Thrombocytopenic purpura. Immune thrombocytopenia in children Idiopathic thrombocytopenic purpura ICD code

RCHRH (Republican Center for Development of Health Protection of the Ministry of Health of the Republic of Kazakhstan)
Version: Clinical protocols of the Ministry of Health of the Republic of Kazakhstan - 2016

Idiopathic thrombocytopenic purpura (D69.3)

Child oncology, Pediatrics

General information

Short description

caught
Unified committee for yakistyu medical services
Ministry of Health Protection and Social Development of the Republic of Kazakhstan
from "29" falling leaves 2016 to rock
Protocol No. 16

Immune thrombocytopenia - autoimmune disease It is characterized by isolated thrombocytopenia (less than 100,000 / μl) in case of an undetectable / ovish number of megacariocytes in the cystic marrow and presence on the surface of the blood plates and in the plasma complex of anti-thrombocytoplasmic membranes. IX, to produce up to the ruining of thrombocytes with cells of phagocytic mononuclear systems, which appears to be a hemorrhagic syndrome.

Specialized codes ICD-10 and ICD-9

Classification

ClassificationAmerican Society of Hematology, 2013:
Over the course of:
· Forwardly revealed - triviality up to 3 months;
· Persistent (protracted) ITP - triviality 3-12 months;
· Chronic ІТП - triviality more than 12 months.

For the degree of severity of hemorrhagic syndrome:
· Vazhka - patients with clinically significant bleeding are not stale due to platelets. Symptoms of bleeding during the onset of illness, as well as the need for renewal of bleeding due to the need for supplementary therapeutic drugs in supplementary therapeutic patients, increases the number of platelets lykarsky zasobiv.
· Refractory - the unwillingness of the obsession with any reason (thrombocytes less than 30x109 / l) for splenectomy therapy; loss of reason for splenectomy and need drug therapy with the method of minimization of clinically significant bleeding. At the same time, it is necessary to reinforce for the prevention of other causes of thrombocytopenia and confirmation of the diagnosis of ITP. In the main, to be seen at the grown-ups.

per stages; Standardization of ITP, Sept 2006 IMBACH]:

Diagnostics (outpatient)

DIAGNOSTICS ON THE AMBULATOR RIVNI

Diagnostic criteria: NB! Primary immune thrombocytopenia is diagnosed in case of decreased platelets less than 100x109 / l in case of other causes of thrombocytopenia.

Diagnostic criteria for setting a diagnosis:
skargi:
· Increased bleeding from mucous membranes;

anamnesis:
· Noses, ash bleeding;
· Menorrhages, subways;
· Blood in the sclera;
· Blood in the brain;
· Hematuria;
· Bleeding from the shlunkovo-intestinal tract (crooked blues, melena);
· Hemorrhagic visibility at viglyadi petechii and ekhimosi in shkiri.

Physical details:
Zagalny look:
The nature of the haemorrhagic syndrome:
· Raztashuvannya і size of petechiae і sintsіv;
· The appearance of hemorrhages on the mucous emptying of the company, conjunctivi;
· Glass of blood on the back stints of the pharynx;
Anomalies of budov and denunciations ( triumphantly denouncing, Small eyes, epicant, other figures of exposure) and cints (anomalies of the 1st finger of the hands, six fingers, syndactyly, clinodactyly);

Laboratory Doslidzhennya:
· KLA with manual pedrachnoid of leukocyte formula and morphology of thrombocytes - in hemogram thrombocytopenia is isolated - a decrease in platelets less than 100x10 9 / l without a change in leukocyte indices and eritrograms. In some cases, post-hemorrhagic anemia, destruction in the leukogram, tied to the patient may be restructed. for infectious diseases, Allergyu;

dumb.

Diagnostic algorithm on an outpatient basis:

Diagnostics (stationary)

DIAGNOSTICS at the stationary РІВНІ

Diagnostic criteria:
skargi: see outpatient r_ven.

anamnesis:
· Triviality and nature of bleeding;
· Carrying out vaccination (especially combined vaccination against bark, mumps and rubella) 2-3 days before the development of hemorrhagic syndrome;
Transferred (respiratory virus, rubella, infectious mononucleosis) 2-3 times before the development of hemorrhagic syndrome;
Zastosuvannya stretching out the remaining 2-3 types of preparation (zokrema heparin);
· The appearance of pain in the hands and losses in the vases;

Physical details: see outpatient rіven .

Laboratory Doslidzhennya:
· UAC with manual blood cell leukocyte formula and morphology of thrombocytes - in the hemogram, thrombocytopenia is isolated - a decrease in platelets less than 100x109 / l without any change in indicators of leukocytes and serytrograms. In some cases, post-hemorrhagic anemia, destruction in the leukogram, associated with patients with infectious diseases, allergies may be restructuring;

Instrumental doslіgennya: dumb.

Diagnostic algorithm on stationary level: dumb.

The transition of the main diagnostic visits, which is carried out at the stationary test:
OAC (thrombocyte і reticulocytes in a smear);
· Blood group and Rh factor;
· Biochemical analysis of blood (bilok, albumin, ALT, AST, bilirubin, creatinine, sechovina, glucose);
· Mylogram: hyperplasia of a megakaryocytic stump with the appearance of young generations of megacaocytes and growing together in their midst;
· Triviality of bleeding according to Sukharev;
OAM;
· IPA for markers of viral hepatitis (HbsAg);
· IPA for markers of viral hepatitis HCV;
· IPA on VIL markers.

A change of pre-diagnostic diagnostics, which is carried out at a stationary test:
· Biochemistry analysis: GGTP, electrolity;
· Coagulogram;
· IPA for antithrombotic antibodies;
· Immunophenotyping of peripheral blood cells;
· Immunogram;
· Antiphosphol_p_dn_ anti_la;
PLR on viral infections (viral hepatitis, cytomegalovirus, virus herpes simplex, Virus Epstein-Barr, virus Varicella / Zoster);
· Echocardiography;
Ultrasonic inspection of organs black empty(Pechinki, spleenki, slurry jelly, zhovchny mikhura, lymphatic universities, Nirki), middle, transverse to the space and small pelvis - for vyklyuchennya blood in the inner organ;
· Computer tomography to the brain: carried out with the presence of an intracranial hemorrhage - head bill, Bluvota, paresis, svidomosty deterioration; for the victorious GPMK;
· UZD OCHP.

Differential diagnosis

Likuvannya beyond the cordon

Take a lykuvannya in Korea, Izrail, Nimechchin, USA

Otrimati the consultation on medturism

lykuvannya

preparations ( diyuchі speeches)

Likuvannya (outpatient clinic)

LIKUVANNYA ON AMBULATORNY RIVNI

Likuvannya tactics: dumb.
− Non-drug treatment: dumb.
− Drug treatment: dumb.

