Possible subtypes of malignant leukemia in chicken. Hostry myeloid leukemia - symptoms of prominocytic, monoblastic, malomonocytic myeloid leukemia

Leukozy, or, apparently, my medicine, hemoblastosis is a whole lot of puffiness, which resembles blood-forming cells. Leukemia is a clone of blast (young) blood cells, or adult forms, leukemia can be hospitable and chronic. Hostrii mioblastny leukemia of the warehouse is 20% of all types of child hematological malignancies. In the midst of a grown-up illness, it grows up to 60 years of age.

Zagalna characteristic

Intermediates of blood cells are divided into 2 large groups - lymphocytic and myelocytic steam. Lymphocytic effusion of the lymphocyte sash: cellini, "vidpovidalny" for the reaction to immunity. Myelocytic steam develops (differentiates) into erythrocytes, thrombocytes, neutrophilic leukocytes and granulocytes. Immature blood cells are called blast.

In such a rank, gostriy myloblastny leukemia is a tse of pukhlin, which is a winikla from an immature clitin of a mylocytic hematopoietic steam.

Diagnosis will be involved in the establishment, even in the analysis cystic brain(Myelogram) more than 20% of blast cells appear.

Reasons and mechanisms of development

Gostriy myloid leukemia (GML), as if it were leukemia, is the result of one mutation of cellini, as it consumes the health of ripening and starting to multiply uncontrollably. To say for sure, they themselves from all kinds of carcinogenic officials provoked mutations in a specific skin type of disease, especially if we are talking about children. In general, there are:

• Biological factors: oncogenic viruses, the most common one - Epshtein-Bara.
• Cheerful speeches. All in all, there are several thousand carcinogenic spolucs. To them it should be mentioned: speeches, scho to win in case of non-persistent oxidized fat (grease in deep frying); virobnichi "shkіdlivosti", which are used during thermal processing of naphtha, resins, vugіll; products of life colors; the chances to get stuck for chemotherapy of malignant poohlinas (it’s impossible to think about it, if leukemia is diagnosed in 10-20 years after successful cancer recovery).
• Physical factors. In the main case of x-ray vypromoynuvannya: vidomo, for the proprietors of x-ray companies, the possibility of getting sick, lower in the middle in the population.

Krim call-in injection low value drop: vidomy, for example, "twins leukemia", or transmitted in the homeland from generation to generation. It is not the ailment itself that will settle down, but rather chromosome mutations, which cause the disease to grow. In addition, the development of leukemia, zokrem, myeloid leukemia:

• Down syndrome;
• type 2 neurofibromatosis;
• Falcon's anemia;
• important vrodzhena anemia;
• congenital thrombocytopenia or thrombocytopathy.

In the basis of pathogenesis, albeit the mechanism of development, microblastic leukemia is a competition between normal and puffy cells. A collection of one - one atypical clitin for 3 months of won is built 1012 - one trillon - daughter blasts, a huge mass of ponad kilograms. Wicked cells live better, as they have the mechanism of "old" and natural bend. The stench vibrates speech, as it drives the activity of healthy elements of the blood, so drives the growth factor. In such a situation, the capacity of normal blood formation gradually hangs up.

Besides, the organism, "bachachi" is a great number of microblasts in the cystic marrow, the judiciary, which repairs the activity of blood-forming organisms: some of all the cells are so badly differentiated, the cells are degenerate. There is one mechanism that allows oncology to play a role in competition. In the world of the development of hemoblastosis, malignant cells repair proliferation in their tissues and organs: liver, selets, lymph nodes, shkiri and nave brain membranes.

The very substitution of healthy blood cells for the mass of blasts, non-latent viconuvati functions due to immaturity, the form of symptoms of blockages.

key picture

Show a hospitable nonspecific myloleukemia - it means that on the cob stage the symptoms are indicative of signs of illness.

anemic syndrome

Due to the lack of blood formation, the number of erythrocytes changes. Zagalnaya weakness, bliss, lameness of nigtіv and vipadannya nіgtіv and vipadannya hairy beloved, if not to screw up the respect of the patient or his relatives, or to be associated with other problems. In the world of the development of ailments, there is a weakness of the build-up minimum options, Children cease to be grateful in ruffled іgri (in a zagalі, a decrease in the activity of a child - pride respectfully pride themselves on their health).

hemorrhagic syndrome

In the blood, there are few not only erythrocytes, ale and thrombocytes. The sore throat will collapse. Bleeding is detected with a low intensity: from point children until the empty ones (shlunkovo-intestinal, uterine, etc.).

