Likarskiy dovidnik GEOTAR. Report on the instructions for the administration of tablets and ampoules of amiodarone, patients and cardiologists, admissible analogs of amiodarone before replacement, dobova dose

Amiodarone - for purposes of stagnation in cardiological ailments. The drug is actively used to treat angina pectoris, to break the rhythm of the heart. It is permissible to be victorious in case of supra-slurry, slurry tachycardia, tripoxia in front of the heart, as well as other types of extrasystoles.

Patients who receive a medication against angina pectoris start to grow faster and normalize their heart rhythm. Meta statti: know the reader about the area of ​​storing the licks, describe the rules for receiving the best, you may not want to show it.

Amiodarone should be treated with antiarrhythmic problems. The name of the drug is not patented internationally - Amiodarone. OKPD code - 24.42.13.727.

Mechanism of Diya

The medication is administered to the 3rd class of antiarrhythmic drugs, causing repolarization (relaxation of the heart muscle). Krym tsyogo, wine is poured into the body in such a rank:

Pharmacokinetics

I would like to start pouring it into the body only for 2-3 days, and if the signs are even greater. One day the day is repaired only through the month of receiving. likuvalny effect You can choose to go to school and more after reviewing the therapy.

Pharmacokinetic power based on offensive characteristics:

1. Vmoctuvannya active speech in the roof to become 30-50%.
2. Bioavailability is also indicators.
3. The maximum concentration in the bloodstream is reestablished already after 4-7 years. The drug is good for tissue distribution.

Amiodarone is good to be found in fats, so the concentration of the drug will reach the top of the pediatric fat cell and visceral fat. Seems kindly to get wet in peck, nirk, heart. The drug is consumed in the brain, placenta, and milk.

Amiodarone is metabolized in the liver tissue. The main speech in the course of metabolism is desetilamiodarone. Vivodina speech nirkami and pechinka with a zhivchny secret. The amount of vivenny through the nirk tissue is even smaller (1%), therefore, for ailments with pathologies, nirok correction of the dose is not carried out.

With a trivial rate of consumption, liquids can circulate through the blood for up to 40 dB. In case of overdose, amiodarone should not be administered for additional delay.

Form and price

Likas are carried out in the following forms:

The rate of shares in Moscow will become 88-120 rubles. The price in St. Petersburg pharmacies is 96-117 rubles. For Russia, the partnership for Amiodarone will be 100 to 136 rubles. Ampoules cost more: in the boundaries of 208 rubles.

Showing that obmezhennya

Amiodaron is shown to be married (Table 1). When the signs are recognized, the likar is bound to be guilty of the vrahovuvati, which will be unknowable.

Table 1 - Indication and intercourse before taking Amiodarone

It is necessary for young people to accurately recognize the signs, so as they increase the number of signs of an important bradyarrhythmia. Vagitnykh likarskiy zabit not vikoristovuєtsya. Before the hour of the clinics viprobuvan the drug did not get enough information about the sale for the fruit.

When breastfeeding, the liquids do not become stagnant, since the active warehouse easily penetrates into the mother's milk. Yaksho є it is necessary to take Amiodarone from a one-year mother, then it’s more beautiful to pinch it up until the end of the course course. The lactation was spared, during the treatment the milk was added. When the drug is administered, it is possible to change the breast tissue.

Lykarsky drug vicoristovuyutsya only in grown-up patients. In children up to 18 years of age, the drug is not consumed. After an hour of clinical viprobuvan, there was a lack of information about how to pour the drug into the child's body. At the children nirk deficiency Likki vicoristovuvati is possible, as the metabolism of the cat is mainly healthy in the oven.

Instructions for the reception of a lykarskiy zasob

Dose-ups are picked up individually according to the sick person. It can be used as a tablet, as well as in a form

Yak take Amiodarone tablets (200 mg)?

The drug is priznachayut in tablets for an hour or even for a day. Do not form a tablet, drink it with water. The starting dosage for additional delivery is 600-800 mg (maximum 1200 mg). The amount of the drug is required for three doses. Also, the dose (600-800 mg) is vikoristovuu As the efficiency of the dosage is low, then it increases up to 1200 mg for the dosage.

If the sick man showed signs of accumulating the drug, then the doctor would go on until the additional dose of lykarsky zasoba. To adjust the concentration of liquor, take a dose of 100-400 mg. Її is divided into 2 priyomi. As soon as the patient is feeling self-conscious, there is no sign of arrhythmias, then 1 time per week I will take a break for 2 dobi.

Dose the drug:

• therapeutic for 1 time - 200 mg;
• therapeutic for dobu - 400 mg;
• the maximum dose for 1 dose is 400 mg;
• maximum for dobu - 1200 mg.

Preparation in ampoules

You can have vikoristovuvati for kids lykarskiy zasib in ampoule form. Zokrema, tsya form is indicated when important, clutter up the life damage to the heart function, if the oral intake of the drug does not give the necessary effect, but because of the sickness.