Algorithm for non-emergency situations:

· Consultation of an oncohematologist - in case of adolescence for hematoblastosis;
· Consultation of a gynecologist - for metrorrhagias, menorrhagias;

Likuvannya (shvidka dopoga)

DIAGNOSTICS І LIKUVANNIA AT STAPI SHVIDKOЇ NEVIDKLADNOЇ HELP

Diagnostics come in:
· Zbir skarg and history of illness;
· Physical regulation.

Drug treatment:
Symptomatic therapy , zgіdno IVBDV is the core of the WHO for the most widespread illnesses in the hospitals of the primary village, adapted to the minds of the Republic of Kazakhstan.

Likuvannya (stationary)

LIKUVANNYA on stationary РІВНІ

Likuvannya tactics:
In case of immune thrombocytopenia, the tactics of correcting hormonal drug(Prednizolone). If you are susceptible to the likelihood of a decrease in the number of platelets, the number of platelets will increase (increase for 7-10 days) and try to use a high-quality drug. Even though the remission did not occur, immunotherapy was indicated - internal immunoglobulin. As long as it is not going to take the patient into remission for additional medication therapy lasting 6 months, splenectomy is recommended. In case of a serious interruption, splenectomy can be carried out in a large early term.

To accept solutions in the tactics of treatment, the international group of experts has broken up a scale of bleeding and recommendations on how to proceed
before therapy:

Alemtuzumab *:

Transfer of pre-daddish licars:

Zasosuvannya transfusions of thromboconcentrate:
show:
· Evidence of non-threatening bleeding.
Transfusions with thrombocyte concentrate are dependent on additional specific therapy for ITP (VVIG or glucocorticoid) and are not guilty of being stuck in monotherapy. Even the severity of bleeding with ITP, such as thromboconcentrate transfusion, is recommended for shot transfusion - skin from 6-8 years. In especially important vapadas, "hyperfraction" transfusion with small doses of thromboconcentrate is stagnant: 1-2 doses (0.7-1.4x10 11) of skin two years. In the quality of pre-hemostatic hemostatic therapy, etamzilate, antifibrinolytic drugs are used.
NB! In case of nircovy bleeding, the introduction of іngіbіtorіv fіbrinolіzu is contraindicated.

Hirurgic involvement:
splenectomy(UD-B)
Shown for engaging:
· Recurrent, important recession of ailments for more than 6 months;
· Patients over 6 years of age for anterior vaccination of Haemophilus influenzae type b + S. pneumoniae + N. Meningitidis.
Prototype shown for engaging:
· Children younger than 6 years;
· Pervinnі ІТП.

Інші vidi lіkuvannya: Nemaє.
Additional hemostatic therapy:
· Etamzilat sodium 12.5% ​​in a dose of 10-15 mg / kg;
· Para-aminobenzoic acid tranexamic acid: in patients older than 12 years in a dose of 20-25 mg / kg.

Shown for consulting fahivts:
· Consultation of an infectious disease specialist - in case of suspicion for an infectious process;
· Consultation of an endocrinologist - for the development of endocrine debris for aphids;
· Consultation of an obstetrician-gynecologist - in case of vaginosis, metrotraining, menorahgy, in case of prescribed combined oral contraceptives;
· Consultation of the leading university faculty - for the show.

Indicated for transfer in the form of intensive therapy and reanimation:
· Visibility / loss of testimony (rating on the Glasgow scale); supplement number 1
· Gostra heart-sudinna lack (heart rate less than 60, or more than 200 in khvili);
· Gostre destructive dikhannya (DN 2 - 3 steps, NP more than 50, reduction of saturation less than 88%, the need to carry out the SHVL);
· Gostre damaged blood circulation (shocks of the stan);
· AT systolic, less than 60 / more than 180 (require continuous administration of vasoactive drugs);
· Damage to the exchange of critical words (electrolyte, water, bilkovy, acid-base balance, ketoacidosis);
· Intensive care and intensive pharmacotherapy, which will require continuous monitoring of vital functions;
· Destruction of the throat and anti-coagulation blood systems.

Indicators of efficiency of treatment:
· After 4 years from the ear, the increase in platelet production is 100x10 9 / l (75% of patients with ІТП).
· Pislya visible spleen - an increase in platelet level in peripheral blood.

further away
Laboratory Doslidzhennya:
· UAC on the basis of the number of platelets and the manual leukocyte formula (obligatory) is carried out 1 time per month at the first stage of caution. Distant in fallowness from the clinical stand and the stability of the hematological picture;
· Biochemistry analysis of blood in dynamism is carried out in case of manifestation;
· serological dosage markers of VIL, hepatitis B and C, should be carried out after 3 months of vipiski from the hospital and after 3 months of skin transfusion of blood preparations.

Mind transfer of the patient for the month of stay:
· Pediatrician (child hematologist) for the month of living follow the recommendations given to the hospital worker;
· The frequency of looking around a patient from the ITP is to become 1 time in 2-4 months in the first 3 months of life, far in the fallowness from the clinical stand and hematological dynamics, but not earlier than 1 time in 2 months.

instrumental doslіgennya carried out with the presence of clinical demonstrations.

hospitalization

Shown for planned hospital:

Shown for emergency hospital:
Decrease in the level of thrombocytes in the UAC<50х10 9 /л.
· Evidence of hemorrhagic syndrome (bleeding from mucous nasopharynx, mouth emptying, intestinal bleeding, uterine bleeding).

information

Dzherela and Literature

1. Protocols of the United Committee for the quality of medical services of the Ministry of Health and Social Development of the Republic of Kazakhstan, 2016
   1. 1) Child Hematology, 2015. Edited by A.G. Rumyantsev, A.A. Maschan, E.V. Zhukovskaya. Moscow. Vidavnichi group "GEOTAR-Media" 2015r. C - 656, C-251, Table 6.2) The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia Cindy Neunert, Wendy Lim, Mark Crowther, Alan Cohen, Lawrence Solberg, Jr and Mark A. Crowther 2011; 16: 4198-4204 3) Standardization of ITP, Sept 2006 IMBACH. 4) Adequate support, 2005. Algorithm for uncomplicated situations: the IVBDV is a critical health care provider for the most widespread ailments in the hospitals of the first year of the RK (adapted) to the minds of 2012 5) ESH. The Handbook "Immune thrombocytopenia" 2011. 6) Tarantino & Buchanan, Hematol Oncol Clin North Am, 2004, 18: 1301-1314. 7) Guidelines for the adminis parenteral nutritrion Canada 2010.8) SIGN 104. Antibiotic prophylaxis in surgery. 2014.

information

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The Russian International Classification of ailments of the 10th glance (ICD-10) has adopted a single normative document for the incidence of illness, the reasons for the infestation of the population to the medical establishments, the causes of death.