Infectious and intoxicating syndromes

Granulocytic leukocytes, which lie down to the melodious steams - the cells, whose function is to seize the organism from microbes. The stench is to take revenge on the disease-free bile - natural antibiotics, peroxides, and other words, direct to the depletion of an infectious agent. The impairment of the hematopoietic stew is hardened and destroyed, the organism's health is destroyed by fighting against ailing microbes. It can be manifested by small, inflamed flares: shkirny abscesses, phlegmons, right up to sepsis. Be-yak zapalennya viklikє іntoksikatsіyu - detachment products from the exchange of rechovins of pathogenic microorganisms. Intoxication syndrome is manifested by such signs of a yak:

• weakness;
• temperature adjustment;
• keenness;
• loss of appetite, reduction of vagi;
• unimportant pains in the muscles.

hyperplastic syndrome

It is found in 30-50% of patients. Pukhlinnі cells, not only the cystic marrow, but the lymph nodes, the liver, the spleen. Organize to grow, become painless, its consistency becomes very similar. By itself, hyperplasia is not safe, but lymph nodes grow more easily, as they are in an enclosed space (for example, when the middle is empty, the heart is degraded), the stench can stifle life's important organisms.

neuroleukemia

In 5-10% of children, leukoznі cells develop "metastases" - the breeding of fluff in the empty skull, cerebral membranes, great nerves. As a result, there are signs of a deterioration in the organs of the brain: impairment of sensitivity and function of the brain in case of infiltration of peripheral nerves, symptoms of changes in the brain and swelling of the brain during growth in infiltration of the middle of the brain.

Leukoznі cells can be approved for extramedullary (in the literal translation - roasted posture with a cyst) fluff in the cysts, on skins and mucous membranes, milk vines, matt and appendages, prostate, lungs. At the same time, there are symptoms characteristic of the pathology of cych organs.

diagnostics

The main familiar to leukemia is so called leukemic failure: if in the analysis you can see without blasts, there are few mature cells and more in the daytime transition forms. Ale for practice, as it is indicated in the clinical recommendations, at the early stages of ailments of leukemic cells in the hemogram (blood analysis) may not be present. The head of the department for the diagnosis of gastrointestinal leukemia is more than 20% of blasts (analysis of cystic fibrosis punctate).

Theoretically, diagnostics is guilty of including cytogenetic tests, if specific mutations of genes are introduced, which have caused leukemia. One of the most important prognostic factors and the current classification of the WHO includes a description of more than ten Genetic anomalies that can be safely infused into the forecast. Unfortunately, in Russia, cytochemistry, cytogenetic, molecular-genetic and similar genus, can only grow in great centers.

Lіkuvannya: zagalny principle

In the period of polychemotherapy - treatment, straightened to the bend of a leukemic clone, the patient needs a hospitalization and a special eye: mind, close to sterility. Kharchuvannya is povnotsinnym, with a high vistom bilka. The whole їzha obov'yazkovo is susceptible to temperature obrobtsі.

In addition to chemotherapy, which is directly related to the cause of the ailment, with leukemia, it is necessary to carry out and adaptive therapy. It is needed in order to catch and correct the main ailment syndromes: in case of anemia, they overflow erythrocytic mass, in case of hemorrhages - thrombocytes, infecting with antibiotics and so on. Supplementary therapy is required for the prevention of accelerated chemotherapy.

Go to the liking of children and grow up.

Likuvannya and forecast: children

V childish standard - intensive polychemotherapy, supplemented with cystic marrow transplantation.

You will need a selection of remixes. For a wide variety of vicious preparations, a combination of 5 preparations should be administered according to the singing scheme. In addition, since the blast cells in the cystic marrow are less than 5%, switch to additional therapy: up to 4 courses of cytostatic drug. It’s possible, however, to hesitate to transplant the cystic brain (with the blame of patients from a group with a friendly prognosis). But the possibility of transplantation lies in the name of the one who is known to be a common donor. In practical terms, it means that you don’t have to appear among close relatives, the possibility of transplantation is practically nil: the register of donors of the cystic brain in Russia is stored, but you can leave to go through such a trip far from all great worlds.

Presence to a group of easy-going, intermediate and uncomfortable prognosis is due to the genotypic characteristics of leukemia. In addition, there is a significant individual response of the patient to therapy: as soon as after 2 days, the number of blasts in the cystic brain decreases to 5-15%, and the rate of successful growth.

Even though the remission is more than 5 years old, leukemia is involved in vilikuvanim. A little more relapse. The cycle of relapse-remission can be trivial, or before stabilization, I will become, or the additional use of blood-forming resources - in a general way, the prognosis of unpleasantness.

In case of recurrence, polychemotherapy should be carried out in 3 stages: induction of remission, consolidation of remission and course of additional therapy.

For wild rice, the forecast of life expectancy can be described using additional tables:

It can be seen that vilikuvati gostry myloid leukemia in children is generally possible.

Likuvannya and forecast: older

Factors that can be used in the prognosis for older patients can be divided into 3 groups:

• Individual specialties to the body and health;
• Biological characteristics of a leukemic clone;
• Correct pidbir method of treatment.

individual specialties

Yak leukemia itself, so і th lіkuvannya - majestically nurturing on organism. Tom who is older than the patient, the forecast is better. In the first place, due to the chronic pathology, it grows more and more, and the stench is getting more important. To help children over 60 years of age tolerate healthier than they are young.

