NOLIPREL Instructions for storing. NOLIPREL: Likki from a pivot vise

At this statty, you can learn from the instructions and from the lykarsky drug NOLIPREL... Presented by the guide to the site - from the survivors of the given name, as well as the thoughts of the friends from the victorious Noliprel in their practice. There is a great way of actively giving your advice about the drug: it helped or did not help the person to get sick, because it was slowed down and side effects, It may not be declared by the virobnik in the abstract. Analogs of Nolіprela with obvious structural analogies. Vikoristannya for lykuvannya arterial hypertensionі lowering the grip of the grown-ups, children, as well as with vaginosti that year of bathing.

NOLIPREL - drug combinations To take revenge on perindopril ( іngіbіtor APF) I indapamide (spore diuretics). Pharmacological diya to the drug was zoomed in accordance with the data on the strength of the skin components. The combination of perindopril and indapamid synergy will result in antihypertensive effect synergism in terms of skin components in the environment.

The drug has a dose-dependent antihypertensive effect on systolic, as well as on diastolic AT in the supine and standing positions. Diya to the drug is 24 years old. A strong clinical effect is insisted less after 1 month from the ear of therapy and not to be supervised by a tachycardia. Pipinennya lykuvannya is not supervised by developmental syndrome of vidmini.

NOLIPREL changes the steps of the hypertrophy of the lynch, reduces the elasticity of the arteries, reduces the OPSS, does not infuse on the metabolism of lipids (deep cholesterol, HC-LPVSCH, HC-LPNSCH, triglycerides).

Perindopril - іngіbіtor enzyme scho peretvoryuє angіotenzin 1 angіotenzin 2. Angіotenzinperetvoryuyuchy enzyme (ACE) abo kіnaza, Je ekzopeptіdazi, yak zdіysnyuє yak peretvorennya angіotenzinu 1 angіotenzin 2 scho volodіє sudinozvuzhuvalnu dіyu because i ruynuvannya bradikіnіnu scho volodіє sudinorozshiryuvalnu dіyu, to inactive heptapeptide. As a result, perindopril decreases the secretion of aldosterone, due to the principle of negative vortex, the activity of renin in blood plasma increases, with a trivial change in OPSS, which is more rationalized, in the main, due to the judgment in the world. The goal is not to be supravitated by salt and water or by the development of reflex tachycardia in case of trivial stasis.

Perindopril also has an antihypertensive effect in patients with low and normal renin activity in blood plasma.

On the basis of perindopril stagnation, a decrease in both systolic and diastolic AT in the position of lying and standing is meant. Do not use the drug until the arterial vise is increased.

Perindopril is capable of developing a vascular dilatation, with the renewal of the elasticity of the great arteries and the structure of the vessel wall of other arteries, as well as a reduction in the hypertrophy of the lynx.

Perindopril normalizes the heart to the robot, reducing the anterior and postnavant.

Spilne stasis of thiazide diuretics due to the antihypertensive effect. Besides, combining the ACE Ingibitor and hydrochlorothiazide can also reduce the risk of hypochondriasis against the background of the intake of diuretics.

In patients with a heart deficiency, perindopril viklikє has a decrease in the grip of the right and lіvny shlunochka, a decrease in OPSS, an increase in the heart wikis, and a decrease in the heart index, an onset of hemorrhage regurgitation.

Indapamid - less sulfonamide, according to pharmacological authorities close to thiazide diuretics. It is responsible for the reabsorption of sodium ions in the cortical segment of Henle's loop, so that it can be reabsorbed with sodium ions, chlorine, and in the small world of ions in calories and magnesium. The hypotensive effect is manifested in doses, it is practical not to wick the diuretic effect.

Indapamid decreases the hyperreactivity of sudin in terms of adrenaline.

Indapamid does not infuse on the change of lipids in the blood plasma (triglycerides, cholesterol, LPNSH and LPVShch), on carbohydrate metabolism (including in patients with adolescent diabetics).

Indapamid spriiaє reduction of the hypertrophy of the lynx.

warehouse

Perindopril arginin + Indapamide + additional speech.

Pharmacokinetics

Pharmacokinetic parameters of perindopril and indapamide during the combination do not change in proportion to their separate stasis.

perindopril

When I get it in the middle of perindopril, it gets wet. Approximately 20% of the intrinsic amount of absorbed perindopril is converted into the active metabolite of perindoprilat. When the drug is taken for an hour or so, the conversion of perindopril into perindoprilat changes (this is not an effective clinical value). Perindoprilat vivoditsya s organism s cross section. T1 / 2 perindoprilat to become 3-5 hours. Vivedennya perindoprilat is reduced in patients with kidney disease, as well as in patients with nirk deficiency and heart deficiency.

indapamid

Indapamid quickly and is absorbed from the intestinal tract. Repeated intake of the drug does not lead to cumulation in the body. Vivoditsya in the main section (70% of the administered dose) and feces (22%) in the form of inactive metabolites.

showing

Essential arterial hypertension.

formy vipusku

Tablets 2.5 mg (NOLIPREL A).

Tablets 5 mg (NOLIPREL A Forte).

Tablets 10 mg (NOLIPREL A Bi-Forte).

Instructions for sucking and sucking

I mean everything in the middle, even if it’s wrong, before you take it, 1 pill 1 time per dob. Even after 1 month, after a cob of therapy, the hypotensive effect did not last, the dose of the drug can be increased up to 5 mg dose (the company is allowed to use it trade name NOLIPREL A forte).

Patients who are kidnapped in therapy should be repaired with 1 tablet 1 time for extra.

NOLIPREL does not mean to give children and toddlers through the daytime the efficiency and safety of the sick of this group.

Pobichna diya

dryness in the mouth;
nudota;
decreased appetite;
beating in the stomach;
ruined relish;
constipation;
dry cough, which is a trivial hour to save for the hour of taking the drug in the whole group and when you know it;
orthostatic potency;
hemorrhagic visip;
visipannya on shkіri;
zagostrennya systemic chervony vovchak;
angioneurotic nabryak (Kvinke nabryak);
photosensitivity reactions;
paresthesia;
head b_l;
asthenia;
disturbed sleep;
labile mood;
zamorochennya;
spasms of myaziv;
thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia;
gipokaliyamiya (especially significant for patients who lie before a group of risiks), giponatriyamiya, gipovolemia, which can lead to dehydration and orthostatic hypotension, hypercalcemia.

Prototype

angioedema in the anamnesis (including on the smallest admittance of the first angiotensin ACE);
decay / idiopathic angioedema;
nirkova lack of an important step (QC< 30 мл/мин);
hypocalypse;
bilateral stenosis of the nirkovy arteries or stenosis of the artery of the single nirka;
pechinkova deficiency (including encephalopathy) is manifested;
one-hour intake of the drug, when the QT interval is podovzhuyut;
one-hour reception of antiarrhythmic arrhythmias, such as the possibility of a vicious arrhythmia of the "feasting" type;
vagіtnіst;
period of lactation (breastfeeding);
Sensitivity has been increased to perindopril and other ACE ingibitors, to indapamides and sulfonamides, as well as to other additional components in the drug.

Stagnation during vaginosis and breastfeeding

The drug is not used in the 1st trimester of vaginosis.

In case of planned vaginosity, or in case of being on the onset of the drug NOLIPREL, it is inaccurate to relieve the onset of the drug and indicate hypotensive therapy.

No specific control of the previous ACE testing was carried out in the patients. It is clear that the drug was infused in the 1st trimester of vaginosity, but the drug was taken without causing any defects in development, we will tie it to fetotoxicity.

NOLIPREL contraindications in 2 and 3 trimesters of vaginosti.

Vіdomo scho trivaly vpliv іngіbіtorіv on ACE plіd pid 2 i 3 trimesters vagіtnostі Mauger prizvoditi torn down to Yogo rozvitku (znizhennya funktsії nirok, olіgogіdramnіon, upovіlnennya utvorennya kіstkovoї skull rechovini) i rozvitku uskladnen at novonarodzhenogo (nirkova nedostatnіst, arterіalna gіpotenzіya, gіperkalієmіya).

Trivial stasis of thiazide diuretics in the 3rd trimester of vaginosis can cause hypovolemia in the mother and decrease in uteroplacental blood flow, which can lead to fetal-placental ischemia and fetal development. In newborns, on the background of receiving diuretics, hypoglycemia and thrombocytopenia develop in newborns.

If the patient was taking the drug NOLIPREL in 2 or 3 trimesters of vaginosity, it is recommended to take ultrasound dosage fetus for the assessment of the skull and function nirok.

NOLIPREL contraindications in the period of lactation.

special requests

Stagnation of the drug NOLIPREL does not lead to a hundred reductions in the frequency of side effects, due to the blame of hypocalypse, in the context of perindopril and indapamide in the most appropriate doses allowed for stagnation. On the cob of therapy with two hypotensive drugs, since the patient has not been removed earlier, it is impossible to turn on the increased risk of idiosyncrasy. To build up to the minimum of such a risk, we must conduct a retail monitoring of the patient’s camp.

Nirkova lack

In patients with nirkovy lack of a difficult step (KK< 30 мл/мин) данная комбинация противопоказана.

In children with arterial hypertension without anterior impairment of the function of the child on the basis of Noliprel therapy, there may be laboratory signs of functional nirkova lack... Have a lot of vipad lіkuvannya slіd pinch. Nadal it is possible to introduce a combined therapy, vikoristovuyu and low doses of drugs, or vikoristovuvat drugs in the mode of monotherapy. Such patients need regular monitoring of the level of calories and creatine in their blood - after 2 minutes of therapy and in the other skin 2 months. Nirkova lack of frequent diagnoses in patients with severe heart deficiency or disabilities in the function of nirok, incl. with stenosis of the nirkovo artery.

Arterial hypotension and damage to the water-electrolyte balance

Hyponatremia is associated with the development of arterial hypotension (especially in patients with stenosis of the artery of a single nyrka and bilateral stenosis of the nirkovy arteries). Tom, with the dynamical care of the children, I respect the animals any symptoms The heat and the decrease in the level of electrolytes in the blood plasma, for example, when the blood plasma is getting diarrhea or blues. Such patients need regular monitoring of blood plasma levels of electrolytes. In case of arterial hypotension, intravenous injection of 0.9% sodium chloride can be used.

Transient hypotension is not contraindicated for continued therapy. For renewal of BCC and AT, it is possible to update therapy, low dose drugs, or drugs in monotherapy mode.

According to perindopril and indapamid, he did not develop hypocalypse, especially in patients with diabetic diabetics, because of their lack of health. Even if you take any antihypertensive drug in conjunction with a diuretic, if you take this combination, then regularly monitor the blood plasma.

Additional speeches

Slid vrahovuvati, before the warehouse of additional speeches, the preparation includes lactose. NOLIPREL patients should not be diagnosed with slump intolerance to galactose, lactase deficiency and glucose-galactose malabsorption.

Neutropenia / agranulocytosis

The development of neutropenia on the background of the reception of the ingibitoriv ACE is of a dose-delaying nature and the occurrence of the taken lykarsky zasobu and explicitness fellow sickness... Neutropenia is rare in ailments without a concomitant ailment, however, a risik grows in ailments with a deteriorated function of nirok, especially on aphids systemic illnesses with good fabrics(Including systemic chervonia vovchak, scleroderma). Pislya vіdminіngіbіtorіv ACE signs of neutropenia pass independently. To unify the development of similar reactions, it is recommended to suvoro pretrimuvatisya the recommended dose. With the recognition of ACE ingibitorіv, a given group of patients is followed by a retinal spіvvіdnositi factor of cinnamon / risik.

Angioneurotic embryo (Kvinke embankment)

In children who are sick on the background of therapy by the ACE angiocytes, angioedema develops in the face, kintsovok, rota, move, pharynx and / or larynx. In such a situation, it is inaccurately pinned by the use of perindopril that will prevent the control of the patient's body until the patient is recovered. As soon as you get overwhelmed only by exposing and mouth, then show the urge to pass without special treatment, however, for more rapid relief of symptoms, antihistamines can be used.

Angioneurotic larynx, which can lead to a lethal result. Lump of tongue, pharynx or larynx can cause obstruction dikhalnyh nobles... In such a case, it is inappropriate to inject adrenaline (adrenaline) s / c in a dose of 1: 1000 (from 0.3 to 0.5 ml) inconvenient help... Patients with an anamnesis of some kind of Kvinke have not been tied with the intake of ACE ingibitors;

Angioeurotic intestinal obstruction develops in children with ACE in the background of therapy with ACE angibitors.