ICD-10 was introduced into the practice of protecting health in the entire territory of the Russian Federation in 1999 by the order of the Ministry of Health of Ukraine dated 27.05.97. No. 170

A new look (ICD-11) is planned by WHO in 2017 2018 roci.

From the changes and additions of the VOOZ rr.

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Thrombocytopenia - description, causes, symptoms (signs), diagnostics, treatment.

Short description

Thrombocytopenia is a decrease in platelets in the peripheral blood, the most common cause of bleeding. With a decrease in platelet count less than 100 '109 / l, an hour of bleeding will increase. In large cases of petechiae, purpura appears with a decrease in platelet count to 20-50 '109 / l. Serious spontaneous bleeding (for example, shlunkovo ​​- intestinal) or hemorrhagic stroke occurs when thrombocytopenia is less than 10'109 / l.

cause

Thrombocytopenia may manifest itself as a carcinogenic allergy (allergic thrombocytopenia), accumulated with antiplatelet antiplatelet antibodies (autoimmune thrombocytopenia), viklicana infections, thrombocytoxicosis

In neonatal women, thrombocytopenia can be found to penetrate the placenta (transimmune thrombocytopenia).

Patologіya trombotsіtopoeza Dozrіvannya megakarіotsitіv vibіrkovo prignіchuyut tіazidnі dіuretiki that INSHI drug, vikoristovuvanі Especially when hіmіoterapії, etanol especial reason trombotsitopenії - neefektivny trombopoez, pov'yazany of Megaloblastic type of hematopoiesis (vinikaє at defіtsitі vіtamіnu At 12 i folієvoї acid and takozh at mієlodisplastichny i ​​peredleykoznoyu syndromes ). In kіstkovomu mozk viyavlyayut morfologіchno i funktsіonalno anomalnі (megaloblastnі abo displastichnі) megakarіotsiti scho give ear defective trombotsitіv pool, SSMSC ruynuyutsya in kіstkovomu mozk amegakariotsitarna trombotsitopenіya - rіdkіsna reason trombotsitopenії, obumovlena vrodzhenim defіtsitom megakarіotsіtarnom kolonієutvoryuyuchih odinits.

Anomalies in the formation of a pool of platelets occur with the elimination of blood platelets in the bloodstream, the most common reason is deposition in the bloodstream. When the size of the spleen is even greater, 90% of the entire pool of platelets can be deposited, but 10% is lost in the peripheral blood flow, but the normal rate of circulation is 10%.

Increased thrombocytopenia on the periphery - the most widened form of thrombocytopenia; These are characterized by a shorter period of platelet life and an increased number of megacariocytes in the cyst. Thrombocytopenic purpura (thrombocytopenic purpura) Idiopathic thrombocytopenic purpura (ITP) is a prototype of thrombocytopenia, immune mechanism of thrombocytopenia. Div. Purpura іdіopatichna trombotsitopenіchna INSHI autoіmunnі trombotsitopenії, obumovlenі synthesis of antiplatelet antibodies: posttransfuzіynі trombotsitopenіya (s pov'yazana vplivom іzoantitіl) lіkarska trombotsitopenіya (napriklad, viklikana hіnіdinom) trombotsitopenіya, zumovlena sepsis (frequency rozvitku Mauger dosyagati 70%) in trombotsitopenіya poєdnannі with VKV and іnshih autoimmune illnesses. Lіkuvannya is focused on the correction of the main pathology. It is necessary to pin the reception of all potentially unsafe medical devices. CC therapy is not necessarily effective. The transfusion of thrombocytes is given to such an accelerated destruction of non-immune thrombocytopenic purpura of infection (for example, viral or malaria) Massive transfusion of conserved blood from a low vascular thrombocyte valve

Thrombocytopenia (* 188000, Â). Clinical manifestations: macrothrombocytopenia, hemorrhagic syndrome, aplasia of the ribs, hydronephrosis, recurrent hematuria. Laboratory dosage: autoantitila before platelets, short life of platelets, an hour of delay, turnicet test in normal, defect of the plasma component, hemostasis.

May-Hegglin anomaly (Hegglin syndrome, Â). Macrothrombocytopenia, basophilic inclusion in neutrophils and eosinophils (tiltsya Döhle).

Epstein's syndrome (153650, Â). Macrothrombocytopenia in the presence of Allport's syndrome.

Syndrome of Syme Fechtner (153640, Â). Macrothrombocytopenia, included in leukocytes, nephritis, deafness.

Thrombocytopenia congenital (600588, 11q23.3-qter deletion, Â). Clinical manifestations: congenital dysmegakaryocytic thrombocytopenia, slightly reversible hemorrhagic syndrome. Laboratory progress: deletion of 11q23.3-qter, increased number of megacariocytes, giant granules in platelets of peripheral blood.

Thrombocytopenia is cyclic (188020, A). Hemorrhagic syndrome, cyclical neutropenia.

Thrombocytopenia Paris-Trousseau (188025, 11q23 deletion, TCPT gene defect, Â). Clinical manifestations: hemorrhagic syndrome, thrombocytopenia, hypertelorism, abnormalities of the vuh, rosum formation, coarctation of the aorta, extension into development in the fetal period, hepatomegaly, syndactyly. Laboratory dosage: giant granules in platelets, megacariocytosis, micromegacariocytosis.

TAR syndrome (type: thrombocytopenia-absent radius). The appearance of the interchangeable cyst in the second place with thrombocytopenia (it is common in children, it starts to smooth out); thrombocytopenic purpura; defective megacariocytes in the red cystic marrow; In some cases anomalies in the development of nirok and VPS.

Symptoms (signs)

key picture This is the main reason for the main problems with thrombocytopenia.

diagnostics

Dіagnostika Trombotsitopenіya - svіdchennya for doslіdzhennya kіstkovogo mozk nayavnіst on megakaryocytes їh vіdsutnіst svіdchit about trombotsіtopoeza torn down and nayavnіst - abo about peripheral character ruynuvannі trombotsitіv, abo (at nayavnostі splenomegalії) about deponuvannya trombotsitіv in selezіntsі Patologіya trombotsіtopoeza. Diagnosis of megacariocytic dysplasia in a smear of cystic marrow Abnormalities in the formation of a pool of platelets. Dіagnoz hypersplenism nent of pomіrnіy trombotsitopenії, viyavlennі a smear kіstkovogo mozk normal kіlkostі megakarіotsitіv i digit zbіlshennі selezіnki Dіagnostika іdіopatichnoyu trombotsitopenіchna purpura vimagaє viklyuchennya zahvoryuvan scho protіkayut of trombotsitopenієyu (napriklad, GVH) i trombotsitopenіy, zumovlenih priyomom lіkіv (napriklad, hіnіdinu). Given the availability of non-specific methods for detecting antiplatelet antibodies.

lykuvannya

Pathology of thrombocytopoiesis. Lіkuvannya zasnovane on usunennі pozhkozhuyuchy agent, which is costly, or lіkuvannі the main grievance; an hour of thrombocyte transfusion is normal, allowing platelet transfusion in case of thrombocytopenia and signs of bleeding. Thrombocytopenia, zoomed with a deficiency of vitamin B 12 or folic acid, is due to the renewal of the normal level.

