Vilprafen 250 Instructions for storing. Vilprafen (instruction, storage, analogs, supplementation, diya, secondary effects, indications, prototypes)

* At the moment of theoretical activity 951 MO / mg.

Antibacterial drug from the macrolide group. Mechanism of dressing for the destruction of the synthesis of bile in microbial cells in the case of reverse linkage for 5 0S -subodities of ribosomy. In therapeutic concentrations, as a rule, there is little bacteriostatic effect, they develop and multiply bacteria. When the vognisch is set, it has a high concentration of bactericidal efficacy.

Josamicin is active in the presence of gram-positive bacteria (Staphylococcus spp., incl. Meticillin-sensitive plugsStaphylococcus aureus, Streptococcus spp., incl. Streptococcus pyogenesі Streptococcus pneumoniae, Corynebacterium diphtheriae, Listeria monocytogenes, Propionibacterium acnes, Bacillus anthracis, Clostridium spp., Peptococcus spp., Peptostreptococcus spp.), gram of natural bacteria( Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Bordetella spp., Brucella spp .. Legionella spp., Haemophilus ducreyi, Haemophilus influenzae, Helicobacter pylori, Campylobacter jejuni), sensitivenessBacteroides fragiliscan be variable,Chlamydia spp., incl. C. trachomatis, Chlamydophila spp., incl. Chlamydophila pneumoniae(Previously calledChlamydia pneumoniae), Mycoplasma spp., incl. Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma spp., Treponema pallidum, Borrelia burgdorferi. As a rule, it is not active, apparently enterobacteria, so it infuses slightly into the microflora shlunkovo-intestinal tract... In a number of vipads, the activity in the resistance to erithromycin and other 14- and 15-membered macrolides (streptococci, staphylococci) is observed. Resistance to Josamicine grows up, down to 14 and 15-membered macrolides.

If you get it all the way, you can easily get wet from the shlunkov-intestinal tract, but it doesn’t flow into the bioavailability. The maximum concentration of josamycin in plasma is reached after 1 year after receiving. When taken in a dose of 1 g, the maximum concentration in blood plasma becomes 2-3 μg / ml. Nearly 15% of josamycin is bound to plasma proteins. good growth in organs and tissues (behind a vignette to the brain), flammable concentration, how to transplant plasma and save for a therapeutic period of trivial hour.

Particularly high concentration of valves in the lungs, mydalins, sleepless, sweaty and lacrimal lines. Concentration in sputum changes in plasma concentration in 8-9 times. Pass the placental bar'єr, secretion in breast milk. Metabolize in the liver to the lowest active metabolites and become the head rank in the mouth. The period for which the drug is administered is 1-2 years, however, it can be podovzhuvatisya in patients with damaged liver function. Excretion to the drug with nirkami does not change 10%.

Infectious and igneous illnesses, microorganisms sensitive to Dzhozamitsin:

- Infectious diseases of the upper dysfunctional nobility and ENT organs:

tonsillitis, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis, diphtheria (as augmented with diphtheria toxoid), scarlet fever (as an alternative to beta-lactam antibiotics, mutely)

- Infections of the lower dichally nobles:

gostry bronchitis, aggravated chronic bronchitis, Posal carnial pneumonia, Whooping cough, psittacosis.

- Infections of children and soft fabrics:

foliculitis, furuncle, furunculosis, abscess, Siberian fever, erysipelas, acne, lymphangitis, lymphadenitis, phlegmon, panaritus, early (including hypooperative) and diagnostics.

- Infections of the empty company:

gingivitis, pericoronitis, periodontitis, alveolitis, alveolar abscess.

Eye infections:

blepharitis, dacryocystitis.

- Infections of the Sechostatic System:

non-gonococcal infections of the urogenital tract (including urethritis, cervicitis, epididymitis, prostatitis, chlamydia and / or microplasmas, syphilis (with hypertension to penicillin),

- Indigestion of the slunk-intestinal tract, association with N. pylori:

Virazkov's ailment slunk і twelve-fingered intestines, chronic gastritis that in.

- ebastin,

- agony of dopamine receptors :, lisuride, pergolide,

- triazolam,

- halofantrine,

- disopiramid,

- tacrolimus,

- terfenadine і (div. razdіl "Vzaєmodіya s іnshih lіkarsky drugs").

