Immunodepression. Lykarski zosobi immunosuppressive activities II

18.03.2016

Mabut, we have feelings for those who are so important for the skin people as immunity, which injecting wine into all systems and organisms of people. The managers of the obvious activity of all the forces of the human being are only able to resist the attacks of infectious diseases, viruses and other aggressive particles.

A great number of people are majestic for the reduction of the immune system. But in deyakyh situations, it is normal to work with such a system, and it can be shkoditi, in which the doctor should be brought vipisuvati immunodepressant. As for the preparations, like the smell of dyut, and the lists are given below.

Diya likarskoy group

immunodepression- tse drugs, such as are straightened to the stifling of the immune system and people with a piece shlyah.

In a large number of vikoristovuvati such it is necessary to have an hour of operative engagement, for example, when transplanting organs, so as from others it is possible to get ahead of the organisms being introduced to new tissues. Krim tsyogo, immunosuppressant can nadati ineffectively lіkuvannya with autoimmune diseases.

On a current day, you can see a list of groups of such drugs, which can characterize for yourself the manifestation of immunosuppressive qualities. The skin from them is a great deal of pressure on the body of the people.

So, for example, such drugs, like cytostatics, appear in the manifestation of well-developed immunosuppressive power. Explain themselves in their presence, oppressive injected into the processes of lymphocyte growth. True, a similar category of drugs cannot be used to vibrate, and it can often be caused by a number side effects.

Preparations Cytostatics of the health cause the processes of blood formation, which can cause the cob to develop thrombocytopenia, leukopenia, secondary infections, anemia and resti. Azatioprin is the most popular drug from the group of groups.

Immunosuppressants also include glucocorticoids, which are important for the production of interleukin and proliferation of T-lymphocytes. Podbnі preparations zdatnі nadati viborche pouring on organіzm, before them it is possible to bring Betamethasone, Triamcinolone, Methylprednizolone and Prednizolone.

Also, in the number of immunosuppressants, a number of effective antibiotics: Tacrolimus and cyclosporine, as well as a monoclonal antibody drug - Daklizumab. They will be able to build an effective response to the immune system of the people, in case of any incidents of sickness.

Vikoristannya lykarsky drugs

There are only a few of the most advanced medications that can be used effectively because of illnesses. We provide a list of available and requested licenses, which can be found in the pharmacy.

azathioprine

Vibrating immunosuppressant, it is recommended to turn your back to Azatioprin. Take a likarskiy zazvichy to vipisutsya sick people in addition to the chotiroh miligrams on the skin kilogram of the yogi vagi. When taking the drug, it is necessary to fix it 1-7 days before the prompt engagement, For whom the number of kosti goes down to two or three milligrams per kilogram of ailing mass. In case of the manifestation of those ailments, the necessary obligation to live with the lykarskiy is guilty of becoming close to the author of the miligrams per kilogram of the people in the dob.

cyclosporine

It is necessary to inject such a lykarsky drug internally, the dobova dose is guilty of being divided into two doses. The known concentration of the drug needs to be diluted in a five-hundredth grade of glucose, and its introduction into the body can take two to six years. dobova dose on the cob stage of the process, set three-five milligrams per kilogram of human vagi. Internally, the introduction of the drug in this way is shown to be ill, who plan to start a transplant cystic brain.

Rozchin, indications for internal introduction it is necessary to add fruit juice, milk or chilled chocolate drink with vikoristannyam. It is recommended to vipiti such a warehouse immediately. Capsules, in their own heart, are required by the co-workers.

If an ailing person needs an organ transplant, then they should receive 10-15 milligrams of value per kilogram of carriage for 4-12 years before the ear of the operative engagement. Nadal also dozuvannya zasobu zastosovuєtsya stretching one or two tizhnіv. Nadal vona change to an additional storage capacity of 2-6 milligrams per kilogram of carriage. For carrying out the korektsії autoimmune disease the sick is assigned 2.5-5 milligrams per kilogram of vagi cyclosporine in dob.

Daklizuma

Such immunosuppressive drugs are used for intravenous injection, injecting it into the central or peripheral vein. In a large number of vykoristovuyut 1 mg / kg likarskoy vasoba for doba, breeding it in front of 0.9% solution to sodium chloride. The first introduction of the drug is carried out before the planned organ transplantation, further the introduction of the drug is carried out at an interval of two times.