Amegakaryocytic thrombocytopenia is good to go to therapy, get ready for anti-thymocytic immunoglobulin and cyclosporine.

Abnormalities in the formation of the platelet pool. Likuvannya please do not carry out, if splenectomy might resolve the problem. When transfused, a part of thrombocytes is deposited, so that transfusions are less effective, less when there is a decrease in the activity of the cystic marrow.

Likuvannya idiopathic thrombocytopenic purpura - see Purpura idiopathic thrombocytopenic.

Uskladnennya i suputnі will Znizhennya utvorennya trombotsitіv poєdnuєtsya of aplastichnu anemіyu, mіeloftіz (zamіschennyam kіstkovogo mozk puhlinnimi klіtinami abo fіbroznoї tkaninoyu) i deyakimi rіdkіsnimi vrodzhenimi syndromes Evans syndrome (Fіshera-Evans syndrome) - poєdnannya autoіmunnoї gemolіtichnoї anemії i autoіmunnoї trombotsitopenії.

ICD-10 D69 Purpura and other hemorrhagic beds

Thrombocytopenia: symptoms and treatment

Thrombocytopenia - main symptoms:

• Chervoni by plami on shkiri
• improvement of lymph nodes
• Adjusted temperature
• Improvement of lymph nodes in the country
• Drobnі bloodshed on skіrі and mucous
• Blue beaches on shkiri

Infection, as a result of a decrease in the number of thrombocytes in the blood, is thrombocytopenia. Itself about the new power and the report of the article. Thrombocytes are a whole lot of other bloodsheds, as they do not spoil the color and significant components, as they take part in the hypogastric blood. To get sick seriously, the disease can lead to hemorrhage in the internal organisms (especially in the brain), and even fatally to the end.

Classification

As well as a large number of medical ailments, thrombocytopenia has its own classification, as it is formed on the basis of pathogenetic factors, causes, symptoms and early manifestations.

By the criterion of ethology, I see two types of discomfort:

It is characterized by the stench that the first type is manifested in a self-conscious illness, and the second one is provoked by the order of those who are ill or pathological.

For the triviality of overcoming ailments in the body of people, people add up to two types of health: hospitality and chronicity. Gostre - is characterized by non-triviality flowing into organism (up to pivrok), it is a little bit symptomatic. Chronic respect for the power of the trivial decrease in platelets in the blood (ponad pivroku). The most chronic type is more not safe, as it can be borrowed up to two rockies.

According to the criteria for the severity of overcoming the disease, which is characterized by a small storage of thrombocytes in the blood, there are three stages:

• I - warehouse door 150-50х10 9 / l - criterion of severity of goods;
• II - 50-20x10 9 / l - depreciation, which can be manifested with insignificant changes in the shkirny cover;
• III - 20x10 9 / l - characterized by zones of internal bleeding in the body.

The rate of blood-bearing children in the body is given to / μl. Alle the same in the organism of a woman, the indicators are constantly changing. The following factors are injected on the window:

Thrombocytes are in the organism from the cystic marrow, as a way of stimulating megakaryocytes in the synthesis of blood. The synthesized blood plates circulate through the blood for a stretch of seven dB, for which the process of stimulation is repeated.

According to the International Classification, ailment of the tenth clicks (ICD-10), the disease has its own code:

• D50-D89 - infestation of the circulatory system and other types of deficiencies.
• D65-D69 - collapse of the throat of blood.

cause

The most common cause of illness is an allergic reaction to an organism on a medical preparation, as a result of which and the prevention of lycars' thrombocytopenia. With such a nondual antithelium, a direct anti-lycopene drug is violated by the organism. Before drug preparations, which are infused into the appearance of a blood-borne deficiency, there is a sedative, alkaline and antibacterial effect.

The reasons for the diagnosis of shortcomings can be problems with immunity, with inherited blood transfusions.

Especially often, the disease manifests itself when the blood groups are lost. Most often, it is spostering in the body of people and autoimmune thrombocytopenia. In this way, the immune system is undefined before the development of their platelets and the organisms. As a result, antibodies are released from the detection of foreign cells. The reasons for such thrombocytopenia are:

1. Pathological deficiencies of nirok and chronic hepatitis.
2. Vovchak, dermatomyositis and scleroderma.
3. Leukoznі ill health.

If the disease is manifested in the form of an isolated ailment, then it is caused by an idiopathic thrombocytopenia or Verlhof's illness (code for MKH-10: D69.3). Ethiology of idiopathic thrombocytopenic purpura (ICD-10: D63.6) is still not left behind, even if it is a medical one, to such a thought, as the reason for the decline is decay.

It is also a powerful manifestation of an illness in the presence of congenital immunodeficiency. Such people are most mentally ill, and the reasons for this are:

• pooddennya of the red cystic brain from the infusion of drugs;
• to produce immunodeficiency to the level of megakaryocytes.

The productive nature of the disease is developed, such as the accumulation of lack of blood platelets in the cystic marrow. In such a way, there is a lack of it, and in a bag it flows into a lack of food. The reasons for the diagnosis are myelosclerosis, metastasis, anemia, etc.

The lack of platelets in the body is more likely to be observed in people, due to a decrease in vitamin B12 and folate acid storage. Do not switch and overwhelm radioactively, or exchange the action for the manifestation of the lack of blood children.

In this rank, you can see two types of reasons for infusing thrombocytopenia on the diagnosis:

1. To produce before the ruining of blood diseases: idiopathic thrombocytopenic purpura, autoimmune diseases, surgical treatment in the heart, clinically impaired blood circulation in female women.
2. Also, you can take a decrease in anti-cystic brain virality: viral injections, metastases do not manifest, chemotherapy and optimization, as well as transplantation to alcohol.

symptomatology

Symptoms of thrombocytopenia may develop. Tse deposit:

• in Pershe, from the cause of the blame;
• in a different way, due to the nature of the prevention of ailments (chronic abo gostry).

