolac is a racemic sum [-] S і [+] R enantiomers, with a zeoluvial effect zumovlen [-] S form. For the strength of the analgesic effect, it is possible to change it with morphine, meaningfully overturning the NPZP.
The drug is not injected onto the opioid receptor, it doesn’t drive the reaction, it doesn’t get sick, it doesn’t have a sedative and anxiolytic effect. When received in the middle of the development of the analgesic project, it will be determined after 1 year.
Pharmacokinetics
When you take it all the way, ketorolac is good and quickly get wet in the intestinal tract (SCT). Bioavailability of ketorolac is 80-100%, the maximum concentration (Cmax) for oral administration of 10 mg is 0.82-1.46 μg / ml, an hour of reaching the maximum concentration (TCmax) is 10-78 minutes. Bagata with fats will lower the maximum concentration of the drug in the blood and will overtake it for a year. Coupling with plasma beads - 99%.
The hour of reaching an equally important concentration of the drug (Css) with oral administration of 10 mg 4 times for the addition becomes 24 years and the concentration becomes 0.39-0.79 μg / ml.
Obsyag rozpodilu - 0.15-0.33 l / kg. In ailments with a nirkovy lack of volume, the drug can be reduced by 2 times, and the increase in the amount of R-enantiomer - by 20%.
Penetration into breast milk: when taking 10 mg of ketorolac Cmax in young people reach after 2 years, or after taking the first dose and become 7.3 ng / ml, after 2 years, after taking another dose of ketorolac (when taking 4 times) - 7, 9 ng / l.
More than 50% of the administered dose is metabolized in the form of pharmacologically inactive metabolites. The head metabolites are glucuronid, which are metabolized by nirks, and p-hydroxyketorolac. Vivoditsya 91% nirkami, 6% - through the intestines.
The period of time (T1 / 2) in patients with normal function in the middle is 5.3 years (2.4-9 years after oral administration of 10 mg). T1 / 2 growth in young children and short boys in young. Defective liver function does not flow to T1 / 2. In patients with impaired function of nirok, with creatine concentration in plasma 19-50 mg / l (168-442 μmol / l), T1 / 2 - 10.3-10.8 years, with a large turn of nircovy deficiency - more than 13.6 hours.
When taken orally with 10 mg, the zagalny clearence becomes 0.025 l / year / kg; in patients with nirkovy deficiency (at a concentration of creatine in plasma of 19-50 mg / l) - 0.016 l / year / kg. Chi does not get through to hemodialysis.
Shown to sucking
Pain syndrome of severe and moderate intensity: injuries, toothache, pain in the psychoactive and operative period, oncological incapacitation, more in myases, more in snow, neuralgia, radicular pain The meanings for symptomatic therapy, the change in the intensity of the pain and the burning at the time of victoriousness, for the progress of the disease is not infused.
Prototype
- sensitivity to ketorolac is increased;
- on top of that, not even more bronchial asthma, recurrent polyposis of the nose, or nasal sinuses, and the intolerance of acetylsalicylic acid and other non-steroidal anti-fatigue diseases (including, in anamnesis);
- erosive-vyrazkovі snaps of the mucous membrane of the shlunk і 12-palate intestine, active shlunkovo-intestinal bleeding; cerebrovascular or bleeding;
- zapalnі zagvoryuvannya intestines (Crohn's ailment, swelling colitis) in the phase zagostrennya;
- hemophilia and laryngeal loss of blood;
- decompensated heart failure;
- pechinkova lack of liver disease;
- nirkova deficiency is manifested (clearance to creatine less than 30 ml / hv), progressive incapacitation of nirok, pidtverzhena hyperkalієmiya;
- period of time for coronary artery bypass surgery;
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- vagіtnіst, period of canopy, period of lactation;
- childish vіk up to 16 years old.