It is necessary to take care of the alcohol intake of josamycin with the next drugs :, indirect anticoagulants ,.

Unimportant to those who are given a lykarska form, it is intended for children, below it is indicated about the consumption of josamycin during the period of pregnancy and breastfeeding.

availability

Stagnation of the drug for an hour of vaginosity is possible in the same way that the cinnamon is transferred to the mother, I change the potential for the fetus. The need for the drug to be consumed during the period of vaginosity is guilty but assessed by the drug. Between the clinics, be careful to inform about those who do not take josamycin for an hour to increase the frequency of uncomfortable inheritances of vaginosity and are not tied to children in specific situations. No teratogenic and fetotoxic effects of josamycin have been revealed in preclinical preliminaries.

lactation

It has been established that macrolides are secreted from mother's milk, moreover, the concentration of the drug in the young, or even changing the concentration in the blood plasma. The main thing is not safe polyagaє in the preparation for the intestinal microflora of the child. Thus, taking the drug Vilprafen® is indicated for breastfeeding. The need for the drug to be consumed during the lactation period is guilty but assessed by the drug. When a child is diagnosed with dislocations from the side of the intestinal tract (diarrhea, candidiasis of the mucous membrane mouthwash), breast year bath slid pinch (or pinch with lykarsky drug). In case of a recognized cisapride of a neonatal genital, or for children of breastfeeding, they are treated with natural vigor, taking macrolide in the mother of contraindications throughPotential risk of interaction of the preparation, not safe development of the slurry tachycardia type "feasts" in the child.

dosage regimen

The drug Vilprafen® is dispensed in decilkoh lykarsky forms and dosages. Likarska form "granules for preparing a suspension for receiving vseredin" is specially designed for children in 3 doses: 125 mg / 5 ml, 250 mg / 5 ml and 500 mg / 5 ml.

At the same time with the drug in the kit, there is a special syringe with pods and mitts, like vases of children. The Danish syringe is used for accurate dosing and reception of the prepared suspension in the middle.

Recommended dobova dose josamycin 50 mg / kg vaginna buty is divided into 2 doses: 25 mg / kg vrance and 25 mg / kg in the evening, does not overtake a dose of 1 g in case of skin priyomy. 5-7 days.

In case of missing a drug reception, it is not necessary to take a sub-dose of the drug.

preparation of suspension

(1) do it well instead of the bottle

(2) Dodati chilled boiled water to a circular riziki

(3) Shake and stand with a stretch of dumplings in order to look good.

(4) Add the water (if necessary) to the circular shape on the bottle, so that the guilt is always known to be over the whole mite

(5) Before filling, I am ready to prepare a suspension

drug administration

(1) Place a syringe with grates near the bottle, so I’m ready to replace the suspension

(2) Collect the suspension from the syringe by tightening the syringe plunger to the mite, like a vase of the child

(3) Pislya vikoristannya promiti syringe with water

(4) Glue the syringe holder, attachments to the package, on one side of the bottle, from the applied information (bazhano)

(5) Pislya vicoristannya put a syringe in trimach on a bottle

Dozing the drug to deposit form masi tila ditini:

The drug Vilprafen® in a dose of 125 mg / 5 ml for children with a weight of 2-5 kg. A syringe should be added to the preparation with application of pads from 2 to 5 kg. One portion of this syringe is for 0.5 kg vase and a dose of the drug Vilprafen * 12.5 mg per 1 kg of vagi.

The drug Vilprafen® in a dose of 250 mg / 5 ml for children with a weight of 5-10 kg. A syringe is added to the preparation with application of pads from 2 to 10 kg. One portion of this syringe is for 1 kg of vase and a dose of 25 mg of Vilprafen® per 1 kg of vagi.

The drug Vilprafen® in a dose of 500 mg / 5 ml for children with a weight of 10-40 kg. A syringe with the application of pads from 2 to 20 kg should be added to the preparation. One portion of the given syringe is suitable for 1 kg of vase and a dose of 50 mg of Vilprafen per 1 kg of vagi.

It is necessary to depend strictly on the limitation of the dosage designated by the doctor. If there is evidence of the correctness of the determination, then consult a doctor.

The drug Vilprafen® is used in the middle of the suspension form, so it can be prepared without the middle before the suspension.