Anaphylactic reactions during desensitization

Є okremi about development clutter up the life anaphylactic reactions in ailments, who recognize the ingibitoria of the ACE for an hour of desensitization therapy with a severe overset of frequent coma (including bjolin, aspen). Angibitories of ACE need to be guarded to recognize patients who are sick to allergic reactions and undergo desensitization procedures. It is a unique sign of the drug's recognition for patients who receive immunotherapy from abrupt overreturn of frequent coma. Protest, anaphylactic reactions can be uniquely identified by a team of hours of administration to the drug not less than 24 years before the cob to the course of desensitization therapy.

cough

A dry cough may occur during the therapy with an ACE inhibitor. Cough is likely to occur on the basis of a single drug intake from the group and during the course of the conversation. When a patient has a dry cough, there is a memory of a possible iatrogenic characteristic symptom. Iakshcho lykar vvazhaє, scho therapy with an ACE inhibitor is necessary for patients, taking the drug can be continued.

Risks of hypothesis and / or any disability (including in times of heart failure, water deficiency and electrolytes)

When deyakih patologіchnih mills Mauger vіdznachatisya-valued aktivatsіya sistemi renіn-angіotenzin-aldosterone Especially when virazhenіy gіpovolemії i znizhennі rіvnya elektrolіtіv plasma krovі (on fonі dієti without solі abo trivalogo priyah dіuretikіv) at patsієntіv of Pochatkova nizkim arterіalnim vise of dvostoronnіm stenosis nirkovih arterіy or due to stenosis of the artery of the single nirka, chronic heart deficiency, or liver cirrhosis with swelling and ascites. Stagnation of an ACE inhibitor to the blockade of the systemic system and that can supervise a sharp decrease in the arterial grip and / for the increase in creatine in the blood plasma, in order to indicate the lack of developmental development. Quite often, it is spontaneous when taking the first dose of the drug, or by holding out the first two types of therapy. One of the countries is being developed by the state government and in the other terms of therapy. In such cases, with newer therapy, it is recommended to use the drug in a smaller dose and then step by step increase the dose.

Patients of the kidnapped vik

Before the ear, the taken preparation needs to assess the functional activity of the blood plasma and the concentration of calories in the blood plasma. On the cob of therapy, the dose of the drug is taken, in the way of lowering the arterial vise, especially in times of heat and consumption of electrolytes. Please come in to allow uniknuti the sharp decrease in the arterial grip.

Patients with the establishment of atherosclerosis

Rizik hypotensiveness in all ailments, even with special protection, the drug should be used in patients with ischemic ailments of the heart or lack of cerebral blood circulation. In such cases, the liking should be repaired from a low dose.

renovascular hypertension

Method of treatment of renovascular hypertension є revascularization. Tim is not less, Viktoriannya Ingibitoriv APF nadaє a friendly diyu at the given category of patients, yak clean up prompt engagement So, in that case, if it is difficult to carry out a surgical procedure. Treatment with the drug NOLIPREL for patients with diagnosed or diagnosed with bilateral stenosis of the nirkovy arteries or with stenosis of the artery of the single nirka with a low dose of the drug in the brain of the patient, monitoring Some ailments may develop a functional deficiency, as it is known when the drug is administered.

Інші group riziku

Patients with severe heart deficiency (stage IV) and those with insulin-dependent diabetes mellitus (not safe for spontaneous improvement in calories) are treated with the drug before fixing it with low doses and taking care of it.

Patients with arterial hypertension and heart deficiency do not have beta-adrenergic blocking agents: ingibitori ACE followed at once with beta-blockers.

anemia

Anemia can develop in patients who have undergone transplantation of nirka, or in patients who are on hemodialysis. Chim vishche buv vikhіdniy rіven hemoglobin, thym more swelling yogo reduction. Daniy is effective, mabut, not doze-up, but it can be tied with the mechanism of the ingibitoriv ACE mechanism. The decrease in hemoglobin is insignificant, it is infused with a stretch of the first 1-6 months of circulation, and then it stabilizes. When the change is detected, the hemoglobin level will increase. Likuvannya can be continued by monitoring the picture of peripheral blood.

Surgery / General anesthesia

Stagnation of ingibitoriv APF in ailments surgical engagement from the stagnation of anesthesia, it can lead to a swiveling decrease in the arterial vise, especially in case of vicarious needs for anesthetic anesthesia, which gives a hypotensive effect. It is recommended to pinch the reception of the ingibitoriv ACE of the trivalo diy, incl. perindopril, for add to surgical operations... It is necessary to tell the doctor-anesthesiologist about those who are receiving the ACE in the patient.

Aortic stenosis / Hypertrophic cardiomyopathy

Angіbіtori APF blame for the protection we are sick with the obstruction of the outward tract of the lіvnі slunochka.

pechinkova lack

In childbirths on the background of the reception of ACE ingibitors, the diagnosis is cholestatic. In case of progressive syndrome, there is a strong development of liver necrosis, in some cases with a lethal result. Mechanism of development of the syndrome of ambiguity. With the appearance of a papillary, or with a significant increase in the activity of hepatic enzymes on the ingestion of ACE, the patient should be treated with the drug and turned to the drug.

indapamid

With the manifestation of a deterioration in the functions of the liver with the use of thiazide and thiazide-like diuretics, it can lead to the development of hepatic encephalopathy. In this vipadku slid inaccurately pinch the drug.

Disruption of the water-electrolyte balance

Before a cob of treatment is necessary, it is necessary to replace the sodium in the blood plasma. On a single drug, the indicator is regularly monitored. All diuretic drugs are good for giponatriyumiyu, yak inodі produce to serious delay. Hyponatremia on the cob may not be superficial key symptoms This requires regular laboratory control. More frequent monitoring in place of some of the indications we are sick with liver cirrhosis and individuals of the kidnapped veterinarian

Therapy with thiazide and thiazide-like diuretics is associated with the development of hypocalis. It is necessary to unify the hypocalis (less than 3.4 mmol / l) in the advanced categories of patients from the group high rhiziku: About a kidnapped vik, and young children, or to get rid of a friend drug therapy, Ailments to cirrhosis of the liver, peripheral ridges or ascites, ІХС, heart failure. Hypokalinemia in cichs with ailments suffers from toxic effects of heart glucosides and increases the development of arrhythmias. Before a group of adrenal rhiziks, it is also possible to have ailments due to an increase in the QT interval, at which it is not important, because of any increase in the number of reasons, for any reason.

Hypokalієmiya, yak and bradycardia, the development of important problems heart rhythm Especially, arrhythmia type "feasts", which can be fatal. In all the diseases described above, it is necessary to have more regular monitoring in place of the calories in the blood plasma. The first phase of concentration of ions in calories must be carried out with a stretch of the first pressure from the cob of therapy.

In case of detection of gipokalієmiyi, it is recognized as a type of treatment.

Thiazid and spore diuretics change the amount of calcium in the blood plasma, bringing to an insignificant and hourly increase in the concentration of calcium in the blood plasma. Hyperparathyroidism is often affected by hyperparathyroidism, which has not been diagnosed before. Before additional functions parathyroid followed by a change in the reception of diuretic problems.

It is necessary to control the level of glucose in the blood of patients with diabetic diabetes, especially when hypocalypse is present.

Sečovaya acid

Patients with high volume of sech acid in their blood during the therapy with Noliprel develop the development of gout.

Function of nirok and diuretics

Thiazide and spore diuretics are effective in the general population only in patients with normal or slightly impaired function (instead of creatine in the blood plasma in adults, children are below 2.5 mg / liter). On the ear of a diuretic in ailments through hypovolemia and hyponatomy, it is possible to reduce the fluidity of the glomerular filtration and increase the concentration of the blood plasma in the creatine. Tsya transient functional nirkova lack of safety is safe for patients with normal function nirok, however, for patients with nircovy lack of rotation can do.

photosensitivity

On the other hand, thiazide and thiazide-like diuretics were observed to develop the development of photosensitivity reactions. The development of photosensitivity reactions to the ingesting drug should be corrected. If there is a need for further therapy with diuretics, it is recommended to seize a small number of sleepy exchanges, or one-off ultraviolet exchanges.

athlete

INDAPAMID MAY DATE positive reaction when carrying out doping control.

Inflow to the building of keruvati by transport means and mechanisms

Diya rechovin, scho enter the drug NOLIPREL to the warehouse, do not lead to the destruction of psychomotor reactions. However, in some people, in the case of a decrease in the arterial clutch, there may be development of individual reactions, especially to the cob of therapy, even if given before therapy, other antihypertensive drugs may be carried out. In general, the performance of a carousel by car or other mechanisms can be reduced.

lykarska vzaєmodiya

NOLIPREL

With a one-hour intake of drugs in the lithium and ingibitorіv ACE, it may be possible to increase the concentration of lіthіyu in blood plasma and associated with cym toxic effects. Prior to that, the signs of thiazide diuretics can be increased by increasing the concentration of lithium and increased toxicity. It is not recommended to immediately consume the combination of perindopril and indapamide with lithium preparations. If necessary, such therapy should be continuously monitored instead of lithium in the blood plasma.

Baclofen is hypotensive to Noliprel. With a one-hour zasosuvannі slіd іtlіlno kontroluvati arterial vise і function nirok and the need to coriguvati dose Nolіprel.

With a one-hour consumption of non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid in high doses (more than 3 g per supplement), there can be a decrease in diuretic, natriuretic and hypotensive effect. With significant losses of birth, it is possible that there may be a lack of GOST (due to a decrease in glomerular filtration). Before the cob is taken with the drug, it is necessary to memorize the infusion of age and on the cob to control the function of nirok.

With a one-hour stagnation of Noliprel and tricyclic antidepressants, antipsychotics can improve the hypotensive action and increase the risk of developing orthostatic hypotension (additive effect).

Glucocorticosteroids (GCS), tetracosactide to reduce the hypotensive effect of Noliprela (intake of water and electrolytes as a result of GCS).

Інші hypotensive in order to support the performance of Nolіprela.

perindopril

Іngіbіtory ACE to replace the use of nirkami, wiclicane with a diuretic. Calcium-containing diuretics (for example, spironolactone, triamterene, amyloride), preparations of calium and potassium-containing alternatives grub salt It can lead to a sutta increase in the concentration of calories in the bloodstream up to a lethal result. It is also necessary to ensure that the intake of ACE inhibitor and the value of the drug (in the case of an approved hypocalmus) should not be taken into account should be taken care of and regular monitoring of the concentration of blood plasma and blood plasma parameters.

Combinations, in case of stagnation of such requirements, special protection is required

With stagnation of ingibitoriv ACE (captopril, enalaprilu) in patients with diabetes, it is possible to improve the hypoglycemic action of insulin and older sulfonylate. I will become hypocritical in the region (for the increase in tolerance to glucose and decrease in consumption in insulin).

Combinations, in case of stagnation of such needs, protection is required

On the other hand, allopurinol, cytostatic or immunosuppressive drugs, systemic corticosteroids, or prokayinamid induce the development of leukopenia.

Angibitorium ACE can enhance the hypotensive effect of the drug for anesthesia.

Prior treatment with diuretics (thiazide and "loops") in high doses can lead to a decrease in BCC and arterial hypotension when perindopril is indicated.

indapamid

Combinations, in case of stagnation of such requirements, special protection is required

Through the development of hypocalmus followed by antiarrhythmic drugs (chinquidin, sotalol, hypotensive drugs) Slid a unique development of the hypocalypse and, if necessary, carry out a correction. Slid control of the QT interval.

Amphotericin B (i / v), gluco- and minerlocorticosteroids (for systemic signs), tetracosactide, which is passed on, which stimulates intestinal motility, increases the development of hypocalcemia (additive effect). Necessary control of the level of calories in blood plasma, if necessary - yogo correction. I especially respect if we get sick, we immediately catch the hearts of glucosides. Slide vikoristovuvati carry you, but it does not stimulate intestinal motility.

Hypocalypse is a toxic effect of heart glucosides. With a one-hour intake of indapamide and heart glycosides, the level of calories in blood plasma and EKG indicators and, if necessary, coriguvati therapy are monitored.

