Captopril sandoz as a supplement. Captopril Sandoz - ingibitor APF for lowering the vice

Antihypertensive disease, іngіbіtor APF... Mechanism of antihypertensive dressing with competitive antihypertensive activity of ACE, to reduce the efficiency of converting angiotensin I into angiotensin II (which can increase the pressure of the alimentary sequester) In addition, captopril, mabut, is injected onto the kinin-kallikrein system, overshooting the drop to bradikinin. The hypotensive effect does not lie in the activity of renin plasmas, a decrease in the arterial clutch in a normal condition and a decrease in the concentration of the hormone, which is poured into the tissue of the RAAS. Zbіlshu coronary and nircovy blood circulation.
The managers of the shipworms, change the OPSS (postnavantage), the grip of the wedge in the legene capillaries (forwardnavantage) and the opir in the legenevian ships; advancing the healthiness of the heart and tolerance to the new option. With a trivial stagnation change, the swelling of the myocardium hypertrophy of the lone duck, the progression of the heart failure and the promising development of the dilatation of the duck. A decrease in the amount of sodium in children with chronic heart failure. Expanding the artery of a larger world, lower veni. I will paint the blood circulation of the ischemic myocardium. Change in platelet aggregation.
Reducing the tone of wine arterioles of nirok glomeruli, reducing internal glomerular hemodynamics, changing the development of diabetic nephropathy.

Shown to sucking

Arterial hypertension(Including renovated), chronic heart failure (in the warehouse of combined therapy), impairment of the function of the lingual slurry due to myocardial infarction in patients, which should be clinically stable. Diabetic nephropathy in case of type 1 diabetes mellitus (with albuminuria more than 30 mg / dob).

How to secure

When taking a dose, the dose is 6.25-12.5 mg 2-3 times / dob. In case of insufficient effect, the dose is gradually increased to 25-50 mg 3 times / dob. When the functions are damaged, I will add a dose of slid change.
Maximum dobova dose become 150 mg.
Slid the mother on uvaz, so that captopril is consumed in the II and III trimesters of vaginosity, it is possible to suffer a deterioration in the development and bend of the fetus. When the vaginosity of the captopril is established, it is safe to skasuvati.
Captopril is seen in breast milk. If necessary, during the period of lactation, follow up on the nutritional status of breastfeeding.
Prototype indications for up to 18 years. Stagnation of captopril in children is only possible due to the difference in effectiveness of other drugs.

vzaєmodiya

With a one-hour consumption of immunosuppressants, cytostatics, the development of leukopenia is increased.
With a one-hour intake of calyzbergyuchimidiuretics (including spironolactone, triamterene, amyloride), calories preparations, substitutes for salt and dietary supplements until the end of the day, so that calories can be consumed, and can be used for the development of hyperthermia instead of aldosterone, to produce calories in the body before being absorbed into the body on the other dodatkogo hope in organizm.
With a one-hour consumption of ingibitoriv APFs and refineries, the risk of development of the deterioration of the function of the oil refinery is increased; Ridko sposterіgaєtsya hyperkalієmiya.
With a one-hour stagnation with "loop" diuretics and thiazides, arterial hypotension may be affected, especially if you take the first dose of a diuretic, mabut, for a hypovolemic shock, which can lead to transient mitigation. Є Risik development of hypocalypse. Pidvischennya risiku the development of porushennya funktsii nirok.
With a one-hour zasosuvannі from zasoba for anesthesia can be severe arterial hypotension.
With a one-hour consumption of azathioprine, there is a potential development of anemia, which is increased due to the increase in the activity of eritropoietin with the addition of ingibitoriv APF and azatioprine. Descriptions of the development of leukopenia, which can be tied to additive functions cystic brain.
With a one-hour consumption of alopurinol, the development of hematologic depressions will develop; describe the development of important responsiveness reactions, including Stevens-Johnson syndrome.
With a one-hour consumption of aluminum hydroxide, magnesium hydroxide, magnesium carbonate, the bioavailability of captopril changes.
Acetylsalicylic acid in high doses, you can change the antihypertensive dose of captopril. There is no residual, altering acetylsalicylic acid the therapeutic efficacy of ACE ingibitors in patients with IXC and heart failure. The nature of the process of intercourse is to lay it down as a result of getting overwhelmed. Acetylsalicylic acid, attracting COX and synthesis of prostaglandins, can lead to vasoconstriction, which can lead to a decrease in the heart wickedness and the loss of heart disease in patients with heart deficiency.
Є Whenever there is an increase in the concentration of digoxin in the blood plasma with a one-hour intake of captopril with digoxin. risik lykarskoї vzaєmodії Allowances in patients with impaired functions of nirok.
With a one-hour consumption of endometacin, ibuprofen, the antihypertensive effect of captopril, mabut, in the case of an injection at the refinery injected into the synthesis of prostaglandins (such as,
With a one-hour stagnation with insulin, hypoglycemic diseases, obsolete sulfonyls, there is a possible development of hypoglycemia for the development of tolerance to glucose.
With a one-hour consumption of ACE іngіbіtorіv і interleukinu-3, the development of arterial hypotensiveness is inevitable.
With a one-hour consumption of interferon alfa-2a and interferon beta, the development of important granulocytopenia is described.
During the transition from taking clonidine to captopril, the antihypertensiveness of the rest develops step by step. Once a raptor seeks to clonidin in patients who take captopril, you can rіzke pіdvischennya AT.
With a one-hour consumption of carbonate lithium, the concentration of lithium in the blood is increased, and symptoms of intoxication are observed.
With a one-hour consumption of minoxidil, sodium nitroprusside, an antihypertensive action will take place.
With a one-hour stagnation with orlistat, there can be a change in the efficiency of captopril, which can lead to an increase in the arterial vise, hypertensive crisis, and descriptions of bleeding into the brain.
With a one-hour antihypertensive effect, the antihypertensive effect is more potent than pergolide.
With a one-hour consumption of probenecid, the nirkovy clearence of captopril changes.
With a one-hour zasosuvannі z procaїnamіdom you can increase the risk of development of leukopenia.
With a one-hour consumption of trimethoprim, the development of hypercritical growth, especially in patients with impaired function of nirok.
With a one-hour consumption of chlorpromazine, the development of orthostatic hypotension occurs.
With a one-hour consumption of cyclosporine, the development of a hostile deficiency, oliguria appears.
Vvazhayut, there is a possibility of a change in the effectiveness of antihypertensive disorders with a one-hour consumption of eritropoietins.