Collect a syringe with a suspension of a suspension, a type of vase of a child, take the dose of the drug for one dose.

Apply dosage of suspension:

For a child wagoyu 4 kg slid vikoristovuvati drug Vilprafen® in a dose of 125 mg / 5 ml with a syringe "2-5 kg". At one stroke, fill with the given syringe the suspension up to a mint "4 kg".

For a child wagoyu 6 kg slid vikoristovuvati drug Vilprafen® in a dose of 250 mg / 5 ml with a syringe "2-10 kg". At one stroke, fill with the given syringe the suspension up to "6 kg".

For a child Vagoyu 15 kg slid vikoristovuvati drug Vilprafen® in a dose of 500 mg / 5 ml with a syringe "2-20 kg". At one stroke, fill with the given syringe the suspension up to "15 kg". As soon as the child is changing the vagu, instructions on the syringe rosettes, take the necessary suspension of the suspension in two times. For example, for a child of 30 kg, pick up a suspension from a syringe "2-20 kg" from a syringe to a "20 kg" mint, then to a "10 kg" mint.

When the bottle opens and the suspension is prepared, the term of the suspension at room temperature is set to 7 days.

Be respectful! The dosing syringe is viciously used for oral administration of the suspension to the drug Vilprafen® and is not guilty of being used for dosing the drug. lykarsky zasobu.

Ns pick up the suspension for the dosage and administration of the suspension to the Vilprafen® preparation (syringe, spoon, pipette from the preparation), crim this special syringe, for a specific dosage (to be supplied with the preparation).

Damage from the side of the shlunkovo-intestinal tract:

Nudity, bloating, abdominal pain, diarrhea, pseudomembranous colitis, shlunnu, stomatitis, constipation.

Destruction from the side of the shkiri and the pedigree klitkovini:

Erythematous maculopapulosis visceralis, multiforme erythema, bullosa dermatitis, Stevens-Johnson syndrome, Lyell's syndrome.

Damage from the side of the immune system:

Hypersensitivity reactions in viglyad strong compassion, Kropiv'yanki, nabryak denouncing, nabryak Kvinke (angioeurotic), complication of dichotomy, anaphylactic reactions and anaphylactic shock;

Syrovatkov's ailment.

Damage from the side of the liver and zhovchivіdnyh shlakhіv:

Adjustment of activity of transaminases and puddle phosphatase, zhovtyanitsya, cholestatic abocytolytic hepatitis.

Destruction from the side court system:

Purpura, shkirny vasculitis.

Rozladi obmіnu rechovins і destructed food:

Decreased appetite.

If there are any different reactions, as well as reactions that are not specified in the instructions, it is necessary to return to the license.

Until now, there is no information about the specific symptoms of overdose. In case of an overdose of subsequent allowances for the diagnosis of symptoms, described in the section " Pobichna diya", Especially from the side of the intestinal tract (zokrema, nudota, diarrhea).

Likuvannya: in case of an overdose of slides, the drug from the intestinal tract is not absorbed active vugillaі ін.) і to carry out symptomatic therapy.

The stagnation of such drugs in a spile from josamicin is contraindicated in connection with the possibility of development of serious side effects:

- Ergotamin, digidroergotamin

As a result of the interaction of the swollen ringing of the sudin (ergotism) with the possible development of the necrosis of the kidneys (through the induction of the liver metabolism and the elimination of alkaloids).

- Cisapride, pimozide

As a result of the interaction, there is a rise in the development of life-threatening arrhythmias, including the type of mucus tachycardia "feasting".

- ivabradin

As a result of the interaction, the concentration of ivabradine in the blood plasma and associated with it side effects (through the induction of liver metabolism of ivabradine) is increased.

- colchicine

The result of the interaction is the promotion of the risk of vicious damage to the colchicine, including potentially fatal ones.

It is not recommended to prescribe such drugs in spile with josamicin:

- ebastin

Advancing the risk of life-threatening arrhythmias in patients with congenital podderzhny syndrome QT.

- Agony of dopamine receptors (, lizuride, pergolide)

Adjustment of concentration of agonists of dopamine receptors in blood plasma with potential improvement of their activity, appearance of symptoms of overdose.

- triazolam

Kilka vipadkіv to be able to overcome the side effects of triazolam (behavior patterns).