Combinations, in case of stagnation of such needs, protection is required

Diuretics (including indapamide) have a functional deficiency, which leads to the development of lactic acidosis with a one-hour reception of metformin. Do not take metformin, as it changes serovatkovogo creatinin in 1.5 mg / dL (135 μmol / L) in choloviks and 1.2 mg / dL (110 μmol / L) in females.

In case of significant dehydration to the organism, like a viclikan with ACE, the risk of development of a nirk deficiency on aphids of sucking of iodine contrasting speech in high doses is increased. Before zasosuvannym iodine contrasting speech, it is necessary to carry out a rehydration.

With a one-hour consumption of calcium salts, there is a high growth rate of hypercalcification as a result of a decrease in the efficiency of the cut.

In case of stasis ingestion on aphids of persistent ingestion of cyclosporine, the level of creatine in plasma increases with a normal state of water-electrolyte balance.

Analogs of Likarskiy drug NOLIPREL

Structural analogs for common speech:

Ko-Perineva;
NOLIPREL A;
NOLIPREL A Bi-forte;
NOLIPREL A forte;
NOLIPREL forte;
Perindid;
Perindopril-Indapamide Richter.

When there are analogs of a drug for a daily speech, you can go to the lower level for an illness, such as a supplementary drug, and an analogy for a drug.

For those quiet, who have a value no more than the top of the eye, I will change the dosage of the medication in the instructions to the drug, but in any case it is not a problem to engage in self-abuse, the purpose and delay of guilt is prescribed. All the nuances of the reception, the instructions and the guides about the new guidance in the statistics.

The whole drug is dispensed in decilkoh pisnovidy. Smells are recognized by the dozens of active speeches. He has two. At the guidance of the table, it is indicated more precisely їх zmіst.

In drugs, the prefix "A" means that in the whole form of tablets, perindopril is found spirally with the amino acid arginine. Acid to mend an additional beneficial effect on the camp of the heart and the Sudin. Naybilsh dіevim і reduce the grip of the drug є NOLIPREL A Bі-forte, alе just one dose, even more strongly, аіlіkar signifies that the new men are strong іnvіdіvіy, wіth thе smallest amount of young people.

Vipusku form

NOLIPREL is carried out in viglyadi oval tablets of dovgastoy form white color If you need to take half a dose, you will need to take a half dose. pills new species go by weight:

NOLIPREL A - 2.5 mg;
NOLIPREL A Forte - 5 mg;
NOLIPREL A Bi-Forte - 10 mg.

One blister can take 7 or 10 trips. All in pachtsi buvaє 14 or 30.

Instructions of Noliprel

Wine is a combination of medication, and two active speeches are given to food. Skin of them has a lot of powers, zavdyaki їkh spіlnoї dіyalnosti zdatny preparation:

Give in to the activity of the renin in the blood;
Zmenshiti Sudinniy Opir;
Normalize the myocardial connection to the robot;
Decrease secretionaldosterone;
Reducing the inheritance of re-assignment to organism;
I lower the AT indicator;
Pidvishuє heart wikid;
Pereshkodzhaє zbіlshennyu lіvogo shlunochka;
I will paint the elasticity of the Sudins.

The drug, unimpressed in its strongest action, does not infuse a quantity of cholesterol and lipids, does not take part in exchange processes, and does not take into account salts and rinine organisms. Diya triva, hold out to finish. A bazhany effect, which is to be seen in the next month. Pislya papinennya yogo received a mute syndrome.

NOLIPREL - shown before zasosuvannya

People are most likely to be seen in case of an illness, to get ahead of the risk of an illness in a small court, who are suffering from a disease, as well as a diabetic.

Features of the welcome

A lot of combinations of medicines, to take revenge in one’s active speeches, so that we’ll drink a lot of money on the body, so it’s take more than once a day. the wound has risen, having taken the first day without the need for memory.

Take the drug more beautifully in the early hour, by stretching 5 types of drink in one dose, then the doctor can quickly take the dose of liquor in the fallowness, as long as it is used. If it is necessary to use the drug, then it is useful to drink liquids, as they act as calcium antagonists.

In quiet cases, if the grip drops sharply, then the drug will change the dose.

In the first few days, Nolіprela has gone to work out of the car and robots on high-current mechanisms, which are overwhelmed by another, but then need to go to their camp.

Drinking liquor in case of vaginosity and lactation

During the period of planning and vynosuvannya child NOLIPREL And it is more beautiful not to use it, but as soon as it is prescribed before it, then it is necessary to fix it with a preparation.

The whole medication without going through the clinical dosages is injected with the ACE ingibitors for an hour of vaginosity. If the drug was taken in the first trimester, then it was not infused into the development of the fetus, but the fetotoxic infusion was not detected.

In the II and III trimesters of NOLIPREL A, it is contraindicated for zastosovuvati. Leak components can be inserted into the baby's rosette. It is markedly marked on the function of nirok, the formation of the cranial cysts, and in the new-born one may have an overgrowth “dzhereltsya”, the development of hypotension and development of nirk's deficiency.

It is necessary to pass an ultrasound scan, and also to reconsider the cranium of a newborn.

For an hour the baby is breastfeeding NOLIPREL contraindications, as it changes the amount of breast milk, and drives the lactation process. At the same time, the baby may have a baby, hypocalypse and sulfonamide.

If the drug is superbly important for the health of a young mother, then it is possible that you will be able to change from a breast cancer, but not a naughty child.

Overdose

Vona wiklikak in the organism of water-electrolyte vidhilennya, which vilivayutsya in hyponatremia and hypocalypse. The symptoms are as follows:

drowsiness;
Anuria and polyuria;
Stronger change in vice;
Nudota, scho lead to blues;
Decreased frequency and heart rate;
obscurity;
Cold pit with chills;
sudomi;
Zamorochennya.

Prototype

NOLIPREL can not be accepted, even if a sick person is susceptible to hypersensitivity to the drug. Do not take the drug for such ailments:

Severe form of nirkovo deficiency;
We are sick when undergoing treatment with hemodialysis;
Have a childish vice;
Pechinkovo encephalopathy;
Timi, who has previously received an analogy with an anxiety disorder;
Stenosis of nirok і їх arteries.

Vicious Effects

With the use of Noliprel, the growth may develop side reactions to the body from the side of the other systems:

Sechostatev. Ridko, ale buv depletion of functions of nirok, depletion of potency. And if you take the drug at the same time with other diuretics, then it will be transplanted instead of creatine in the blood and in the blood.
Sertsevo-sudinna. You may be susceptible to replacement with orthostatic collapse, due to hypotension, rarely, but all the time you end up with arrhythmia, myocardial infarction or an insult.
Herbal. Supravoduyuvtoya bloody, abdominal pain, cholestasis, dry throat dryness, sometimes pain in the abdomen, zdutty and constipation.
Nervova. There are trivial headaches, supra-juveniles are spoiled, they are lost, and sometimes they are a little bit dizzy, appetite goes down, there is a judgment, there is little galmuvans in the worlds, and they sleep in that.
Dichny. Dry cough, like trivial, undead, twisting, spasms in the bronchi.
Bloody. Hyperglycemia, the number of sechivines, pancytopenia, thrombocytopenia, hemolytic anemia and agranulocytosis are increasing.
Shkirni pokrivi. On them, in case of an overdose, there is a visip, like the inheritance of allergic reactions, a spillage, a hemorrhagic vasculitis, and a chervony vovchak.

Priyom Nolіprela with other medicines

Apparently the sum of the drug with the lines in the tabular view.

Naymenuvannya drug	Tastes of the whole social welfare office with Noliprel
baclofen	I will paint the antihypertensive drug
Corticosteroids	I change it by pouring the preparation into the vise
Antihypertensive funds	to produce an overwhelming decrease in the arterial vise
Іmіpramіnopodіbni antidepressants, neuroleptics	admit the effectiveness of the drug, but at the same time increase the risk of orthostatic hypotension
Preparations for revenge lithium	increase the toxicity of the cat
Calcium-based medicines	to make up to an increase in the speech in the blood
Insulin and іnshі zukroznіzhuvalny sulfanіlamіdi	tsukru
Cytostatics, systemic corticosteroids, alopurinol	to produce leukopenia to develop

The drug can not be taken at once with alcohol, so that it will take a little more effort.

NOLIPREL forte - analogues

Among the former candidates for the preparation they see:

Akkuzid ®. Win stasis for ailments, which is a complex treatment of diuretic and quinapril.
Iruzid. Likuє people with easy and middle hypertension, as they are encouraged to maintain a stable course of therapy.
Capotiazid. To become stagnant in alcohol with other antihypertensive drugs, in any form of arterial hypertension.
Kvinard. be recognized when chronic deficiencies and hypertension.
Ko-renetek. Freeze for patients who undergo complex therapy.
Lisinopril / hydrochlorothiazide. Drug indications for lykuvannya easy and the middle stage of hypertension.
Lizopres. Likuh hypertension.
Liprazide. Made for the treatment of any form of hypertension, including the renovascular.
MIPRO. I lower the arterial vise.
Rami compositum. Є a gateway for quiet patients, who cannot control their arterial grip during monotherapy.
Tritace. Stuck yak for complex treatment, So and can be vicariously with other calcium antagonists and diuretics. Additional help with congestive heart failure.
Fozid. It is used for arterial hypertension.
Ena Sandoz. Stagnate in case of acute hypertension, chronic heart failure, as well as for the prevention of infarction.

Acceptance of Noliprela is guilty of a normal degradation of the body, and of the destruction of the risk of hypotension. For every hour of the day, control of creatine, electrolytes and arterial vise... If the patient is suffering from heart failure, then the drug should be combined with beta-blockers. Needed vrahuvati, scho on doping tests NOLIPREL give a positive reaction.

NOLIPREL - combinations for antihypertensive action, which can become stagnant in the development of an arterial hypertension. Dіyuchі speech - perindopril і indapamіd.

perindopril

Yak Ingibitor APF, approved angiotensin II. As a result, there is an increase in the size of the vessel, the response to sodium and water changes - the arterial grip decreases. There is a camp of ailments, there may be signs of chronic heart failure (CHF). Klasovim efect є Zakhist nirok.

Indapamid is assigned to the second group of sulfonamides. The main effects are related to the vision of the organism of excess sodium and water. And the change of blood supply, which is circulating in the channel of judgment, to produce a vice until it falls.

day funny speeches drive one by one and produce to a strong decrease in arterial vise in patients with arterial hypertension (hypertension).

NOLIPREL Volodya dose-dependent hypotensive dyu, pouring yak on the systolic, and on the occasional arterial vise at the position of the lying or standing. The antihypertensive effect of the drug is prolonged and saved for 1 add. The beneficial effect is to be observed in less than 1 month after a cob of treatment and not to be supervised by a tachycardia.

The drug is dispensed only in the form of tablets with a plush shell of white color. Dovgast form, two sides є risiki. At the warehouse of Noliprel, perindopril arginin is present - 2.5 mg, and also indapamid - 0.625 mg.

Additional components є: silicon dioxide, lactose, magnesium stearate, sodium carboxymethyl starch, maltodextrin. Column revenge macrogol, magnesium stearate, glucerin, titanium dioxide.

In tablets NOLIPREL A Forte - 5 mg perindopril and 1.25 mg indapamid. NOLIPREL A Bi-forte - 10 mg perindopril and 2.5 mg indapamid.

What additional help is NOLIPREL? I mean the drug in offensive drops:

for the lіkuvannya of sensual arterial hypertension.

Instructions on filling in NOLIPREL, posting

Tablets for oral administration We will grow to the patients, including those who have been abducted, and will receive 1 tablet of NOLIPREL \ 1 time for doba.

We are sick with nirkovyu deficiency in case of creatinine clearance ≥30 ml / hv dose correction is not required.

In patients with a small degree of nirkovo deficiency (CC 30-60 ml / hv) dobova dose it is not guilty to change 1 tablet, with a CC of 60 ml / xv and a dose correction is not required. Likuvannya is necessary to supervise the level of blood plasma and creatine levels (for two types of therapy and once every 2 months).

It is necessary to systematically control plasma concentration of creatine and key signs waste salts and water, as well as regularly reduce the concentration of electrolytes in plasma.