Pobichna diya

On the side of the central nervous system and peripheral nervous system: Zamorochennya, head b_l, Vidchuttya vtomi, asthenia, paresthesia.
Three sides heart-vascular system: Orthostatic Potency; Ridko - tachycardia.
On the side of the herbal system: nudota, decreased appetite, loss of relish views; Ridko - abdominal pain, diarrhea or constipation, increased activity of liver transaminases, hypertension; signs of hepatocellular disease (hepatitis); in okremikh vipadk - cholestasis; in some cases - pancreatitis.
On the side of the hematopoietic system: rarely - neutropenia, anemia, thrombocytopenia; even more rarely in patients with autoimmune illnesses - agranulocytosis.
On the side, I will exchange the words: hypercalcium, acidosis.
On the side of the secular system: proteinuria, impairment of the function of nirok (increasing the concentration of sevidin and creatine in the blood).
Three sides mental systems: dry cough.
Allergic reactions: shkirny visip; Ridko - Quinke's quagmire, bronchospasm, syrovatkov's ailment, lymphoadenopathy; in okremikh vipadkah - the appearance of antinuclear antibodies in the blood.

Prototype

Viability, period of lactation, up to 18 years, sensitivity to captopril and other angibitors of ACE has been increased.

special requests

With the protection of patients with anamnesis in history of angioedema, cerebral arthroplasia on the therapy of angioedematous angiotensin fever, subdued or idiopathic angioedema, with aortic stenosis, cerebrovascular disease ill with good fabrics(Including VKV, scleroderma), with associated cystic fibroids, liver disease, hypercalcitis, bilateral stenosis of the nirkoval arteries, stenosis of the arteries of the intestinal tract, stagnant disease , munah, scho supravodzhuyutsya decrease in the BCC (including with diarrhea, bloating), in patients of a kidnapped vik.
In patients with chronic heart failure, captopril stasis under sawing medical control.
Шо виника під hour surgical engagement arterial hypotensiveness on the background of the received captopril is absorbed by the zapovnennyam of the age.
A slid of a unique one-hour consumption of blood-borne diuretics and drugs in calories, especially in patients with nirk deficiency and for diabetics.
If you take captopril, you can be spared pomilkovo positive reaction when analyzing the section for acetone.
Stagnation of captopril in children is only possible due to the difference in effectiveness of other drugs.
Inflow to the building of keruvati by transport means and mechanisms
It is necessary to protect with keruvannas by transport means, as well as for the visibility of the robots, which require additional respect, for that it can be fouled up, especially if you send captopril on the cob.

Three facts about the product:

Instructions for storing

Price in the internet pharmacy site: from 95

Pharmacological diya

Captopril Sandoz is added to the angiotensin converting enzyme. In other words, the drug does not allow another type of angiotensin to be converted. In such a rank, the value of the oligopeptidic hormone trim is significantly reduced, the indicators for the arterial grip in the norm. With the correct dosage, the patient does not normalize only AT, but the zagalny peripheral opir of sudin. The hypotensive action of the lykarskogo does not at all lie in the activity of renin plasmas. The ailments are discouraged from reducing the grip of the hormone when the concentration is normal. Zdatny pidsylyuvati blood circulation through the blood vessels of the myocardium. As a result of the instruction, Captopril Sandoz changes the thrombocyte clinging, blocking the progress of heart failure, and also in the meaning of the world of hopeful children. Medication to be absorbed quickly shlunkovo-intestinal tract... These indicators should be no less than 75%. Patients can remember that one-hour reception of the head component is practically twice as low as the drug is used. The main part of the speeches is to live for help correct robots nirok і all in all, it’s just a small part of being lost in its own innocent viglyad.

showing

Captopril Sandoz is recognized only as a special medicine for passing all the necessary analyzes. Meanings for patients with the presence of a number of such illnesses: renovascular hypertension, the reason for the diagnosis of which was the sign of the nirkov artery abo її gilok; the destruction of the robotic lynx, which is tied to the myocardium transferred earlier; lesion of nirok in connection with the establishment of diagnosis red diabetes; heart failure in chronic form. It is important to note that you knew wider sucking not only in the capacity of monotherapy, but at the warehouse of complex treatment. Patients are guilty of reason, well, if you don’t get the proper value of your health, then the trivial hypertension can be done seryoznі inheritance... Degeneration of the picture and the appearance of bringing people to the point of further slackness. The cerebral blood circulation is destined to collapse, the robot will lose heart, so the mortality rate is minimal in five times. Pidvischennya rivnya zukru in the blood is hostile to the nervous system, it will be possible to change it to the edge. Exercise nirok progresuє with a skin day with advanced indicators arterial vise.

Warehouse and form for the preparation

The main component of Captopril Sandoz is a speech with the same name. Dodatkovy rivers are used to store microcrystalline cellulose, potato starch, lactose, as well as stearic acid. The drug of the Nimetsky virus is supplied to the pharmaceutical market only in tablet form. The skin is one that has a round and smooth surface, and it can take on a classic or chotirilized shape when it is left behind. Pigulka is made in biliy color. Visually, it is not only in the upper sphere, but in retail. On one side, the presence of a rizik for hand-crafting. Ingibuyuchiy medication is dispensed in doses of 6.25 mg, 12.5 mg, 25 mg, 50 mg and 100 mg. A selection of assortments allows you to easily coriguvati dobova dobovannya for patients. The skin tablet is rosted into a contour line, prepared from grub foil. The skin blister has ten units. Cardboard packaging can be from one to ten times.