The strength of the drugs

Such preparations are necessary for transplantation of foreign organs in humans, and allow for the transfer of foreign tissues. It is possible to judge from practice, vikorstannya of similar tasks (supervising the active activity of lymphocytes) and the continuation of the term of life of the transplanted organ.

In case of elimination of the disease of the immune system, a category of drugs is similar to the category of drugs in the course of pathological processes such as the following: rheumatoid arthritis for the trustworthy meaning of the development.

About drugs for the human body

Skin from the descriptions of the ways, which is capable of immunosuppressive qualities, is given to the body as a result of the great list of other side effects. Especially high number of drugs in the group of cytostatics. For example, Azatioprin can lead to blues, tediousness, and appetite. In rare cases, the use of such a drug can lead to the development of toxic hepatitis.

At the same hour, it will mean that drug preparations in the whole group are taken into a natural state of immunity. Apparently, all ailments should go through a test of immunosuppressants, nasty to the infusion of other ailments microorganisms and some aggressive warehouses, including some quiet ones, some of them up to antiquity. Likewise, information that suppresses the immune system and is highly significant for the establishment of oncological ailments.

Preparations that adapt to the immune system strong likes, Stagnation of which can be carried out for the signs of a lykar for an extended period of an hour. In any case, they didn’t go into self-abuse, they accepted the leaks for the authorities.

Immunosuppressive koshty (immunosuppressive) - koshty, which will bring the immune system to the body.
Immunosuppressive stagnation for the reduction of reactions in transplantation, as well as for suppression of allergic reactions and autoimmune processes.
Immunosuppressive activity of speech in different pharmacological groups.

Classification of immunosuppressants

1. Cytostatic data:

1. Glucocorticoid preparations: prednisolone, dexamethasone.
2. Antibiotics with immunosuppressive activity: cyclosporine (Sandimmune), tacrolimus.
3. Antitil preparations:

Yak immunosuppressors from a group of cytostatics are most often used to stagnate azathioprine.
Azathioprine (Imuran) is a synthetic form of imidazole compared to 6-mercaptopurine. Nadaє immunosuppressive and cytostatic efficacy. Immunosuppressive activity is associated with impaired activity of T-suppressors and decreased proliferation of B-lymphocytes. For the mechanism of antimetabolite. In case of oral stagnation in the intestinal stantsi and in lymphoid tissue, azathioprine is metabolized with the formulation of 6-mercaptopurine, then it is converted into 6-thioinosinic acid, as it competes with inosinic acid, the synthesis of yak The Danish mechanism is to lead to the destruction of DNA synthesis and reduplication block of the cellini genome in the S-phase of the cell cycle.
The drug is good to get wet shlunkovo-intestinal tract in the shelter, its bioavailability becomes 20%, which is supplemented by the high presystemic metabolism of azathioprine. The peak of concentration can be reached for 2 years. Metabolize in ovens; tw to become 5 years old. Vivoditsya from zhovchu і from the cross.
To become stuck for tissue insanity during organ transplantation; for the treatment of autoimmune ailments - rheumatoid arthritis, nonspecific inflated colitis, systemic cervical sphincter, lupus nephritis and in. When the drug is prescribed, the following may be: nudity, bloating, anorexia, leukopenia, thrombocytopenia, shkirny visip, arthralgia, malgia, infection, toxic hepatitis.

Mechanism of immunosuppressive drugs in glucocorticoid dressings for adapting products of interleukin and proliferation of T-lymphocytes. On the basis of cytostatic drugs, glucocorticoid preparations produce more vibrations (they do not infuse on erythro-, thrombocytopenia and leukopoiesis, in the smallest world they attract B-lymph products).
Yak immunosuppressive drugs stagnate synthetic glucocorticoids: prednisolone, methylprednizolone, triamcinolone, dexamethasone, betamethasone. synthetic drugs When glucocorticoids are taken in, they get soaked in the middle, 60-70% of the blood is connected with special transport protein transcortin and albumin, are inactivated in the liver, produce more trivial diet, less endogenous glucocorticosteroids.
Yak immunosuppressive preparations of glucocorticoids stagnate for the treatment of autoimmune diseases (rheumatism, rheumatoid arthritis, deformable osteoarthritis, systemic cervical vovchak, scleroderma, Bekhtyrchyna's ailment, hemolysis) complex therapy- to improve the reaction of transplant administration and evil new creatures.
When trivalomu system zastosuvannі preparatіv glyukokortikoїdіv rozvivayutsya takі pobіchnі efekta: ultserogennadіyu, kushingoїdny syndrome (ozhirіnnya perevazhnim vіdkladennyam of fat in dіlyantsі oblichchya, breasts) steroїdny dіabet, osteoporosis, atrofіya shkіri m'yazіv i, i zatrimka natrіyu Vod in organіzmі, arterіalna gіpertenzіya, exacerbation of chronic infections, damage menstrual cycle, Pathology of the central nervous system, cataract, vidmini syndrome.
Cyclosporin (Sandimune) is an antibiotic that is produced by fungi; it is a neutral hydrophobic cyclic peptide that can be stored in 11 amino acids. Imported products to Interleukin-2, which can be produced to differentiate and proliferate T-lymphocytes. Bioavailability in case of vyomі becomes 30%. The maximum concentration is reached through