Instead of ampoules, they can be dispensed in the form of glucose. It is not possible to replace Amiodarone with other methods in the same drip system. For one drip tray, 2 ampoules of 500 ml of glucose are required.

Introduce the head from the drip into the central vein. I have no access to the central vein, vicoristy to the peripheral veins. Rozrahunok starting dosage of the drug is carried out in the following order: 5 mg per 1 kg of the patient's mass. infusion therapy carried out 20-120 quilins. The introduction of leaks can be carried out in three ways for adding to the fallowness due to the severity of the sick person.

Adding dose: 10-20 mg per 1 kg of weight of the sick person. For such a dose, 250 ml of glucose is needed. The introduction is carried out in 3 dB. For a cob of adaptive therapy, a sick person should be given an oral drug, so that it is necessary to transfer it to a tablet form.

If the sick person needs reanimation, come in, if there is a central catheter, they should be inserted into the new one. As far as there is no access to the central vein, the infusion goes through the peripheral great vein. The starting dose is 300 mg. It is necessary to dilute a 20 ml dose of glucose. Inject the drug in a stream. If the therapy is ineffective, add more than 150 mg.

Amiodarone cannot be combined with other drugs in one syringe.

Undesirable reactions to organisms

The drug is injected into the nerve, heart-sudin, dichny, herbal systems, organ zoru, communication processes. An ailing person has nudota, stomachache, vestibulopathy, rumors of deception, tremors of the hands, foul memory, neuritis of the healthy nerve. The drug is a good form of admission, insignificant appearance of a sieve.

On the lid of a likarsky zasobu, the ailments often win over the rhythm of the heart, the tachycardia “feasts”. Mossy transition to a more important form of arrhythmia when it is evident before the drug is prescribed. Ailments may have symptoms of heart failure.

Amiodarone can be added to the organi dichannya. Patients may have a cough, difficulty breathing, symptoms of pneumonia (interstitial type), alveolitis, fibrosis fabrics and legends, Pleurisy. Changes can be made in the equations of the system.

It hurts to jump for dyspepsia, b_l at the slunk, inappropriate views in the area of ​​the slurry, unstable viporozhnennya. There may be hepatitis, congestive symptoms in the galls, zhovtyanichny syndrome, cirrhotic lesions of the liver.

In blood analyzes, it is possible to increase the level of liver enzymes, anemia. In some cases, there are allergic reactions. The stench is manifested in viglyad visipa, dermatitis.

Development of thyrotoxicosis induced by the drug

Amiodarone may cause damage to thyroid function. This pathology is called amiodarone-induction thyrotoxicosis. Infections develop more often than a 3-ric vikorystannya drug, but in some ailments pathology can be found on the cob of amiodarone.

The frequency and incidence of sickness among men and women becomes 3: 1. Symptoms of sickness can be acquired when the body is getting sick, so as it accumulates in the tissues of the body, as it is a trivial hour to live. There are few options for the development of pathology in relation to the drug used (Table 2).

Table 2 - Species of forms of inducible AMIODARON thyrotoxicosis

In sick people, there is also a type of thyroiditis on the type of amiodarone. In any form, patients have the following symptoms:

• change of vagi;
• frequent heart rhythm;
• weakness of myaziv;
• minlity of mood;
• easing style;
• p_dvischena stomatomy;
• Decrease in the amount of blood from the hour of menstruation.

In patients with induced AMIODARON thyrotoxicosis, the symptomatology can also be erased, so that the diagnosis of illness can be accelerated. If there are minor symptoms of thyrotoxicosis when taking Amiodarone, it will be necessary to take a decision and eventually turn up to the point of failure.

Overdose

With uncontrolled high doses of amiodarone, a decrease in the frequency of heart rates, arrhythmias, liver dysfunction, AV blockade is observed. If there is a sign of an overdose, a lykarsky drug is required terminova skasuvati.

As the sick person's camp is important, it is necessary to carry out the washing of the slunk, to give the sick person. Vugilla and prominence will only help if the preparation has not yet gotten wet. In case of symptoms of withdrawal from AMIODARON, vicorystannya dializu does not help to take intoxication. Virazhena bradyarrhythmia can be suppressed by signs of atropin, beta-adrenergic drugs. If you come in ineffective, the sick person needs a cardiac pacemaker.

analogs to the drug

Amiodarone has structural and non-structural analogs (Table 3). Structural analogs take revenge on the very same speech. Non-structural - behind the warehouse there are a few similarities to the efficiency.

Table 3 - Analogues to Amiodarone

Kordaron is an analogue of Amiodarone, with the same active speech. Kordaron is carried out in ampoules and pigulka. The dosage of the active ingredient is insured in the same rank as for Amiodarone. Fakhіvtsі vverzhuyuyut, where the drugs are delivered: additional components, which are included in the warehouse of drugs, allow the delivery of іх to of different classes antiarrhythmic disorders (Amiodarone - up to the first, and Kordaron - up to the third).