With protection
Pіdvischena chutlivіst to іnshih nesteroїdnih protizapalnih zasobіv, Bronchial asthma, іshemіchna hvoroba sericite, zastіyna Sertsevy nedostatnіst, nabryaki, arterіalna gіpertenzіya, tserebrovaskulyarnі zahvoryuvannya, dyslipidemia patologіchna / gіperlіpіdemіya, torn down funktsії nirok (klіrens kreatinіnu 30-60 ml / hv) tsukrovy dіabet, cholestasis , active hepatitis, sepsis, systemic chervonia in vovchak, obstruction of peripheral arteries, curriculum, one-hour reception with other non-steroidal anti-inflammatory drugs, abductions of HIV (older than 65 years), history of treatment of alcohol-related diseases suppression of therapy with advanced drugs: anticoagulants (for example, warfarin), antiaggreganti (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective antioxidant antioxidant
How to store that dosi
In the form of tablets, the dose should be taken in a single dose of 10 mg. In case of severe pain syndrome, the drug should be taken repeatedly at a dose of 10 mg up to 4 times per additional period in the amount of pain in the degree of pain. The maximum dobova dose is innocent of 40 mg. Slide vikoristovuvati the minimum effective dose. When you are in the middle, the triviality of the course is not to blame for 5 days.
During the transition from parenteral administration to the drug for the first time, the total dose of both lykarsky forms per day is not guilty of transferring 90 mg for ailments from 16 to 65 years and 60 mg - for those over 65 years of age, or because of impaired function. With a single dose of the drug in tablets on the day of the transition, it is not guilty to change 30 mg.
Pobichna diya
The frequency of side effects is classified in terms of the occurrence of the frequency and the drop: often (1-10%), inodi (0.1-1%), rarely (0.01-0.1%), even rarely (less than 0.01%) , including okremі povіdomlennya.
On the side of the herbal system: often (especially in young patients over 65 years of age, who have a history of erosive disorders of the intestinal tract) - more in the shlunku, diarrhea; mensch often - stomatitis, flatulence, constipation, bloating, appearance of replenishment of the slunk; Ridko - tediousness, erosive damage to the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, spasm, or liver disease in epigastric disease, melena, bluish type cholestatic zhovtyanitsya, hepatitis, hepatomegaly, gostry pancreatitis.
On the side of the secular system: Ridko - gostra nirkova deficiency, bile at the crossroads with or without hemorrhage and / or azotemia, hemolytic-uremic syndrome (hemolytic anemia, nirkova deficiency, thrombocytopenia, purpura), often, adenitis ...
Chuttya on the side of the organs: Ridko - a decrease in hearing, dzvin in wuhah, ruined zoru (including the unclearness of a healthy spirits).
On the side of the mental system: Ridko - bronchospasm, sluggishness, rhinitis, laryngeal swelling.
On the side of the central nervous system: often - headache, zamorochennya, drowsiness; Ridko - aseptic meningitis (hot, strong headache, sudomy, rigidity of the spine and / or back), hyperactivity (mood change, restlessness), hallucinations, depression, psychosis.
On the side of the heart-vascular system: mensh often - p_dvischennya arterial vise; Ridko - a bunch of legends, obscurity.
On the side of the blood-forming organs: rarely - anemia, eosinophilia, leukopenia.
On the side of the hemostasis system: Ridko - bleeding from the operative wound, nosebleeds, rectal bleeding.
On the side of the curved curves: mensch often - shkіrny visip (including maculo visip), purple; Ridko - exfoliative dermatitis (hot with a chill or without, dermatitis, depletion or peeling of shkiri, swelling and / or ailment of infantile migdalin), sprinkling of Lyceum, Stevens-Johnson syndrome, syndrome.
Allergic reactions: ridko - anaphylaxis and anaphylactic reactions (changes to the colorah of the convicts, shkirnі visipannya, kropivyanka, sverbіzh shkiri, tachypne abnormal, dysplasia, perirbital, severe
Інші: often - embarrassment (incriminating, homily, kistochok, fingers, step, shifting masi tila); mensh often - p_dvischena p_tlivist; Ridko - nagryak movi, feverish woman.
Overdose
Symptoms: abdominal pain, nudity, bluing, erosive-virazkovy lesion of the slunk-intestinal tract, impaired function of nirok, metabolic acidosis.
