Droperidol instructions for use of tablets. The neuroleptic antipsychotic drug Droperidol - even stronger than the anesthetic drug

to describe

Bezbarvny prosperity or slightly zhovtuvaty razchin.

Warehouse for oneat the ampoule

speech is active: droperidol - 12.5 mg;

additional speeches: tartaric acid, water for ін'єкцій.

Pharmacotherapeutic group

Antipsychotic use. Pochіdni butyrophenone. ATC code: N05AD08.

Pharmacological authorities

Pharmacodynamics

Droperidol is a neuroleptic, similar to butyrophenone. yogo pharmacological authorities tied mainly with dopamine-blocking and weak α1-adrenolytic effects. Droperidol is not an anticholinergic or antihistaminic power. Ingіbuyuchu dіyu droperidol on the dopaminergic receptor of the critical area of the bloody center is given a tense anti-bruising effect, which is important, both for prophylaxis, as well as for the treatment of patients with an operative trouble / bruising.

At a dose of 0.15 mg / kg droperidol wiklik arterial vise due to a decrease in the heart wikidu in the first phase, and then, as a result, a decrease in anterior protection. The changes occur directly due to the rapid activity of the myocardium and the court support.

Droperidol does not infuse on the rate of the myocardium or the heart rhythm, which does not affect the negative inotropic effect. Yogo weak α1-adrenergic blockade can reduce the hypotension, reduce the peripheral vascular opir, and reduce the grip in legendary artery(Especially, if it is significant). Also, α1-adrenergic blockade can reduce the incidence of adrenaline-induced arrhythmias, which does not cause the appearance of other types of cardiac arrhythmias.

Droperidol has a specific antiarrhythmic effect in doses of 0.2 mg / kg, injected into the rate of myocardium (podovzhu refractory period) and lowering the arterial grip.

With the internal introduction of the infusion in 2-3 minutes after the introduction. Sedative dіyu zberіgaєatsya, as a rule, stretching for 2-4 years, if you want the damage from the side, you can be spared for close to 12 years.

Pharmacokinetics

With an internal introduction, the maximum concentration in the plasma is reached after 15 min. Coupling with plasma beads - 85-90%. The period for which it is necessary to become in the middle 120 130 min. Metabolizes in the liver for the participation of isoenzymes in cytochrome P450: CYP1A2, CYP3A4 and in the smallest world CYP2C19. To be seen as nirkami in viglyad metabolites (75%), in an unchanged viglyad (1%); through the intestines (11%).

Shown to sucking

Prevention and treatment of tediousness and bluing for every hour of diagnostic and surgical procedures and in during the operational period.

How to store that dosi

wayNSApplication: internally.

Prevention and treatment of operational boredom and blues.

older: 0.625-1.25 mg (0.25-0.5 ml).

letters: 0.625 mg (0.25 ml).

Nirkova / Pechinkova lack: 0.625 mg (0.25 ml).

Children (from 2 to 11 years) and children (from 12 to 18 years): 10-50 μg / kg (maximum up to 1.25 mg).

The appointment of droperidol is recommended 30 minutes before the ochikuvannya end of the operation. Reappointment can be made through the skin for 6 years as required. The dosage is guilty but adapted to the specific skin type, due to the reasons for such factors as vik, masa tila, vikorstannya іnіh lіkarsky zasobіv, type of anesthesia and surgical engagement.

Pobichna diya"Type =" checkbox ">

Pobichna diya

The frequency of development of side effects is given in the offensive gradation: even more often (≥ 1/10); often (≥ 1/100,

Destruction on the side of the blood lymphatic systems : even more rare: pathological changes from the side of the blood.

Destruction from the side immune system Ridko: sensitivity, anaphylactic reactions, angioedema.

Destruction from the side: Nevidomo: syndrome of inadequate secretion of antidiuretic hormone.

deranged psyche: infrequently: zanepokєnnya, akatizia; Ridko: interlocking of testimony, agitation; even more rarely: dysphoria; unavoidably: hallucinations.

Destruction from the side nervous system : Often: drowsiness; infrequently: dystonia, ruhu real apples; even more rarely: extrapyramidnі rosladi, sudomi, tremor; unavoidably: epileptic attacks, Parkinson's ailment, psychomotor

zbuzhennya, coma.

Destruction from the side of the heart: infrequently: tachycardia, spoiled; Ridko: heart arrhythmia, including shlunochkov arrhythmia; even more rarely: zupinka heart, feverish tachycardia (torsades de pointes); raising the QT interval.

Destruction from the side of the Sudin: Often: hypotension; unavoidably: obscurity.

Destruction from the side mental systems, organs breast cancer and middle: Nevidomo: bronchospasm, laryngospasm.

Damage from the side of the shkіri and pedshkіrnyh fabricsRidko: hang.

Headquarters and damage in the introductionRidko: malignant neuroleptic syndrome (NSS); even more rarely: rapt death.