Prototype

Be it a likarskiy zasіb, right from thіth region іs sosuvannya, Volodya is not only a list of indications, ala і diagnoses, as they would take a course of lіkuvannya. In the instruction from the storage of Captopril Sandoz, there is no sign of being ill with a number of offensive ailments: individual intolerance to one of the components in the warehouse, as well as hypersensitivity; dynamic allergic reactions, including angioeurotic nagging, showing up to reach the great zone of shkirny cover; transfers instead of nitrogenous products to exchange in blood, vivoditsya through nirki; advanced indicators feces in the blood; chastkovo abo povnotsinne ringing of nirkovy arteries, aortic arteries, mitral valve abo nirok; during the week of the nirka transplantation; clinical syndromes, As a result of excess production of aldosterone; the manifestation of the re-code for the blood flow from the lynch; arterial vice; acceleration of myocardial infarction, as it often ends with a lethal result; overnight zasuvannya given lykarsky drug from the way, in the basis of which there are aliskiren. When a sick person is spared, it’s accelerated from the list presented to him;

sundown

Most of the number of key students and edgukiv, Captopril Sandoz followed about a year before the reception. Tablets are more beautiful not to rozzhovuvati and drink a great amount of pure water. It is necessary to make sure that someone else is guilty of rozrobiti medical worker according to the profile. The most basic is the classical scheme of lykuvannya, designated by virobnik. The patient is safe to repair the course with a dose of 12.5 mg at a time. Take a trip twice a day. In addition, as ailment has consumed the first dose, the remedy for goiters is monitored for the first time. As far as Lyudin is seen, she is fine, in any way contraindicated to the occasional stasis of the day. for more effective treatment lіkar pіd hour lіkuvannya can koriguvati dobova dobovannya yak on one side, so and in іnshu. For quiet ailments, such as demanding a dose of pulp and supplementary therapy, it will usually be 25 mg in one dose. The maximum dobova dose in the whole range is not to blame for the transfer of 50 mg. If necessary, the drug is increased to 150 mg, which should be distributed for three days over the course of the day. We are sick, if we are suffering for a heart failure, it is necessary to carry out the process of taking care of it with special protection and only under the watchful eye of a doctor. Traditionally, with a similar diagnosis, the doctor proposes to repair the dose with a dose of 6.25 mg. With positive dynamics and daytime side effects, The dose is given to the correction.

Pobichna diya

First, start to a therapeutic course with the drug, then, as soon as you become aware of the possible negative inheritances, and the symptoms of ailments. Zvychayno, zasib Captopril Sandoz - a symbol of the funniest shops and technologies. However, a number of onset manifestations: a decrease in the number of neutrophils, leukocytes, thrombocytes, eosinophils and glucose concentration; significant lymphatic universities; ruin in robots immune system If the fabrics are lousy, they are lost as aliens and they repair them by the organism itself; adduction of indicators of feces in the blood; ruin is not just a dream, ale and robots relish receptors, Scho supervodzhuyutsya migrennyu, sleepy, zamorochennyam, depressive camps; in absolutely epizodic types of ailments, they can get confused with the deterioration of svidomosty, uncommon and insults; sickly accelerated heart rate, zby in frequency and triviality heart rhythm, That supervodzhuyutsya rushes of blood before exposure, or navpaki blіdіstyu, as well as peripheral ridges; dry cough without expectoration of phlegm, burning legends, zadishka; inappropriate views in the area of ​​the abdomen at the sight of boring, and heavy; damage to the frequency of style; the appearance of small twists and turns on the mucous membrane and mov. If you are a patient, without a doctor's name, you will have a higher dose, you need to spend more need to come in according to the prominence of the slunk, it seems that it will be absorbed, and it will indicate an additional symptomatic therapy.

lykarska vzaєmodiya

Persh nіzh buy Captopril Sandoz slіd rozumіti, giving the medicine "to be friends" not with us. It is strongly discouraged to take any drugs that are included in the class of Ingibitoris at once, just by pouring them into the renin-angiotensin system into the human organism. A slid of memory, a kind of tandem can be wicked at the ailing reduction of the arterial vise and serious destruction of the robot. One-hour reception is allowed, ale only by the retailer monitoring of the eligible liquor. Immediately implanting with aliskiren is strongly recommended to unique patients who suffer for problems with nirkas, as well as for another type of diabetes. Slіd unicati on the basis of small preparations of kalіy. Podibny blows more and more to provoke hypercalmia. As a matter of fact, it’s not possible to get into such a situation, the whole course is guilty of changing the patient’s course by visualizing the doctor, regularly providing all the necessary analyzes. Likarskі zobi on the basis of lіtіyu, permeated in the body, by itself increasing the concentration of the main component in the blood of people.

special requests

Captopril Sandoz is a seryozny drug, go to what is necessary, so self-assimilated. Bazhano, before the cob of passing the course, check the grip of the time, check the grip, the space in which the boundaries and for which the surroundings are the indicators. A similar picture is even more important in case of frivolity. The head component of the warehouse can be subject to gratuity when giving a cut for acetone. At the same time, it should be pinned for the ear and only after a couple of days, re-create the analysis. For the entire period of the therapeutic course, the ailing one needs to be able to see from the transport system, and also from other people to take a special concentration. Reliable monitoring of merit and those patients who are suffering for diffusion of the ignition processes on the walls of blood-bearing vessels. If there is a symptomatology, if you do, you will be more likely to skasuvati for a day and give analogy for a day.