- halofantrine

Pidvischennya to rhizik of mucus arrhythmias, including mucous tachycardia type "feasts" (" torsades de pointes If possible, follow the decision on the intake of josamycin. QT and EKG.

- disopiramid

Advancing the development of side effects in the disopiracy: important hypoglycemia,increase of triviality to interval QT and life-threatening arrhythmias, including the mucus tachycardia type "feasts". Necessary monitoring of clinical and laboratory data, as well as regular monitoring of the EHC.

- tacrolimus

Increasing the concentration of tacrolimus and creatine in blood plasma as a result of the ingestion of the metabolism of tacrolimus in the liver.

- Terfenadine i astemizole

Before an hour of spinal consumption of josamycin and antihistamines, to take revenge on terfenadine or else, you can improve the development of life-threatening arrhythmias.

Stasis of such drugs in a spile from josamicin in order to preserve:

- carbamazepin

An increase in the concentration of carbamazepine in blood plasma and the development of symptoms of overdose is possible due to the reduction of liver metabolism. It is recommended to monitor the patient's patient and the concentration of carbamazepin in the blood plasma. A decrease in the dose of carbamazepin may be known.

- cyclosporine

The allegory of josamycin and cyclosporin can be reduced to the level of cyclosporine and creatine in blood plasma and increased risk of nephrotoxicity. Slid regularly monitored the concentration of cyclosporine in the blood plasma and the function of nirok. The dose of cyclosporine is guilty but was scored for the hour of alcohol consumption with josamycin, as well as for the administration of josamycin.

- Indirect anticoagulants

You can improve the effect of anticoagulants in the indirect way, and increase the risk of developing bleeding.

Necessary part of the control of the international normalized business (INR). There may be a need for a change in the dose of anticoagulants in the indirect period before the hour of consuming josamycin, and also, in some cases, for a dose of josamycin.

- sildenafil

You can increase the concentration of sildenafil in blood plasma, increasing the risk of hypotension. If there is a need for a social welfare provider, it is recommended toTake the lowest dose of sildenafil.

- Teofilin i aminofilin

There is also a slight increase in care in case of alcohol intake of josamycin with theophylline or aminophylline, that is, there is a significant increase in the concentration of theophylline in blood plasma, especially in children.

- digoxin

With a spinal sign of josamycin and digoxin, it is possible to increase the level of remaining in the blood plasma.

- іnshі antibacterial drugs

Oskilki bacteriostatic antibioticsin vitroYou can change antimicrobial antibiotics for bactericidal antibiotics, їх one-hour storing of antibiotics. do not go overnight with linkosamids in conjunction with any possible changes in efficiency.

When practically all antibacterial diseases are present, including the description of the development of pseudomembranous colitis, which can become a threat to life. Possibility of the examination of this non-prescriptive manifestation follows the mother on the respect of the children from the background on the background, or the reception of josamycin. Necessary retelny anamnesis, evidence of diarrhea, viclikanClostridium difficile, You can develop with a stretch of 2 months after the end of the course of antibiotic therapy. In case of diagnosis of pseudomembranous colitis, the drug should be taken and considered necessary. Lykarskі drugs, which іngіbyuyut intestinal peristalsis, in the given situation of contraindication.

Have sick people nirk deficiency therapy for josamicin is followed by urachuvannya of the results of general laboratory tests (ascertaining the endogenous creatinine clearance).

As soon as there is a possibility of cross-resistance to early antibiotics from a group of macrolides: microorganisms, stirs to spores for the chemical structure of antibiotics, you can resist until A Danish drug to take away sodium from a dose of less than 1 mmol per 5 ml of suspension (or a dose of 5 kg).

Private nutritional violation of the international normalized delivery (INR)

There is a numerical increase in the activity of indirect anticoagulants in patients taking antibiotics. Riziku factors є explicitness infectious disease(I supporter ignition process), Vіk і zagalny camp of the patient. At the connection with the cym it is easy to reach the essential value of the external factors - infectious disease or antibiotics, which is used for therapy, in the range of the INR value. Protect, the next step is powerful in a number of antimicrobial agents: fluorohinoloniv, macrolidiv,tetracycline, co-trimoxazole and cephalosporins.