Practical solutions seem to be about the greater efficiency of Amiodarone itself, plus the rest, it can also be more low. For Kordaron, you will have to pay a sum twice as much - from 280 to 350 rubles for 30 tablets. In case of intolerance of the components, it is necessary for normalization heart rhythm Can be used as a drug on the basis of the other dialectical words.

Some of the most effective non-structural analogs can be named as follows:

1. Preparations based on propafenone hydrochloride - Propafenone, Ritmonorm and Propranorm. May anesthetize and membrane-stabilize, block the ß-adrenergic receptors and calcium channels. On vidminu from Amiodaron, you can sign up in childish, Protecting the reception of people from the kidnapped vіku. The price for drugs in a row is in the range of 210-250 rubles.
2. Etatsizin is a drug based on Etatsizin, which is active as antiarrhythmic and is characterized by a trivial effect. Chi does not get stuck for symptomatic therapy, as with a one-time stasis does not change the frequency of heart rates. Prototype indications for children lіkuvannya. The price to reach the top is 1200-1300 rubles.

Amiodarone is a class III antiarrhythmic drug (ingibitor of repolarization). Decreased blood flow through the heart, reducing the function of the heart, lowering the frequency of the heart quickly and arterial vise.

Antianginal effect of coronary artery dilatation and antiadrenergic effects, changes in myocardial consumption in acid.

Nadaє galm injected on the alpha- and beta-adrenergic receptors of the CCC (without any additional blockade). Changes in sensitivity to hyperstimulation of sympathetic nervous system, The tone of the coronary vasodins. Increased coronary blood flow, reduces heart rate, increases the energy reserves of the myocardium (for the increase in the amount of creatine sulfate, adenosine and glycogen). I lower OPSS and systemic arterial vise (with intravenous injection).

Antiarrhythmic activity is amazed by the influx of electrophysiological processes in the myocardium - increasing the potential of cardiomyocytes, increasing the effective refractory period of the anterior heart, slugs, AV institute, bundle

Blocking the activation of "shvidki" natrіevі channels, nadaє efekti, characteristic for antiarrhythmic drugs of the I class. Galmu on the basis of (diastolic) depolarization of the membrane of the sinus node cytitis, onset of bradycardia, onset of AV conduction (antiarthritis effect of class IV).

For its structure, it is adjusted to thyroid hormones. Infusion on the exchange of thyroid hormones, driving the conversion of T4 into T3 (blockade of thyroxin-5-deiodinase) and blocking the accumulation of hormones in cardiocytes and hepatocytes, should lead to a decrease in the stimulation of thyroid hormones.

Ear of food (navit at victorian "navantazhvalny" doses) - from 2-3 days to 2-3 months, the triviality of days from decilky to months (visually start in plasma for 9 months).

Shown to sucking

Who does Amiodarone help from? It is obvious from the instructions that the drug is prescribed for pathology of the heart, so that the rhythm and frequency of the heart are affected very quickly:

• Supraventricular arrhythmias - disturbance of the rhythm, the cause of which is a change in the generation of impulses in the anterior and sinus nodes.
• Shlunochkovy arrhythmias - important breakdown of the rhythm, with such superfluous nerves, impulses are generated in the conductive system of the heart in shlunochki (shlunochkova tachycardia, fibrillation of shlunochkiv).
• Arrhythmias that develop on aphids ischemic ailments(Lack of blood circulation) heart, chronic heart failure.
• Extrasystole - the formation of pre-cephalic transcranials is very fast, such as ventricular or anteriorly progression.
• Heart arrhythmia, developing on myocarditis.
• Angina pectoris abo unstable angina heart.

Instructions for the administration of Amiodarone, administration

Tablets are suitable for oral administration. Take it until you drink it with a good amount of pure water.

As a result of the instructions, the effective dose of Amiodarone is to become:

• On an outpatient basis - from 600 to 800 mg per dose. Likuvannya continue until the total dose of 10 g is reached (stretching for 10-14 days).
• At the stationary - the cob dose should be 600-800 mg per dose. The maximum allowable is 1200 mg per doba. Likuvannya continue until the total dose of 10 g is reached (for 5-8 days).

The permissible dose of the drug reaches 100-400 mg per dose. You should take the cumulative tablets every other day. It is also possible to take a break in the morning - 2 days per day.

For instruction, the average therapeutic single dose is 1 tablet of Amiodarone 200 mg. Medium therapeutic dobova dose become 400 mg.

• The maximum single dose of the drug is 400 mg.
• The maximum dobov dose is 1200 mg.

For angina pectoris, the dose should be 400-600 mg per day, divided by 2-3 times, and after 1-2 times, lower the dose to 200 mg per day.

internally

For the suppression of the gostrich destructive rhythm, 5 mg / kg should be injected internally from the rozrakhunka, in patients with CHF - 2.5 mg / kg.