In other words, there is accumulation of side effects for the genotype, and the number of mutations with a bad prognosis of food.

Biological characteristics of a leukemic clone

In the same way, as in children, the most important predictor is the genotype of leukemia clitin. Cytogenetic dosage and presentation to a group of an uncomfortable, uncomfortable or intermediate prognosis is necessary for the correct selection of a therapy regimen. At the practical training in Russia, no more than 60% of the patients are carried out. The quality of the drink is the third factor.

adequacy of chemotherapy

In foreign clinical recommendations, there is no factor, unfortunately, which is only relevant for Russia. It is less effective to find the correct medication, but it is not necessary, with a change in the dosage of the drug, underreported intervals between courses and some "call" officials. Besides, belonging to this group of children in older adults, the need for transplantation of the cystic marrow, as well as cytogenetic prediction is not very important, to bring the patient to one patient. Russian Clinical Recommendations key signs yak bureaucrats unwelcoming forecast:

• Вік over 40 years old;
• blood leukocytes> 100 × 10 9 / l;
• the appearance of extra-medical exercises;
• after the first course of chemotherapy there was no remission;
• Secondary GML (wine for the course of chemotherapy and new malignancy);

Prototype

Polychemotherapy is the only way to protect a clone of leukemic cells. Ale kolimov idde about grown-up children supporters, To be able to see the prototype:

• myocardial infarction is less than a month before the ear of the disease;
• lack of heart;
• ruin heart rhythm, Which is supervised by unstable hemodynamics;
• nirkova lack of blood pressure, if viclikana has leukemic infiltrate;
• hostile viral hepatitis;
• pechinkova lack of crimson diseases, vicious leukemia infiltration;
• importance of pneumonia, crimson leukemia cells;
• sepsis;
• bleeding, which will block the life;
• important pathology of the psyche;
• visnazhennya;
• Diabetes mellitus with an indicator of blood glucose> 15 mmol / l, so there is no need to compensate;
• oncological pathology with uncontrolled interruption.
• When cich stans, aggressive polychemotherapy will definitely bring more shkodi, less corysti. If the camp has gone into stabilization, then through the day you can start a course of treatment.

Chemotherapy itself lasts 3 stages:

1. індукції remіsії (1-2 courses);
2. consolidation of remission (1-2 course) - the most aggressive and high-dose stage;
3. anti-recurrent treatment.

Specific schemes and the triviality of the course are highly variable in terms of prognosis and early recurrences.

In order to reach the remission of patients from a group of high-risk patients, it is recommended to transplant the cystic brain from a sumy donor. As for children, the possibility of applying the method is limited by the availability of the donor. Unimportant for transplantation safety for new patients (mortality rate 15-50%), recurrences for her are practically impossible.

Adopting chemotherapy is meant to last 1-2 years after a cob of remission (you can choose from 4 to 12 courses). The number and the triviality of the courses, as well as the intervals between them to lay down on the belonging of the sick to the group risk and reaction to the treatment.

Unfortunately, at least 60% of older patients have a relapse for 3 years. Talk to Tom about the prospects of vilіkuvatisya to finish smoothly.

The five-fold visibility varies from 4 to 46%. The prognosis is due to the genetic features of leukemia, the backward camp of the ailing and trivial remission.

Hematological pukhlini wiklikali great alertness... The inability to visually support the evil new solution, most often - gostry overrun, is characteristic key pictureі even foldable early diagnosis.

All of the characteristics can be easily brought to the hospital microblastic leukemia. The pathological process, which is mainly opposed to the cystic marrow, develops most often in the elderly population (85% of 100 ailments). Nybilsh razliviy vіk 60-65 rockіv. Children with ailments are significantly higher (15% of all children).

Hostry myeloblastic leukemia is a very bad degeneration of myeloid blood layer of healthy blood cells. New, pathological cells, with a great shvidkіstyu mend the proliferation, vitіsnyayuchi health.

And with a great stench, you can’t see all the signs of this function. Spread through the flow of blood, changes in leukocytes, penetrate into the organisms and systems and human organisms. It will be seen in its normal function.

cause

The root cause of the evil process has not been established until the end. There is a number of factors that can be screwed on, which are even more strongly infused into the development of the pathological process. Before them you can add:

• chromosomal damage(more often given pathology develop in patients, such as Down syndrome);
• decay rate without gene mutations: When close relatives have a history of malignant leukemia, the risk of illness grows 5 times. Identical twins are introduced to the group. If one is ill, the development of a pathological process in another, becomes 25%;
• falling ill of the hematopoietic system;
• Ionizuyuche vipprominuvannya(Rizik of the regeneration of healthy cells in cancer grows proportionally to the growth in the dose of radioactivity), pathological camp, vicious radioactive vippromises, often develop in a child's life;
• contact with toxic streams(Toluene, benzene), the disease can be developed through 1-5 rockets without contact with chemistry;
• reception of lykarsky zasob_v(The whole group includes drugs that are used for chemotherapy, for revenge mischief, Fenilbutazone, Chloramphenicol), likarsky hospitals for microblast leucoses store up to 20% of the backbone;
• kurnnya(Significantly pogirshu forecast for the development of ill health);
• infusion of biological factors(Infusion of oncogenic viruses).