In this lykarsky drug Methyl parahydroxybenzoate and propyl parahydroxybenzoate, which can be susceptible to allergic reactions (the most favorable type).

It was not noted that the drug was added to the health of the keruvati by transport means and by means of mechanisms.

Granules for preparing suspensions for receiving vseredin 125 mg / 5 ml, 250 mg / 5 ml і 500 mg / 5 ml.

Dose 125 mg / 5 ml і 250 mg / 5 ml:

15 g of granules in a bottle-free bottle are mixed with 100 ml with a 60 ml circular line and screwed with a plastic screw with a ring with the control of the first opening and a polyethylene stop valve.

Dose 500 mg / 5 ml:

20 g of granules in a bottle-free bottle should be put in 100 ml with a 60 ml circular line and screwed with a plastic screw with a ring to control the first opening and a polyethylene stop valve.

1 bottle at a time from the instructions from the filling and the plastic dosing syringe with the trimach for the syringe put into a cardboard box.

Take at a temperature of 25 ° C.

Take a suspension at room temperature.

Zberigati out of the reach of children.

3 rock. Do not go back to the end of the term of affinity indicated on the package. The term of the suspension is 7 days from the moment of preparation.

Vilprafen Solutab is an antibiotic-macrolide.

Form vipusk and warehouse

Lykarska form Vilprafenu Solutab - tablets are dispersed: dovgastoy form, white or white with zhovtuvatiem color, with the writing "1000" on one side, with a risk and writing "IOSA" - on the smallest, with the smell of the floor for blisters, 2 blisters each in a cardboard box).

Warehouse 1 tablet:

• diyucha speech: josamycin (in viglyadі propionate) - 1000 mg;
• additional components: microcrystalline cellulose (564.53 mg), hyprolose (199.82 mg), midnight flavor (50.05 mg), magnesium stearate (34.92 mg), aspartame (10.09 mg), sodium docusate (10 , 02 mg), coloidal silicon dioxide (2.91 mg).

Pharmacological authorities

Pharmacodynamics

Active speech to Vilprafen Solutab - dzhozamitsin - antibacterial for a group of macrolides. Mechanism of the yogo process of building up the synthesis of the protein in the microbial cell of the reverse link with the 508-subunit of ribosome. When consumed in therapeutic doses, the drug is usually bacteriostatic, capable of multiplying and growing bacteria. In the case of the stem, in the presence of high concentrations, there may be a bactericidal effect.

Vіlprafen Soljutab activity vіdnosno such mіkroorganіzmіv: grampozitivnі bakterії (Staphylococcus spp, Vklyuchayuchi metitsilіn-chutlivі strains of Staphylococcus aureus, Propionibacterium acnes, Corynebacterium diphtheriae, Bacillus anthracis, Listeria monocytogenes, Streptococcus spp, i Vklyuchayuchi S. pyogenes S. Pneumoniae..), Gramnegativnі bakterії (Moraxella catarrhalis, Helicobacter pylori, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Haemophilus ducreyi, Brucella spp., Campylobacter jejuni, Legionella spp., Bordetella spp.), vnutrіshnoklіtinnі mіkroorganіzmi (Borrelia burgdorferi, Treponema pallidum, Ureaplasma spp., Chlamydia spp ., including C. trachomatis, Chlamydophila spp., including C. pneumoniae, Mycoplasma spp., including M. hominis, M. pneumoniae and M. Genitalium), deyaki anaerobi (Peptococcus spp., Clostridium spp., Bacteroides spprestilis, Pepptocopp. .).

Vilprafen Solyutab, as a rule, is not effective for enterobacteria, that is, to prevent infusion on the microflora of the intestinal tract.

In some types of josamycin, the activity is active in case of resistance to erithromycin and other 14 and 15-membered macrolides (staphylococcus, streptococcus). Stay up to Josamicine grows up, down to 14 and 15-membered macrolines.

Pharmacokinetics

For oral administration, the speech of Vilprafenu Solutab is actively absorbed from the intestinal tract. Yogo bioactivity does not lie in the reception of the yogi. Peak concentration in plasma, yak at a dose of 1000 mg becomes 2-3 mcg / ml, the drug is reached through 60 quiline.