In some cases, there were symptoms associated with the ZNS, for example, temperature changes, muscle rigidity and fever. Spostering changes in mental status: decay or agitation and confusion. Vegetative dysfunction can be manifested in vigilatus tachycardia, colony arterial vise, overwhelming sweat / sleepiness and tremor. In extreme cases, the ZNS can lead to the Komi, the deterioration of the function of the nirok and / or hepatobiliary system.

Amenorrhea, galactorrhea, gynecomastia, hyperprolactinemia and oligomenorrhea were diagnosed with droperidol trivial therapy.

There were some cases of venous thromboembolism, including cases of severe thromboembolism and thrombosis of glib veins;

Something about non-fancy kids

It is important to talk about the non-fatal reactions of the drug reestablishment in order to ensure the uninterrupted monitoring of the "cinnamon - risik" drug. medical workers it is recommended to be advised about any non-desired reactions of a drug through the national system of notifications about non-desired reactions (UE Center for Expertise and Viprobuvan in Health Protection M3 RB» ).

Prototype

hypersensitivity to droperidol, whether from ancillary words; hypersensitivity to butyrophenones; at the same time, if the QT interval is increased (QTc> 450 ms for women and 440 ms for choloviks), including in patients with an increase in the QT interval; may have a family history of congenital QT elevation; how to get the therapy with drugs, how to add the QT interval; hypocalypse or hypomagnesemia; bradycardia (heart rate

Overdose

Having shown an overdose of droperidol є a lot of overwhelming pharmacological activities.

Symptoms of a hateful overdose: psychotic baiduzhst with the transition to sleep, sometimes in the absence of a blood pressure.

At higher doses, or in hyper-sensitive patients, there may be some extrapiracytic changes (sleeplessness, rupture of ruffles, little - myazova rigidity). At toxic doses, it can be vicious sudomi.

lykuvannya: There is no specific antidote. In case of diagnoses of electrophilic disorders, it is necessary to introduce anticholinergic diseases.

Patients with overdose of droperidol need to be careful about the trivial QT interval.

Slid brothers to respect bureaucrats, to produce until the iniquity of the feast of the tachycardia ( electrical damage: Hypokalієmiya, hіpomagnієmiya; bradycardia).

Drug treatment should be carried out in the development of hypotension, increased volume of circulating blood and if you take it in. To blame for the trouble dikhalnyh nobles and adequate oxygenation. Oropharyngeal and endotracheal tube is also indicated.

If it is necessary for a patient for 24 years and more, it is necessary to take care of the safety, to ensure the optimal temperature of the room and to live a sufficient number of days.

Zapobizhnі come in

Central nervous system

Droperidol can be a powerful infusion on the central nervous system of some of the others, which can adjust the central nervous system. Patients who are undergoing anesthesia, as they recover from straining depression, or symptoms of CNS impairment, are guilty of a suvor Likarsky's caution. Immediate consumption of metoclopramide and other antipsychotics can lead to an improvement in extrapiracytic symptoms, such as a combination of drugs in several uniqueness. It is necessary to protect the patients from the epilepsy (for they have a history of epilepsy) and in the minds, to take the development of the epilepsy in court.

Sertsevo-sudinnasystem

Potential development of hypotension and incoli reflex tachycardia for the consumption of droperidol. Qia reactions urge to pass spontaneously. However, when hypotensive growth is spared, the growth of hypovolemia is spared, in such a way it is necessary to store the age.

The possibility of taking droperidol in patients with the presence of, or with adolescence, for the appearance of onset factors in the development of heart arrhythmia was shown to be reliably assessed:

Serious impairment of the heart, including serous sinus arrhythmias, atrio-sinus arrhythmias, atrio-sinus blockade of another or third stage, dysfunction sinus node, Stiffening heart failure, ischemic ailment of the heart and hypertrophy of the little one; raptus death in family history; nirkova lack of (especially with chronic disease); chronic obstructive ailment is swollen and dyshally deficient; a factor in the deterioration of the electrolyte balance, which is promoted in patients who are taking the miscarriages, glucocorticoids, blood-borne diuretics, spilorally with insulin therapy, and in some cases

In patients with risky development of heart arrhythmia, before the consumption of droperidol, it is necessary to increase the concentration of electrolytes and creatine and to increase the possibility of increasing the QT interval.

In patients with emerging or susceptible risiks, the development of a sluggish arrhythmia should be carried out without interruption with a pulse oximeter, as it should be continued with a stretch of 30 minutes for a one-time intravenous injection of the drug.

zagalny

To prevent the increase in the QT interval, it is necessary to be careful, as the patient is taking medications, as they can reduce the electrolyte imbalance (hypocalcium and caloric intake),

Drugs that reduce the activity of cytochrome P450 (CYP) CYP1A2, CYP3A4 isoenzymes can reduce the metabolism of droperidol and reduce the rate of pharmacological injection. In general, it is necessary to take care of the need for such additional preparation.

Patients who are malignant with alcohol are guilty of but reliably obsolete before the consumption of droperidol.

In case of imperturbable hyperthermia, it is necessary to fix the treatment, as it can be one of the signs of a malignant neuroleptic syndrome.