Uninvolved on the developmental factor, as there can be provocations of development of the evil process, there will be only one bag - the change of DNA blood cells. Post-gradual progress and mechanism, which is responsible for the natural decline of the clitin. Crayfish cells become "immortal".

see

It is necessary to select the correct tactics for selection.

The presence of characteristic genetic changes:

• translocation between 8 and 21, 15 and 17, 9 and 11, 6 and 9, 1 and 22 chromosomes;
• changes in 16 and 3 chromosomes;
• mutation in genes: Sevres, NPM1.

Tying with malodisplasia:

• change to karyotype;
• unbalanced and unbalanced chromosomal anomalies.

• Viclikans in front of others(Chemotherapy, exchange therapy - change to the chromosomal rivnі).
• Myloid sarcoma.
• Myloproliferative pathological processes associated with Down's syndrome.
• Blastnykh plasmatitoid dendritic cell fluff.

In the medical literature there is a French-American classification of malignant leukemia:

• differentiated clientele minimally (5%);
• without ripening (20%);
• the presence of signs of maturity (30%);
• prominulocytic (15%);
• myolomonocytic (25%);
• monocytic (10%);
• erythroic (5%);
• basophilic (5%);
• megacariocyte (10%).

Most of them are uncomfortable for the course of the disease and the result of illness is infestation of malonocytic leukemia and monocytic leukemia.

key picture

During the relocation of the disease gostry, myloblastic leukemia can be cleverly transferred to a number of stages:

• camp of pre-leukemia (asymptomatic);
• state of the stage of pathological process;
• the country of a new or uncommon remisia;
• the manifestation of a recurrent interruption;
• the stage is concluded.

For that, as I see the persha mutation on the clerical rivn and until the development of the classic picture of the gostry mієloblastny leukemia, close to 2 mіs... Over the course of the period, in the cystic brain, accumulated pathological changes in cells are observed.

The stench will increase, bring life in the normal function of elements circulatory system... The result is a characteristic symptom complex.

symptomatology

The primary symptomatology of malignant leukemia will be the onset of manifestation:

Unprimed stripe of lowering the backbone mass є characteristic of all crayfish ailments.

Even more versatile, the clinical picture and the many symptoms of the brain's amazement, so that all organisms, which may be better bloodstatic, will not perceive the health of the clit, but the puffy ones.

Symptoms do not appear overnight. To see the growth of ailments in the world of progress.

diagnostics

Putting the correct diagnosis of gostriy myloblastic leukemia, spiraling on one symptom is not a good thing. It is necessary to carry out a number of additional diagnostic methods:

So, at the early stages of a pathological process, no one is ill at ease - it is possible to detect it with a prophylactic look at the creation of a standard set of clinical analyzes.

The zealous appointing to the scholarly prof. I’ll look around, and I’ll be overloading with a pass for a poor health problem.

lykuvannya

At this stage of the development of medical science, there are two methods of therapy for myloblastic leukemia: chemotherapy, which has a rich-component nature and a method of transplantation of the cystic brain.

Chemotherapy is carried out in three stages:

• the number of blast cells changes to such a level that it cannot be boiled by laboratory methods;
• liquidation of leukemia cells;
• repetition of the first step.

In all cases of chemotherapy, additional therapy with oral cytostatics is carried out. The triviality of the love becomes up to 2 rocky.

Dodatkove lіkuvannya includes:

• blood transfusion;
• disintoxication preparations;
• antibiotic therapy;
• optimization of the area of ​​the brain with the help of prevention of development of neurological damage;
• Endolumbar introduction of cytostatics;
• anti-fungal and anti-virus drugs;
• vitiminotherapy.

Cystic marrow transplantation it is necessary to spend the first hour of the first remission. And, if there is a relapse of ill health, it’s just the right choice of tactics.

Promeneva therapy vikorystovuєtsya nagato rіdshe with a whole evil new establishment.

When a patient enters the camp of the stage of recurrent remission, the new person is guilty of the following symptoms:

• a few obvious manifestations of the development of a pathological process;
• in blood not more than 5% of blast cells and in normal blood cells;
• blast cells in the peripheral hematopoietic system;
• dumb evil new creatures go beyond the main localization of evil new establishment.

For quiet ailments, for which a cardinal method of treatment is projected, an immunomodulating and adaptive therapy is required.

forecast

Cancer of the blood - no danger not uncomfortably ill... Ale і yogo, you can, vilikuvati, how to introduce the patient to the camp of stiykoy remіsії.