The main signs of damage to the body are є to show on the screen at the eyes of the blood and bleeding. Spostering blood flow most often on kintzivka and tulubes. It is not possible to expose the face and lips of the people. For the purpose of displaying bloodsheds on those people, the photo below is presented.

Thrombocytopenia are characteristic symptoms of trivial hemorrhages due to a visible tooth. Moreover, the triviality of blood can be as one-day, as well as super-blooming over a span of decilkoh days. Tse to lie down on the step of becoming ill.

In case of symptomatology, an increase in liver growth is not observed, and even more often it is more common to promote an expansion of lymph nodes. It is also a phenomenon that it is not very common to change the temperature to subfebrile values ​​(from 37.1 to 38 degrees). Increasing the rate of erythrocyte spilling in organisms due to the evidence of nonduzhannya, the chervony vovchak is changing.

It is still easy to reach the symptomatology of a lack of platelets for taking blood for analysis. A small warehouse will often be considered according to the border norms. With a decrease in the number of platelets in the blood, there is a decrease in the size of the blood. On skіrі tse, to be seen at the viglyadі, sing red and bluish beaches, to talk about the transformation of blood children. It also spares the ruining of erythrocytes, which leads to a decrease in the number of reticulocytes of growth. Stimulate the appearance of a leukocyte formula in the blood.

The organism of people with a decrease in the warehouse of blood cells is characterized by a decrease in the warehouse of megakaryocytes, which is accumulated by frequent and great bleeding. The triviality of blood thinning can grow, and the fast thickening of blood, which is seen from the wound, decreases.

There are three stages of acceleration: easy, middle and important.

An easy step is a characteristic cause of the diagnosis of ailments in women with prolonged and rapid menstruation, as well as with internal bleeding and bleeding from the nose. Alle at the stage of an easy step of diagnostics of ailment є in the edge of the fold, so it is possible to turn into the manifestation of ailment by conducting a detailed medical check-up.

The middle step is characterized by the manifestation of hemorrhagic visipus in terms of body, which is a numerical point of hemorrhage from the skin and on the mucous membrane.

An important step is characteristic of the dislocation of the shlunkovo-intestinal tract, accumulated with blood. Indicators of platelets in blood warehouses may be up to 25x10 9 / l.

Symptoms of secondary thrombocytopenia are similar to signs.

Vigor and lack of health: symptoms

Thrombocytopenia in vaginal women is characterized by significant differences in the number of children in the blood of women. As soon as there is a day of diagnostics of sickness among women, or the indicator of platelet count slightly decreases, then we should inform you about those who are going to change their life and get involved in blood circulation.

If there is a decrease in the storage of platelets in the blood of the vagina, then it is straightforward to change your mind and the development of the disease. The reasons for the decreased number of platelets are in the high stages of the decline in the number of thrombocytes and the small indicators of the acceptance of new ones. Clinical signs are characterized by pediatric hemorrhages. The reasons for the lack of barren children are the wrong warehouse and norms of food, for a small number of living lives, as well as the deterioration of the immune system and the risk of blood loss. For the help of the toltsya, the cystovymus in the smallest number is violated, or it is an irregular shape.

Thrombocytopenia with vaginosti is even more insecure, so nutrition is diagnosed, and especially lіkuvannya, maximum respect comes. It’s not safe because there are not enough platelets in the mother’s blood before the hour of her vaginosity. Naybilsh is not without bleeding in the womb of the mother - cerebral, which is characterized by fatal marks for the fetus. At the first signs of such a factor, there is a decision about early canopies, schob vyklyuchiti patches.

Child thrombocytopenia: symptoms

Thrombocytopenia in children is manifested to the end of the day. Before the group, the risky should have children of the school age, the incidence of some parts often manifests itself in the winter and spring period.

Thrombocytopenia і її symptoms in children are practically not recognized as grown-ups, but at the same time it is important for fathers in early terms to develop ailments for diagnosing them for the first signs. Before childish symptomatology, part of the bleeding from the nasal emptying and the diagnosis of any other symptoms on the patient's side. A handful of hanging wines are on the lower pictures of the body, and sometimes they can be played on the hands. With minor strokes, swelling and hematomas are detected. These are the most frequent signs that do not wake up at the fathers' sleep, for the symptoms of pain in the daytime. The pardon is important, even if you get sick in a zanedbane viglyad, you become not safe.

Bleeding is clear to indicate the lack of platelets in the blood of both children and older adults. Feces at a lot of ailing people, and often in children, are seen spirally with blood clots. Do not become involved in bloodshed at the same time.

Falling down the steps into the inflow of the disease on the immune system develop the immune and not the immune deficiency of thrombocytes. Immune thrombocytopenia has been discussed by the mass of the early blood cells being infused with antibodies. In such situations, they do not develop into the immune system of the power of blood and are traded with the body. Chi is not immune to manifest itself with physical infusion on the blood plate.

diagnostics

Lyudina is diagnosed with the first signs and symptoms of illness. The main method of diagnostics is clinical analysis of blood, the results of which show a picture of the platelet count.

When a number of blood cells are detected in the body, it is indicated that they are shown on the passage of the cystic brain. This rank is the beginning of the appearance of megakaryocytes. As soon as the stench comes out, then the thrombosis is damaged, and it’s obvious to talk about the reduction of thrombocytes or the deposition of thrombocytes in the cells.

Reasons for the appearance of a lack of diagnostics for help:

• genetic tests;
• electrocardiograms;
• tests for the presence of antibodies;
• doslіgennya by ultrasound;
• X-ray and endoscopy.

Thrombocytopenia is diagnosed in case of vaginosis due to additional coagulograms, or, in simple words, it seems, to the laryngeal bloodstream. Such an analysis allows for the accuracy of the storage of platelets in the blood. As a result of the number of platelets, it is interrupted to the process of flattening.

lykuvannya

Treatment of thrombocytopenia is to be repaired with therapy, when a drug is dispensed in the hospital under the name Prednizolone.

Important! Ways of treatment are recognized strictly as a doctor only for the passage of a general condition and diagnosis of ailments.

Dose intake is indicated in the instructions, but 1 ml of the drug is implanted into 1 kg of vagina. With progressive ailments, the dose is increased by 1.5-2 times. On the cob stages, nezduzhannya is characterized by quick and effective weariness, so if you take the drug through a few days, you can remember the health improvement. Taking the drug is trivial until quietly, as long as the people don’t have to work, but they are guilty of using an alcoholic drug.

Diya of glucocorticoids is positively indicated on the fight against ill health, or in most cases passing only symptoms, and becoming ill. Vikoristovuyutsya for the lack of disadvantages in children and adolescents.