Vigor and lactation

Uninvolved for the trimester, it is strongly discouraged to accept women. It’s very easy to be quiet, hto perebuaє in the period of breastfeeding. By numerical dosages it has been shown that the component of the building is to inflict incomparable changes in the development of the fetus in the mother's womb.

Stuck in a childish vіtsі

Buried before the recognition of children, as they did not reach the eighteen-century century. In the presence of diagnoses, children are followed by alternative drugs that are allowed for childish vik.

In case of deterioration of the functions of nirok

It is allowed to accept only a visual one. If necessary, the physician can do it.

When the functions of the liver are damaged

It’s not just a matter of harassing yourself, but also regular monitoring not only from the side of the physician, but from the patient himself. If there are any changes in the outhouse, then immediately follow the advice and return for additional advice.

Stuck in the kidnapped vice

For people whose category is 60-65 years old, the course should be repaired with a dose of 6.25 mg twice a day. The price of Captopril Sandoz will become 100 rubles. You can add the drug through our online pharmacy with delivery to home or in the office. Only on the presentation of the recipe.

Antihypertensive disease, ACE inhibitor. Mechanism of antihypertensive dressing with competitive antihypertensive activity of ACE, to reduce the efficiency of converting angiotensin I to angiotensin II (which can increase the pressure of the alimentary sequester) In addition, captopril, mabut, is injected into the kinin-kallikrein system, overshooting the drop to bradikinin. The hypotensive effect does not lie in the activity of renin plasmas, a decrease in the arterial clutch in a normal condition and a decrease in the concentration of the hormone, which is poured into the tissue of the RAAS. Zbіlshu coronary and nircovy blood circulation.

The managers of the shipworms, changing the OPSS (postnavantage), the grip of the wedge in the legene capillaries (the frontnavantage) and the opir in the legenevian ships; advancing the healthiness of the heart and tolerance to the new option. With a trivial stagnation, the swelling of the hypertrophy of the myocardium of the lingering sucker is more likely to progress, and the development of the dilatation of the lingering sucker. The loss of sodium instead of sodium in children with chronic heart failure. Expanding the artery of a larger world, lower veni. I will paint the blood circulation of the ischemic myocardium. Change in platelet aggregation.

Reducing the tone of wine arterioles of nirok glomeruli, reducing internal glomerular hemodynamics, changing the development of diabetic nephropathy.

Pharmacokinetics

If the reception is not less than 75%, it gets wet from the shlunkovo-intestinal tract. One-hour reception of їzhі changes in moisture by 30-40%. C max in blood plasma is reached after 30-90 min. The link with the bottles, over the important with the albumin, become 25-30%. Seeing with breast milk. It is metabolized in the furnaces with the formulations of the disulfide dimer of captopril and captopril-cisteindisulfide. The metabolism is pharmacologically inactive.

T 1/2 become less than 3 years old and grow with nirkovy deficiency (3.5-32 hours). It should be 95% vivodit nirkami, 40-50% in the uncontested viglyad, and іnsha part - in viglyadі metabolites.

With chronic nirkovy deficiency cumulate.

Vipusku form

10 pieces. - packs of middle contour (1) - packs of cardboard.
10 pieces. - packs of middle contour (2) - packs of cardboard.
10 pieces. - packs of middle contour (3) - packs of cardboard.
10 pieces. - packs of middle contour (5) - packs of cardboard.
10 pieces. - packs of middle contour (10) - packs of cardboard.

sundown

When taking a dose, the dose is 6.25-12.5 mg 2-3 times / dob. In case of insufficient effect, the dose is gradually increased to 25-50 mg 3 times / dob. When the functions are damaged, I will add a dose of slid change.

The maximum dose is 150 mg.

vzaєmodiya

With a one-hour consumption of immunosuppressants, cytostatics, the development of leukopenia is increased.

With a one-hour intake of calyzbergyuchimidiuretics (including spironolactone, triamterene, amyloride), calories preparations, salt substitutes and dietary supplements to the end of the day, so that calories can be consumed, and the power of hyperplants instead of aldosterone, it is necessary to produce the calories in the body before they are absorbed into the body on the other hand, to bring the calories into the body.

With a one-hour consumption of ingibitoriv APFs and refineries, the risk of development of the deterioration of the function of the oil refinery is increased; Ridko sposterіgaєtsya hyperkalієmiya.

With a one-hour stagnation with "loop" diuretics and thiazides, arterial hypotension may be affected, especially if you take the first dose of a diuretic, mabut, for a hypovolemic shock, which can lead to transient mitigation. Є Risik development of hypocalypse. Pidvischennya risiku the development of porushennya funktsii nirok.

With a one-hour zasosuvannі from zasoba for anesthesia can be severe arterial hypotension.

With a one-hour consumption of azathioprine, there is a potential development of anemia, which is increased due to the increase in the activity of eritropoietin with the addition of ingibitoriv APF and azatioprine. Descriptions of the development of leukopenia, which can be tied to the additive functions of the cystic brain.

With a one-hour consumption of alopurinol, the development of hematologic depressions will develop; describe the development of important responsiveness reactions, including Stevens-Johnson syndrome.

With a one-hour consumption of aluminum hydroxide, magnesium hydroxide, magnesium carbonate, the bioavailability of captopril changes.

Acetylsalicylic acid at high doses can change the antihypertensive dose of captopril. There is no residual, altering acetylsalicylic acid the therapeutic efficacy of ACE ingibitors in patients with IXC and heart failure. The nature of the process of intercourse is to lay it down as a result of getting overwhelmed. Acetylsalicylic acid, attracting COX and synthesis of prostaglandins, can lead to vasoconstriction, which can lead to a decrease in the heart wickedness and the loss of heart disease in patients with heart deficiency.

Є Whenever there is an increase in the concentration of digoxin in the blood plasma with a one-hour intake of captopril with digoxin. Rizik to the development of likarsky interrelationships among children with impaired functions of nirok.