I was experiencing problems with venous thromboembolism (VTE) with antipsychotic drug problems. Patients who are undergoing therapy with antipsychotic drugs often have a factor in the development of BTE, so it is necessary to assign all possible factors to the development of BTE in the patient before the next hour.

insanity

Insensible with barbіturata. The whole drug does not go downhill with other drugs.

It is necessary to vikoristovuvati only clean, without changes in the color of the drug.

Prolonged pregnancy in the period of lactation

Viability. Interconnected data from key students showed the visibility of the development of the development.

Droperidol did not repair the teratogenic effect in schurivs. A lack of dosage was carried out on the creatures as well as injecting droperidol into the infusion of droperidol for interruption of vaginosity, embryonic / fetal development, the process of flattening and postnatal development.

Descriptions of the team's winnings neurological damage With extrapiracy in nature, newborns are uncomfortable with all kinds of mothers who have taken high doses of neuroleptics for a trivial hour. In practice, in the absence of a foreign visit, it is recommended not to inject droperidol before the hour of vaginosity. Before the hour of pregnancy, when droperidol is required, it is recommended to follow the neurological functions of the newborn.

Breast blowing. Antipsychotics like butyrophenone are seen in breast milk; Droperidol therapy is guilty of but is surrounded by one drug. Reapplication is not recommended.

Fertility. Droperidol did not repair any kind of infusion on fertility due to the results of the recent studies carried out in female and male patients. The clinical effect of droperidol injection on fertility has been established.

Inflow to the building of keruvati by motor transport and by the largest potentially not safe mechanisms

Droperidol is significantly infused into the building of keruvati by road transport and by the most potential non-safety mechanisms. Patients are not guilty of keruvati by motor transport and other potentially unsafe mechanisms lasting 24 years for the consumption of droperidol.

Vzaєmodia with іnshy lіkarskiy zasob

droperidol contraindicationsat one hour zasosuvannі

Lykarsky drugs, as they viklikayut fever tachycardia (torsades de pointes), increased by the increase in the QT interval, not followed by droperidol at once. Until a given group of lykarskiy assignments are made:

Class IA antiarrhythmic drugs (for example, hinidin, disopiramid, procainamid); class III antiarrhythmic drugs (for example, amiodarone, sotalol); macrolide antibiotics (for example, erithromicin, clarithromicin); fluorochinolone antibiotics (for example, sparfloxacin); antihistamines (for example, astemizol, terfenadine); antipsychotic drugs (for example, chlorpromazine, haloperidol, pimozide, thioridazine); protimalarіynі drugs (for example, chloroquin, halofantrine); cisapride, domperidone, methadone, pentamidine.

A slid of a unique alcohol intake of droperidol with medicinal preparations, when using extrapiracytes (for example, metoclopramide and other antipsychotics), so as it is possible to produce before the development of antipsychotics.

Slid unicati vzhivannya alcoholic beverages and drugs, alcohol.

To prevent the increase in the QT interval, it is necessary to be careful when the patient is stuck on medications, in the past, electrolyte imbalance (hypocalcium and / or hypomagnetics, diarrhea); Droperidol can be used for sedative effects (barbiturati, benzodiazepini, morphine and yogo); droperidol can be used as antihypertensive drugs, which can be produced to orthostatic hypotension; droperidol can be used to induce a reaction that is vicious with litter; droperidol blocks the receptor for dopamine, which can be used to detect dopamine agonists, such as bromocriptine, lisuride and levodopa; It is said that the activity of P450 isoenzymes (CYP) CYP1A2, CYP3A4 can reduce the metabolic rate of droperidol and promote the term of the pharmacological activity. Moreover slіd dotrimuvatisya oberezhnostі, Yakscho droperidol priznachaєtsya odnochasno of іngіbіtorami CYP1A2 (ciprofloxacin, tiklopіdin) іngіbіtorami CYP3A4 (diltіazem, eritromіtsin, fluconazole, іndinavіr, іtrakonazol, ketoconazole, nefazodone, nelfіnavіr, ritonavіr, sakvіnavіr, verapamіl) abo іngіbіtorami yak CYP1A2, so i CYP3A4 (cimetidine, mibefradil).

wash away

For the recipe.

For stationaries.

Virobnik

RUE "Belmedpreparati"

Republic of Bilorus, 220007, metro Minsk, st. Fabricius, 30, t./F.: (+37517) 220 3716, e-mail :.

N01AX01 (Droperidol)

Before taking the drug droperidol, you should consult with the drug. This instruction is given for the purpose of providing information. To reject more information, please, turn to the annotation of the virobnik.

Clinical-pharmacological group

02.001 (Antipsychotic drug (neuroleptic))

Pharmacological diya

Antipsychotic zasib (neuroleptic), older than butyrophenone. Nadaє antipsychotic, cataleptogenic, sedative, anti-inflammatory, as well as antibiotic.

Mechanism of antipsychotic dressing with blockade of dopamine D2 receptors of the mesolimbic and mesocortical systems. Sedative action is accompanied by blockade of adrenergic receptors in the reticular formation of the brain, anti-buccal action - blockade of dopamine D2-receptors in the critical zone of the blotting center, hypothermic action - blockade of dophalamine receptors.