1. h. tw in healthy volunteers to become 6.3 years old, and in ailments with important liver diseases - up to 20 years. Vivodit through the intestinal tract and nirkami. The drug of indications for the improvement of allogenic transplantation of hearts, legends, liver, podshlunkovaya zolozi and other organs, with transplantation of the cystic marrow; with autoimmune diseases. When the drug is prescribed, it may develop: impaired function of the liver, loss of appetite, nudity, bloating, diarrhea, pancreatitis, arterial pressure, headache, paresthesias, thrombosis, allergic, hyperactive reactions

Daklizumab is a preparation of monoclonal antibodies to receptors in interleukin-2 (IL-2). Induced IL-2-depleted proliferation of T-lymphocytes, induced the synthesis of antigens and immune responses to antigens. Stasis for the prophylaxis of transplantation during transplantation of nirok. Used in combination with cyclosporine and glucocorticoids. Daclizumab may suffer from such side effects: difficulty in mental illness, fever, hypertension, hypertension, hypotension, tachycardia, stiffening on the legs, accumulation of lesions, tremor, boredom, accelerated arthritis head b_l, Sleeplessness, dyspepsia, diarrhea.
Vzamodiya immunosuppressive vassob_v with the lesser lykarsky vasob

1. Immunostimulants (immunostimulants)

To be released at the viglyadі 0.005% range. Stagnate in case of lycuvanne immunodeficiency - they become stagnant.
All preparations of the whole group are contraindicated for vaginitis, myelopid and imu- Nof are contraindicated in case of Rh-conflagration between the mother and the fetus.

The therapy itself is designed to stifle unwanted reactions to immunity to followers.

Often, this technology is stagnant in order to get rid of autoimmune ailments - a pathology, even if the immune system is already severely affected, the organisms are attacked and attacked by the power of the organization. More reports on the appointment of antiapal and immunosuppressive therapy for rheumatological illnesses and ailments nirok - dal.

So tse take?

It is not often possible to feel about those who, in the course of transplantation, are stuck in immunosuppressive therapy, which is necessary in order to be able to be able to attack the organ being introduced, such as transplantation from the organism. Also, there is a widespread stagnation for transplantation of the cystic marrow. It is also important to take care of it in the region in order to prevent it from getting sick, as well as before the hour of the hostile phase.

accelerating

There are chronic transplant reactions to the new ruler, which is called accelerated immunosuppressive therapy for glomerulonephritis. Tse viklikano tim, but the donor system itself is beginning to infuse negatively on the organism of a sick person. It is a pity that immunosuppressive therapy pulls negative inheritance after itself; infectious disease, by itself methodology given she is guilty of being able to catch up with other visits, which are indicative of a decrease in the risk of infection.

lykuvannya

Specific immunosuppressive therapy in its own right is cytostatic, glucocorticoid. ci lіkuvalny drugs other row, yak і "sirolimus", "Tacrolimus" and іnshi. At the same time, they are stagnant, such as monoclonal antibodies. The stench is meant to be used negative injections on the singing cellar in the immune system.

susceptible immunosuppression

The indication of immunosuppressive therapy for glomerulonephritis is to reach a lot. But the main thing is that the procedure is given, which is guilty of ensuring that there is a greater triviality of life with this transplant, which is supposed to be accommodated in a human body. And tse, in its own accord, є by the initial і, at the same hour, adequate to the suppression of immunity at the time of rizik. In such a rank, the secondary effects are minimized.