The prediction of a successful result is even stronger due to the fact and the general reaction to the body during the test.

The vision of children becomes 60% to 85%. In a mature population: from 20% to 40%.

It’s not like doing it - the triviality of life is significantly speeding up: from 2-3 months. to rock.

Gostrii malignant leukemia is even more important in the early stages. It is important to receive therapy. To that, it is necessary for the first vague symptoms to turn to a drug. Early manifestation of ill health is є the constipation of life or trivial remission.

At the end, it is recommended to admire the video with the educational lecture about the warehouse and the function of blood:

Yaksho vi knew the mercy, be weasel, see a fragment of the text and natisnit Ctrl + Enter.

The development of plump processes with skin rock is gaining wraps. more vchenykh svit We can develop the basic methods of therapy for the treatment of patients, and all types of treatment facilities are used for preventive visits. Growth can be tricked into any organ or system or organism. Myloleukemia - well tse take? The main causes of illness, methods of diagnostics and therapy are clear.

foreign intelligence

Priming on the maturity of young cells - platelets, erythrocytes and leukocytes in parallel with the process of growing up the aging of old people with liver and spleen.

Forms of elements in the blood are styles and plasmas. At the same time, the greatest number of seizures on the blood cells is leukocyte. The stench is indicative of the reaction of the body to the inflow of foreign agents and the reception and allow the preparation of the immune system on a proper basis.

Uncontrolled viroblasting of a great number of leukocytes is called myloid leukemia. Tse puddling zhvoryuvannya, how to supervise critical changes in the blood-bearing channel of immoral forms. An increase in the pathological forms of cytins in the organisms and systems and organisms, as well as the progression of ailments, is observed every year.

Ethiology of affliction

On the given stage, unequivocal officials, scho to develop a disease before development, not viznenі. Isnu kіlka version of the diagnosis of the pathological camp:

1. The appearance of pathological clones - the process of development pathological changes in the structure of stovbrovykh clitin. There is a mutation, before the hour any clones do not just inflame their own clones, but they transmit them to the structures that fire their clones. Tsey stan vilikuvati for the help of cytostatic drugs is uncomfortable.
2. Injection of cheesy words.
3. The action of radioactive viprominuvannya on organism, as it is not only because of the professional need. For example, there is a history of exchange therapy for the treatment of chickens.
4. Acceptance of cytostatics and chemotherapy drugs for the therapy of swollen organs can serve as a trigger mechanism for the development of myeloid leukemia.
5. Genetic illness, decline.
6. Ailments, which may be of a viral genesis.

Besides, on the appearance of a chubby process, it’s pouring in to become, in the patient’s, and in the inflow of radio communication in the living area.

Chronic ailment

Having shown the symptoms of a puffy blood process, lay down a form of ailment. The form is broadened - chronic myloid leukemia. Tsey stan has an evil character.

Chronic myol leukemia - is that so? Tse stan, which is the result of the fact that an abnormal gene appears in the organism, which is an enemy of the blood of the cell. The mice of the localization of the gene is the cystic brain. With the flow of blood, there is an expansion of pathological cells in all organs.

Zagvoryuvannya is not a hospitable cob and a beautiful classic picture. For a new one is characterized by a plinth. Nebezpeka polyagaє in the fact that the form of the ailment can go into the state of the art phase in any period, which can end with a lethal result for the patient.

Myloid leukemia is small in stages of development:

• chronic;
• stage of acceleration;
• thermal stage.

The first stage of chronic form

There are more patients to diagnose themselves in the whole stage. An ear of zhvoryuvannya is definitely a bit unhappy, a little bit of an asymptomatic character, or show it easily. Some of the odds are stamina, heaviness in the slunk, or in the livy pidreber, bad.

It’s an hour for a young person to take a look at the idea of ​​a reappointment in an epigastric day. On palpation, an increase in the spleen is observed. Look around the supravodzhutsya sickly visions from the side of the spleen, radiating to the back. In the analysis of blood, leukocytosis begins, growing in dynamism, as well as thrombocytosis and an increase in the number of granulocytes.

Often, ailments turn into a lykar during the development of an infarction of the spleen. There is a severe pain syndrome in the projection, symptoms of intoxication to the body, the temperature of the body rises.

stage of acceleration

At the stage of the disease, it is practically impossible to show it. In a sick person, there is no scarg, except for periodical temperatures up to subfebrile indicators. I am selling blood cells and leukocytes in blood.

The level of basophilia is increased by a third. When a lot of ailments start, turbuvati saw the heat and bazhanna sverbity. The price is tied to the growth of the gistamin.

Gostra stadiya (thermal)

The development of the third stage will describe a classic picture, I will go to the hospitality with a breakdown of ailments. Chronic mellitus leukemia is progressing, and there is a very classy picture. Patsinti skarzhitsya on such show:

• thinness;
• temporal temperature;
• I have pain in the bumps;
• izke change of a sick person.