Plasma proteins are linked to close to 15% josamycin. It is good to grow up in tissues and organs (behind a vignette to the brain), especially in legends, migdalics, slips, tears and poisons, which contain a concentration of plasma food (for porphyry - in sputum concentration in the preparation in 8-9 plasma), which takes a trivial hour to spend at a therapeutic level.

Josamicin penetrates the placental bar, seen in breast milk.

The drug is metabolized in the setting of the fewest active metabolites. Vivoditsya very importantly, in a small number (not more than 10%) it is hidden by nirkas. Period T 1/2 (napivvedennya) - 1-2 years, in case of deterioration of the furnace function, it can be changed.

Shown to sucking

According to the instructions, Vilprafen Solutab is recognized in case of vicious microorganisms, sensitive to Josamycin, of infectious-igniting diseases of the offensive systems and organs:

• shkirni pokrivi i m'yak_ fabric: Acne, panaritus, furunculosis, boil, phlegmon, Siberian virazka, abscess, foliculitis, madness, lymphadenitis, lymphadenitis, opikov and early (in t.
• sechostate system: epididymitis, cervicitis, prostatitis, urethritis, vicies with trash and / or mycoplasmas, venereal lymphogranuloma, gonorrhea, syphilis (in patients) with hypertension;
• empty mouth (stomatology): alveolitis, pericoronitis, periodontitis, gingivitis, alveolar abscess;
• LOP-organ and top dickheads: Laryngitis, sinusitis, tonsillitis, paratonsillitis, otitis media, pharyngitis, scarlet fever (in patients with hyperchymosis to penicillin), diphtheria (for an additional period before diphtheria toxoid therapy);
• lower dysfunctional paths: psittacosis, whooping cough, gostry bronchitis and acute inflammation of the chronic, post-carnial pneumonia (including viclikan with atypical fever);
• shlunkovo-intestinal tract (association with Helicobacter pylori infection): chronic gastritis, virazkov ailment of the shlunk, virazka 12-paloi intestine;
• organ zoru (ophthalmology): blepharitis, dacryocystitis.

Prototype

• important functional breakdown pechinki;
• tila mass in children less than 10 kg;
• sensitivity is adjusted to any additional component of the drug, josamicine or other macrolides.

Instructions on the preparation of Vilprafen Solutab: methods and methods of preparation

Dispersible tablets Vilprafen Solutab can be taken with a cilimi, washed down with a rinse, or, before taking it, they have been dispensed with water (not less than 20 ml) and separately dispersed the suspension. The remaining option is the most acceptable for children, especially small ones.

For children over 14 years old, the drug should be prescribed in an additional dose of 1000-2000 mg in 2-3 doses. In important cases of protraction of the infectious process, you can increase the dosage up to 3000 mg per dose.

I will add a dose for children with a body weight of not less than 10 kg (call in 1 roku) and take it out of the vagina: 40-50 mg / kg in 2-3 doses.

By such a rank, children are deserted from masi tila:

• from 10 to 20 kg - 250-500 mg of josamycin (¼-½ tablets) 2 times for doba;
• from 20 to 40 kg - 500-1000 mg (½-1 tablet) 2 times for doba;
• more than 40 kg - 1000 mg (1 tablet) 2 times for dobu.

The triviality of the therapy is the beginning of a lycar, it’s fallen into evidence and overcoming the disease may take 5-21 days. On the outside of streptococcal tonsillitis, according to the recommendations of the All-Union Health Protection Organization (OOH), at least 10 days are required.

In case of extreme and kulastic vugras, Vilprafen Solyutab on the cob of a drink (first 2-4 times) of readings in a dose of 500 mg 2 times per dose, during the next 8 times, carry out additional therapy - 500 mg 1 time per dose.

In case of congestion of the slunk-intestinal tract, association with the bacteria Helicobacter pylori, Vilprafen Solutab is indicated in a dose of 1000 mg 2 times / for 7-14 days for a period of 7-14 days for up to one therapy with standard antiheliobacterial schemes:

• 40 mg / dobu famotidine or 150 mg 2 times / dobu ranitidine + 500 mg 2 times / dobu metronidazole;
• 40 mg / dobu famotidine + 100 mg 2 times / dobu furazolidone + 240 mg 2 times / add vіsmutu Trіkali dіtsіrata;
• 20 mg omeprazole (either 20 mg rabeprazole, or 20 mg esomeprazole, or 30 mg lansoprazole, or 40 mg pantoprazole) 2 times / dob + 240 mg 2 times / dobu vismutu Trikalі dicitrate + 1000 mg 2 times / dobu amoxicilі
• 20 mg omeprazole (or 20 mg rabeprazole, or 20 mg esomeprazole, or 30 ml lansoprazole, or 40 mg pantoprazole) 2 times / dob + 1000 mg 2 times / dobu amoxicilin.