One procedure can be divided into several periods, 2 are allowed:

• The first one - tse before the fate of the procedure to get involved in the early pidtrimkoyu. At the end of the hour's progress, the plan is to reduce the dose of immunodepressants.
• Another period is more protracted, it goes through the risk of this, as the function of transplanted nirka can be used for any organ. At that moment, if the immunosuppression is growing more stable and reaching the intermediate level, the rhiziki is accelerated.

Pidbir drugs

For a positive result, micophenolate should be substituted for a positive result. In the case of the porous zastosovnye azatioprine, do not show a hospitable vidtorgnennya, the stench is an order of magnitude smaller. You go out of your way to guarding, growing up, so that you can improve your life for transplantation.

Regardless of the patient's and his specific symptoms, individual immunosuppressive drugs appear. The whole kind of pick-up is bound to be bound, which in any case is impossible to ignore. On a standard preparation, a substitution is assigned, and at the same time, the optimal solutions in the form of ineffective children of the same type of selection of likars' labor.

Diabetes mellitus is unrepentant in order to undergo organ transplantation. It can be steroids with vicyclics in quiet patients, in those who are impaired in glucose, post-traumatic diabetes is diagnosed, as a result of a complete dose change, or to take some of the other steroids. If only some of the situations are going to happen, so that the dates are not going to be helped, then it will be necessary to overlook and the options of the decision.

Gostre for transplantation

Gosdrevodobrazhennya є I am aware of the fact that immunity has given its relapsed appearance, which are indications for the donor's antigens. As soon as there is such a camp, then we can talk about those who are a great risik to increase creatine. And, moreover, it is an order of magnitude lower and there is more and more damage in the area of ​​transport.

Technical symptoms, as presented, may high sensitiveness, May their specific indicators and characteristics, which are infused into immunosuppressive therapy. At the very first stage of treatment, it is necessary to investigate whether there are other causes of dysfunction. And in order to precisely move to the hospital of the transplant, it is necessary to visit the biopsy organ that was transplanted. It seems to mean the fact that the biopsy is a perfect fit for such an unprecedented love affair. This is necessary in order to be able to support the hyperdiagnostics of the state of the art in the event that it has been three hours for transplantation.

Well, how can you be robbing for the first time you hit it?

At that moment, if the perspiration is sharpened, yak, in its own heart, carrying the characteristics of the classroom and sensitivity to increase, I recommend that you recommend pulse therapy in the form of a reaction. Vona is allowed, in the main, to be able to trade. For this purpose, the viconates zayd, vicoristovutsya "Methylprednizolone". The effectiveness of this procedure will be assessed after 48 or 72 years of writing. And until uvaga is taken dynamically equal to creatine. Fakhіvtsі are indicative of the facts, but even 5 more in order to fix the problem, the creatinine indicators turn in the cob position.

There are such vip drops, how the stench will linger for the entire period of the guest's service. If one hour at a time, as the therapy will be carried out, it is necessary to change to the fact that the concentration is in the permissible boundaries. However, if the dose is "mycophenolate", then you won’t be guilty in any way but below the recommended norms. In order to develop a harmless state-of-the-art business, right away from the fact that it is necessary to adequately undergo a preliminary examination, it is necessary to convert to tacrolimus.

If you want to repeat pulse therapy, then you won’t be able to bring the effect only in the case of a state-of-the-art business, but at the same time, it’s a fact that Danish method stagnate no more than two times. It's a pity, another period of sale of an important steroid injected. It is necessary to prescribe the drug, which will fight against antibodies.

At the same time, if you are engaged in a number of meals, it is recommended to fix the antibodies just once, in order to start the pulse therapy. But there are also some of the cranks of this theory, the stench is allowed, but it is necessary to take the course of kidney therapy for a few days and only to save the steroids. It’s just an organ, a kind of instantiation in organism, has begun to pogirshuvat his work, and to talk about those who need to change the course of treatment.

Correct treatment for chronic transplantation

If the transplant step by step does not work out its functions, then it’s worth talking about those who have become aware of the norm, or the nobility of fibrosis, but about itself the nobility is chronically introduced.

In order to correct a good result for a transplant, it is necessary to rationally vikoristovuvati all the feasible possibilities, to fix immunosuppressive therapy, vikoristovuvati to a complex medication technique. Carry out a quick diagnosis, be careful, and make a preventive treatment. For some types of procedures, it is recommended to use a sunscreen cream. In general, immunosuppressive therapy will be more effective.