Possible decrease in AT due to enlargement of peripheral vessels and decrease in TPR; I reduce the grip in the legendary artery (especially, as it has been changed) and change the pressure effect on adrenaline. Droperidol reduces the incidence of arrhythmias caused by adrenaline, but does not cause damage heart rhythmіnshoї etiology.

Not volodya holinblokuyuchu activity.

With i / v or i / m injected diya of droperidol develops after 3-10 minutes, the maximum effect is observed after 30 minutes. The sedative effect is trivial - 2-4 hours, the lateral triviality of the day on the central nervous system can be up to 12 hours.

Pharmacokinetics

Cmax of droperidol in plasma can be reached for 15 minutes. The linkage with the blood plasmas becomes 85-90%. T1 / 2 warehouseє in the middle 134 min. Metabolize in ovens. Vivoditsya nirkami - 75% in viglyad metabolites, 1% - in uncontested viglyadі; 11% is excreted through the intestines.

Droperidol: Dozing

The dose should be started individually, with the help of viku, masti tila, zagalny physical stance, the nature of the illness, one-hour vikorovuvannyh drugs, the type of maybutnoi anesthesia.

For premedication, we will grow for 15-45 minutes before the ear of surgical intervention in / m inject 2.5-5 mg, for children - 100 mcg / kg.

For the introduction into anesthesia - i / v: adults - 15-20 mg, children - 200-400 mcg / kg (or 300-600 mcg / kg i / m).

In case of trivial operations for the preparation of anesthesia, repeat intravenous administration in a dose of 2.5-5 mg.

In the period of the operative period, we will grow up to give an IM in 2.5-5 mg of skin for 6 hours.

likarska vzaєmodiya

With a one-hour consumption of drugs, which may be attracting an infusion to the central nervous system (abandoned benzodiazepines, anesthesia, opioid analgesics, sodas), droperidol is generally attracting.

With a one-hour consumption, droperidol shows antagonism to adrenaline and other adrenal and sympathetic disorders.

With a one-hour consumption, droperidol will do it with antihypertensive drugs.

So, as droperidol blocks the dopamine receptor, with a one-hour consumption of dopamine, it is possible to induce dopamine agony, incl. bromocriptine, lisuride and levodopi.

Vigor and lactation

Zastosuvannya with vaginosti is usually deprived in quiet vapadas, if cinnamon is transferred to the mother, I change a potential risik for the fetus.

Adequate and well controlled dosage of droperidol intake during lactation was not carried out. Butyrophenon is seen with milk and is not recommended until it is consumed in the lactation period. If necessary, the intake of droperidol in the mother breast year bath pinch.

In experimental dosages, no teratogenic effects of droperidol have been found.

Droperidol: Pobichna diya

On the side of the central nervous system: dysphoria, drowsiness in the period of operative periods, navpaki, when stagnant in variable doses - unconsciousness, motor sleepiness, fear; Ridko - extrapyramid symptoms; in single cases in the period of operation, hallucinations, depression are promoted.

Three sides heart-vascular system: In addition, arterial hypotension and tachycardia, which, as a rule, do not require special therapy. Have a lot of children in the fall arterial hypertension(Most effective when combined with droperidol intake with fentanil or other analgesics, which are administered parenterally).

On the side of the herbal system: nudota, loss of appetite, dyspeptic symptoms; Ridko - zhovtyanitsya, transient damage to the function of the liver.

Allergic reactions: rare - anaphylactic reactions, hypothermia, tremor, laryngospasm, bronchospasm.

showing

In surgery: premedication, initial anesthesia, potentiation of backward and regional anesthesia. Neuroleptanalgesia (in combination with fentanil). No sedative effect, no boredom and no blues before hours of diagnostics and surgical procedures, pain and bloating in the operative period.

In psychiatric practice: psychomotor stimulation, hallucinations.

In therapy: pain and shock with injuries, myocardial infarction, severe attacks of angina pectoris, a lot of legends; hypertensive crisis.

Prototype

Extrapiracy degradation, important depression, coma, caesarean roztin, hypocalypse, arterial hypotension, improvement of the QT interval on the EKG, childish vik up to 2 years, sensitivity to droperidol and old morphine is adjusted.

special requests

Droperidol should be used only in the mind of the hospital.

I will protect against stasis in case of deterioration of the function of the liver and nirok, epilepsy and stuns, so that I can overcome an epileptic seizure, in case of depression.

We are sick on pheochromocytoma after the introduction of droperidol may be important arterial hypertension and tachycardia.

When droperidol is victorious, it is possible to transfer the possibility of developing a rotated arterial hypothesis and transferring the appearance of a quick correction. Droperidol can reduce the grip of the legacy artery, so that mothers are on the lookout for surgical and diagnostic procedures. Patients who receive droperidol, the necessary retail drug control.

In patients with a kidney disease, physically weakened and abnormal ailments, as well as with a high degree of risk, a dose of droperidol should change. Adjusting the dose, it is necessary to take care of it as a result.

On the other side of the drug, which should be infused into the central nervous system, droperidol should be prescribed in small doses, and, apparently, if droperidol is consumed, such drugs should be administered in smaller doses.