Short-hour infusion should be carried out with a stretch of 10-20 minutes in 40 ml of 5% glucose, if necessary - repeated infusion after 24 hours.

In case of trivial infusions - 0.6-1.2 g per add in 0.5-1 l 5% glucose distribution with 150 mg per 250 ml retail (with the other drugs in the insignificant range).

Vicious Effects

Instruction in advance about the possibility of developing offensive side effects when prescribed Amiodarone:

• On the side of the nervous system: head bill, Weakness, impairment, depression, symptoms of intramuscular, paresthesia, hearing problems, in case of trivial congestion - peripheral neuropathy, tremor, memory impairment, sleep, extrapiracy, neuritis, manifestation,
• On the side of the organs there is a sense of: uveit, putting lipofuscin in the epithelium of the horns (as well as introducing the signs and partly stopping the junctions - skargs on specks, like to turn up, or in the face of a nice person)
• On the side of the heart-vascular system: sinus bradycardia (refractory to m-cholinoblokatory), AV blockade, with trivial congestive heart failure - progression of CHF, tachycardia of the type "fever", improvement in paired arrhythmia
• On the side of the exchange of words: adjustment of the level of T4 with a normal or slightly decreased level of T3, hypothyroidism, thyrotoxicosis (required for the preparation).
• Three sides mental systems: In case of trivial obstruction - cough, retardation, interstitial pneumonia or alveolitis, fibrosis of the lesions, pleurisy, in case of parenteral obstruction - bronchospasm, apnea (in patients with severe dysfunctional deficiency).
• On the side of the herbal system: tediousness, bloating, decreased appetite, dullness or loss of relish symptoms, feeling of severity in epigastric conditions, abdominal pain, constipation, flatulence, diarrhea, liver disease , zhovtyanitsya, liver cirrhosis.
• Laboratory indicators: with trivial stasis - thrombocytopenia, hemolytic and aplastic anemia.
• Allergic reactions: shkirny visip, exfoliative dermatitis.
• Miscene reactions: with parenteral obstruction - phlebitis.
• Іnshi: myopathy, epididymitis, decreased potency, alopecia, vasculitis, photosensitivity (hyperemia of shkiri, weak pigmentation of incritical dylyanoks of shkiri), alopecia areata

special requests

Before the start of therapy, it is necessary to carry out an X-ray examination of the legends, as well as an assessment of the function of the thyroid gland and liver. In case of trivial therapy, it is recommended to carry out the radiologic dosage of legends in a regular manner.

For the prevention of the detection of photosensitivity, it is recommended to recommend a unique and trivial transfer to the session.

When amiodarone is swallowed, a relapse of the rhythm may occur.

Prototype

Prototypically indicated for the sign of Amiodarone in offensive drops:

• sinus bradycardia;
• weak syndrome sinus node;
• sinoatrіalny or AV blockade of the 2nd and 3rd stage (without the use of a cardiac stimulator);
• cardiogenic shock;
• collapse;
• hypocalypse;
• arterial hypertension;
• hypothyroidism (lack of vision of thyroid hormones);
• thyrotoxicosis;
• interstitial ailments of legends;
• reception of Ingibitoriv MAO;
• period of vaginosti and lactation;
• hypersensitivity to warehouse Amiodarone or to iodine;
• with protection for children and adolescents up to 18 years old.

Overdose

Symptoms of overdose are atroventricular blockade, bradycardia, loss of symptoms of obvious chronic heart failure, paroxysmal and shlunochkova tachycardia of the "fever" type, heart failure, broken function.

In case of an overdose, the preparation of the slurry should be recognized as active and symptomatic therapy. In case of tachycardia type "feasts" to carry out cardiac stimulation and signify the salt of magnesium internally.

Hemodialis is not effective.

Analogues Amiodarone, price in pharmacies

If necessary, substitute Amiodarone 200mg for an analogue according to active speech - the drug:

1. Rіtmorest,
2. Cardiodarone,
3. Cardiodarone,
4. Vero-Amiodarone,
5. Cordaron.

Behind the PBX code

• Cardiodarone,
• cordaron,
• Opakordin,
• Ritmiodarone.

Vibrating analogs are very important, but the instructions for use of Amiodarone, the price and advice on drugs of a similar type do not expand. It is important to take into account the consultation of the doctor and not to change the drug on its own.

Price in Russian pharmacies: Amiodarone 200mg tablets 30 pcs. - from 108 to 150 rubles, 50 mg / ml concentrate for requests. size for ін'єкцій 3 ml 10 pcs. - from 190 rubles, from 492 pharmacies.

Zberigati in a dry, stolen form of light, inaccessible to children, at a temperature of + 25 ° C. Term of accessibility - 2 rocks. Mind that term zberigannya - for the recipe.

Calm and spirits (You can read the tips in the statistics).