Treatment of idiopathic chronic thrombocytopenia is healthy. This procedure in medicine is characterized as splenectomy and is characterized by its own positive influx. Before the operation, the dose of Prednizolone should be added three times. Moreover, it is not introduced into the vein, but into the vein of the people. When splenectomy is performed, the drug is administered in the same doses up to two years. Only when the end of the designated term is completed, an inspection and an inspection of the success of the splenectomy will be carried out.

Even though the operation apparently ended unsuccessfully, then the patient will receive immunosuppressive chemotherapy with cytostatics. Prior to such drugs should be: Azatioprin and Wincristin.

When diagnosing a non-immune deficiency of a non-immune nature, thrombocytopenia treatment is carried out by symptomatic methods by means of estrogen, progestin and androxone.

Greater importance of the form of idiopathic thrombocytopenia, accumulated with vivid hemorrhages. For renewal of blood transfusion is carried out. Likuvannya of a difficult stage, I will accumulate the intake of drugs, which may negatively affect the ability of platelets to form clots.

When diagnosing a patient's illness, the patient is taken on the field and the procedure is being taken not only for the patient, but also for his relatives for collecting a recessive anamnesis.

Children do not feel good and without acceleration, but in some cases, the possibility of carrying out symptomatic therapy is not included.

Likuvannya thrombocytopenia for the help of folk medicine also has its own chimals. First for everything, to alleviate the problem of lack of platelets in the blood, then include honey with hairy mountains in the race. It is also kindly to help you to see the leaves of the sprinkles and the shipshini. For professional visits, birch, raspberry or beetle juices are used.

If you do, you have Thrombocytopenia and symptoms characteristic of a sickness, then a hematologist can help you.

Our service for diagnostics of illness is also promoted online, which is based on the introduction of symptoms of illness.

Diphtheria is a highly infectious disease, provoked by a specific bacterium injected, the transmission of which (infected) is good to go. Diphtheria, symptoms that appear in the activation of the ignition process, especially in the area of ​​the nasopharynx and the oropharynx, are also characterized by subtle manifestations in the eyes of the extravagant intoxication and the order, without a mediocre rank, I get the nerves from the systemic,

Cyr є gostre infectious disease, steps of dryness up to practically becoming 100%. Cyr, the symptoms of such a glare at fever, an ignition process, which is the main cause of the mutilation of the mouth and upper dysfunctional nobles, the appearance of papulopapulosic viscera on children, the middle of the early death

Leptospirosis is an ailment of infectious nature, which can be affected by specific diseases of the genus Leptospira. The pathological process is hostile to the capillary, as well as the stove, nirki and m'yazi.

Faringomycosis (tonsillomycosis) is a pathology of the mucous membrane of the pharynx of a gastrointestinal or chronic nature, the main reason for the development of fungi in the body. Faringomycosis is hostile to people from absolutely all groups of people, including small children. Ridko if the disease is in an isolated form.

A toxic erythema is a fallacy, as a result of the progress of a polymorphic visip on the skirts of the people. Illness is most often hostile to new-born children, but I will not appear among older children. A toxic erythema of newborns develops in 50% of children in the first few days of their life. The Danish camp imagines the adaptation process of the child to the midst of the middle, as well as to the latest bureaucrats.

For the help of the physical, more people can do without medicine.

Symptoms and diseases of ill people

Resurrection of materials is possible only with the permission of the administration and the meaning of active efforts to persevere.

All information is provided for the obligatory consultation by the doctor!

Nutrition and propositions:

Thrombocytopenia coding according to ICD 10

Thrombocytes play a role in the human body and are a group of blood elements.

• 0 - purple, surrounded by an allergic reaction;
• 1 - defect of budov and thrombocytes in case of normal number;
• 2 - purpura іnshy, non-thrombocytopenic walking (when off);
• 3 - idiopathic thrombocytopenic purpura;
• 4 - іnshі shortage of thrombocytes in the primary nature;
• 5 - second battle;
• 6 - unspecified options for pathologies;
• 7 - інші options for hemorrhages (pseudohemophilia, laxity of the swelling and so long);
• 8 - unspecified hemorrhagic stagnation.

A group of illnesses is given in the rubric of pathological blood, hematopoietic organs and immune diseases of clerical genesis.

not safe for thrombocytopenia

Through the severity of clinical manifestations, thrombocytopenia in the international classification of ailments, to avenge the protocols of non-practical assistance in case of severe hemorrhagic syndromes.

It is not safe for life with a strong decrease in the number of platelets, it is not safe to take on the appearance of podryapin, so as the wound does not heal with primary blood clots and continues to bleed.

People with a short amount of bloodsheds can die because of spontaneous internal bloodsheds, thus becoming ill with a free diagnosis and adequate treatment.

Dodati comment Skasuvati view

• Scottped pre-burn Gostria gastroenteritis

Samol_kuvannya can be useful for your health. At the first signs of becoming ill, it turns out to be a lykar.

secondary thrombocytopenia

Viznennya and zagalny vіdomosti [ed]

Lykarska immune thrombocytopenia is most often enriched with antigens to lykarskogo, as it reacts overly with platelet antigens. Previously, the drug is fixed on platelets for the definition of a potent antigen, devin serve as a hapten, and platelets serve as a nose.

Lykarski zasobi, which most often suffer thrombocytopenia, pererakhovani in the table. 16.5.

Heparin-induced thrombocytopenia є induction with heparin, immune-mediated prothrombotic disorders, thrombocytopenia and venous thrombosis.

Approximately 1% of patients receiving heparin for at least one day develop heparin-induced thrombocytopenia, approximately 50% of them have thrombosis. Heparin-induced thrombocytopenia is often observed in women.

Ethiology and pathogenesis [ed]

Heparin-induced thrombocytopenia is the result of humoral immune reaction, conjugated against a complex, including endogenous thrombocyte factor 4 and exogenous heparin, autoantitila growth in thrombocyte endogenous factor 4 The immune complex activates circulating thrombocytes through the surface FcγRIIA receptor, which can lead to thrombocytopenia and hypercoagulation. Characteristics of heparin (scourgeous> porcine), its warehouse (unfractionated> low molecular weight> fondaparіnuks), dose (prophylactic> therapeutic> one-time), dosage introduced (fodder> internal) and all triviality> 4 days factors that begin to develop and turn thrombocytopenia.

Klinichny show [ed]

In case of lykarskoy thrombocytopenia of petechiae, intestinal bleeding and hematuria, it will appear in a few years after the drug has been consumed. The triviality of thrombocytopenia is found in the form of a drug. Check in 7 dib after you see the number of thrombocytes is normal.