If mothers are on good health, consuming droperidol in an adjusted dose (up to 25 mg or more) can lead to rapid death of ailments with heart rhythm disturbances on the basis of hypoxia, impairment of the electrolyte balance of alcohol abnormalities.

When droperidol is consumed in surgical practice, it is necessary to control the parameters of the physiological body. It is necessary to be educated, so that the EEG changes for the operation to know more and more. Stagnation of droperidol during spinal or epidural anesthesia can result in blockade of the intercostal nerves and the sympathetic nervous system, which, in its turn, makes it difficult for the patient to work out, with the expansion of peripheral vascular disease and development of the hypogastric hemorrhage.

In order to unify orthostatic hypotensiveness after taking care of the transport of a patient, a unique change in the position of the body.

Inflow to the building of keruvati by transport means and mechanisms

On the other side of droperidol and with a hand, add a lot of uniqueness of potentially unsafe types of performance, showing a high concentration of respect and high-profile psychomotor reactions.

The antipsychotic Droperidol is used to treat shock conditions, as well as an antipsychotic drug. Let's talk about this year pharmacological group Specifics that are shown prior to consumption with droperidol, for the purpose of allowing wine to be accepted without a prescription, and also to allow discussing the important nuances associated with the drug.

particularity of the drug

Sphere vicoriannia with droperidol - anesthesiology and psychotherapy. Stagnate in a drug of shock and antipsychotic drug.

Neuroleptic є powder with crystals of pastel light, which changes the color to the light in the presence of light and is closed in the presence of children.

Water is not a good choice for powder, like alcohol, and the steps are too small.

warehouse

The main active component with droperidol is a crystalline powder of the same name with labels, the stage of dissociation in water is 0%. The powder is not ethereal, we can’t smell that.

It was named after the medical name Droperidol, a chemical old series of butyrophenones with substitutions of choter hydroxyl groups and fluorine in the molecules of benzimidazolinone.

lykarski formi

Form of dispensing: Droperidol is dispensed in ampoules with a volume of 10 ml. A cardboard box contains 50 ampoules. Zm_st of pure speech in 25% of liquor - 25 mg.

Pharmacological diya

I am pouring into the nervous system, Droperidol is transformed into bloating, which is a sedative infusion on the regulation of somatic and autonomic functions. lykarska diyu Droperidol is tied to galvanized dopamine receptors localized in the brain structures: reticular pharmacy, dopamine and to the brain, Neuroendocrine cells of the hypothalamus. Zvidsi riznomanittya injected on the vegetative and somatic functions of the body.

Let's also understand the mechanism of droperidol.

Pharmacodynamics

Droperidol is not a galvanic receptor, sensitive to the mediator acetylcholine. Zasosuvannya to the drug with a reduction of the Legendary grip for the rakhunok of the Khvilovoy reduction of the pressor effect in the Legendary artery. When diagnosed with epinephrine etiology, droperidol is nada protylezhny, normalization of the heart rhythm, effect. The pathology of the ethiology with droperidol is not known.

Halmus activity of a drug on the side of the receptor appears for 4 years, and the traces of the drug injected from the side of the nervous system appear after 12 years after the introduction of the drug.

Droperidol, when internally or internally introduced, likuvalny effect after 3 hvilini. Maximum concentration with droperidol during histological analysis nerve tissue it is determined through the first day of the introduction of the drug.

Pharmacokinetics

Blood plasma is maximized lykarsky drug in 15 minutes after the introduction. Transport with droperidol in the tissue of the central nervous system is carried by a path through the blood cells. The period for the fall of the speech should be approximately 2.5 years.

Industrial and residual metabolic products are set in epithelial fabrics ovens. Ekskretsiya speech vyroblyaєtsya across the cross section (3/4 obsyagu). Mayzhe 25% droperidol is administered through herbal tract... Less than 1% of speech was trivial to be stored in blood plasma.

showing

Droperidol is known to be used in surgical and therapeutic practice. Surgery has the drug vicoristovy:

v cob stage anesthesia;
yak drug addiction in the preparation of the patient before surgery;
in antipsychotic conditions during muscle anesthesia;
during operative and diagnostic procedures in the form of a sedative;
for lowering the muscle tone and restoring the patient to sleep for the improvement of neuroleptanalgesia.

In therapy, Droperidol is vicarious in vipads:

gostrich crisis pid hour;
prophylaxis of anaphylactic shock in case of rejection of injuries;
crisis period against the state;
the legacy of lack, poured over with a lot;

The drug stagnates in psychiatric practice in case of over-excitation of receptor activity and hallucinations.

Instructions for sucking droperidol in ampoules will be shown below.

Instructions for storing

Dozuvannya is introduced lіkarskogo zasobu rozrahovuєtsya, spiraling onto the wag, vіk і zagalny camp of the sick. In the case of rosters, the patient also has an individual tolerance to the drug, the nature of the ailment, and the administration of anesthetics and the type of anesthesia.