Vicious Effects

It is obvious from the instruction because of the stipulation, designated by NOLIPREL, can be supervised by the coming side effects:

orthostatic potency, over-lowering the arterial grip;
sickness, headache, zapamorochennya, asthenia, lability of mood, dzvin in wuhah, ruined zoru, sudomi, ruined sleep, ruined relish, anorexia, paresthesia;
constipation, diarrhea, nudity, bloating, abdominal pain; Ridko - dryness of the mucous membrane of the mouth;
dry cough;
anemia (in patients with hemodialysis or nirka transplantation);
sverbіzh shkіri і visipannya;
decrease in potential, increase in potential.

In the future, there may be some secondary manifestations of the drug taken.

Prototype

Prototypically shown to indicate NOLIPREL in offensive drops:

severe nirkov lack of;
pechinkova deficiency is manifested (including encephalopathy);
hypocalypse;
anemoneurotic swelling in the anamnesis (including the ingestion of angiotensin converting enzyme (APF));
the preparation is immediately consumed, if the interval is qt;
period of vagina that year of breastfeeding;
childish and adult age up to 18 years (so as safety and efficiency of the drug is not established);
hypersensitivity to perindopril and / or some of the ingibitoris apf, indapamid and sulfonamides.

Overdose

A common symptom of an overdose of age is a decrease in the arterial clutch, and sometimes it is drowsy, dysfunctional, dimmed up, by courtship, boredom, bluesy and oliguric conditions. also develop electrical damage: Gіpokalієmіya or gіponatrієmіya.

An inadvertent help of a polyagus in a vivedenna Noliprela s organism by a walk active vugilla It will supervise the onset of normalization of the water-electrolyte balance.

With a significant decrease in the arterial grip, the patient should be laid in the position lying on his back, having lifted his legs. If necessary, carry out correction of hypovolemia (for example, after additional internal infusion of 0.9% sodium chloride).

perindopril

at - an active metabolite of perindopril - is efficiently seen in the body through a pathway.

Analogues NOLIPREL, price in pharmacies

If necessary, substitute NOLIPREL for an analogue according to active speech - the drug:

Co-presenti,
PRESTARIUM,
Ko-perіneva,
perindopril

Indapamid Richter,
NOLIPREL A forte.

Vibrating analogs are important to reason, but the instructions are from the storage of NOLIPREL, the price and advice on drugs of a similar type does not expand. It is important to take into account the consultation of the doctor and not to change the drug on its own.

Price in Russian pharmacies: NOLIPREL tablets 30 pcs. - from 569 rubles to 685 rubles (A forte).

Zberigati in a dry, stolen form of light and inaccessible to children, at temperatures of +30 ° C. Term of accessibility - 3 rocks. Vidpustka in pharmacies for a prescription.

Warehouse NOLIPREL A

Active speeches:

perindopril arginin 2.5 m,
which is 1.6975 mg perindopril and indapamid 0.625 mg.

Virobniks

Laboratories Serv'є Indastry (France), Laboratories Serv'є Indastri, packed Serdix (France), Serdix (Russia)

Pobichna diya NOLIPREL A

On the side of the water-electrolyte balance:

mozhliva hіpokalієmiya,
reduction of the level of sodium,
how to supervise,
dehydrated organism and orthostatic hypotension.

One-hour injection of ion in chlorine can lead to a compensatory metabolic alkalosis (the frequency of occurrence of alkalosis and its incidence is low).

In okremikh vypadkah - pіvischennya rіvnya kaltsіyu.

On the side of the heart-vascular system:

over-lowering the arterial grip, orthostatic hypotension;
in some cases - myocardial infarction, angina pectoris, stroke, arrhythmia.

On the side of the secular system:

Ridko - a decrease in the function of nirok, proteinuria (in patients with glomerular nephropathy); in okremikh vipadkah - gostra nirkova lack.

The slight increase in the concentration of creatine in the blood plasma (wastes when the drug is taken) is most important for stenosis of nircovar arteries, arterial hypertension due to the additional manifestation of APF.

On the side of the central nervous system and peripheral nervous system:

headache, dysplasia, asthenia, dullness, mood lability, loss of vision, dzvin in wuhah, loss of sleep, sudom, paresthesia, anorexia, loss of relish sleepiness;
in some cases - the confusion of evidence.

On the side of the mental system:

dry cough;
Ridko - difficulty in dikhannya, bronchospasm;
in okremih vipadkas - rhinorrhea.

On the side of the herbal system:

beating in the abdomen, nudity, bloating, constipation, diarrhea;
Ridko - dryness in roti;
in some cases - cholestatic zhovtyanitsya, pancreatitis, an increase in the activity of hepatic transaminases, hyperbilirubinemia, with hepatic insufficiency of the potential development of hepatic encephalopathy.

On the side of the hematopoietic system:

anemia (in patients with nirka transplantation, hemodialysis); Ridko - hypohemoglobinemia, thrombocytopenia, leukopenia, decreased hematocrit;
in some cases - agranulocytosis, pancytopenia, aplastic anemia, hemolytic anemia.

On the side of the exchange of words:

Possibility of increasing instead of glucose and glucose in blood plasma.

Allergic reactions:

shkirnі visipannya, sverbіzh;
Ridko - kropiv'yanka, angioeurotic nabryak;
in okremikh vipadkah - multiforme erythema, hemorrhagic vasculitis, zagostrennya VKV.

Timchasova Hyperkaliyemia;
Ridko - increasing the potential, decreasing the potential.

Prototype shown NOLIPREL A

Sensitivity was adjusted to perindopril and other ACE ingibitors, to indapamides and sulfonamides, as well as to other additional components in the preparation; angioedema in the anamnesis (including on the smallest admittance of the first angiotensin ACE); decay / idiopathic angioedema; nirkova lack of an important step (QC< 30 мл/мин); стеноз артерии единственной почки; двусторонний стеноз почечных артерий или стеноз артерии единственной почки; выраженная печеночная недостаточность (в т.ч. с энцефалопатией); одновременный прием препаратов, удлиняющих интервал QT; одновременный прием антиаритмических средств, которые могут вызывать желудочковую аритмию типа «пируэт»; беременность; период лактации (грудного вскармливания); Не рекомендуется одновременный прием препарата с калийсберегающими диуретиками, препаратами калия и лития и при гиперкалиемии.

How to save and add

In the middle, it’s important, before taking the drug, 1 tablet preparation 1 time per dose.

As soon as through the month of writing a cob of therapy, the hypotensive effect did not reach the point of reaching, the dose of the drug can be added up to a dose of 5 mg + 1.25 mg.

Patients of the kidnapped vik.

The therapy should be repaired from 1 tablet 1 time for additional.

Nirkov's lack.

The drug contraindicates patients with severe nirk deficiency (CC less than 30 ml / min.).

For patients with normal nirk deficiency (CC 30-60 ml / hv) maximum dose the drug should be given 1 tablet for doba.

Patients with QC, which are suitable for delivery or transferring 60 ml / hv., Correction dose is not required.

During the course of therapy, regular monitoring of the level of creatine and calories in blood plasma is required.

Pechinkova lack.

The drug is contraindicated for patients with severe pechinka deficiency.

In case of pomіrnіy pechіnkovіy deficiencies, the dosage correction is not required.

Children and children.

The drug does not show to children and toddlers through the daytime about efficiency and safety in the sick of this group.

Overdose

symptoms:

bends over the decrease of A,
nudota,
vomiting
by the court,
spoiled,
sleeplessness,
low mood,
polyuria or oliguria,
how you can go into anuria (as a result of hypovolemia,
bradycardia,
electrical damage.

slunk washing,
the sign of adsorbents,
correction of water-electrolyte balance.

With a significant decrease in the arterial grip, it should be translated into horizontal position with raised legs.

perindopril

At the same time, visions of the body behind the additional dialogue are possible.

vzaєmodiya

Increased concentration of lithium can lead to symptoms and signs of overdose of lithium. (In addition to the decrease in the number of years by the nirkami).

Addition of perindopril with calyzberyuchimidiuretics and preparations of calories can lead to a significant increase in the concentration of calories in the blood (especially on the basis of low-grade deficiencies) even to a lethal result.

Slid brothers to respect, so іndapamіd in conjunction with kalіzberіgayuchimidіuretikami or drugs kalіu not vyklyu development hіpokalієmiі but hіperkalієmii (especially in those with a lack of hypochondria).

With a one-hour stagnation of erithromycin (for intravenous administration), pentamidin, sultopride, vincamin, halofantrine, bepridil and indapamide of possible development of arrhythmias of the type "fever" (before provoking factors lie down

In case of stagnation of ACE ingibitorіv, it is possible to improve the hypoglycemic development of insulinu and older sulfonylsecovines.

The development of the hypoglycemia is promoted to grow in the edge of the country.

With a one-hour consumption of Noliprel and Baclofen, an increase in hypotensive activity will be achieved.

With a one-hour consumption of indapamid at the refinery in the time of the vigor of the organism of the energetic development of the hospitable deficiency.

It is also necessary to ensure that the refinery is able to reduce the hypotensive effect of the ingibitoriv APF.

It has been installed that the refinery and the ingibitori APF may have an additive effect on the basis of hypercalculation, while also decreasing the function of nirok.

With a one-hour stagnation of Noliprel and tricyclic antidepressants, antipsychotics can improve the hypotensive action and increase the risk of developing orthostatic hypotension (additive effect).

GCS, tetracosactide to change the hypotensive effect of Noliprel.

With a one-hour stagnation of indapamide with antiarrhythmic drugs ІА (chinidin, hydrochinidin, disopiramid) and III class (amiodarone, bretylium, sotalol), there is a potential for development of arrhythmias of the type “prey” (pre-provoking)

When developing an arrhythmia type "feasts" does not go to the antiarrhythmic drugs (it is necessary to pick up a piece of the rhythm).

With a one-hour intake of indapamide and drugs, it is possible to reduce the amount of calories (including amphotericin B in / in, glucose and minineralocorticoids in case of systemic intake, tetracosactide,

Slide to control the concentration of calories, if necessary, coriguvati її.

If it is necessary, the signs of persistent use of the drug without stimulating intestinal motility are observed.

With a one-hour consumption of Noliprela with heart glucosides, a low level of calories can increase the toxicity of heart glucosides.

Slid control of calories and EKG, and if necessary, correct therapy.

Lactic acidosis on the background of adolescent dressings metformin, mabut, with functional deficiency, which was pummeled by another indapamid.

Metformin should not be vicious, as the level of creatine change is 15 mg / l (135 μmol / l) in choloviks and 12 mg / l (110 μmol / l) in females.

In case of significant dehydration to the organism, like a viclikan with ACE, the risk of development of a nirk deficiency on aphids of sucking of iodine contrasting speech in high doses is increased.

Before zasosuvannym iodine contrasting speech, it is necessary to carry out a rehydration.

With a one-hour consumption of calcium salts, it is possible to increase the amount of calcium in the blood plasma as a result of a decrease in the amount of calcium in the section.

In case of stagnation of Nolіprela on aphids of persistent stagnation of cyclosporine, the level of creatine in plasma increases with a normal state of water-electrolyte balance.

Umovi zberigannya

The drug should be kept out of the reach of children at temperatures up to 30 ° C.

order of admission

Take a recipe.

Permanently adjusting the grip in medical terms is hypertension. Lіkuvannya zhvoryuvannya maє zdіysnyuvatisya obov'yazkovo, some of the development of pathology can lead to serious heart problems. For normalization of arterial vise, Fakhivets recommends a course of study by Noliprel. If there is evidence of a contraindication, as long as there is a possibility of an expensive drug, it is possible to recall the original medication to an analogue, ale only with the permission of the drug.

About the drug

Lykarskiy zasib NOLIPREL (virobnitstvo Rosiya) є an effective hypotensive drug. Leaks are poured into the diastolic and systolic grip of blood in the arteries. The drug is administered before a dose-dependent group of drugs.

Vipuskayut NOLIPREL in viglyadі tablets, where to revenge a complex of two active words: indapamide and erbumin perindopril.

Vyrobniki vipuskayut krim zvychaynoi form for the preparation:

NOLIPREL Forte;
NOLIPREL A Forte;
NOLIPREL A bi Forte.

The main indications for the reception of NOLIPREL tablets are the saving of a permanent stagnation of an arterial vise.