Prevention of the recurrence of paroxysmal disturbances to the rhythm is also carried out:

• fibrillation of shlunochkov, tachycardia of shlunochkov and those who are not safe for the life of shlunochkov arrhythmias;
• supraventricular arrhythmias, including organic heart disease, in case of ineffectiveness and ill-health of persistent therapy against arrhythmias;
• documented attacks of recurrent severe paroxysmal supra-mucous tachycardia in patients who are ill on Wolff-Parkinson-White syndrome;
• arrhythmias are blinking and tripping at the front of the heart.

Yak take pills?

Take pills slid to їzhі, kindly drink rіdinoyu. The dosage is designated as a drug individually, if necessary, it must be corrected.

loading dose

At the stationary pochatkova dose, if you take it for a few times, add 600-800 mg (maximum 1200 mg). Take up to a total dose of 10 g for 5-8 days.

An outpatient dose per cob, divided into spikes, in addition to become 600-800 mg according to an additional dose of 10 g for 10-14 days.

Staste the most effective dose, depending on the individual reaction of the sick person, and add 100-400 mg (1-2 tablets) in one or two doses.

If the drug stays for a trivial period of an hour, it is possible to break the dose and start the dose every other day, or do not take the drug two for a day.

The average single therapeutic dose is 200 mg.

Dobova's average therapeutic dose is 400 mg.

The maximum dose (one-time) is 400 mg.

The maximum dose (dobova) is 1200 mg.

Form vipusku, warehouse

Drinking pills white color round, flat-cylindrical form, which can be used for one-sided chamfer and rhizik.

Amiodarone hydrochloride - 1 tab. 200 mg.

Revenge the onset of additional speech: povidon, corn starch, Mg stearate, silicon dioxide calloid, Na starch glucose, microcrystalline cellulose.

Tablets packed in blister (10 pcs), cardboard packaging.

Corinth power

The drug is powerful enough:

• antiarrhythmic;
• antianginal;
• coronary artery disease;
• alpha and beta-adrenergic blocking;
• thyroid-stimulating;
• hypotensive.

Antiarrhythmic activity is characterized as an addition to the electrophysiological process in the myocardium. The drug is a healthy podovzhuvati potential for cardiomyocytes, an effective refractory period of shlunochki and anterior heart.

The antianginal effect is explained by the coronavirus injected, changes in the consumption of heart meat in sour. Galmic inflow appears on the receptor: alpha- and beta-adrenergic receptors of the heart and sudin. The sensitivity to the stimulation of the sympathetic nervous system and the opiate of coronary sudins decreases, the coronary blood flow increases, the heart rate is very old, the energy reserve of the myocardium increases.

bitter appearances

Frequency: less often (more than 10%), often (more than 1% or less than 10%), infrequently (more than 0.1% or less than 1%), rarely (more than 0.01% or less than 0.1%), even less (less than 0.01% + okremі vipadi), the frequency of abnormalities.

Sertsevo-sudinna system:

• often - the dose is less than bradycardia;
• infrequently - sinoatrial and AV blockade of the risky stage, stronger than obvious arrhythmias or new findings, including a heart attack);
• even more rarely - bradycardia, sinus node depression;
• the frequency of miscarriage is the abatement of symptoms of chronic heart failure.

Herbal system:

• even more often - blues and tediousness, loss of appetite, loss of savory tastes, the appearance of heavyness in the slunker, growth of activity of "pechink" transaminases;
• often - toxic hepatitis of the hostile stage (the potential for pechinka deficiency, including fatal);
• even worse - chronic lack stoves, including and fatal.

Dichny system:

• often - alveolar pneumonitis or interstitial, pleurisy, bronchial inflammation at the same time with pneumonia, including fatal inheritance, legenevius fibrosis;
• even more rarely - a spasm in the bronchi with an important dichotomous deficiency, gostry syndrome respiratory, including death;
• frequency of nevidoma - bleeding in the lesions.

Organi chutta:

• even more often - adding lipofuscin in the epithelium;
• even worse - neuritis of the nerve of the healthy abnormal neuropathy.

Endocrine system:

• often - an increase in the T4 indicator with a decrease in T3. In case of borgom stasis, hypothyroidism is possible, hyperthyroidism (the drug is produced);
• even worse - the destruction of the secretion of ADH.

Dermatological reaction:

• even more often - photosensitivity;
• often - pigmentation of the shkiri in the blue of the day;
• even more rarely - erythema, shkirny visip, exfoliative dermatitis, alopecia, vasculitis.

Nervous system:

• often - tremors, sleep disturbance, no nightmares;
• Ridko - peripheral neuropathy, myopathy;
• even more rarely - ataxia of the cornsus, hypertension of the internal skull, headache.

Even more rare with trivial implantation of possible thrombocytopenia, anemia is hemolytic and aplastic.

Even more rarely, epididymitis, decreased potency, vasculitis.

Overdose

Overdose symptoms:

• belittling arterial vise;
• sinus bradycardia;
• atrioventricular blockade;
• the destruction of the robot's stove;
• loss of symptoms of heart failure;
• zupinka heart.