With a one-hour consumption of endometacin, ibuprofen, the antihypertensive effect of captopril, mabut, in the case of an injection at the refinery injected into the synthesis of prostaglandins (such as,

With a one-hour stagnation with insulin, hypoglycemic diseases, obsolete sulfonyls, there is a possible development of hypoglycemia for the development of tolerance to glucose.

With a one-hour consumption of ACE іngіbіtorіv і interleukinu-3, the development of arterial hypotensiveness is inevitable.

With a one-hour consumption of interferon alfa-2a and interferon beta, the development of important granulocytopenia is described.

During the transition from taking clonidine to captopril, the antihypertensiveness of the rest develops step by step. At the time of the rapid response to the clonidine in the patients, who can get rid of the captopril, it is possible to increase the arterial grip.

With a one-hour consumption of carbonate lithium, the concentration of lithium in the blood is increased, and symptoms of intoxication are observed.

With a one-hour consumption of minoxidil, sodium nitroprusside, an antihypertensive action will take place.

With a one-hour stagnation with orlistat, there can be a change in the efficiency of captopril, which can lead to an increase in the arterial vise, hypertensive crisis, and descriptions of bleeding into the brain.

With a one-hour antihypertensive effect, the antihypertensive effect is more potent than pergolide.

With a one-hour consumption of probenecid, the nirkovy clearence of captopril changes.

With a one-hour zasosuvannі z procaїnamіdom you can increase the risk of development of leukopenia.

With a one-hour consumption of trimethoprim, the development of hypercritical growth, especially in patients with impaired function of nirok.

With a one-hour consumption of chlorpromazine, the development of orthostatic hypotension occurs.

With a one-hour consumption of cyclosporine, the development of a hostile deficiency, oliguria appears.

Vvazhayut, there is a possibility of a change in the effectiveness of antihypertensive disorders with a one-hour consumption of eritropoietins.

Pobichna diya

On the side of the central nervous system and peripheral nervous system: zamorochennya, headache, vomiting, asthenia, paresthesia.

On the side of the heart-vascular system: hypotension is orthostatic; Ridko - tachycardia.

On the side of the herbal system: nudota, decreased appetite, loss of relish views; Ridko - abdominal pain, diarrhea or constipation, increased activity of liver transaminases, hypertension; signs of hepatocellular disease (hepatitis); in okremikh vipadk - cholestasis; in some cases - pancreatitis.

On the side of the hematopoietic system: rarely - neutropenia, anemia, thrombocytopenia; even more rarely in patients with autoimmune illnesses - agranulocytosis.

On the side, I will exchange the words: hypercalcium, acidosis.

On the side of the secular system: proteinuria, impairment of the function of nirok (increasing the concentration of sevidin and creatine in the blood).

On the side of the respiratory system: dry cough.

Allergic reactions: shkirny visip; Ridko - Quinke's quagmire, bronchospasm, syrovatkov's ailment, lymphoadenopathy; in okremikh vipadkah - the appearance of antinuclear antibodies in the blood.

showing

Arterial hypertension (including renovascular), chronic heart failure (in the warehouse of combined therapy), impairment of the function of the lymph node after suffering from myocardial infarction in patients who are stable in patients Diabetic nephropathy in case of type 1 diabetes mellitus (with albuminuria more than 30 mg / dob).

Prototype

Viability, period of lactation, up to 18 years, sensitivity to captopril and other angibitors of ACE has been increased.

special features

Stagnation during vaginosis and breastfeeding

Slid the mother on uvaz, so that captopril is consumed in the II and III trimesters of vaginosity, it is possible to suffer a deterioration in the development and bend of the fetus. When the vaginosity of the captopril is established, it is safe to skasuvati.

Captopril is seen in breast milk. If necessary, during the period of lactation, follow up on the nutritional status of breastfeeding.

Stagnation in case of deterioration of the function of the liver

With the protection of stasis in case of pechinkal deficiency.

Zasosuvannya in case of destructive functions of nirok

Taking care of the stasis in the case of transplantation of nirok, nirkova deficiencies.

When the functions are damaged, I will add a dose of slid change.

A slid of a unique one-hour consumption of blood-thinning diuretics and drugs for calories in patients with a severe deficiency.

Zasosuvannya in children

Prototype indications for up to 18 years. Stagnation of captopril in children is only possible due to the difference in effectiveness of other drugs.

Stagnation in lithuanian children

To protect the children of the kidnapped child.

special requests

With the protection of patients with anamnesis in history of angioedema, cerebral arthroplasia on the therapy of angioedematous angiotensin fever, subdued or idiopathic angioedema, with aortic stenosis, cerebrovascular disease congestion with full tissue (including VKV, scleroderma), with a lack of cystic fibrosis, with diabetes mellitus, hyperkalemia, bilateral stenosis of neural arteries, stenosis of arteries from obmezhennya sod, stanah, who are supervised to reduce the BCC (including in case of diarrhea, bloating), in patients of a kidnapped vik.

In patients with chronic heart failure, captopril stasis under sawing medical control.

As a result of an hour of surgical intervention, arterial hypotensiveness on the background of the received captopril is absorbed by the memory of a person.

A slid of a unique one-hour stagnation of blood-thinning diuretics and drugs in calories, especially in patients with a severe deficiency and diabetic diabetes.

When taking captopril, a hypopositive reaction can be promoted during the analysis of the slaughter for acetone.

Stagnation of captopril in children is only possible due to the difference in effectiveness of other drugs.

Inflow to the building of keruvati by transport means and mechanisms

It is necessary to protect with keruvannas by transport means, as well as for the visibility of the robots, which require additional respect, for that it can be fouled up, especially if you send captopril on the cob.