Through їх pouring into circulatory system, The drug is not suitable for the following indications:

hypocalypse;
transferring calories in blood warehouses;
heart failure;
quay Kvinke;
ankyoneurotic swelling;
lack of nirkov;
childish vіk of the ailing;
vagіtnіst (1 trimester);
period of breastfeeding year;
allergic reaction to the obvious lykarsky warehouse.

In case of uncontrolled reception or presence of a contraindication, as well as in case of possible

individual reactions to the body, you may be aware of the effect bit by bit tablets NOLIPREL:

asthenia;
anemia;
rіzke reduction in the grip of lower norms;
slunk / intestinal trash;
vidhilennya zoru;
noise in the vuha;
mіgren;
myazovi spasms;
dermatological allergy;
attack dry cough.

NOLIPREL tablets should be administered before prescription drugs. Їх the price in the pharmacy is to become 550 rubles and vishche.

More cheap analogs

Unimportant for the efficiency of Noliprela in the form of a diagnosis, the need to replace the original medication with an analogue, which may be more appropriate Pharmacological diya... Chi is an analogue of Nolіprela with identical characteristics, followed by a turnaround from an elite lіkar. Do not ask for a word or two on your own, but rather tell the pharmacists.

Analogs of Nolіprela, which are cheaper:

perindopril

indapamid;
Ko-perіneva;
PRESTARIUM;
Co-application;
Lorista.

Chim replaces NOLIPREL by means of a primer on the back of a patient showing a sick person, paralyzed pathology and individual specialties to the body.

perindopril

- Indapamide

Hypotensive medication for

perindopril

Indapamid is carried up to ingibitoriv, so that the enzyme is removed, so that the arterial grip is reduced. The drug is high dose-latency effect.

A cheap analogue of Nolіprela A vikoristovutsya for lowering stably moved arterial vise. Diya medicament rozrahovani on the accumulative effect, which requires a course reception. The result will be recognized only after 2 - 4 times.

The drug is dispensed from viglyadі tablets. Їх warehouse of stocks for utrimanny perindopril erbumina and іndapamidu.

An analogue of NOLIPREL is designated as a drug for diagnostics of persistent hypertension of the arterial type. I want a cheap deputy, mayut tablets analogous diyu through a similar warehouse.

perindopril

- Indapamide, yak cheap analog Nolіprela, not recommended before the reception at the onset of indications:

sensitivity to the components of the preparation;
lack of nirok abo heart;
hemodialis;
childish vіk;
lactation or period of vaginosity.

Potential development of symptoms in bitter diya in viglyad:

blood loss deficiency;
asthenia;
dysfunction of the intestinal tract;
pathology zoru;
mіgren;
spasms of myaziv;
noise in the ear shells;
allergic visip;
dry attack-like cough.

A cheap analogue of NOLIPREL A Bi -

perindopril

-Indapamid, sold in pharmacies with a prescription for a liquor. Tablets may be available at 330 rubles.

Ko-Perineva

The release of the drug is effective in the form of tablets. Mechanism injected into the organism of storage at the warehouses: indapamide in the complex with perindopril.

By the way, by the value in the instructions for consumption, cheap tablets - an analogue of the drug NOLIPREL are recognized in the development of stable hypertension.

Prototype to Ko-Perinev:

pathology of normal functioning;
the quincke's embankment is abnormally ankyoneurotic;
hyperkalієmiya is reflexive;
stenosis of the nirkovy arteries;
pathology of the heart;
dializ;
individual intolerance to the warehouse;
vіk paciєnta less than 18 years old;
breastfeeding;
the period of the marriage of children.

Possible reaction to the cheap analogue of NOLIPREL A Bi:

zapamorochennya, abo m_gren;
thrombocytopenia;
lowering the vice;
problems in sight;
damage to the slunk-intestinal tract;
noise in the vuha;
spasmodic attacks of myaziv;
dermatological allergy.

Ko-Perino kostu is cheaper than the tablets NOLIPREL A BI. The average price for the drug is 400 rubles.

PRESTARIUM

Displaying cheap generics Noliprela so you can see the drug PRESTARIUM, for which it is straightened on a lower grip in arterial vessels, as well as the very change in its walls.

The drug is used in tablet form, instead of perindopril arginin. Tablets are recommended for the presence of a sick person:

hypertension;
ischemia of a stable form;
heart failure.

Take the cheap drug PRESTARIUM in ridkisnyh vypadki to produce before it appears:

problems with nirkami (damaged functions);
time-consuming cough;
pancreatitis;
eritemi;
pogirshennya appetite.

A side effect of the reaction of the deputy Noliprel may be as a result of an individual reaction;

galactosemia;
lactation;
allergy to warehouses;
ankyoneurotic swelling;
vagіtnіst;
quay Kvinke;
Вік under 18 rockіv.

The price for an analogue of NOLIPREL is good - 350 rubles.

Co-introduction

When replacing NOLIPREL BI Forte with analogues, vicoristovuyut so cheap drug- Co-introduction. The analogue is vicarious for therapeutic purposes while saving the post-mortem slid in a vice.

So, in the warehouses of the other deputies, there is an analogue of Co-application to revenge the components - indapamid and perindopril. The cheap deputy of Noliprel is called a likarem in case of permanent hypertension.

Zasosuvannya cheap analogue NOLIPREL not bazhano, if the patient appears:

allergy to one or a few components in the warehouse;
swelling of an ankyoneurotic type;
hypovolemia or hypocalypse;
pathology nirok.

Side reaction:

rise to a lower grip;
headaches;
zadishka, or cough;
dysfunction of the intestinal tract;
dermatological reaction in the form of allergy;
pathology nirok.

The price for a cheap analogue of Noriprel Ko-preneseni is 300 rubles.

Lorista

The drug Lorista is indicated when sparing a sick person with a vise in the arterial vessels, as well as when there is a lack of heart activity.

An analogue of Noliprel - Lorista reveals the active component - losartan, which is poured into the body of the circulatory system.

Shown to the cheap deputy Noliprel:

hypertrophy grows into a livy duck;
hypertension of arteries;
heart failure;
progress of nephrology in case of diabetic diabetes.

low arterial vise;
hypercalm;
feverishness;
intolerance to the warehouse;
breastfeeding;
allergy to warehouse components;
vagіtnіst;
category of ailments up to 18 years.

Side effect:

sleeplessness;
depression;
destruction of memory;
mіgren;
tachycardia;
cough;
gastritis;
dysfunction of the secular nobles;
myazovi boli;
problems in sight;
gout;
Allergy nabrya abo visip.

Part for Russian tablets analogue of Lorist in the middle - 400 rubles.

visnovok

Visually, it is more beautiful for the treatment of arterial hypertension, maybe only fahivets. Self-vibrating, which is an effective drug - NOLIPREL or analogs are not recommended, oskilki diya medicaments individually for the skin organism.

NOLIPREL - strong liquids against a sliding vice. The drug is often used for hypertension.

vidi Nolіprela

Vipusku form

NOLIPREL A - 2.5 mg;
NOLIPREL A Forte - 5 mg;
NOLIPREL A Bi-Forte - 10 mg.

NOLIPREL forte - analogues

Lizopres. Likuh hypertension.
MIPRO. I lower the arterial vise.

Vidgooks

Tetyana, 54 rocky: They gave me two rockets to NOLIPREL. For the help of a new one, I lost weight. A little bit later, I started to get up, but the wine became a gnaw on me in the water, and it was spinning in the persistent headaches and in the wrinkles. Bringing the beast to the licker, which explained the point, that the first time the bullet had been rooted in my colossal vaga and a significant vice, and now offending indicators have become less, and for a long time already it is time to change the number of people. I’m happy with everything, I’ll accept that distance.

Elvira, 63 rock: Vrantzi is the head of the NOLIPREL A, the vise is overwhelming, and recently she became yogo accept mentally with Cardiomagnol. I wish I had a dream, as I do it all in the evening. On my grip, I didn’t fit in, I’m skinny day to sleep, but from self-esteem I was polished.

Who is the drug to be stored in?

One of the combined versions є "NOLIPREL" - tablets in a vise. The therapeutic effect is to provide two active components of speech:

perindopril;
indapamide.

To add the necessary technological powers, there are additional components in the lines:

microcrystalline cellulose,
lactose monohydrate,
magnesium stearate;
silicon dioxide.

In the form of vipuskayut liquors

Dispense with Noliprel form of dovgastikh tablets of white color with rises on both sides. The carton pack contains 30 tablets and instructions and supplies.

Principle of the ACE Ingibitoriv

Yak drug for organism

The therapeutic result of "Noliprela" will be taken care of by active words, as it is driven by one by one.

Better from them (perindopril) to lay down to the class of ingibitoriv angiotensin converting enzyme. Angiotensin ACE is responsible for the transformation of the inactive hormone angiotensin I into the active hormone angiotensin II, which makes a sound of judgment and a squeeze. The stench also overwhelms the ruin of bradykinin, which expands the judgment, and reduces the concentration of aldosterone in the blood, so that the vice grows.

As a result, both systolic and diastolic grip decrease.

Perindopril also expands the blood-bearing vessels, reduces the hypertrophy of the louse, and changes the elasticity of the arteries.

Іndapamid to be included in the group of sechoginnyh zasobіv. Win galmu again soaktuvannya sodium in the nephrons of nirok. As a result, sodium and chlorine are seen at once from the cross section.

Indapamid grows up because I reduce the grip at such doses, as it is practically impossible to cope with this effect.

Perindopril and indapamide quickly get wet into the roof. The biological availability of the first speech is up to 70 weights, the bioavailability of indapamide is 95 weights. The maximum concentration of indapamid is spontaneous in a year after receiving, perindopril - in three chotiri years.

Obitvі speeches vivodіt s organіzm through nirki.

Yaki ailments like "NOLIPREL"?

The drug is stuck during therapy hypertensive ailments... The diagnosis is made, if the grip is easily trimmed to the level of 140/90 mm Hg. Art. The hypertension of the need to recover from an advanced grip, as it can appear because of the strong physical options... In a whole vipadku grip independently turn to the vyhіdny rіven. In case of hypertension, the grip is possible only behind the help of antihypertensive disorders.

Negative infusion of hypertension on the organ

Symptoms of hypertension lie in the stage of development of the ailment and the stage of prevention in the quiet of the other organ-targets.

on cob stage AT does not change 180/115 mm Hg. Art. The central nervous system and the organisation's stage do not function.
At the other stage, the grip stitches between 180-210 / 115-125 mm Hg. Art. It is evident that the sound of the eyes of the eye, the increase in the size of the louse, transient ischemic attacks. There is a hypertensive crisis.

Analyze the cells in the blood and the growth of creatine in the blood.

The remaining stage of illness is characterized by important hypertensive crisis. The vice can reach 300/130 mm Hg. Art. Lovoshlunochkova lack of development, thrombosis of the brain, retinal growth of the brain, bursting of the healthy nerve, nirkova lack.

Folded arterial vise є:

angina pectoris;
infarction;
insult;
pack of legends;
heart asthma;
aortic aneurysm;
delivery of the link;
self-defense to organism through a test of nirok.

If "Noliprelom" cannot get rid of

The drug stagnates if the patient is sensitive to the components.

Nabryak Kvinke

Prototype indications є the strength of the people to angioedema.
Do not prescribe liquids with a reduced amount of calories in the body.
Yet another contraindication is the importance of a deficiency.
It is possible to become susceptible to stagnation during the turn of the liver deficiency.
Through the presence of the lactose preparation in the warehouse, it is possible to recognize it for people who do not overtravel lactic acid due to enzyme deficiency.

The preparation of the harrowing during the year of bathing

Chi does not get stuck with vaginosity breastfeeding, Oskіlki active speech "Nolіprela" builds up the placental bar'єr, and also penetrate into the breast milk.

Having infused perindopril on the fetus in the other and third trimesters can turn into a development in a newborn hypotension, damage to robots, to a loss of cranial cysts. The beginning of a change in the number of nascent births. Іndapamid can wicklikati zatrimku in the development of the fetus.

Well, the vagina came in the period of taking "Noliprel", taking the drug to cringe.

Criminally, there is a proof, to understand the situation, when any vicarious "NOLIPREL" needs to be protected.

There is a short list of pathologies, for which the reception of the face is littered with non-preferable inheritances such as Rizke Padinnya AT, deterioration of water-salt exchange. Before them, stenosis of the nirkovy arteries, stenosis of the aortic valve, systemic chervonia vovchak, cuckold diabet, Hyperuricemia.