Yak and in any kind of direct, immunosuppressive symptoms may cause side effects. Everything is fine, but it’s absolutely possible to show any kind of drug in the body, about which it is necessary to know first and then we’re preparing to fight.

Before an hour the preparation is consumed, signs for a drink, especially respect to come arterial hypertension... I would like to be aware of the fact that, in a trivial manner, arterial vise to grow more often, it is practical to develop in 50% of ailments.

Newly developed immunosuppressive drugs may have fewer side effects, alas, it’s a pity, some of them are injected onto the body before the patient has psychotic disorder.

"Azatioprin"

In immunosuppressive therapy for glomerulonephritis, the drug stagnates for 20 rockets, then brothers to respect. Winning good reason for the synthesis of DNA and RNA. As a result of the carried out robots, there is a deterioration before the hour of the growth of healthy lymphocytes.

"Cyclosporin"

Tsei lykarskiy is rich in peptide, which can be very similar. Win vidobuvatsya from fungi. Danium drug take care of the team to disrupt the synthesis and block the reduction of lymphocytes and the expansion of the lymphocytes into the organism.

"Tacrolimus"

The drug is a fungal podrozhdennya. By the way, the vicon is the same mechanism of action, like and in front of the house, alas, it's a pity, as a result of the stagnation of the number of people who get sick for diabet... Unfortunately, the drug is less effective during the renewal period for liver transplantation. Ale at the same hour, Daniy Lykarskiy would be recognized as being in that kind of fall, if a nirka transplant is going on, and if he is at the stage of being transplanted.

"Sirolimus"

Daniy lykarskiy zasib, also, like і in front of two, a fungal prodigy, but at the newest mechanism flowing into human organism. Win a team that deserves proliferation.

Judge from the children, as well as the children, the old ones will see that there is an hour of transplantation, so that there will be a chance to survive the transplantation any reason yogo vidtorgnennya.

The first period of an hour the patient will be overbuying before the saw control of the fakhivts, the stench will be constantly taken by the time in order to monitor the health of the patient, to take into account the different reactions on those robots for the organ that is necessary for the organ that is needed

Table extension 4

GLUCOCORTICOSTEROЇDI
Glucocorticosteroids store one of the main groups of immunosuppressants in cell humoral immunity z to finish with a gliboko vivcheny mechanizm of diy. Immunosuppressive effect of glucocorticosteroids not tying up with destruction and lysis of lymphocytes, as well as mice in case of vicious cytotoxic drugs. Better for all the wines of dressings due to the change in the migration of leukocytes and their functional health, as well as the development of clinical products, as well as the development of the development of mediators. Functional changes in lymphocytes, related to the intake of glucocorticosteroids, including reduction of differentiation and proliferation, reduction of the number of surface receptors, asphyxiation of products and
Glucocorticosteroids are injected into the rich phase of the immune system. The inductive phase can galvanize the blockages of the lymphocyte surfaces. The optimal immunosuppressive effect is to be observed when there is a short-term depression. Trivale zasosuvannya wiklikaє manifest bit by bit... All the similar groups of speech in the main give the same effect, different stages of development of the secondary action. Especially often prenizolone, trimtsinolone and dexamethasone are vicious.

immunosuppressive likarski zasobi(Immunodepression) - a range of drugs from different pharmacological and chemical groups, which induce immunological reactions to the body. Assign for the treatment of important autoimmune diseases and the inducing reaction of the transplant, as well as for weakening ignition processes unclear ethology... Deyaki immunodepressants are included in the arsenal of anti-alcoholic lykarskie.

Classification of immunosuppressive drugs:

1. Antimetabolites: mercaptopurine, azathioprine, methotrexate, brekvinar, mycophenolate mofetil, alopurinol and іn .;

2. Alkіluyuchi s'єdnannya: cyclophosphamide, chlorbutin and ін.

3. Antibiotics cyclosporin A, tacrolimus (FK 506), chloramphenicol, antiuchlinic (actinomycin: dactinomycin) and in;

4. Alkaloids: vincristine, vinblastin;

5. GCS: hydrocortisone, prednizolone, dexamethasone and in.;

6. Anti-lymphocytes: anti-lymphocytic globulin (ALG), anti-lymphocytic globulin (ATG), monoclonal antibodies (OCT-3, Simulect, Zenapax) and in;

7. Emerging oil refinery groups ( acetylsalicylic acid, Paracetamol, diclofenac sodium, naproxen, mefenaminov acid and in.), enzyme preparations(Asparaginase), derived 4-aminochinolin (delagil), heparin, aminocapronov acid, gold preparations, penicylamin and in.

mid modern methods imputation to immunity (recognition specific antigens anti-lymphocyte, anti-lymphocytic and anti-monocytic agents, x-ray analysis, visualization of lymphoid tissue) reversal are indicative of the signs of immunosuppressants as in monotherapy.