Vipusku form

pills

warehouse

1 tablet to revenge: Speech is active: captopril 25 mg.

pharmacological effect

Antihypertensive disease, ACE inhibitor. Mechanism of antihypertensive dressing with competitive antihypertensive activity of ACE, to reduce the efficiency of converting angiotensin I into angiotensin II (which can increase the pressure of the alimentary sequester) In addition, captopril, mabut, is injected onto the kinin-kallikrein system, overshooting the drop to bradikinin. The hypotensive effect does not lie in the activity of renin plasmas, a decrease in the arterial clutch in a normal condition and a decrease in the concentration of the hormone, which is poured into the tissue of the RAAS. Zbіlshu coronary і nircovy blood flow. Thanks to the vascular dilatation, changes in the OPSS (postnavantage), the grip of wedging in the legene capillaries (anterior vantage) and opir in the legene vaults; advancing the healthiness of the heart and tolerance to the new option. With a trivial stagnation change, the swelling of the myocardium hypertrophy of the lone duck, the progression of the heart failure and the promising development of the dilatation of the duck. A decrease in the amount of sodium in children with chronic heart failure. Expanding the artery of a larger world, lower veni. I will paint the blood circulation of the ischemic myocardium. Reduces the aggregation of thrombocytes. Reduces the tone of the grape arterioles of the glomeruli of nirok, reddening the inner glomerular hemodynamics, and changing the development of diabetic nephropathy.

Pharmacokinetics

If the reception is not less than 75%, it gets wet from the shlunkovo-intestinal tract. One-hour reception of їzhі changes in moisture by 30-40%. Cmax in blood plasma is reached after 30-90 min. The link with the bottles, over the important with the albumin, become 25-30%. Seeing with breast milk. It is metabolized in the furnaces with the formulations of the disulfide dimer of captopril and captopril-cisteindisulfide. Metabolites are pharmacologically inactive. T1 / 2 become less than 3 years old and increase with normal deficiency (3.5-32 hours). It should be 95% vivodit nirkami, 40-50% in the uncontested viglyad, and the insha part - in viglyad metabolites.

showing

Arterial hypertension (including renovascular), chronic heart failure (in the warehouse of combined therapy), impairment of the function of the lymph node after suffering from myocardial infarction in patients who are stable in patients Diabetic nephropathy in case of type 1 diabetes mellitus (with albuminuria more than 30 mg / dob).

Prototype

Viability, period of lactation, up to 18 years, sensitivity to captopril and other angibitors of ACE has been increased.

Zapobizhnі come in

In perіod lіkuvannya mozhlive zagostrennya psorіaza.Prі pheochromocytoma propranolol mozhna zastosovuvati tіlki pіslya priyah alpha adrenoblokatora.Posle trivalogo rate lіkuvannya propranolol slіd vіdmіnyati postupovo, pid perspicuity vracha.Na tlі lіkuvannya propranolol slіd Unikat / introduction verapamіlu, dіltіazema.Za kіlka before dnіv For anesthesia, it is necessary to prescribe with propranolol, or give an anesthesia with a minimal negative inotropic effect. Influencing the health of keruvati by transport means and managing the mechanisms of the patients, the efficiency of those who are responsible for the provision of propranolol on an outpatient basis, after seeing the children on the basis of educational reactions

Stagnation during vaginosis and breastfeeding

Slid the mother on uvaz, so that captopril is consumed in the II and III trimesters of vaginosity, it is possible to suffer a deterioration in the development and bend of the fetus. When vaginosis arises, captopril should be safely canceled. Captopril is seen in breast milk. If necessary, during the period of lactation, follow up on the nutritional status of breastfeeding.

How to store that dosi

When taking a dose, the dose is 6.25-12.5 mg 2-3 times / dob. In case of insufficient effect, the dose is gradually increased to 25-50 mg 3 times / dob. In case of functional impairment, the dose should be reduced. The maximum dose should be 150 mg.

Pobichna diya

On the side of the central nervous system and peripheral nervous system: hypothermia, headache, vomiting, asthenia, paresthesia. On the side of the cardiovascular system: orthostatic hypotension; Ridko - tachycardia. On the side of the herbal system: nudota, decreased appetite, loss of savory visions; Ridko - abdominal pain, diarrhea or constipation, increased activity of liver transaminases, hypertension; signs of hepatocellular disease (hepatitis); in okremikh vipadk - cholestasis; in single vipads - pancreatitis. On the side of the hematopoietic system: rarely - neutropenia, anemia, thrombocytopenia; duzhe rіdko in patsієntіv of autoіmunnimi zahvoryuvannyami - agranulotsіtoz.So side obmіnu rechovin: gіperkalієmіya, atsіdoz.So side sechovidіlnoї system: proteїnurіya, torn down funktsії nirok (pіdvischennya kontsentratsії sechovini i kreatinіnu krovі in) W side dihalnoї system: Sukhiy kashel.Allergіcheskіe reaktsії: shkіrny visip; Ridko - Quinke's quagmire, bronchospasm, syrovatkov's ailment, lymphoadenopathy; in okremikh vipadkah - the appearance of antinuclear antibodies in the blood.