People who are suffering from ischemic ailments Sertsya, for lack of blood circulation to the brain, blame it for fixing it with a lower dose.

Lіtnіm patients before admission wіll hеlіkіn tіlіkіonіalnі pozvіlіvі nіk and rіven kalіv in the blood. It is necessary to reduce the risk of hypotonia.

People with a severe heart deficiency, a decrease in the volume of circulating blood, cirrhosis of the liver, are susceptible to rhizik.

Therapy "Noliprel" in the process of continuous control of the level of the main electrolytes in the blood plasma (calories, magnesium, calcium, sodium, chlorine, salt). Such control is of particular importance for the elderly people who are weakened by small chronic illnesses, such as the temptation to take over the licks.

Yak needs to be accepted

The drug is prescribed for hypertension of all stages. The standard dosage for older adults is one tablet for doba.

Dozuvannya for people of the kidnapped vіku is the same. It is recommended to drink a Vrantzi pill.

Likuvalnye effect of writing to the receptionist is secured by reaching out. A persistent therapeutic result can be reached in less than a month. In case of re-registration, the effect of the swap is displayed.

Yakim can be a bitter inheritance

The stench is the beginning of a reaction of the body to perindopril and indapamid. The first component of "Nolіprela" can lead to an overwhelming decrease in the blood vice, provoke orthostatic hypotension. Angina pectoris, arrhythmia, myocardial infarction, insult do not occur in children with diseases.

The sečovaya system can be developed as a development of hospitality nirkova deficiencies, advancing bilka in the sech.

Perindopril may be viclicati head b_l

You can change your reaction from the side of the nervous system. Before them, weakness and swelling of stampede, zamorochennya, headache, mood swings, feeling puking and giving goose bumps, dvd in wuhah, anorexia, problems with sleep are known.

You may have a dry cough, bronchospasm, clear watery vision from the nose (even worse).

Negative infusion of perindopril on the herb system can lead to pain in the abdomen, diarrhea, or constipation, boredom, dryness in the mouth. In small vapors, there was a burnt-out of the flesh, internal cholestasis (congestion of the gall), and hyperbylirubinemia (growth in the blood).

Shkirnі show up in the main until the sverbіnnya and visipan, rarely spontaneously sprinkle and angioeurotic nabryak.

Analysis can determine the decrease in hemoglobin and platelet levels.

Reshta of reaction - the increased energy, the reduction of the potential.

Negative infusion of indapamide on the central nervous system manifests itself as headache, foul-smelling, paresthesia, weakness.

You can sposter nudota, hanging the mucous membrane of the company. Sometimes pancreatitis and pechinkova encephalopathy.

The hematopoietic system can lead to leukopenia, thrombocytopenia, anemia.

Dermatological effects most often rotate in small viscera, manifestations of hemorrhagic vasculitis.

Indapamid can reduce the concentration of sodium, chlorine, and inodi - calium. Low vm_st to natri can provoke a change in the amount of circulating blood, dehydration of the body.

How robiti, how did you become overdosed?

As a result of self-indulgence, or gratefully trapping with the overworldly drink "Noliprela", there is a possibility of intoxication. Її symptoms є:

rise to a grip;
blues;
attitudes adjustments;
sleeplessness;
confidence in the heart rhythm;
polyuria (decreasing the statement of the battle) or oliguria (decreasing the vision of the battle);
damage to the water-electrolyte balance.

When there is a sign of stripping, it is necessary to thread the shlunny. To clean the slurry, it is necessary to drink five flasks of warm water and a small amount of sodium or salt. To wickle the blues, it is necessary to press on the root of the tongue with two fingers.

For the production, you can take a sorbent (not active).

As soon as the people are out of the way, they have strongly fallen into a grip, they need to lay them on their backs, their legs should be lifted, having pushed some kind of object under them.

Yak NOLIPREL

When treating with Noliprel, it is not recommended to use drugs for treatment, as it becomes stagnant for the treatment of manic and hypomanic phases of bipolar breakdown, important depressions. Angibitories of ACE and diuretics are responsible for the development of lithium from the body, which can lead to the detachment of the body with a chemical element.

In case of intoxication of lithium, the development of neurological and psychotic(Tremor, impaired coordination of ruffles, epileptic seizures).

It is not possible to learn from life from time to time, it is necessary to constantly control this change and introduce correctives into the course.

Unfriendly є after taking any medications, there is no reason for the development of hypercalculations. A pathological camp to produce serious changes in the robot's heart, as it can clutter the life of people.
Perindopril can improve the health of the patient.
There is a slid of a unique alcoholic drug intake (erythromycin, pentamidine, vinkamin, bepridil, halofantrine), but the development of non-safe arrhythmias does not occur.
There is also a threat to sleep when given antiarrhythmic drugs (chinidin, amiodarone, sotalol).
Muscle relaxant of the Central Department of Baclofen for the hypotensive effect "Noliprela".
A similar result can be found in combination with antipsychotics and tricyclic antidepressants.
Ibuprofen, diclofenac and other non-steroidal anti-epileptic drugs, glucocorticoid and antihypertensive effects.

Yaksho accept the refinery at the same time with the help of the APF, not to include a cumulative effect, sprying hypercalculation. There is a threat especially to the temple, if the patient has a reduced concentration of calories, an increase in the QT interval, and a bradycardia.

Likas, which reduce calories in the body (delivered, glucose with insulin, calcium), when combined with indapamid, can lead to hypocalm.

"NOLIPREL" increased toxicity of heart glucosides on aphids in the body.
There can be damage in robotic nirok with vikorystanny x-ray contrast speeches with vmist iodine.
Immunosuppressive cyclosporine increases the level of creatine in the blood.

One of the analogs of "Noliprela"

What can replace the drug?

In case of unhappiness of pribati NOLIPREL, it can be replaced by analogs. Among them are the following:

"PRESTARIUM arginin kombi";
"Prilamid";
"Co-Preening".

The stench may be the same as the most active speeches, as well as "NOLIPREL". Є There are few indications in the list of additional components, so before implanting analogs, you should respectfully read the descriptions of the labels.

Analogues are being developed for the price, as it may be found in the country where the drug is carried out. "NOLIPREL" є effective drug against hypertension. However, it is not recommended to register without a license through the manifestation of evidence and side effects.

Dodatkova information on the topic "NOLIPREL (instruction from storing): at any grip of drinking?" can be edited from video:

You can learn more about hypertension from the upcoming video:

NOLIPREL - strong liquids against a sliding vice. The drug is often used for hypertension.

NOLIPREL - strong liquids against a sliding vice. The drug is often used for hypertension.

vidi Nolіprela

The whole drug is dispensed in decilkoh pisnovidy. Smells are recognized by the dozens of active speeches. He has two. At the guidance of the table, it is indicated more precisely їх zmіst.

On yakіy rutsі work the vice correctly - read in the tsіy statty.

Why do you need the grip of writing?

Algorithm for setting hypertonic cliques.

Vipusku form

NOLIPREL is carried out in the form of oval oval tablets of a long form of white color, from both sides on them є the rhizic, which lays down the tablets, if it is necessary to take half a dose. Tablets of different types of food should be taken by weight:

NOLIPREL A - 2.5 mg;
NOLIPREL A Forte - 5 mg;
NOLIPREL A Bi-Forte - 10 mg.

One blister can take 7 or 10 trips. All in pachtsi buvaє 14 or 30.

NOLIPREL forte - analogues

Among the former candidates for the preparation they see:

Akkuzid ®. Win stasis for ailments, which is a complex treatment of diuretic and quinapril.
Iruzid. Likuє people with easy and middle hypertension, as they are encouraged to maintain a stable course of therapy.
Capotiazid. To become stagnant in alcohol with other antihypertensive drugs, in any form of arterial hypertension.
Kvinard. It is used for chronic deficiency and hypertension.
Ko-renetek. Freeze for patients who undergo complex therapy.
Lisinopril / hydrochlorothiazide. A drug of signs for the treatment of light and middle stage of hypertension.
Lizopres. Likuh hypertension.
Liprazide. Made for the treatment of any form of hypertension, including the renovascular.
MIPRO. I lower the arterial vise.
Rami compositum. Є a gateway for quiet patients, who cannot control their arterial grip during monotherapy.
Tritace. It’s stagnant for a complex treatment, so it can be spillover with other calcium antagonists and diuretics. Additional help with congestive heart failure.
Fozid. It is used for arterial hypertension.
Ena Sandoz. Stagnate in case of acute hypertension, chronic heart failure, as well as for the prevention of infarction.

Acceptance of Noliprela is guilty of a normal degradation of the body, and of the destruction of the risk of hypotension. Before the hour of the day, control of creatine, electrolyte and arterial grip is carried out. If the patient is suffering from heart failure, then the drug should be combined with beta-blockers. Needed vrahuvati, scho on doping tests NOLIPREL give a positive reaction.

NOLIPREL tablets are a combination of antihypertensive drugs that can be stored in two active words: perindopril - angibitor ACE and indapamide - sulfonamide diuretic.

The managers of the joint perindopril and іndapamіdu will accept the dermal treatment from them. The maximum antihypertensive effect Noliprela develop in a stretch of 1 month and take a trivial hour without a tachyphilaxis.

When assigned to the reception NOLIPREL, the effect is not recognized. It is necessary to readme, scho likuvalny effect NOLIPREL dose-dependent. The maximum concentration of perindoprilat in blood plasma is reached in 3-4 years after receiving. The stage of stable concentration is reached after 4 days of periodic stagnation in equal intervals of an hour.

One of the most important words to the drug - Perindopril is changing the robot with a heart path:

- vasodilating effect on veni (possibly, through changes in prostaglandin metabolism)
- change of OPSS - change of navantazhennya on the heart.

In the number of pre-adolescent patients with heart failure, it has been reported that perindopril consumption should be reduced to:
lowering the grip of the left and right slingshot;

- lowering the OPSS;
- improvement of the heart wikid and the improvement of the heart index;
- improvement of the regional blood flow in the meat.

It has been delivered that the NOLIPREL tablets are consumed with a change in the hypertrophy of the heart.

Indapamid synergistically with perindopril reduces hypertension, reduces the hypotension. In terms of the mechanism of action, indapamides are closer to thiazide diuretics and are produced by the head of the disease (70% of the dose) and feces (22%) in inactive metabolites. Patients with a lack of pharmacokinetic parameters do not change.

Shown to zasosuvannya NOLIPREL

Zastosuvannya NOLIPREL і NOLIPREL Forte 2.5 \ 5 is shown for mills and pathologies:

Essential hypertension
secondary hypertension

Importantly - NOLIPREL is lowering the arterial diastolic and systolic vise. With a lot of welcome there is no supervising of frequent hearts.

At therapeutic doses of NOLIPREL in patients with chronic heart failure, it is clinically indicated to change the way of front-to-back, so to on-back. As a result, the heart is more effective (the power of the cardioprotector) - the growth of the heart vikid, the blood loss of the myocardium.

NOLIPREL - instructions from the supply, the supply

Until їzhі or pislya accept NOLIPREL? Oskіlki priyom їzhі hopeful of converting perindopril into perindoprilat, NOLIPREL followed once on a second before a snidank.

Yak accept NOLIPREL, dozuvannya?

The maximum dose is 2 tablets 1 time per dose of Noliprel A 2.5 mg.
The maximum dose is 1 tablet for NOLIPREL Forte 5 mg.

features:

Patients of the kidnapped vik. Likuvannya needs to be repaired with an extra dose - 1 tablet to the drug Noliprela 1.25 for dobu.

With nircovy deficiency of a severe step (clerance to creatine<30 мл/мин) лечение препаратом противопоказано. При почечной недостаточности умеренной степени (клиренс креатинина 30–60 мл/мин) максимальная доза - 1 таблетка препарата Нолипрел А в сутки.
In patients with a creatine clearance of ≥60 ml / hour, there is no need for a change in dosage NOLIPREL.

Not dopomagaє, why robiti?

When the dosage of NOLIPREL is adjusted, the antihypertensive effect does not change, only a few side effects of growth. As soon as the effectiveness of the deficiency is not observed, the recommended dose should not be changed. Become a doctor for a correction to the course of a license.