Heparin-induced thrombocytopenia can develop in any occasion (> 3 months); Thrombocytopenia is reduced to heal in 5-10 days after the introduction of heparin. As soon as the patient is already given heparin injected for the last 100 days, there can be a quick reaction, if a few platelets are lost, heparin is used for a period of time. Heparin-induced thrombocytopenia is also possible, thrombocytopenia can develop as soon as the preparation is processed. Thrombocytopenia starts to develop asymptomatically, bleeding is rare. Heparin-induced thrombocytopenia is susceptible to a high risk of thrombotic acceleration (for example, legeny embolism, myocardial infarction, thrombotic insult) with a strong tendency to thrombosis arterial thrombosis. Dodatkovy microsudic thrombosis can lead to the development of venous gangrene / amputation of the disease. The most rapid onset include necrosis of the skin in the symptoms of heparin and anaphylactic reactions (for example, feverishness, hypotonia, bile in the slopes, delusions, heart-healthy lack of internal pain)

Secondary thrombocytopenia: Diagnostics [ed]

Diagnosis of heparin-induced thrombocytopenia can be diagnosed at the stage of clinical picture - thrombocytopenia, thrombosis, the appearance of the main cause of thrombocytopenia. Diagnosis is suspected of detecting antibodies to the complex of endogenous platelet factor 4 / heparin and susceptible to detecting pathological antibodies, thus activating platelets, for an additional analysis of thrombocytogenesis and heparin test

Differential diagnosis [ed]

Diferentsіalny dіagnoz vklyuchaє neіmunny heparin asotsіyovanu trombotsitopenіya (via pryamoї vzaєmodії heparin of timey, SSMSC tsirkulyuyut platelet scho vіdbuvaєtsya in Pershi dnі pіslya heparin) and takozh pіslyaoperatsіynu gemodilyutsіyu, sepsis, scho non-heparin-іndukovanu trombotsitopenіyu, disemіnovane vnutrіshnosudinne zgortannya i polіorgannu lack.

Secondary thrombocytopenia: Likuvannya [ed]

For children who are taking heparin, it is recommended to regularly monitor the number of platelets. At times, in case of suspicion of suspected heparin-inducible thrombocytopenia), in patients with heparin and alternative anticoagulants - for additional anti-factors of Xa without heparin Warfarin is contraindicated for an hour of the thrombocytopenic phase, some cases of microsudine thrombosis, with the potential for necrosis of ischemic disease (venous gangrene syndrome). Thrombocytopenia is allowed to be allowed in the middle after 4 days, with indicators greater than 150 × 10 9 / l, if in some cases it can be known from 1 month to 1 month.

The prognosis for the renewal of platelets is good, however, there can be a diagnosis of post-thrombotic acceleration (for example, amputation of symptoms in 5-10% of patients, stroke, bilateral hemorrhagic necrosis of the upper back) Mortality due to heparin-induced thrombocytopenia (for example, deadly Legeny embolism) is accelerated in 5-10% of cases.

Prevention [ed]

Inshe [ed]

Thrombocytopenic purpura

1. Klinichna picture. Thrombocytopenic purpura is a rare rapid transfusion of erythrocyte mass. It is manifested by raptus thrombocytopenia, bleeding from mucous membranes and petechiae, which occur in 7-10 dB after transfusion. Diagnosis of data on anamnesis. The thrombocytopenic purpura is the most common form of thrombocytopenic purpura in people who have suffered from bagatoraz transfusion of erythrocyte mass. For the mechanism of development of the won is similar to thrombocytopenia of neonatal diseases, viclican maternal antibodies. Thrombocytopenic purpura, viclikana to transfusions of erythrocytic mass, vinica in individuals, in some of the daily antigen Zw a. It has been shown that the antigen can enter before the store of glycoproteins IIb / IIIa. Transfusion of the erythrocyte mass from the platelet house, which carries the Zw a antigen, is produced until the antigen appears. Vvazhayut, the stench is overly reactive with glycoprotein IIb / IIIa of the sick thrombocytes.

a. Do not carry out transfusion of thrombocyte mass, because the splinters are ineffective. In addition, donors of platelet mass in case of a lot of sickness may be less than 2% of people, in which platelets do not carry the Zw a antigen.

b. Prednisone, 1-2 mg / kg / add vseredin, reduces the hemorrhagic syndrome and increases the number of platelets.

v. If you are sick, it should be done on your own, so that the sick person's shelter will be caused by the donor's platelets.

m. For the transfusion, the vicorists are guilty of the erythrocyte mass of donors, in which the antigen is Zw a.

ICD-10 code

ANEMIA Fanconi

ANEMIA DIMONDA-Blackfena ICD-10 CODE

ICD-10 code

D61. Інші aplastic anemia. Vidi AA:

Vrodzhen [Fanconia anemia (AF), Diamond-Blackfen anemia (ADB), congenital dyskeratosis, Shvachman-Diamond-Oski anemia, amegakaryocytarna thrombocytopenia];

Prydbani (idiopathic, vicious viruses, licks or cheeky words).

AA make up with a frequency of 1-2 drops per 1 TOV TOV population in the Rik and vvazhayut small ailments of blood. Pridbani AA grows at a rate of 0.2-0.6 per 100,000 children per day. The average indicator of AA incidence among children in the period from 1979 to 1992 in the Republic of Bilorus is 0.43 ± 0.04 per 100,000 children. Riznitsi in the indicator of sickness AA in children before the disaster at the Chornobil AES, and I can't feel anything.

ADB is described by names; partial red cell aplasia, congenital hypoplastic anemia, true erythrocytic anemia, primary red cell ailment, eritrogenesis imperfect. Zahvoryuvannya ridkisne, L.K. Diamond and spivavt. in 60-i pp. XX Art. described only 30 types of ailments, up to the present hour more than 400 types have been described.

It took a trivial hour that the ADB's disease became 1 per 1,000,000 living newborns. In 1992, L. Wranne, having experienced a high degree of disability, was 10 per 1,000,000 newborns. The rate of incidence of ADB for the data of the French and English registries of the warehouse is 5-7 vypadkiv per 1 000 000 living newborns. The rate of maturity is the same. More than 75% of ADBs are sporadic; 25% of the family's character, moreover, a few ailments have been registered in the family. The ADB USA and Canada register of ailments includes 264 ailments from 10 months to 44 years.

D61.0. Constitutional aplastic anemia.

AF - rarely autosomal-recessively ill, characterized by multiple congenital physical anomalies, progressive cystic deficiencies and smartness to development evil new creatures... Zahvoryuvanist AF - 1 vipadok per 360 000-3 TOV TOV population. Enlightenment broadened among all nationalities and ethnic groups. Mіnіmalniy wіk show key signs- period of Novonarodzhene ™, maximum - 48 years. In the register of ailments of the AF NDI child hematology of the Ministry of Health of the Russian Federation, 69 ailments have been recorded. The middle period of the Manifestation of Sickness - 7 rock (2.5-12.5 cm rock). 5 family names were revealed.