Approximately for six months before the operation, the patient will remove up to 5 mg of the drug by the intramuscular method, for children Droperidol will be dispensed for 1 kg - 100 mcg of the drug.
With vikorystannі droperidol yak anesthesia practice internally introduced 15 mg of the drug, children are injected with 0.3 μg per 1 kg of oil.

It is obvious from the instruction because of the intake, the dose of droperidol is reduced, or the drug is interconnected before implantation in case of pecinous nirkova lack, Prolonged depressive camps, sweeping epilepsy.

Patients, who have a zagalny camp, mean that they are weak, which may cause great problems with your body, blame the lower dose with droperidol. When developing in the body, there is more frequent heart rhythm and stan.

Droperidol can be contraindicated, we'll talk about them.

Prototype

It is not recommended to vikoristovuti the drug in gynecological practice during cesarean surgery dovzhastogo brain in the fetus, one can see the impingement of the effect.
Extrapiracy loss (damage to the activity of the tone of the mucus) is also a transition for the introduction of the drug.
It is not recommended to take a trivial hypotensive drug і droperidol for the risk of a strong decrease in systolic vise.
The drug of contraindications is ailment from trivial depression, covered with phobias.

Potential effects of droperidol

In small cases, sucking droperidol in CLINIC PRACTICE There may be some secondary manifestations:

allergic reactions in spasms of spasmodic nobles;
if you are sick from surgery, you may feel sleepy, and if you overdosed with droperidol, navpaki, you will get overwhelmed by the need for an hour, a depressive camp;
it is not uncommon to mean tediousness, zhovtyanichny manifestations, waste of appetite;
naturally lowering the systolic vice.

special requests

The drug for ін'єкцій Droperidol permits at the indicated only in the main minds. The galvanic infusion on the structure of the brain allows the creation of a pattern about an undesirable input to the robot by reaching out for the drug, especially on the type of robot, in order to need a concentration of respect and the collapse of the nerve processes.

Overexposure of the dose (25 mg per food) can be the cause of the lethal outcome of the patient. It is not necessary to change the patient's position as well. The loss of galvanization is due to the increasing amount of swiftness, but not from the deterioration, since the introduction of the drug Vimaga regularly introduces parameters in the standard of physiological systems to the body.

Let us know, like the advice є about taking droperidol.

Instructions for storing:

Droperidol is a drug for antibiotics, antipsychotic and anti-shock drugs.

Form vipusk and warehouse

Droperidol is dispensed in the form of a retail package for ін'єкцій (in ampoules of 2 or 5 ml, 5 or 10 ampoules in carton packs, or 5 ampoules in contour charunk packs, 1, 2, 20, 30, 50, 100 packs in carton packs; 5 or 10 ml each in bottles, 5 bottles each for contour charunk packs, 30 or 50 packs in carton packs).

Up to a warehouse of 1 ml, an active speech is included: droperidol - 2.5 mg.

Shown to sucking

Surgery: initial anesthesia, premedication, potentiation of backward and regional anesthesia; neuroleptanalgesia (one hour with fentanil); failure of sedative effect, loss of bloating and pain in the period of operative period, bloating and boring for hours of surgical and diagnostic procedures;
Therapy: shock and pain in case of injuries, important angina attacks, myocardial infarction, hypertensive crisis, lesions;
Psychiatric practice: hallucinations, psychomotor stimulation.

Prototype

coma;
Extrapіramіdnі damage;
Increased QT interval on the EKG;
Important depression;
hypocalypse;
Kesariv rostin;
Arterial hypertension;
Вік up to 2 rockіv;
Hypersensitivity to components of the drug and old morphines.

Stagnation of droperidol by vaginal women is possible only in vipads, if cinnamon is transferred for the health of the mother, as a potential rhizic for the fetus. If there is a need for the drug to be consumed by women, it is necessary to pinch the breast before the hour of lactation.

How to save and add

The dose with droperidol is individualized, vrakhoyuchi character of the anesthesia, vik, zagalny physical stun, masu tila, the drug is stagnant one hour, a type of anesthesia.

Doroslim for premedication for 15-45 quilins before the ear of surgical administration by internal injection of 2.5-5 mg droperidol, for children - 100 mcg / kg.

Doroslim for the introduction into anesthesia of the drug priznachayut in a dose of 15-20 mg (internally). Children can be administered internally (in doses of 200-400 mcg / kg) or internally (in doses of 300-600 mcg / kg).

For the preparation of anesthesia during trivial operations, it is possible to re-inject internally with droperidol in a dose of 2.5-5 mg.

In the case of the operative period, we will grow skin 6 years internally at 2.5-5 mg.

Pobichna diya

When zasosuvannі droperidol, there is a lot of development from the side of some systems to the body:

The central nervous system: drowsiness, dysphoria in the period of operative period, navpaki, in case of stagnant dose adjustments - fear, motor sleepiness, unconsciousness; Ridko - extrapyramid symptoms; in okremikh vypadki in the period of operation - depression, hallucinations;
Heart-vascular system: tachycardia and arterial hypotension (special therapy is not required); in even inferior types - arterial hypertension (most importantly - when combined with fentanil or parenteral analgesics);
Herbal system: dyspeptic symptoms, loss of appetite, nudota; Ridko - transient damage to the function of the liver, zhovtyanitsya;
Allergic reactions: rare - malfunctioning, anaphylactic reactions, tremors, bronchospasm, laryngospasm.

special requests

Droperidol is used only in stationary minds.