Interaction with other drugs

When odnochasnomu zastosuvannі of іmunodepresantami, cytostatics pіdvischuєtsya rizik rozvitku leykopenіі.Prі odnochasnomu zastosuvannі of kalіyzberіgayuchimidіuretikami (including spironolactone, triamterene, amіloridom) kalіyu drugs, dietary supplements zamіnnikami solі i to їzhі scho mіstyat kalіy, mozhlivy rozvitok gіperkalієmії (y osoblivo patsієntіv of funktsії nirok torn down), to scho іngіbіtori ACE zmenshuyut vmіst aldosterone scho generally produces up zatrimki kalіyu in organіzmі on tlі obmezhennya vivedennya kalіyu abo yogo dodatkovogo nadhodzhennya in organіzm.Prі odnochasnomu zastosuvannі іngіbіtorіv ACE i NPZZ pіdvischuєtsya rizik rozvitku funktsії nirok torn down; Hyperkaliemia is apt to develop rapidly. Є Risik development of hypocalypse. Increased risk of development of impaired kidney function. Descriptions of the development of leukopenia, which can be tied to the additive functions of the cystic brain. Descriptions of the development of important reactions to sensitivities, including Stevens-Johnson syndrome. There is no residual, altering acetylsalicylic acid the therapeutic efficacy of ACE ingibitors in patients with IXC and heart failure. The nature of the process of intercourse is to lay it down as a result of getting overwhelmed. Atsetilsalіtsilova acid prignіchuyuchi COX i prostaglandinіv synthesis, Mauger viklikati vazokonstriktsіyu scho generally produces up zmenshennya Sertsevy vikidu i pogіrshennya will patsієntіv of Sertsevy nedostatnіstyu, SSMSC otrimuyut іngіbіtori APF.Іmeyutsya Notification about pіdvischennya kontsentratsії digoxin in plazmі krovі at odnochasnomu zastosuvannі captopril of digoxin. Rizik to the development of likarsky interrelationships among children with impaired functions of nirok. With a one-hour consumption of endometacin, ibuprofen, the antihypertensive effect of captopril, mabut, in the case of an injection at the refinery injected into the synthesis of prostaglandins (such as, When odnochasnomu zastosuvannі of іnsulіnami, gіpoglіkemіchnimi zasobami pohіdnimi sulfonіlsechovini mozhlivy rozvitok gіpoglіkemії for rakhunok pіdvischennya tolerantnostі to glyukoze.Prі odnochasnomu zastosuvannі іngіbіtorіv ACE i-3 іnterleykіnu іsnuє rizik rozvitku arterіalnoї gіpotenzіі.Prі odnochasnomu zastosuvannі of іnterferonom alpha 2a chi іnterferonom beta opisanі vipadki rozvitku vazhkoї granulocytopenia. During the transition from taking clonidine to captopril, antihypertensive drugs continue to develop in steps. In razі raptovoї vіdmіni klonіdinu in patsієntіv, SSMSC otrimuyut captopril, mozhlivo rіzke pіdvischennya AD.Prі odnochasnomu zastosuvannі lіtіyu carbonate zbіlshuєtsya kontsentratsіya lіtіyu in sirovattsі krovі scho suprovodzhuєtsya symptoms іntoksіkatsіі.Prі odnochasnomu zastosuvannі of mіnoksіdіlom, nitroprusside natrіyu posilyuєtsya antigіpertenzivny deystvіe.Prі odnochasnomu zastosuvannі h orlistat mozhlivo zmenshennya efektivnostі captopril, scho Mauger lead to pіdvischennya arterіalnogo vise gіpertonіchnogo crisis, descriptions vipadok krovovilivu in mozg.Prі odnochasnomu zastosuvannі іngіbіtorіv of ACE pergolіd mozhlive posilennya antigіpertenzivnogo effekta.Prі odnochasnomu zastosuvannі of probenecid zmenshuєtsya nirkovy klіrens kaptoprіla.Prі odnochasnomu zastosuvannі of prokaїnamіdom Possibility of promoting the development of leukopenia. In the case of an one-hour consumption of trimethoprim, the development of hyperkalinemia, especially in patients with impaired kidney function. Nika rhizik p osvitok orthostatic hypotensive. In the case of an overnight consumption of cyclosporine є depending on the development of a hostile deficiency, oliguria.

special requests

With the protection of patients with anamnesis in history of angioedema, cerebral arthroplasia on the therapy of angioedematous angiotensin fever, subdued or idiopathic angioedema, with aortic stenosis, cerebrovascular disease congestion with full tissue (including VKV, scleroderma), with a lack of cystic fibrosis, with diabetes mellitus, hyperkalemia, bilateral stenosis of neural arteries, stenosis of arteries s obmezhennya soda, stanah, who supervise lower blood volume (including with diarrhea, blues), in patients of elderly age. patsієntіv of hronіchnoyu Sertsevy nedostatnіstyu captopril zastosovuyut pid retelnim medichnim kontrolem.Voznіkayuschuyu pid hour hіrurgіchnogo vtruchannya arterіalna gіpotenzіya on fonі Priya captopril and usuvayut zapovnennyam obsyagu zhіdkostі.Sleduet Unikat odnochasnogo zastosuvannya kalіyzberіgayuchih dіuretikіv that preparatіv kalіyu, Especially in patsієntіv of nirkovoyu nedostatnіstyu i tsukrovim dіabetom.Prі priyomі captopril Mauger sposterіgatisya hibnopozitivna reaktsіya at analіzі sechі on atseton.Prіmenenіe captopril in dіtey mozhlivo tіlki in razі neefektivnostі іnshih preparatіv .Vlіyanіe on zdatnіst keruvati transport zasobami that upravlіnnya mehanіzmamіNeobhodіma oberezhnіst at keruvannі transport zasobami abo vikonannі іnshoї robots scho potrebuє pіdvischenoї uwagi, to scho Mozhylo zapamorochennya, especially when the cob dose of captopril.