In case of an overdose of the drug, it is not possible to take the active ingredients, if you have recently taken the drug. Symptomatic therapy is indicated in the diabetic vomiting.

In case of bradycardia, there is more capacity for beta-adrenostimulants, atropin or the installation of a cardiac stimulator. Prescribed internally administered Mg salts, or to carry out cardiac stimulation.

Prototype

• sinus node weakness syndrome;
• atrioventricular blockade of 2-3 steps, two- and three-beam blockade without a pacemaker
• arterial hypertension;
• dysfunction of the thyroid gland;
• vagina and lactation;
• odnochasny priyah of lіkami, SSMSC zbіlshuyut QT-іnterval i viklikati viniknennya paroxysmal tahіkardіy (hіnіdin, dizopіramіd, prokaїnamіd, dofetilіd, sotalol іbutilіd, bretіlіya tosylate іbutilіd, sotalol i INSHI not antiaritmіchnі zasobi vіnkamіn, bepridil, deyakі neuroleptics, cisapride, tritsiklіchnі antidepressant ; erithromicin, spiramicin; azole; quinin, mefloquine, chloroquin, halofantrine; pentamidine; diphemanil methyl sulfate; astemizole, mizolastine, terfenadine and fluorochinoloni;
• hypocalypse and hypomagnese;
• increase in QT interval;
• interstitial contemplation of legends;
• reception in the complex of ingibitoriv monoaminooxidase;
• children up to 18 years old;
• intolerance to lactose, lack of lactase (glucose-galactose malabsorption);
• temporal sensitivity to iodine and amiodarone, to the other components in the preparation.

It can be taken care of in case of: hepatic insufficiency, bronchial asthma, summer patients, chronic heart failure, AV blockade of the first stage.

likarska vzaєmodiya

Combination of contraindications:

• antiarrhythmic drugs of Ia and III classes, sotalol;
• of іnshogo not antiaritmіchnі zasobi: bepridilom, vіnkamіnom, deyakimi neuroleptics: fenotіazinom (chlorpromazine, tsіamemazin, levomepromazine, tіoridazinom, trifluoperazine, Flufenazіn) benzamіdіv (Amіsulprid, sultopride, sulpіrid, veralіprіdom, tіaprid), butyrophenones (droperidol, haloperidol), Sertindole, pimozide; tricyclic antidepressants, cisapride, macrolides (erithromycin when administered internally, spiramycin), azoles; anti-malarial lykarsky zasob (chinin, chloroquin, meflochin, halofantrine, lumefantrin); pentamidine (parenteral), diphemanil methyl sulfate, mizolastine, astemizole, terfenadine, fluorochinolones (including moxifloxacin).

Release form: Solid lykarski formi... Pills.

General characteristics. warehouse:

Pharmacological authorities:

Shown to zasosuvannya:

Important! Get to know the likuvannyam,

How to store that dose:

Features of storing:

Pobichna diya:

Vzaєmodia with іnshy lіkarskiy zasob:

Prototype indications:

Overdose:

Umovi zberigannya:

Term of attachment - 3 rock. Do not store the drug after the end of the term of adherence indicated on the package. List B. In a dry, stolen light at a temperature of 25 ° C. Zberigati out of the reach of children.

Umovi vidpustki:

For the recipe

package:

Tablets 200 mg. For 10, 15, 20 or 30 tablets in a contoured charunk package of polyvinyl chloride and aluminum foil lacquered. 1, 2 or 3 contoured charunk packaging with instructions and packing into a carton box.

The anxiety of the heart-vascular system occupies the first place for the broadening of the pathology of all systems to the human organism. From the statistics it is possible to find out why Amiodarone is stored, as a drug that can help with heart rhythm disturbances, especially in case of heart failure, and as a part of lykarsky vasobu.

Warehouse i form vipusku

Amiodarone is a lykarsky zasib, who can be treated to antiarrhythmic events of the 3rd class (blockers of caliber channels), for which the process of repolarization and the increase in the potential of action is not typical.

Before the warehouse, the drug has an active speech line - amiodarone hydrochloride, And also additional items:

• magnesium stearate;
• lactozymonohydrate;
• corn starch;
• natriyukroscarmellose;
• silica coloide anhydrous oxide.

Likarskiy zasіb in viglyadі bіlich tablets ploskocylіndrichnoy form with a risk, weight in 200 mg.

In addition, it is possible to create Amiodarone in ampoules of 3 ml of 5% retail.

Mechanism of Diya

For Amiodarone is characterized by a decrease in the rapid health of the myocardium. In addition, the drug decreases opir in the coronary vasculature, and decreases the reduction of coronary blood flow. Zavdyaki - vasodilatory action on peripheral arterial and venous vessels to reduce the frequency of heart speed, change the level of arterial grip.

The amount of creatine phosphate and glycogen as a result of the drug taken will increase in order to bring a positive inflow to Amiodarone for energy exchange.