When the patient is well-nigh, it is possible to develop the growth of small groups of lymphatic universities, liver, spleen, development of the crisis - the final stage of ailment, which is characterized by the onset of critical manifestations:

• lympho, or microblasts, grow by 20% more in the cystic brain or the bloodstream;
• biopsies of the cystic brain due to large groups of blasts;
• development of malignant sarcoma - malignant chickens with immature large blood cells.

At the tsіy stage, the patient's life becomes ill, to lie down for a long time as a part of paliative therapy.

Hostry myloid leukemia

A clever picture develops quickly, but it is a sign of illness. Without the recognition of adequate therapy, the result can be unpleasant even after the end of the decile or miscellaneous.

Gostriy malleukemia - well tse take? Tse evil swollen process of myeloid blood stream. Ailments of clinics do not stand up to infections, because they want the main function. Along with the changes in the blast structures, there is a change in the formation of blood elements.

Erythropenia and shortage of hemoglobin are manifested by the sheer curvatures, zadishkoy, vtomu. A decrease in the number of thrombocytes should be brought to an increase in the schooling capacity of the child up to the disease, increased bleeding, the appearance of petechiae and hematomas.

The first symptoms are not specific. It is even easier to confuse them with manifestations of respiratory viral infections. In addition, gostry malleukemia supervises progress most of the views in kissts and slopes.

diagnostics come in

The success of the ear of the diagnosis lies in the quality of the diagnosis and the setting of the correct diagnosis. In order to start the foreign camp and the phase of the patient's seizure, at any age for myol leukemia, the analysis is carried out in the offensive steps:

1. Analysis of peripheral blood of flaring - fixes the level of all forms of blood elements in dynamism.
2. Biochemistry of blood, showing damage to the robotic liver and spleen, as a result of the development of ailments.
3. The biopsy of cystic carcinoma aspirate is carried out for the collection of the necessary material from stegnova tassels... The manifestation of blast forms begins.
4. Hybridization allows for a mutational or abnormal chromosome.
5. PLR is tailored for the detection of an abnormal gene.
6. Directly on the identification of abnormal chromosomes in the leukemic cells.
7. If necessary, carry out Computer tomography, Magnetic resonance tomography and ultrasound detection.

Principles of Illness Therapy

Myloid leukemia is caused by a non-removable ear of the ear. The physician-oncologist determines the scheme of therapy, during the stages of discomfort, and in its manifestation. on early stage vіtamіnnа dієta, zagalnozmіtsnyuchі drugs are recognized.

The treatment of myeloid leukemia is primed on the intake of drugs, which are usually affected by the oncogene. Main features:

• "Imatinib" - because of attracting the activity of the child, which is violated by the oncogene of myeloid leukemia;
• "Dasatinib" - the drug is vicorized in the difference of ineffectiveness or intolerance to the patient "Imatinib";
• "Nilotinib" - for analogous, Scho to be carried to the next generation of oncogenic іngіbіtorіv;
• "Ponatinib" is one of the new drugs, strong for its effectiveness against blast cells, and for its weakness, it is important to accelerate the side of the sick person's body.

Also for a change immune system to the patients it is recognized as receiving "Interferon". The drug is not suitable for patients with illnesses, it can be used in complex therapy for young children.

Chemotherapy is carried out with the help of cytostatic agents. Tsyu chastinu terapii vikoristovuyut yak predatkove lіkuvannya during transplantation of cystic cells. Effectively vvazayutsya "Hydroxycarbamid", "Busulfan", "Vinblastin", "Wincristin", "Cytarabin".

The optimization in oncology is carried out behind the aid of high-energy exchanges, as well as in those areas. Stagnate individually, as a matter of necessity. In case of malleukemia, exchange therapy is vicious for replacement pain syndromes in kissts and slopes. The same is true for oncology of the hematopoietic system and for vikoristocy before transplantation of the cystic marrow.

Blood cell transplantation

Hirurgicne involvement є to expand it by the method of lykuvannya, albeit expensive. Chi is not a skinny patient in the snake of being allowed. Oncology center on Kashirka - one of the famous institutes for the therapy of chubby new products - to conduct additional prompt engagement, In addition to helping your patients.

Transplantation of the cystic brain itself is not so frequent at a time, as it is taken from peripheral blood. There are two options for the procedure:

1. Vikoristovuyt hematopoietic cells of the donor's cystic marrow. There can be some of the relatives, it’s important to know the donor, not having been in our homeland because we are sick.
2. Transplantation of peripheral vascular cells. This procedure is foldable, so that at the same time healthy cells can be healthy and healthy.

The oncology center on Kashirka is not the only thing to do surgical engagement They allowed the mortality of the patients to be reduced, and the vikoristov modern methods thermoablation, thermoablation and radiochilles surgery.

visnovok

At the statti, the term “myloleukemia” is discerned. Scho tse take, you now see. A successful result is possible with main course lykuvannya cob stages getting sick. The thermal stage of transferring to palatal therapy. Pizni and malignant stages of ailments produce to a lethal result in patients.