Pharmacodynamics. Dia of immunosuppressants on cells of immunocompetent systems is nonspecific. Infusion of їх conjugations on the fundamental mechanisms of the cell line and key stages and the biosynthesis of the library in small clientele, Including immunocompetent. Uninvolved on universal cytostatic powers, immunosuppressants are developed for direct action on the stage of immunogenesis, but it is important to ensure that when choosing a drug that is adequate to the specific skin situation (Fig. 15.1). Pharmacology of okremikh groups was introduced at the distributor. "Prototyphlinnі zasobi".

All types of immunosuppressants are active. M'yaku of immunosuppressive drugs at the refinery, heparin, gold preparations, penicylamine, chloroquin and deyaki іnshі, in conjunction with which they are often called "malimi" immunosuppressants. Pomirniy immunosuppressive effect appears in the middle dose of GCS. Try є cytostatics (drugs that can become stagnant), antimetabolism and alcohol recovery, antibiotics, antibiotics, and antibiotics.

Small. 15.1. Points of application of immunosuppressants

Shown. For the vibration of immunodepression, the foreign organization can serve as a classification, in which there are 3 main groups:

I group ob'єdnu z'єdnannya, as there are most bends of the immunosuppressive effect when introduced before antigenic stimulation, or at once with her. Possibly points into the flow of mechanisms for the development, processing of the AG and transmission of information. Prior to the whole group, there should be actions of alkylating systems, GKS and ін.

II group the drug has a healthy immunosuppressive effect when administered after 1-2 dibs of antigenic stimulation, which means that the galvanization of the proliferative phase of the immune response occurs in the whole hour. When they are introduced into the organism in the hypertension, or more or less through a period of writing, the immunosuppressive effect does not develop. The group includes antimetabolites, alkaloids, actinomycin and a large number of alkylating compounds.

III group to take revenge on spoluks, which are effective before, as well as for antigenic injection. The stench, as a rule, is a drop of points of application in the languages ​​of the immune system. Before the group, there should be, for example, Alg, ATG, cyclophosphamide, asparaginase.

Adopting classifications, preparations of the 1st group should be considered for organ transplantation, if it is necessary to achieve immunotolerance by means of promoting the development of the "transplant against the government" reaction. In case of autoimmune disabilities, if it is necessary to induce proliferative processes, in the case of trivial sensitization by antigen for the type of "lanceol reaction", the drugs of the II or IN groups are taken into account.

The range of drugs, as it is necessary to be victorious, and the dosage scheme is based on the specifics of the drugs. In table 15.3, there are indications of the aspects of the clinical stagnation of immunosuppressive disorders.

Table 15.3

Shown before the appointment of immunosuppressants

Practical demonstration of how immunodepression is easy to drive the first immune response, more importantly - the second. At the zyazyka z tsim immunodepression it is recommended to mark it on the very cob to get sick. There are a large number of secondary immune suppressors, which may be interrupted by injection into the effective mechanisms of immune responses, immediately after them, glucocorticosteroids and refineries are stagnant, which changed the intensity of intensive reactions.

It is necessary to realize that if the drugs are to be stagnant in chemotherapy for cancer, to become immune to immunosuppression, to develop certain categories of ailments, they are based on different principles. Growth in the nature and kinetics of proliferation of chubby and immune cells Allowing to prevent a greater vibration of toxic substances in the preparation of an undesirable immune clone in case of autoimmune diseases, but not in case of illicit swelling. For immunosuppressive cytostatics, vikoristovuyut in low doses. Also, during chemotherapy, cancer is often recognized in high doses, and in the renewal of immunity with "shock" courses.

Immunosuppressive drugs, a trace of memory, and a number of drugs (for example, azatioprine, mercaptopurine, dactinomycin, cyclophosphamide, etc.) with a dose, less drug, can stimulate the area of ​​immune response, such The effect of "pendulum") .That immunosuppressiveness must be prescribed with such a dose, as it will not prevent galvanizing immunity (proliferation). then go to an acceptable dose, 2-3 times lower.