Lіkuvannya: the preparation of the slurry, the introduction of adsorbents (actives not of the worm) and the implementation of symptomatic therapy (the development of vital important functions to the body). Chi does not live in abundance in the world for additional dialogue.
Vzaєmodia with іnshy lіkarskiy zasob
One hour consumption of ketorolac with acetylsalicylic acid or other non-steroidal anti-pyretic drugs, calcium preparations, glucocorticosteroids, ethanol, corticotropin can lead to the establishment of a vortex of the intestinal-intestinal tract and the development of the intestinal tract. Allegedly, paracetamol is associated with nephrotoxicity, with methotrexate - hepato and nephrotoxicity. The use of ketorolac and methotrexate can only be achieved with low doses of the rest (control of the concentration of the drug in blood plasma).
Probenecid changes plasma cleansing and volume of ketorolac, which increases its concentration in blood plasma and increases the period of its formation. On aphids the consumption of ketorolac is more likely to change the clearing of methotrexate and lithium and to improve the toxicity of the cich rechovins. Immediately marked with indirect anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefotetan and pentoxiphilin cause bleeding disorders. Decrease the effect of hypotensive and diuretic drugs (decrease in the synthesis of prostaglandins in nirkahs). When combined with opioid analgesics, doses of the remaining can be reduced.
Do not pour antacids into the liquor.
Adopt a hypoglycemic dose of insulin and oral hypoglycemic drugs (a necessary overdose).
Alimentary sign of valproic acid is the destruction of platelet aggregation. Increased concentration in blood plasma of verapamil and nifedipin.
With the signs of nephrotoxic drugs (including gold preparations), the development of nephrotoxicity rises.
Likarski zasobi, how to block tubular secretion, reduce the clearance of ketorolac and increase its concentration in blood plasma.
special requests
Ketorol ® maє dvі lykarskі forma (tablets, in a pluvkovy shell, і rozchin for ін'єкцій). Vibir to the method of the introduction of the drug to lie down at the stage of the turn of the pain syndrome and become ill.
Rizik development of lykarsky accelerated growth in case of an increase in terms of treatment more than 5 days and an additional oral dose of the drug is more than 40 mg / add.
Do not take the drug overnight with other oil refineries.
In case of a spilny reception with the other non-steroidal anti-fatigues, there can be a reduction in the appearance of the birth, decompensation of the heart, and an increase in the arterial grip. The infusion on platelet aggregation will creep in 24-48 hours.
We are sick with the loss of blood larynx only when there is continuous control of the number of thrombocytes, it is especially important for the operative ailments, which require real control of hemostasis.
The drug can change the power of thrombocytes, but does not replace the prophylactic action of acetylsalicylic acid in case of heart disease.
To reduce the risk of development of NPZP-gastropathy, antacid drugs are used, misoprostol, omeprazole.
During the period of life, it is necessary to take care of the safety in the water transport and to be busy with the most potentially unsafe types of activity, to require an increased concentration of respect and a high level of responsiveness.
Vipusku form Tablets, ckritі plіvkovyu envelope, 10 mg. 10 tablets in PA / aluminum / PVC // aluminum blisters. For two blisters at once with the instructions from the packing, they were packed into a carton box.
Umovi zberigannya
List B.
In dry, stolen light mice at a temperature of no more than 25 ° C.
Zberigati out of reach for children!
Term of attachment
3 rock.
Do not store the drug after the end of the term of adherence indicated on the package.
Mind that term zberigannya
For the recipe.
Virobnik
Dr. Reddy's Laboratories Ltd.
m Hyderabad, Andhra Pradesh, India.
Addresses місця virobnitstva
Dilyanki No. 42, 45 and 46, Bachupalli Village, Qutbullapur Mandal, Rangu Reddy
District, Andhra Pradesh, India.
Claims from the support officers to the address:
Representative of the company "Dr. Reddy's Laboratories Ltd.":
115035, Moscow, Ovchinnikovskiy nab., Bu. 20, bld. 1