Zaphvoryuvannya blood is even more important for the people. Perche, the shelter is in contact with the tissue and the organs in the middle of the body. For vikonannya of their functions according to the nasichennyu klin kisnem, live rhymes and enzymes, blood circulation is correct, and the cell warehouse is in between the norms. In a different way, blood cells will become immune to the robot's immune system and organism. Gostrii myloblastny leukemia will destroy the structure of the clitin and vikliku reduce immunity.

Gostra i chronic form

Hostry microblastic leukemia (GML) develops, if the cells are not healthy cells - blasts. With a whole body, there are no healthy elements, at that hour yak pathological form transformation of blasts to grow up with the great shvidkistyu. The process of changing the clerical structure of non-gates is impossible to control with medication... Hostrii malignant leukemia is often produced before the death of the patient.

The type of blood cells, granulocytes, is one of the types of blood cells, which is expanded among the people and I will call it "blood cells". I want, absolutely, the color of blood does not change before the hour of getting sick. Leukocyte cells, such as granules (granulocytes), change.

Chronic malignant leukemia (CML) is diagnosed, if there is a change in the cell structure of mature granulocytes. From the hour of the cyst pathology to the organisms in the state of the virality of the new cells, as they ripen and transform in the health of the granulocytes. To that, chronic myloleukemia does not develop so quickly, like a host.

Lyudin can’t think about the serpent of great bloodshed children.

Myloleukemia is even broader than the disease of the middle of the blood ailments. On the skin 100 yew. Osib seizure 1 ailment with leukemia. Tsia ailment is hostile to people independently of races, stati and viku. However, leukemia is often diagnosed in 30-40 years old people.

Causes the development of ailments

There is a reason for the appearance of granulocytes, brought by medical prescriptions. Chronic myloleukemia is a disease in many cases and there are many factors that cause leukemia. However, medicine cannot proponate the disease, as it could have been 100% effective for the sick person. Leukemia, leukemia, why not?

The main reason for the development of myloblastic leukemia is called chromosomal translocation by doctors, which is also called “Philadelphia chromosome”. As a result, the destruction of chromosomes is reduced by small pieces and a DNA molecule is established with an absolutely new structure. Then there are copies of evil cells and the pathology of the beginning is expanding. For budovi bіlikh klіtin krovі vykorystovutsya myloidna tissue. Because the blood cells change and the patient develops myloid leukemia.

Until the end of the process, the following officials can do it:

• Radioactive optimization. Dental infusion of radioactivity on organism is widely seen. Viprominuvannya people can come to the zones of technogenic catastrophes and on deyaky vyrobnichnyh dilyankas. More often than not, myloblastic leukemia has become much of a previous exchange therapy for a type of cancer.
• Viruses get sick.
• Electromagnetic vipromagnuvannya.
• Diya deyakikh lіkarskih drugsіv. Most often it’s about getting sick against cancer, as it smells like an intensely toxic infusion on the body. Likewise, pre-malignant leukemia can be caused by the use of certain chemical words.
• Spadkov's smartness. DNA changes are often smart people, as they calmed down the power of their fathers.

Symptoms of the form

at gostromu ailments of leukocyte cells appear to change and multiply with uncontrolled swiftness. Rapid development of cancer ailment to produce before such signs of ailment appear, as a person cannot be ignored. Gostriy myloblastic leukemia manifests itself in severe non-articulation and in most severe symptoms:

• One of the first characteristic signs leukemia є blida shkira... This is a symptom of supravodzhu of all ill health of the hematopoietic system.
• There is a small increase in temperature in the range of 37.1-38.0 degrees, while the temperature is low for an hour or so.
• On the shkіrny curvature there is a visip at the viglyadі of small red chicks. Visipannya is not a wiklikє sverbinnya.
• Gostriy myloleukemia wiklikak nadishku navit with weak physical problems.
• Lyudin skars on ill-feeling in cistes, especially in rus. At the same time, beloved by a weak and a lot of children, they simply do not berate them with respect.
• On clear there are swellings, bleeding and development of gingivitis can be possible.
• Gostri leukozy wicks on those with hematomas. Chervono-blue beaches can appear on one of the obvious characteristic symptoms, Yaki viklikak tse fell ill.
• If Lyudin is often ill, in a new decrease in immunity and temporality to infections, the car may be susceptible to malignant leukemia.
• With the development of leukemia, Lyudin started to work quickly.
• snake okremikh vidiv to produce leukocytes to a decrease in immunity and people become infused to infectious diseases.

Chronic form symptoms

Chronic leukemia may not show the same symptoms in the first month, but rather to become ill. The body is magnetized to self-reliance, vibrating new granulocytes natomy changes. Ale, yak vіdomo, the cancer cells dwindle and degenerate more and more healthy, and ailments step by step will burst into organism. Some of the symptoms appear weakly, sometimes more strongly, and people are tempted to turn to a doctor without a mouth.