Hemorrhagic disease Purpura and other hemorrhagic beds

D69.3. Idiopathic thrombocytopenic purpura.

Idiopathic thrombocytopenic purpura (ITP), on the thought of haematologists, is often hemorrhagic. However, it has been shown in the only one in our country that the indicator of the incidence of ITP in the Chelyabinsk region is 3.82 ± 1.38 per 100,000 children on the risk of growing up.

If you are sick, you have to fix it if you have a hemorrhagic syndrome. Type of bleeding in thrombocytopenic purpura of petechial-plyamistia (blueberry). per key manifestations I see two options for thrombocytopenic purpura: "dry" - in a sick vine, only shkirny hemorrhagic syndrome; "Vologiy" - bleeding with bleeding. Pathognomonic symptoms of thrombocytopenic purpura - hemorrhages in the skin, mucous membranes and bleeding. The visibility of the cichs is a sign of the wickedness of the sum in the correctness of the diagnosis.
Shkirny hemorrhagic syndrome of vinikє in 100% of ailments. The number of ecchymosis varies from single to many. The main characteristics of the hemorrhagic syndrome in thrombocytopenic purpura onset.
-Invidability of the turn of the hemorrhage of the stage of the traumatic infusion; You can spontaneously appear (even at night).
-Polymorphism of hemorrhagic visipans (from petechii to great bloods).
-Polychromicity of hemorrhagic hemorrhages (storage from crimson to blue-green and new in fallowness from a long time ago), which is linked to the step-by-step conversion of hemoglobin through the intermediate stages of rosemary
-Asimmetry (not a favorite localization) of hemorrhagic elements.
-Painlessness.
It is not uncommon to see blood in the mucous membrane, the most often migdalin, soft and hard fatigue. You can bleed into the tympanum, sclera, sclop-like tilo, very bottom.
If you bleed in the sclera, you can lead to the threat of a blood thinning of thrombocytopenic purpura - bleeding into the brain. As a rule, it’s like a rape wine and a fast progress. Klіnіchno hemorrhage in the brain manifests itself in headache, zapamorochennyam, sudoma, bloating, serebral neurologic symptomatology. The result is a hemorrhage in the brain to lay down as a result of the ossuary, localization of the pathological process, the freedom of diagnosis and adequate therapy.
Thrombocytopenic purpura is characterized by bleeding from mucous membranes. It does not smell like a profuse character, yaka will load the life sick. Most children often have bleeding from the mucous membrane of the empty nose. Bleeding is clear for the sake of a menshy, ale and a stench can become unsafe when extracting teeth, especially in ailments with undiagnosed ailments. Bleeding due to a visible tooth in case of thrombocytopenic purpura in the presence of a thrombocytopenic purpura immediately after it is in hand and can not be renewed if it is due to the appearance of increased bleeding in case of hemophilia. For girls of puberty, there are many important men-and-and-metrorages. On the other hand, there are shlunkov-intestinal and nirkovy bleeding.
characteristic snakes internal organs when thrombocytopenic purpura is visible. The temperature is normal. In some cases there is a tachycardia, with auscultation of the heart - a systolic murmur at the top and at the point of Botkin, weakening the I tone, amumatizing anemia. An increase in the spleen is uncharacteristic; it is more likely to diagnose thrombocytopenic purpura.
Over the course of Seeing hospitality (trivial up to 6 months) and chronic (trivial more than 6 months) forms of grief. at to the first to get up the character, it is not a good idea to get sick. At a later stage, the manifestation of a hemorrhagic syndrome, indicators of blood in the interruption of a disease are seen three periods: a hemorrhagic crisis, a clinical remission and a clinical hematological remission.
Hemorrhagic crisis is characterized by a swelling syndrome of bleeding, significant changes in laboratory indicators.
Every hour of clinical remission of a hemorrhagic syndrome, an hour of bleeding will speed up, secondary changes in the heart of the blood system will change, even thrombocytopenia may occur, if you are less likely to have a hemorrhagic crisis.
Clinical and hematological remission is not only on the visibility of bleeding, but on the normalization of laboratory parameters.

Congenital thrombocytopenia in a large part of its and partly recessive syndromes, such as Viscot-Oldrich syndrome, Fanconia anemia, Bernard-Soult syndrome, May-Hegglin anomalies, etc. yakіsnі zmіni thrombocytes, it was accepted to thrombocytopathy.
The causes of thrombocytopenia in the region are rіznomanіtnі. Thus, the increase in blood loss by infusion mediums, plasma, erythrocyte mass can lead to a decrease in the concentration of platelets by 20-25% and, so called, thrombocytopenia breeding. The basis of thrombocytopenia is the sequestration of thrombocytes in the spleen and the vertebral puffins - hemangiomas with significant amounts of thrombocyte mass from the bloodstream. Thrombocytopenia can develop in case of ailments, which is supervised by massive splenomegaly: lymphomas, sarcoidosis, portal hypertension, splenic tuberculosis, alcoholism, Feltic syndrome.
A large number of thrombocytopenes are included in the number of thrombocytopenia. The stench can develop yak into a link with mechanical thrombocyte rupture (for example, with prosthetic heart valves, piece blood circulation, paroxysmal low hemoglobinuria), as well as with the presence of an immune component.
Alloimmune thrombocytopenia can be a lot of blood transfusion; transimmune - penetration of maternal antibodies to platelets through the placenta to the fetus. Autoimmune thrombocytopenia associated with viral antibodies to blood-borne antigens of thrombocytes, developing in case of idiopathic thrombocytopenic purpura, systemic chervonia in chronic thyroiditis, autoimmune
Heteroimmune thrombocytopenia is accumulated by antibodies against foreign antigens, which are fixed on the surface of thrombocytes (lykarsky, viral, etc.). Lykarsko-indukovana pathology of winyє when taking sedatives, antibacterial, sulfanilamide drugs, alkaloids, gold spoluks, bismuth, heparin іn'єktsіah, etc. foreign infections(Adenovirus infection, influenza, virus, rubella, bark, infectious mononucleosis), vaccination.
Thrombocytopenia, accumulated by the lack of thrombocytes (productive), develops in case of deficiency of stovburov hematopoietic cells. Such a camp is characteristic of aplastic anemia, hostile leukemia, Myelofibrosis and myelosclerosis, puffy metastases in cystic brain, Deficiency of hair, follic acid and vitamin B12, effects of exchange therapy and cytostatic chemotherapy.
Nareshty, thrombocytopenia with the recovery of a vinicum in conjunction with the increased need for platelets for the prevention of laryngeal blood, for example, with disseminated intravascular coagulation syndrome, thrombosis.