The drug should be used to protect us from disease. functional damage nirok і liver, depression, epilepsy, as well as with camps, scho to overcome an epileptic seizure.

When pheochromocytoma is administered with droperidol, tachycardia and an important arterial hypertension may develop.

Before the hour of therapy, it is necessary to transfer the possibility of developing a rotated arterial hypothesis. Also, the drug can reduce the grip in the legacy of the artery, but it is necessary to carry out diagnostic and surgical procedures for an hour. If we get rid of Droperidol, we need a retail drug control.

The pochatkova dose of the drug should change to the patients of the kidnapped vik, weakening and physically weakening the ailment. With an increase in dosage, it is necessary to keruvatis to be removed by the effect.

Droperidol should be prescribed in a small dose with a one-hour consumption of drugs, to induce a fitting injection on the central nervous system. Apparently, when using droperidol, the dosage of such drugs can also be reduced.

Intrusion with droperidol in adjusted doses (25 mg or more) can lead to raptor death ailments with impaired heart rhythm on aphids of alcohol withdrawal, hypoxia or impaired electrolyte balance.

In surgical practice, when the drug is consumed, it is necessary to control the parameters of the physiological body. With epidural abnormal spinal anesthesia, the development of the blockade of the sympathetic nervous system and the intercostal nerves can lead to complications, the development of arterial hypotension and enlarged peripheral vascular disease.

It is recommended to take precautions when transporting an ailing one, a unique change in the position of the body.

On the other hand, droperidol and lasting 24 years, for this purpose, it is necessary to uniquely identify potentially insecure robots in order to achieve quick psychomotor reactions and high concentration of respect.

likarska vzaєmodiya

With a one-hour consumption of droperidol with actions of a drug addict, you can get some neat effects:

Preparations that infuse a suitable infusion onto the central nervous system (old benzodiazepine, add for anesthesia, opioid analgesics, sodas): harden the inflow into the central nervous system;
Antihypertensive drugs: potentiation of їх дії;
Epinephrine and adrenergic and sympathetic activity: manifested in all related antagonism;
Agony of dopamine, including bromocriptine, lisuride and levodopa:

analogs

Analogues of droperidol є: Diprivan, nitrous oxide, Ketamin, KseMed, Sodium hydroxybutyrate, Medksenon, predion, Propovan, Propofol Fresenius, Pofol, Provayv, Rekofol.

Terms and conditions

Take in stolen light, dry, inaccessible to children at temperatures up to 20 ° C.

Term of attachment - 5 years.

To deliver often in a modern medical practice lykarskiy zasib Droperidol. Instructions for storing, showing that intercourse, power and power side effects- a lot of information, which is a lot of patients. So what are the leaks?

Form vipusku and warehouse for the preparation

The drug "Droperidol" is dispensed in the form of a rosette for ін'єкцій. Ridin is sold in 2, 5 or 10 ml glass ampoules. The main active speech here is droperidol - crystalline powder of zhovtuvaty koloru. The concentration of the whole component in the range is 0.25%.

Yakim power of Volodya Lika?

Bagato paciєntiv, yakim bouv of signs Danium drug, To provide information about those who are the authorities of the Volodya Lika "Droperidol". Diya yogo on the organism of humans is amused by the blockade of D2 receptors in dopamine in the brain.

The drug is administered to a group of antipsychotics. Zavdyakov pouring into the receptor of the mesocortical and mesolimbic systems of the viroblya antipsychotic effect. It also has sedative powers, as it blocks the adrenergic receptor in the reticular formation of the stovbur to the brain. The administration of blockade of receptors in the hypothalamus and the critical zone and in the bloody center, the drug is nada hypothermic and anti-bucid. Also, the speech of Volodya is cataleptogenic and anti-shock power.

When the drug is taken, the enlargement of the peripheral sudins is promoted, as a result of which the arterial vise decreases, as well as the vise in the legenevia artery. To the effect of the drug, it is possible to make a change in the adrenal pressure in the flow. Since the last few years, given the leaks, I reduce the incidence of arrhythmias, which is the cause of adrenaline, but we cannot prevent a breakdown in the heart rhythm of your walking.

For internal or internal introduction, the effect of the drug appears after 3-10 quilins. The maximum concentration in the blood is promoted after 15 minutes of consumption, and the maximum effect - after 30 minutes. The stage of linking with plasma beads is 85-90%. The sedative effect is trivial, it is close to 2-4 years old, if the zagalny inflow to the central nervous system is trivial and becomes 12 years old. The metabolism of active speech occurs in the tissues of the liver. Nearly 75% of metabolites are metabolized by nirkas, and 11% are metabolized by calories.