In addition to the block of caliber channels, for Amiodaron it is also typical to block the channel on:

• natrіevi channels;
• beta adrenergic receptors;
• kaltsіevі canals (it is turned the least).

In general, for the drug the characteristic mechanism of action, which is the power of antiarrhythmic in the first, other and fourth groups, but all the basis of the action of Amiodaron Polyagus in reduced automatism, the alertness of the syncope-overhead

The antiarrhythmic drug develops in different ways. Trivial vikorystannya lykarsky zasobu supervise to improve the triviality of the potential, effective refractory period atrium, anterocerebral institute and shlunochkiv. Mechanism of increasing the triviality of the potential of tying with a block of caliber canals, which is to reduce the vision of all types of cardiomyocytes to a decrease. Repolarization at all times will develop. On the electrocardiogram, the QT interval is adjusted.

Pharmacokinetics

When the drug is taken in the middle, it gets wet in the organs shlunkovo-intestinal tract by 50%. Introduce zzvychay 1 time for doba. The effect is infused through a few drops of pills. When it enters the liver, it is metabolized.

For Amiodarone, material cumulation is reversed, as the cause of the general administration of the drug through the intestines, in which wine I consume at once. The drug is actively accumulated in the liver itself, in an unchanged view, or in the quality of metabolites, as well as in lesions and secretions and deposited in adipose tissue. Lykarskiy zasiby high rate of spores with blood plasmas - 96%.

In case of vikorystanny Amiodarone in the form of a solution for the general (drip) internal introduction, it is possible to speed up the hour of validation of the results up to 1-2 years for the reception.

Shown to sucking

The drug vikoristovuyutsya for lіkuvannya:

• Supraventricular tachycardia - to bring about a change or confidence.
• Ischemic ailments of the heart.
• Pathology, which leads to the deterioration of the function of the lynx - in yakosti complex therapy So, it’s not enough to infuse on those who become ill and additionally help normalize the conductivity and speed of the myocardium.

The efficiency of the preparation at (yak clinical form ischemic ailments of the heart) polyagaє in the change in the consumption of myocardium in kisn.

Amiodarone vikoristovuyutsya as prophylactic in case of relapses:

• , Yak will block the life of the sick. Lіkuvannya, when it is necessary to fix it in the stationary minds, or in the presence of the possibility of continuous control over the patient's camp.
• Symptomatic shlunochkovo tachycardia, yak to make people unpopular.
• , Yaka will need a taste. Most often they become vicious in case of ineffectiveness of the other antiarrhythmic disorders.
• Fibrillations of shlunochkiv.

Victory Day Rules

Pochatkova therapy polyagaє in 1 tablet 200 mg 3 times a day. I recommend vikoristovuvati Amiodarone until you receive it, not rozzhoyuchi.

In some cases, a sick person needs to take a higher dose, as you can get 4-5 tablets for doba. At the same time, this therapy is short-term, supervised by regular electrocardiographic control (you can use the method of additional EKG-monitoring according to Holter).

When switching to additional therapy, the patient should start lowering the dose, if the necessary effect is prevented. Falling down on the severity of the fall, the reaction of the sick person to the drug, the dosage can become half a tablet to 2 tablets per dose.

I will look at, but for Amiodarone, the material cumulation is characteristic, it will take 5 days a day with a break of 2 days.

Prescribed to the drug for children, vaginal and one-year-old breastfeeding women

The active language of the lycea penetrates through the histological barriers, including the transplacental, hematoencephalic ones. At the zyvazka z cyme Amiodarone is hardened for signs of vaginal women. Lykarsky zasib to rob the negative injection on thyroid fetus. The drug can be vikoristovuvatisya with vaginosis only in quiet drops, if a positive effect for the mother, it is significant to change the viscera of the child.

As soon as the woman took Amiodarone before the fact of her vaginosity was established, she was quick to talk and help the patient about may inheritance.

The drug is strictly contraindicated in the period thoracic treatment So, the active speech penetrates to the baby at once with milk і wiklica іnvorotnі poroshennya. As the woman is awed by the tachycardia, as I will obstruct her health and life, Amiodaron can only have the signs of only when the child is translated into piece vigodovannya.

Likarskiy does not recognize children who have not reached the 18th century.

Prototype

In addition to an incomplete period, the period of vaginosity and breast care in women, the middle of the testimony before the implantation of Amiodaron is seen:

• hypersensitivity to the drug, its components, iodine;
• sinoatrial blockade of the heart during the daytime of the endocardial cardiac pacemaker as a piece of heart rhythm;
• syndrome of weakness of the sinus node without a pacemaker in a sick person - dressing with a high rizik sinus nodes;
• failure of atrioventricular conduction of a severe stage of development without a pacemaker in a patient;
• damage to the function of the thyroid gland.