Prototype shown NOLIPREL

hypersensitivity or allergy to the components of the preparation of any of the other subassemblies (sulfonamides and / or ingibitoriv ACE);
nirkova lack - creatine clearance less than 30 ml / min;
pechinkova lack of mental strength to encephalopathy;
hypocalypse;
summing up the leaks, which podovzhuyut the QT interval;
fenced in the Russian Federation up to 18 rocks;
lactase deficiency, galactosemia, syndrome of glucose or galactose malabsorption (to avenge lactose).

Through the availability of sufficient clinical information, NOLIPREL A / NOLIPREL Forte does not mean to patients who are on hemodialysis, as well as in case of heart failure in the phase of decompensation.

The level of sodium in the blood plasma must be monitored before the ear and regularly every hour. Therapy with a non-mature can zoom in the diagnosis of hyponatriyemia, innocent ma serioznі inheritance. Be respectful, and do not ruin the connection indicated in the instructions for payment.

When developing an arrhythmia type, "feasts" does not go to antiarrhythmic drugs (it is necessary to vikoristovuvati one-piece rhythm).

If, with a stretch of the first month of treatment with perindopril, winy of the unstable angina pectoris (be it severe), it is necessary to take good care of the dietary risk / creep before feeding the nutritional supplements. You may need to replace the drug.

Overdose NOLIPREL

The effect of overdosing NOLIPREL most often manifests itself in hypotensive (overworldly sinking grip), which can sometimes be superfluous in nudota, blues, vessels and seizures. You can become sleepy and confused.

Likuvannya to conduct in the minds of the stationary.

With vaginosti:

Prototype indications of Noliprela in case of vaginosis and in the period of lactation through negative infusion on the child (increased mortality of newborns, anomalous development of the musculoskeletal apparatus, a lack of protozoan disease, lack of water circulation)

If the woman took NOLIPREL before the fact of the establishment of vaginosity, then it was innocently pinned. Necessity in carrying out a change of vaginosti nemeє, The protector is guilty, but it is informed about the possible inheritance.

vzaєmodії

To understand the insecure interactions with other drugs. In case of a one-hour reception, it is necessary to have a prior consultation with a doctor.

Analogs of NOLIPREL, a list of drugs

The drug NOLIPREL Ace nayblizhcha is an analogue of NOLIPREL forte. To be honest, because the instructions are from the definition of NOLIPREL, the price and advice to the analogue does not go, until the end of the day and is shown to be guilty but corrected by the drug.

NOLIPREL And another analogue, earlier it was just as simple as NOLIPREL. The name of the changing song of the formation of the release of one of the common speech is perindopril becoming the release of the arginine salt, and not the tert-butylamine salt. Pay your respects to the active speech.

Description of licarskoy form

Form vipusku, warehouse and packaging

Tablets, including a plastic sheath white color, dovgasti, with a risk on both sides.

Additional speeches: sodium carboxymethylcrochmal (type A), silicon dioxide coloidal anhydrous, lactose, magnesium stearate, maltodextrin.

Warehouse for ply casing: macrogol 6000, SEPIFILM 37781 RBC (glucerin, hypromelose, macrogol-6000, magnesium stearate, titanium dioxide (E171)).

14 pcs. - bottles of polypropylene with a dispenser (1) - packs of cardboard with control of the first opening.
30 pcs. - bottles of polypropylene with a dispenser (1) - packs of cardboard with control of the first opening.
30 pcs. - bottles of polypropylene with a dispenser (3) - packs of cardboard with control of the first opening.

Clinical-pharmacological group

antihypertensive drug

Pharmacological diya

Combinations of a drug to avenge perindopril (ingibitor ACE) and indapamide (spore diuretics). Pharmacological diya to the drug was zoomed in accordance with the data on the strength of the skin components. The combination of perindopril and indapamid synergy will result in antihypertensive effect synergism in terms of skin components in the environment.

The drug has a dose-dependent antihypertensive effect on systolic, as well as on diastolic AT in the supine and standing positions. Diya to the drug is 24 years old. A strong clinical effect is infused less in 1 month from the ear of therapy and not to be supervised by a tachycardia. Pipinennya lykuvannya is not supervised by developmental syndrome of vidmini.

NOLIPREL ® A changes in the steps of the hypertrophy of the lynx, reduces the elasticity of the arteries, reduces the OPSS, does not infuse on the metabolism of lipids (zagalny cholesterol / Chs /, Chs-LPVShch, ChS-LPNs).

perindopril- Ingibitor to the enzyme, which converts angiotensin I into angiotensin II. Angiotensin-converting enzyme (ACE), or kinase, є exopeptidase, as a result of converting angiotensin I into angiotensin II, which volodynuyu vysokuzuvnuyu dіyu, so that hepatization is not active before braking As a result, perindopril decreases the secretion of aldosterone, due to the principle of negative vortex, the activity of renin in blood plasma increases, with a trivial change in OPSS, which is more rationalized, in the main, due to the judgment in the world. The goal is not to be supravitated by salt and water or by the development of reflex tachycardia in case of trivial stasis.

Perindopril also has an antihypertensive effect in patients with low and normal renin activity in blood plasma.

On the basis of perindopril stagnation, a decrease in both systolic and diastolic AT in the position of lying and standing is meant. Do not use the drug until the arterial vise is increased.

Perindopril normalizes the heart to the robot, reducing the anterior and postnavant.

indapamid- the origin of sulfonamide, for pharmacological authorities is close to thiazide diuretics. It is responsible for the reabsorption of sodium ions in the cortical segment of Henle's loop, so that it can be reabsorbed with sodium ions, chlorine, and in the small world of ions in calories and magnesium. The hypotensive effect is manifested in doses, it is practical not to wick the diuretic effect.

Indapamid decreases the hyperreactivity of sudin in terms of adrenaline.

Indapamid does not infuse on the change of lipids in the blood plasma (triglycerides, cholesterol, LPNSH and LPVShch), on carbohydrate metabolism (including in patients with adolescent diabetics).

Indapamid spriiaє reduction of the hypertrophy of the lynx.

Pharmacokinetics

Pharmacokinetic parameters of perindopril and indapamide during the combination do not change in proportion to their separate stasis.

perindopril

Wetness and metabolism

When I get it in the middle of perindopril, it gets wet. Bioavailability to become 65-70%. C max of perindoprilat in blood plasma is reached after 3-4 hours. Approximately 20% of the amount of absorbed perindopril is converted into the active metabolite of perindoprilat. When the drug is taken for an hour or so, the conversion of perindopril into perindoprilat changes (this is not an effective clinical value).

Rozpodil i vivedennya

The concentration of blood plasma levels should be less than 30% and the concentration of perindopril in the blood plasma should be deposited. Dissociation of perindoprilat, associated with ACE, is spovilnena. In addition, T 1/2 to become 25 hours. Re-assigned perindopril should not be brought to its cumulative rate, and T 1/2 perindoprilat during repeated use of perindopril during the period of its activity, in such a rank, an equally important stage is reached after 4 dobi. Perindopril penetrates through the placental bar.

Perindoprilat vivoditsya s organism s cross section. T 1/2 perindoprilat become 3-5 years.

Vivedennya perindoprilatu is reduced among the patients of a kidnapped person, as well as among the patients with a nirk deficiency and a heart deficiency.

Clirens perindoprilat with dialis becomes 70 ml / min.

Pharmacokinetics of perindopril changes in ailments for liver cirrhosis: perindopril's liver cleansing changes 2 times. However, the concentration of perindoprilat does not change, so a dose correction is not required for the drug.

indapamid

soaktuvannya

Indapamid quickly and is absorbed from the intestinal tract. C max in blood plasma can be reached in 1 year after being received in the middle.

rospodil

Linkage with blood plasma blood - 79%.

Repeated intake of the drug does not lead to cumulation in the body.

vivedennya

T 1/2 becomes 14-24 years old (in the middle of 19 years). Vivoditsya in the main section (70% of the administered dose) and feces (22%) in the form of inactive metabolites.

Pharmacokinetics in special clinical forms

Pharmacokinetics of indapamide does not change in ailments with nirkovy deficiency.

Shown to the preparation

- essential arterial hypertension.

dosage regimen

I mean everything in the middle, which is important, before the reception of the їzhі, 1 tab. 1 time / day Even after 1 month, after an ear of therapy, the hypotensive effect was not reached, the dose of the drug can be increased to 5 mg, a dose of +1.25 mg (it is released by the company under the trade name NOLIPREL ® A forte).

To the patients of the kidnapped vik therapy slid to fix for 1 tab. 1 time / day

contraindication drug for patients with nirkovy lack of a difficult step (CC<30 мл/мин). for patients with nirkovy deficiency of the middle stage of severity (CC 30-60 ml / min) the maximum dose for the drug NOLIPREL ® A is 1 tab. / day Patients with QC ≥ 60 ml / min, Dose change is not required. During the course of therapy, regular monitoring of the level of creatine and calories in blood plasma is required.

contraindication drug for patients with severe pechinka deficiency... at with pechin deficiency Dose change is not required.

NOLIPREL ® And not a sign of for children and adolescents through the availability of data about the efficiency and safety of the ailments of this group.

Pobichna diya

Perindopril іngіbuє system of renin-angiotensin-aldosterone and changes in the delivery of calories with nirkami on the basis of the intake of indapamid. In 2% of patients on aphids on the use of the drug Noliprel ® A, hypocalypse<3.4 ммоль/л).

The frequency of side reactions, which may occur before an hour of therapy, is induced at such a gradation: more often (> 1/10), often (> 1/100,<1/10), нечасто (>1/1000, <1/100), редко (>1/10 000, <1/1000), очень редко (<1/10 000), неуточненной частоты (частота не может быть подсчитана по доступным данным), включая отдельные сообщения.

On the side of the herbal system: often - dryness in rot, nudota, decreased appetite, beating in the stomach, beating in epigastria, loss of relish, constipation; Ridko - angioneurotic intestinal obstruction, cholestatic tuberculosis; even more rarely - pancreatitis. Patients with pechinkovy lack of mobility develop pechinkovo encephalopathy.

On the side of the mental system: often - on the smallest part of the ACE, you may have a dry cough, it’s a trivial hour to take the drug from the whole group, and when you’re talking about it. When a patient has a dry cough, there is a memory of a possible iatrogenic characteristic symptom.

On the side of the heart-vascular system: infrequently - a decrease in the arterial grip (including orthostatic potency).

Dermatological reactions: infrequently - reactions of susceptibility to sensitivity, mainly, in patients with dermatological reactions in patients who are sick to allergic and asthmatic reactions, hemorrhagic visipus, hanging on the brain, macular papules; even more rarely - angioeurotic nagging (nabryak Kvinke), photosensitivity reactions.

On the side of the nervous system: infrequently - paresthesia, headache, asthenia, disturbed sleep, labile mood, spoiled.

On the side of the kistkovo-meat system: infrequently - muscle spasms.

On the side of the hematopoietic system: even more rarely - thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia. In singing clinical situations (patients for transplantation of nyrka, patients for hemodialysis), ACE angina may experience anemia.

Laboratory indicators: gіpokalієmіya (osoblivo znachuscha for patsієntіv, SSMSC nalezhat to groupies riziku) gіponatrієmіya i gіpovolemіya scho prizvodyat to degіdratatsії i ortostatichnoїgіpotenzії, pіdvischennya rіvnya sechovoї acid i of glucose in krovі pid hour priyah preparation (small pіdvischennya rіvnya sechovini i kreatinіnu in plazmі krovі scho pass during therapy, often in patients due to stenosis of the nirkova artery, in cases of arterial hypertension with diuretics, in the case of nirkal deficiency), hypercalculation (often in the past); Ridko - Hypercalculus.

Prototype indication prior to drug administration

- angioedema in the anamnesis (including on the smallest admittance of the first angioedema in the ACE);

- drooping / idiopathic angioedema;

- nirkova lack of a heavy step (CC< 30 мл/мин);

- hypocalypse;

- bilateral stenosis of the nirkovy arteries or stenosis of the artery of the single nirka;

- Pechinkova deficiency is manifested (including encephalopathy);

- one-hour intake of the drug, which will increase the QT interval;

- an one-hour reception of antiarrhythmic arrhythmias, such as the possibility of a malignant arrhythmia of the "feasting" type;

- availability;

- period of lactation (breastfeeding);

- sensitivity is adjusted to perindopril and other ACE ingibitors, to indapamides and sulfonamides, as well as to other additional components of the drug.