Likarskiy zasib "Droperidol": shown before zasosuvannya

In what vypadno vikoristovuvati daniyu drug? As a matter of fact, in modern medical conditions, it is often the case that Likarsky zasib "Droperidol" is used. Shown to yogo reception rіznі. For example, in psychiatric practice, vicarious attempts are made for usunenia hallucinations and psychomotor stimulation.

In modern surgery, the drug is used for the potency of postoperative and regional anesthesia (such as initial anesthesia). It also gives patients a sedative effect, as well as for usunenia tediousness and bloating for hours of surgical or diagnostic procedures. In the next hour, when I go to work.

Shown until sucked also є strong painі shock in case of important attacks of angina pectoris, trauma, myocardial infarction, a lot of legends. The drug is suitable for patients with hypertensive crisis.

Liki "Droperidol": instructions and supplies

In ampoules, the price is also suitable for sales. It’s a good idea, more accurately, the graph and the triviality of the therapy, to lie down without a second before the patient, the patient’s course of treatment, the manifestation of the quiet ones who are ill. Tilki likar has the right to sign the droperidol liquor. Instructions for storing revenge on the deprivation of foreign recommendations.

As soon as we talk about premedication, we will grow up to the patients, as a rule, to inject 2-2.5 mg of active speech for 15-45 minutes before the surgical procedure. For children, the dose should be 100 mcg per skin kilogram. For anesthesia, we will grow up with an intake of 15-20 mg lykarsky component(For children, the dose is 200-400 mcg / kg). In a single operation for the preparation of anesthesia, it is recommended to reintroduce 2.5-5 mg of liquor internally.

For the operation, the drug vicoristoyut yak is sedative, as well as for the weakening of blues. Patients are given 2.5-5 mg of skin for 6 years.

Of course, it means that the introduction of the gap can reduce the arterial grip, as well as the grip in the legacy of the vein - the officials are importantly vrahovuvati, especially before the hour of the operation.

It is not recommended to take the drug "Droperidol" in case of alcoholism, as it can be attributed to the central nervous system. As a rule, some of the detoxification procedure should be taken into account, for which therapy is carried out only before the constant visualization of the medical staff (most often the drug is vicoristoyut for the treatment of alcoholic psychosis).

Prototype shown before the treatment

Why can all categories of patients be able to use Likarskiy zasib "Droperidol"? Instructions on how to talk about what kind of intercourse before the therapy is carried out, everything is right here, and from the other side of the story. Prior to the indication of the statement:

hypersensitivity to any kind of warehouse components;
extrapyramidal damage;
reduction of arterial grip;
the period before an hour of caesarean growth, so as the drug can bring the activity of the dyshal to the center of the fetus, it will clog up with oil and reduce it to a lethal result;
hypocalypse;
childish vіk (preparation of contraindications for children, who did not accept two rockіv).

In addition, if there is evidence of some kind of therapy behind other cycles, it is possible, but only because of a simple glance of the drug, and because of that, as a fachivist will be fascinated by all risics. Zokrema, a drug for protection, is indicated for vaginosis, nirkovy and pechinkovy deficiencies. Likarskiy zasib "Droperidol" with alcoholism can also be not safe. Until the next few days, there are also epilepsy and depressive episodes.

How many side effects are there?

Is it safe to drink the drug "Droperidol"? Instructions for storing information about those who give Lykarskiy because of the possible vicious actions of the vicious effects, that is why we are aware of these changes:

Among the children of the children, they meant the development of extrapiracy, including the breakdown of the normal coordination of the order due to changes and problems, and the appearance of a tremor.
It is also possible to bring to the side effects of the driven, depressive stance, in case of any overloading for no reason in the face of fear.
Great doses of the drug can reduce the arterial grip.
There are also possible allergic reactions. different symptoms, Fixing from the shkіrnyh pochevonіnnya and visipu and ending in a big way.

How much is a drug?

This is a season for bagatykh children and food for those who are Likarsky zasib "Droperidol". Shown to the point of stagnation, intercourse and secondary effects - the information is also very important. Ale for bagatokh people is not the least important part of the drug.

Immediately, you can say that the prices will be found among the bagatokh factors, including the place of residence, I will find you a pharmacy and a company-virobnik. In the middle five ampoules of 2 ml volume will cost 50-65 rubles. A package of five ampoules, ale in 5 ml, can be bought in a pharmacy for about 110-135 rubles.

What are the effective analogs?

For quiet reasons (for example, if there is evidence of a contraindication), it is far from the skin patient that the patient should be guessed. What is the recommendation to replace Droperidol? Analogues of yogo exist, so, if necessary, you can change more of the lines. Before a change of synonyms (preparations with the same active speech), it is possible to include "Dridol", "Droleptan", "Sintodril" and "Inapsin".

Є a lot of zasob_v, as they put on an organism approximately the same ones. Zokrema, lykarі, it is not easy to give patients such drugs, such as "Ketamin", "Propovan", "predion". In the capacity of substitutes it is not easy to vikoristovuyutsya "Rekofol", "Propofol", "Diprivan", "Pofol".

Whether it’s a kind of vaping, it’s not safe, but it’s categorically hardened. Tilki fahivets is right to pick up the deputy.