Call only when diagnostics for chronic myloleukemia is carried out.

Medicine sees three stages of illness:

• Chronic myloleukemia is repaired in a step-by-step manner, with the help of decilkokh clitin. Chronic malignant leukemia and symptoms, such as mild swelling, do not occur in the patient to a positive turn up to the doctor. At the end of the stage, it is possible to find out only for an additional blood analysis. Ailment can be caused by an increase in morbidity and severity, or pain in the lavage of the skin (in the area of ​​the spleen).
• At the stage of acceleration, there are signs of leukemia, as well as earlier weak. The increase in temperature and swelling is indicated. Number of changes and normal growth leukocytes. A report analysis of the blood can reveal an increase in basophilia, immature leukocyte cells and promyelocytes.
• The thermal stage is characterized by the manifestation of severely varying symptoms of chronic myloblastic leukemia. The temperature rises, in the vicinity of drops up to 40 degrees, strong pain in the slopes and the camp of weakness. When looking at the children, there is an increase in lymphatic universities, an increase in the spleen and a decrease in the central nervous system.

diagnostics

Diagnosis of malignant leukemia medical mortgage and create an analysis. Stagnant diagnostic procedures for the detection of leukemia. To repair the diagnosis before experiencing that look around. For people who suffer from myloleukemia, it is characteristic of an increase in lymph nodes, an increase in liver and spleen.

For the results, an analysis and diagnostics procedure is considered:

• Zagalny blood analysis. As a result of the advancement of leukemia ailments, there is an increase in the number of immature blood cells (granulocytes). The number of thrombocytes also changes.
• Biochemical analysis of blood. Biochemistry of vitamins B12, vitamins and enzymes. However, the resultant type of development can be deprived of the risk of inflicting on myloblastic leukemia.
• Biopsy of the cystic brain. One of the most accurate dosages in the diagnosis of leukemia. Carried out for analysis of blood. As a result of punctures in the tissues of the cystic marrow, a large number of immature leukocyte cells can also appear.
• Cytochemical analysis. The test is carried out on samples of blood and cat's brain. Special chemical reagents, upon contact with the patient's biological samples, start the steps of enzyme activity. With myloblastic leukemia, the amount of photophosphase decreases.
• Ultrasound dosage. The whole diagnostic method allows for the hardening of the liver and spleen.
• Genetic dosage. It is not carried out for diagnostics, but for the folding of the prognosis for the patient. The nature of chromosomal damage allows the formation of patterns of potential methods of treatment and efficiency.

Forecast and policy

Hostry myloid leukemia is often inflicted before the patient's death. Projections can only be made if the patient is thoroughly refined and the young people become ill. Yak lіkuvannya gosstry mієloblastny leukemia vikorystovutsya chemotherapy. The basic plan of treatment and the principle of therapy, which is called "induction".

Before an hour of carrying out a treatment, a complex of preparations is formed, taking a number of prescriptions every day.

At the other phase of treatment, as well as spraying therapy and remission, the preparation of drugs is carried out to consolidate the result according to the individual characteristics of the patient. For an hour of decreasing granulocytes drugs... Deyakiy їkh kіlkіst to become ill and a possible relapse of the ailment. for the reduction of the re-development of microblastic leukemia, it is carried out complex therapy This includes the transplantation of stovburovikh clitins. Diagnosis of chronic myloleukemia and leukemia is guiltyly carried out under suvorim lykarsky control. All the results of the analyzes of the guilty are deciphered by the doctors, so that they can be specially analyzed on the blood-sickness.

Medicine proponents advanced methods of treatment:

• Chemotherapy.
• Promeneva therapy.
• Transplantation of cystic marrow and stem-boron cells from a donor.
• Vityag of changes in leukocyte cells from organism for additional leukapheresis.
• Vividness of the spleen.

Vilіkuvati zhvoryuvannya even more smoothly. Therapy, as a rule, is intended for the reduction of the sick person and the preparation of his life functions. However, with a successful lіkuvannі, people suffer chronic leukemia dozens of rockivs live. Likuvatisya is necessary, ale medical statistics are known to be ineffective in remissions in patients with blood cancer.

In contact with

Blood sickness represent the temple is not safe for the people... Same tsya rіdina contact with usіma organs and tissues. The body cannot become more and more sour and lively talk, if blood circulation is damaged or the blood warehouse is poorly regulated. Blood cells will become healthy for the immune system and organism. Hostrii mioblastny leukemia is an ailment that will ruin the function of the circulatory system.

Poisonous growth when the blasts change - immature clitin, When the dosage is ripened, they become components of the blood. The body at the whole moment sees the marriage of healthy elements. Don't be monitored or medically controlled. In most cases, malignant leukemia becomes the cause of death of the sick.

There is a change in blood flow - granulocytes. This is called "bіlokrіv'ya" among the people.