Due to the availability of sufficient clinical information, the drug is not used in patients with untreated decompensated heart failure and in patients who are on hemodialysis.

Z protection then prescribe the drug for systemic disease with full tissue (including systemic red blood clotting, scleroderma), immunosuppressive therapy (negative development of neutropenia, agranulocytosis), associated with cystovomoretic hematopoietic ), angina pectoris, cerebrovascular disease, renovascular hypertension, hypertensive disease, chronic heart failure (IV functional class for the classification of NYHA), hyperuricemic hypertension (especially hypertension) hemodialysis of high-flow membranes, desensitization, before the procedure of apheresis of low-flow lipoproteins; at the stage of transplantation nirok; aortic valve stenosis / hypertrophic cardiomyopathy; the manifestation of lactase deficiency, galactosemia and glucose-galactose malabsorption syndrome; as well as to the patients of the abducted person or to the patients under 18 years of age (efficiency and safety has not been established).

Intrusion of the drug in case of vaginosity and year of breastfeeding

The drug was not used in the first trimester of vaginosis.

In case of planned vaginosity, or in case of instillation on the ingestion of NOLIPREL ®, and then it is inaccurate to prescribe with the preparation and indicate hypotensive therapy.

No specific control of the previous ACE testing was carried out in the patients. It is clear that the drug was infused in the first trimester of vaginosity, but we didn’t lead to developmental defects by taking the drug, we would tie it to fetotoxicity.

NOLIPREL ® A contraindications in II and III trimesters of vaginosis.

Vіdomo scho trivaly vpliv іngіbіtorіv on ACE plіd in trimesters II i III vagіtnostі Mauger prizvoditi torn down to Yogo rozvitku (znizhennya funktsії nirok, olіgogіdramnіon, upovіlnennya utvorennya kіstkovoї skull rechovini) i rozvitku uskladnen at novonarodzhenogo (nirkova nedostatnіst, arterіalna gіpotenzіya, gіperkalієmіya).

Trivial stagnation of thiazide diuretics in the third trimester of vaginosis can cause hypovolemia in the mother and decreased uterine-placental blood flow, which can lead to fetal-placental ischemia and fetal development. In newborns, on the background of receiving diuretics, hypoglycemia and thrombocytopenia develop in newborns.

As soon as the patient took off the drug NOLIPREL ® A in the II or III trimesters of vaginosity, it is recommended to carry out an ultrasound pre-examination of the fetus to assess the cranium and the function of nirok.

NOLIPREL ® A contraindications in the period of lactation.

Stagnation in case of deterioration of the function of the liver

at for the broken function of the stove No dose correction is required for the drug. at serious damage to the function pechinki zasosuvannya drug contraindicated.

Zasosuvannya in case of destructive functions of nirok

at nirkovaya lack of severe stage (CC less than 30 ml / min) zasosuvannya drug is contraindicated. at nirkovy deficiency of the middle stage of severity (CC 30-60 ml / min) the maximum dose of Noliprel A is 1 tab. / day at CC ≥ 60 ml / hv No dose correction is required for the drug. During the period of testing, it is necessary to carry out partial control instead of serum creatine and calcium.

special requests

NOLIPREL ® A

Stagnation of the drug NOLIPREL ® A does not supervise the hundredth decrease in the frequency of side effects, due to the blame of hypocalypse, in some cases with perindopril and indapamide in the most appropriate doses. On the cob of therapy with two hypotensive drugs, since the patient has not been removed earlier, it is impossible to turn on the increased risk of idiosyncrasy. To build up to the minimum of such a risk, we must conduct a retail monitoring of the patient’s camp.

Nirkova lack

In patients with nirkovy lack of a difficult step (KK< 30 мл/мин) данная комбинация противопоказана.

In children with arterial hypertension without anterior impairment of the function of nirok on the basis of therapy with Noliprel, there may be laboratory signs of functional nirkova deficiency. Have a lot of vipad lіkuvannya slіd pinch. Nadal it is possible to introduce a combined therapy, vikoristovuyu and low doses of drugs, or vikoristovuvat drugs in the mode of monotherapy. Such patients need regular monitoring of the level of calories and creatine in their blood - after 2 minutes of therapy and in the other skin 2 months. Nirkova lack of frequent diagnoses in patients with severe heart deficiency or disabilities in the function of nirok, incl. with stenosis of the nirkovo artery.

Arterial hypotension and damage to the water-electrolyte balance

Hyponatremia is associated with the development of arterial hypotension (especially in patients with stenosis of the artery of a single nyrka and bilateral stenosis of the nirkovy arteries). To that, with the dynamical care of the patients, I will respect the possible symptoms of anger and decrease in the level of electrolytes in the blood plasma, for example, when there is diarrhea or bloating. Such patients need regular monitoring of blood plasma levels of electrolytes. In case of arterial hypotension, intravenous injection of 0.9% sodium chloride can be used.

Transient hypotension is not contraindicated for continued therapy. For renewal of BCC and AT, it is possible to update therapy, low dose drugs, or drugs in monotherapy mode.

Additional speeches

Slid vrahovuvati, before the warehouse of additional speeches, the preparation includes lactose. It is not a sign of NOLIPREL ® But also a decline in galactose intolerance, lactase deficiency and glucose-galactose malabsorption.

perindopril

Neutropenia / agranulocytosis

The risk of development of neutropenia on the background of the reception of the ACE ingibitors is of a dose-delaying nature, and it stays in the form of the accepted lykarsky zasobu and the manifestation of the concomitant ailments. Neutropenia is rare in ailments without supportive ailments, however, in ailments, in ailments due to impaired function of nirok, especially on aphids of systemic worms in a tissue) Pislya vіdminіngіbіtorіv ACE signs of neutropenia pass independently. To unify the development of similar reactions, it is recommended to suvoro pretrimuvatisya the recommended dose. With the recognition of ACE ingibitorіv, a given group of patients is followed by a retinal spіvvіdnositi factor of cinnamon / risik.

Angioneurotic embryo (Kvinke embankment)

Angioneurotic larynx, which can lead to a lethal result. A lump of the tongue, the pharynx or the larynx can lead to the obstruction of the dickheads. In such a case, it is inappropriate to inject adrenaline (adrenaline) s / c in a dose of 1: 1000 (from 0.3 to 0.5 ml) and in the last few visits of non-emergency help. Patients with an anamnesis of some kind of Kvinke have not been tied with the intake of ACE ingibitors;

Angioeurotic intestinal obstruction develops in children with ACE in the background of therapy with ACE angibitors.

Anaphylactic reactions during desensitization

Є About the occasion of the development of anaphylactic reactions that are dangerous for the life of ailments, such as the reception of ACE angiotics for an hour of desensitizing therapy with a severe retraction of frequent coma (including osteoarthritis), including Angibitories of ACE need to be guarded to recognize patients who are sick to allergic reactions and undergo desensitization procedures. It is a unique sign of the drug's recognition for patients who receive immunotherapy from abrupt overreturn of frequent coma. Protest, anaphylactic reactions can be uniquely identified by a team of hours of administration to the drug not less than 24 years before the cob to the course of desensitization therapy.

Anaphylactic reactions during LPNS apheresis

In children, in patients who recognize an ACE membrane, during an apheresis of low-grade lipoproteins with short-lived dextran sulfate, in patients in a patient with a hemodialysis To prevent an anaphylactic reaction, take the therapy with an ACE inhibitor, shonaimensha, 24 years before the apheresis procedure.

cough

Risks of hypothesis and / or any disability (including in times of heart failure, water deficiency and electrolytes)

Patients of the kidnapped vik

Patients with the establishment of atherosclerosis

renovascular hypertension

Method of treatment of renovascular hypertension є revascularization. Tim is no less, the victoriousness of the APF’s Ingibitators is very friendly with the given category of patients, as it’s to clear up the operative task, so in the same way, if it’s not a matter of surgical involvement. Treatment with the drug NOLIPREL ® A patients with diagnosed or diagnosed with bilateral stenosis of nirkovy arteries or stenosis of artery and single nyrka should be repaired with a low dose of blood plasma in the patient's brain, control of the patient's brain. Some ailments may develop a functional deficiency, as it is known when the drug is administered.

Інші group riziku

Patients with arterial hypertension and heart deficiency do not have beta-adrenergic blocking agents: ingibitori ACE followed at once with beta-blockers.

anemia

Surgery / General anesthesia

Stagnation of ACE in patients with ailments, which is susceptible to surgical intervention due to stagnant anesthesia, can lead to a severe decrease in arterial pressure, especially in the case of acute anesthesia for anesthesia. It is recommended to pinch the reception of the ingibitoriv ACE of the trivalo diy, incl. perindopril, for add to the surgical operation. It is necessary to tell the doctor-anesthesiologist about those who are receiving the ACE in the patient.

Aortic stenosis / Hypertrophic cardiomyopathy

Angіbіtori APF blame for the protection we are sick with the obstruction of the outward tract of the lіvnі slunochka.

pechinkova lack

indapamid

Disruption of the water-electrolyte balance

Before a cob of treatment is necessary, it is necessary to replace the sodium in the blood plasma. On a single drug, the indicator is regularly monitored. All diuretic drugs are good for giponatriyumiyu, yak inodі produce to serious delay. Hyponatremia on the cob may not be supportive of clinical symptoms, which requires regular laboratory monitoring. More frequent monitoring in place of some of the indications we are sick with liver cirrhosis and individuals of the kidnapped veterinarian

Therapy with thiazide and thiazide-like diuretics is associated with the development of hypocalis. It is necessary to have a unique type of hypocalmus (less than 3.4 mmol / l) in the onset of the disease category of patients with a high risk group: those who are abducted, young patients or to recognize the presence of medication for liver disease, chronic liver disease, chronic liver disease. Hypokalinemia in cichs with ailments suffers from toxic effects of heart glucosides and increases the development of arrhythmias. Before a group of adrenal rhiziks, it is also possible to have ailments due to an increase in the QT interval, at which it is not important, because of any increase in the number of reasons, for any reason.

Hypocalypse, as bradycardia, the development of severe heart rhythm disorders, especially, arrhythmias of the "fever" type, which can be fatal. In all the diseases described above, it is necessary to have more regular monitoring in place of the calories in the blood plasma. The first phase of concentration of ions in calories must be carried out with a stretch of the first pressure from the cob of therapy.

In case of detection of gipokalієmiyi, it is recognized as a type of treatment.

Thiazid and spore diuretics change the amount of calcium in the blood plasma, bringing to an insignificant and hourly increase in the concentration of calcium in the blood plasma. Hyperparathyroidism is often affected by hyperparathyroidism, which has not been diagnosed before. Before the preliminaries of the function of the parathyroid gland, there was a decline in the development of diuretic diseases.

It is necessary to control the level of glucose in the blood of patients with diabetic diabetes, especially when hypocalypse is present.

Sečovaya acid

Patients with a high volume of sech acid in their blood during the therapy with Noliprel A develop the development of gout.

Function of nirok and diuretics

photosensitivity

athlete

Indapamid can give a positive reaction during doping control.

Vikoristannya in pediatrics

Do not sign NOLIPREL ® A for children and adolescents up to 18 years old Therefore, the efficiency and safety of this category of patients have not been established.

Inflow to the building of keruvati by transport means and mechanisms

Diya rechovin, before entering the warehouse with the drug NOLIPREL ® A, does not lead to the destruction of psychomotor reactions. However, in some people, in the case of a decrease in the arterial clutch, there may be development of individual reactions, especially to the cob of therapy, even if given before therapy, other antihypertensive drugs may be carried out. In general, the performance of a carousel by car or other mechanisms can be reduced.

Overdose

symptoms: loss of arterial pressure, tediousness, bloating, sudomy, dullness, drowsiness, confusion of symptoms, oliguria, which can go into anuria (as a result of hypovolemia), breakdown of the water-electrolyte balance (

lykuvannya: shlunk promivannya, the introduction of an active vugil, correction of the water-electrolyte balance in the minds of the stationary. With a significant decrease in the arterial grip, the patient should be transferred to a horizontal position with raised legs. If necessary - in / in the infusion of physiological difference, come in, direct to the BCC update.

Perindoprilat can be a vision of the body behind the additional dialogue.