If the patient has atrophy of the mucous slurry, who is supressed with achlorhydria, susceptible to pH-measurement, Vilprafen Solutab is indicated in a dose of 1000 mg 2 times / add to the dose before the onset of therapy: 1000 mg / 240 mg 2 times / time dіtsіrata.

Pobichna diya

• from the side of the shlunkovo-intestinal tract: often (from> 1/100 to< 1/10) – тошнота, ощущение дискомфорта в желудке; нечасто (от >1/1000 to< 1/100) – ощущение дискомфорта в животе, диарея, рвота; редко (от >1 / 10,000 to< 1/1000) – стоматит, снижение аппетита, запор; очень редко (< 1/10 000) – псевдомембранозный колит;
• from the side of the stove and zhovchivіdnyh nobles: even more rarely - zhovtyanitsya, pechinkova dysfunction;
• hypersensitivity reactions: rare - sprinkling, anaphylactoid reactions, Kvinke's embryo; even more rarely - bullosa dermatitis, bagatoformna erythema;
• on the side of the organs there is a sense of: even worse - a dose of delayed loss of hearing;
• іnshі: douzhe rіdko - purple.

Overdose

Until now, let’s know about the winnings specific symptoms in times of overdose did not come. Imovirno, when the dose is changed, the authorities can develop the Josamicin side effects, especially from the side of the herbal system.

special requests

As long as the therapy with the drug vinicum is important for diarrhea, it is necessary to ensure the development of life-threatening pseudomembranous colitis, associated with antibiotic therapy.

We are sick because of the lack of nirkovyu for an hour of treatment, the necessary re-control of the camp of nirok (viznennya clerance endogenous creatine) and if necessary, correcting the dose of josamycin.

When recognized by Vilprafen, Solutab will show the manifestation of stiffness to some antibiotics-macrolides, some microorganisms, resistant to spores due to the chemical structure of such antibacterial agents, to

Inflow to the building of keruvati by motor transport and folding mechanisms

During the period of treatment with this drug, it was not possible to develop any reactions that could have negatively impacted on the health of people with folding mechanisms, with a car, or with the help of a car, but also with the potential for good, good results.

Stagnation in vaginosis and lactation

For adult and year-old women, Vilprafen Solutab 1000 mg indicates a drop in that, as the cinnamon is purified to overtake the moss. The European Public Health Organization recommends josamycin in the capacity of the main drug for the treatment of trash infectious diseases in women.

Stuck in a childish vіtsі

Applied to the drug can be used for children with a weight of at least 10 kg.

In case of deterioration of the functions of nirok

If it is evident that the drug is indicated to Vilprafen before being consumed in patients with a lack of deficiency, the drug is guilty of being guilty of the control of the function of the sick person.

In case of deterioration of the function of the liver

Welcome to the instruction, Vilprafen Solutab of contraindications to patients with important impairments of the liver function.

likarska vzaєmodiya

Do not use josamycin in combination with lincozamides, some of them can be changed from one another to another.

Dzhozamitsin is confident in the elimination of xanthines (for example, theophilin). I would like to pour in the smallest one, due to some of the other representatives of the macrolid group, followed by the development of toxicity.

Immediately the consumption of astemizole or terfenadine increases the number of arrhythmias that are threatening for life.

Josamicine can induce cyclosporine in blood plasma and increase nephrotoxicity. When this combination is consumed, it is necessary to control the concentration of cyclosporine.

Josamicine can induce digoxin levels in blood plasma.

In addition to the occasional vasoconstriction due to the use of antibiotics-macrolides and alkaloids in vasoconstriction.

analogs

An analogue of Vilprafen Solutab (1000 mg) є the drug Vilprafen (500 mg).

Terms and conditions

Zberigati in a city, stolen from light and increased visibility, inaccessible to children, with temperatures up to 25 ° C.

Term of attachment - 3 rock.