It is unwise to inject into isolated groups of cells and to carry out selective immunotherapy, which is often the most effective therapeutic effect in combination with the formation of immunosuppressive disorders. Combined Likuvannya Allowing a decrease in the dosage dose of the drug in 2-4 times and of the opposite and not only to the reduction of the effect, but to the reduction of the tolerance of the drug.

Pobichna diya. Immunosuppressants are even more toxic. Also, since the storage of immunosuppressants during organ transplantation is necessary for life, the nutrition for the superiority of the recognition of these for the treatment of autoimmune diseases of the skin is once guilty of virginity. The importance of immunosuppressive agents is only one of those, if the potentials of the therapy are victorious, and the chances of success will change the risks of immunosuppression.

Decreased, wicked with immunosuppressive drugs, supervisingly insecure and guilty of being responsible for skin nutrition about the adequacy of the immunosuppressive therapy. Some of the effects can be recognized in early and early terms for the purpose of immunosuppressive therapy.

In early terms this kind of acceleration is often promoted.

1. Damage to the functions of the cystic brain. The process of accelerating the effects of low selectivity of immunosuppressants, which oppose all cells with high mitotic activity. The cystic brain is practically effective in all ailments with trivial therapy with high doses. Damage to hematopoiesis is especially often diagnosed when using methotrexate and alkylating spoluks. When the average doses of azathioprine and actinomycin are consumed, the stench is rarely observed.

2. Damage to the functions of the shlunkovo-intestinal tract. In case of stagnation of immunosuppressive drugs, it is often the case that nudota, bloating, and penetration are observed. In some ways, you can independently learn to navigate with a trivial love affair. In some cases, intestinal bleeding occurs, especially for methotrexate. For knowledge of any reduction in the number of side effects, it is recommended to administer the drug parenterally.

3. Disease before infection. Naybіlsha is not safe for the diagnosis of infections to be promoted when combining immunosuppressants with corticosteroids. Slide to mean that one can navigate on a whole background, it can be important to protect against fungi bacterial illnesses... When carrying out prophylactic chips, immunosuppressive therapy is considered.

4. Allergic reactions. Most often, the stench is detected with the introduction of immunosuppressants from the group of antibodies, and it is manifested in the eyes of children with disabilities, drug fever, eosinophilia.

Destruction, which manifests itself in different terms, is not enough for vivification. The last step of the development is from the manifestation of the illness itself, and from the cases of problems, from the emergence of the immunosuppressants:

1. Carcinogenic diyu. Cytostatic drugs can produce oncogenic effects, as they can produce a stench of DNA and at the same time - a genetic code. Immunological control over the induction and growth of chubby cells can be blocked at once. Malignant chickens (lymphosarcoma) in ailments, who suffer from immunosuppression due to a suppressed reaction to the transplant, appear 100 times more often, below the population.

2. Infusion on reproductive function and teratogenic effect. Immunosuppressive therapy can be successful in women and children. The price is accelerated from 10 to 70% of the range. The data on teratogenic drugs are not unambiguous. At the very least, it is recommended to have a unique experience for 6 months after the end of the course.

3. Immunosuppressive effects on growth in children.

4. Інші accelerated (fibrosis of the lungs, syndrome of hyperpigmentation, hemorrhagic cystitis, alopecia). When antimetabolites are consumed, the liver functions deteriorate. Alkaloids can cause neurotoxic effects.

Rational immunosuppressive therapy can be deprived of the brain for immunological control and post-mortem prevention of the drug.

Prototype shown. Oscillations of immunosuppressive disease are often susceptible to unpleasant prognosis, then the contraindication for carrying out immunosuppressive therapy is obvious. Especially take care of the next step in such situations: the manifestation of infection, lack of function of the cystic brain, decreased function of nirok (not safe for accumulation), vaginism, impaired function of the liver, niro, organ failure Slid goes and vivazhno to the sign of immunosuppressants in children and adolescents.

• Previously, the terms "immunodepression" and "immunodepression" were used.
• Lykarski zasobi, meaning in the whole rubric, do not conceal the independent clinical meaning, їkh mean in the complex immunosuppressive therapy in combination with the other immunosuppressive drugs, which can be grouped up to 1-5.