Vicious Effects

Among the most advanced effects for the patients, the following are possible:

• dyspeptic symptoms;
• over-the-top decrease in the frequency of the heart is fast;
• anterocerebral block;
• werewolves attached to microcrystals in rogivtsi;
• pigmentation of the shkiri, when you turn people around, you will take a siro-blakitny color;
• photodermatitis (a sick person is susceptible to an increase in sensitivity to ultraviolet viprominuvannya, with a glance at the time of therapy with vicarious Amiodaron varto, a unique trivial transfer to sleep);
• dysfunction of the thyroid gland;
• fibrosis of legends;
• neuropathy of the healthy nerve, which can progress to the point of additional sloughing;
• syndrome of inadequate secretion of antidiuretic hormone - is more likely to occur in small drops, most often in case of alcoholic drugs, as there is a significant decrease in the level of sodium in the blood (hyponatremia);
• bronchospasm - the most common scarga ailments, as they suffer from mental deficiency and bronchial asthma;
• epididymis, if the fiery appendage of the yuchka is fired up, is a side effect of the lykarsky zasobu, the sound of which is insufficiently clear at a given moment; can lead to empathy;
• urazhennya nirok, scho supervising to increase the rate of creatinine clearance;
• angioedema;
• hemolytic or aplastic anemia, thrombocytopenia.

The implantation of the drug in doses that can change the therapeutic, often leads to the appearance of neurological disorders, the middle in patients with the most common paresthesias and tremors.

In case of lіkuvannі from vikorstannya Amiodaronu also went wrakhovuvati, bіtіchnі efekti to see the message of witness lіkarskogo, you can take a trivial hour. Pigmentation, poured out by the drug, disappears only after 1-2 years after the trivial reception.

Consistency with other drugs and alcohol

With a spiral vicorian Amiodarone with other antiarrhythmic conditions, it is possible to prevent a short therapeutic effect, especially in vipadkas, if the drugs are used in other classes of groups. Alle the process of detecting vimage with respectful care for the reaction of the patient's body and indicators of heart activity.

Vikoristovuvati Amiodarone with medications of the whole group, such as Ornid, Sotalol and Dofetilide, is contraindicated, so that I can get more frequent and stronger and I will show side effects.

There is also a memory about those who are victorious in the capacity of combined therapy of decilkoh lykarsky zasobiv, which can be vicious feverish tachycardia, fenced off. Prior to such drugs, there are Amiodarone, Sotalol, Chinidinovyh z'adnannya, Disopiramid. It is also a risk of diagnosing pathology of growth with a decrease in the level of calories in the blood, which is typical for bagatose diuretics, with bradycardia, a natural or ditched QT interval.

In the midst of strict contraindications to the use of amiodarone, one can see:

• antiarrhythmics in class Ia (Hinidin, hydrochinidin);
• class III antiarrhythmic drugs;
• spoluky mish'yaku, Tsizaprid, Vinkamitsin, Toremifen, Spiramitsin, erithromicin (especially when administered enterally).

All pererakhovanі vische combіnatsії to produce until more often and hardening of side effects from the side of the heart;

Bedroom victoriannya Amiodaron zi step by step maє suvoro kontrolyuvatisya likarem:

1. cyclosporine- Likki, like to lay down to cyclic polypeptide antibiotics and immunodepressants. Nephrotoxicity is characteristic for the drugs in the whole group, and it appears more often with amiodarone at once with amiodarone.
2. Diltiazem in the form of a retail solution for ін'єкцій. In a sick person, there is a development of bradycardia and atrioventricular blockade.
3. Antipsychotics, which can cause tachycardia. To cich zasob_v lie: Amisulpride, Chlorpromazine, tsiamemazine, Droperidol, Haloperidol. In addition, such combinations can lead to the diagnosis of lingering arrhythmias.
4. Methadone. Rizik viniknennya destructive heart rhythm to move.
5. Verapamil in the form of a rosette for ін'єкцій. Accelerating the manifestation of side effects of the preparations, especially from the side of the heart - the diagnosis of the atrioventricular block in the patient, a decrease in the frequency of the heart.

With a spiral vicorian Amiodarone with a sick person, it is necessary to monitor with electrocardiograms, so as the combination of the effect of both lykarsky wines is often produced to the point of trusting the heart rhythm.

It is not recommended to live in an hour of drug therapy. Tied with ethanol injected on the tone of the peripheral sudin and in the injected alcohol on the level of the arterial vise.

Is it possible to add the preparation?

Amiodarone can be bought in such pharmacies:

• The planet is healthy;
• Neopharm;
• Cosmoteque;
• Lighthouse;
• Melody of health;
• Samson-Pharma;
• Pharmacy ІФК.

Price the drug costs in the area of ​​89-208 rubles.

The drug Amiodarone MA wide range Proof of side effects, albeit in case of a suvoromnij rules of reception, monitoring of the EKG, indicators of hemodynamics and health, the patient will take away the chance to confront important pathologies of heart and rhythm disorders.