Instructions for the preparation of Captopril 25
Buy Captopril 25 TB 25mg
lykarski formi

tablets 25mg
Virobniks
Geksal / Salyutas Pharma (Nimechchina)
Group
Antihypertensive - ingibitories of angiotensin converting enzyme
warehouse
Diyucha Rechovina - Captopril.
International non-patented name
captopril
Sinonymi
Angiopril-25, Blokordil, Vero-Captopril, Capocard, Capoten, Capto, Captopril, Captopril Sandoz, Captopril Herd International, Captopril-Akos, Captopril-Acri, Captopril-Biosynthesis, Captopril-NI-S, Captopril-N_S. STI, Captopril-Ferein, Captopril-FPO, Katopil, Rilkapton, Tenziomin
Pharmacological diya
Hypotensive, sudinosilicidal, cardioprotective, natriyuretic. It triggers ACE, converting angiotensin I to angiotensin II and converting endogenous vasodilators. The hypotensive effect manifests itself in 15-60 minutes after oral administration, reaching a maximum in 60-90 minutes and in 6-12 years. Zmenshu OPSS, before - and postnavantazhennya on the heart, a vice in a small number і opіr sudin legends, zbіlshu heart wikid (heart rate does not change). Viyavlyak cardioprotective diyu. Shvidko and get wet from the shlunkovo-intestinal tract. Sublingual victoriousness will reduce the availability and quickening of the ear of a child. Pass through the gistogematic bar'єri, vklyuchuyu hematoencephalic bar'єr, through the placenta and penetrate into breast milk. The period of time is 2-3 years. Excreted in the main nirkami.
Shown to sucking
Arterial hypertension (mono- and combined therapy), congestive heart failure, cardiomyopathy, impairment of the function of the little one in case of a stable stagnation in patients with unhealthy myocardial infarction,
Prototype
Hypersensitivity, the presence of anamnestic evidence about the development of Kvinke in case of anterior signs of ACE inflammation, a decrease or even an idiopathic increase in Quinke, primary hyperaldosteronism, vaginal hypertension, vaginal hypertension Obmezhennya to stasosuvannya: Assessment of spivvidnoshennya rhizik-acridity is necessary in the onset of the disease: leukopenia, thrombocytopenia, aortic stenosis or else. Obstructive changes that make it difficult to see blood from the heart; hypertrophic cardiomyopathy with low heart wikidum; turns of destructive functions of nirok; bilateral stenosis of the nirkovy arteries or stenosis of the artery of the single nirka; the appearance of transplanted nirka; hypercalm; childish vіk.
Pobichna diya
On the side of the nervous system that organs are sensitive: stamina, malnutrition, headache, impairment of the central nervous system, drowsiness, confusion of fatigue, depression, ataxia, judgments, problems with malignancies. On the side of the heart-vascular system and blood (blood formation, hemostasis): hypotension, incl. orthostatic, angina pectoris, myocardial infarction, impaired heart rhythm (atrial tachy-abo bradycardia, blinking arrhythmia), Sercebitty, state of cerebral blood circulation, peripheral embryos, lymphadenopathy, anemia, bile in breast cancer, thromboembolism legendary artery, Neutropenia, agranulocytosis (in ailments with impaired function of nirok, on aphids), thrombocytopenia, eosinophilia. Three sides respiratory system: Bronchospasm, retardation, interstitial pneumonitis, bronchitis, unproductive dry cough. On the side of the organs in the slunk-intestinal tract: anorexia, loss of relish, stomatitis, anorexia of the mucous membrane of an empty company and slunk, xerostomia, glosses, difficulty in copulation, nudity, bloating, abdominal dyspepsia, meteorosis, flatulence liver (cholestasis, cholestatic hepatitis, hepatocellular necrosis). Three sides sectional system: Damaged functions of nirok, oliguria, proteinuria, empowerment. On the side of shkіrnykh pokrivіv: pochvonіnnya shkіri accusation, visip, sverbіzh, exfoliative dermatitis, toxic epidermal necrolysis, pemphigus, operitic lichen, alopecia, photodermatitis. Allergic reactions: Stevens-Johnson syndrome, kropivyanka, Kvinke's boil, anaphylactic shock, etc. Іnshі: temperature increase, chills, sepsis, arthralgia, hypercalemia, hynecomastia, synovial fever, increase in the blood of liver enzymes, nitrogen of the nucleus test, antigenic acid reaction
vzaєmodiya
Potential hypoglycemic effect of oral contraceptive drugs, as much as possible hypotensive effect of anesthetic drugs. Zmenshu secondary hyperaldosteronism and hypocalypse, caused by diuretics. Increases concentration of lithium and digoxin in plasma. Effectively hypotensive problems, including beta-blockers, incl. with systemic wetting from ophthalmologic lykarsky forms, diuretic, Clonidin, narcotic analgesics, antipsychotic drugs, alcohol, indolent - estrogen, non-steroidal anti-inflammatory drugs, sympathomimetics, antacids. Calaisberic diuretics, cyclosporine, potassium-containing lykarski zasobiі additives, substitutes for salt, milk with low content of salts, increase the risk of development of hyperkaliєmi. Drugs that adjust the function of the cystic brain (immunodepression, cytostatics and / or alopurinol), promote the development of neutropenia and / or agranulocytosis with a lethal end. Alcohol stimulates the central nervous system. Probenecid is reliant on vivedennya captopril with a cross section.
Overdose
Symptoms: arterial hypertension, cerebral blood circulation impairment, myocardial infarction, thromboembolism, angioedema. Likuvannya: a change in the dose, or more on the basis of the drug; washing the slunk, transferring the sick person to horizontal position, Carrying out visits to improve the BCC (introduction of an isotonic sodium chloride solution, transfusion of blood cells), symptomatic therapy: Adrenaline (n / a abo i / v), antihistamines, hydrocortisone (i / v). Carrying out hemodialysis, if necessary, setting up a piece of rhythm.
special requests
Lykuvannya is carried out under regular lykarsky control. During the hour of therapy, it is necessary to monitor the arterial grip, pictures of peripheral blood, blood sugar, calories in plasma, nitrogen, creatine, function of nirok, mass, life. With the development of hyponatrium, dehydration, it is necessary to correct the dosage regimen. Safety is necessary when carrying out prompt engagement(Including stomatologic), especially in case of vicious anesthetics, hypotensive effect. Recommended viklyuchiti vzhivannya alcoholic beverages pid hour of love. With the protection of storage for an hour, the robots are driven by transport workers and people, the profession of which is tied to the increased concentration of respect. If you miss a dose, you will add a dose. When a test for acetonuria is carried out, a possible positive result.
Umovi zberigannya
At temperatures of 15-25 C.