Cefuroxime, powder for preparation of rosters for ін'єкцій (vials). Cefuroxime is effective for the treatment of the secular system Cefuroxime

Cefuroxime is a drug that can be used to antibiotics-cephalosporins for 2 generations. Efficiency against high microbes and resistance to beta-lactamases allow vicoristovuvati at dear ones bacterial nature.

Form vipusk and warehouse

Tsey antibacterial drug is dispensed by pharmaceutical companies in the form of tablets, powder for further preparation of suspension and powder for injections.

In the case of parenteral administration, the active ingredient is cefuroxime sodium, and for internal administration, cefuroxime axetil is used.

Krim cefuroxime, before the warehouse of drugs should be included and additional speeches. Х viglyad and the number of deposits to form a vypusku і company-virobnik. For example, Cefuroxime Sandoz tablets are available in:

• cefuroxime axetil 250 or 500 mg;
• croscarmelosi sodium;
• castor oil;
• sodium lauryl sulfate;
• methyl cellulose;
• crospovidon;
• coated silicon dioxide.

Pharmacological efficiency

Cefuroxime exhibits a bactericidal effect, and therefore, a vicious bend of microbes in organisms. It will not take care of the impairment of transpeptidase synthesis and damage to the synthesis of bacterial cells. A drug against large gram-positive and gram-negative bacteria. Resistance to beta-lactamases has a wider spectrum of antibiotics, as a result of which it is effective against microbes, which do not suffer from amoxicillin and ampicilin.

Cefuroxime is ready to soak in the intestines. Its accessibility can be improved when the patient is implanted. The greatest amount of money in the blood will appear in 2-3 years or after being received in the middle.

Do you get stuck with some ailments?

Daniy antibiotic can be successful with success for the treatment of non-human ailments, provoked by a thin to new microflora. It is a good guide from the administration of Cefuroxime Sandoz, which is valid for:

• pneumonia;
• sinusitis;
• pharyngitis;
• bronchitis;
• otitis media;
• urethritis;
• cystitis;
• cervicitis;
• impetigo;
• polyonephritis;
• persistent gonorrhea;
• pioderma;
• furunculosis;
• Lyme ailments.

Efficiency with sinusitis

Cefuroxime should be applied to antibiotics, but by first line in case of sinusitis. Yogo zasosuvannya can be recognized in case of ineffectiveness of treatment antibacterial drugs penicillin series due to insensitivity of pathological microfloria.

Visoka efficacy Cefuroxime with sinusitis will not be provided with good penetration into the tissue and age of the body, sputum - in the mucus and sputum. If you need to get rid of bacterial sinusitis, you need to knock in all microorganisms, in order to take revenge in the slime and pus maxillary sinuses, Tilki so you can turn the sterility.

In which vipadas it is not possible to take antibiotics?

Cefuroxime is hardened to accept:

• in case of hypersensitivity to antibiotics, cephalosporins, or any component of the drug;
• if there is evidence in the anamnesis, show allergic reactions to antibacterials in the penicillin series through a possible development of perekhresnoy allergy.

Possible little ones

After an hour of treatment with Cefuroxime, one of the following are meant:

• quay Kvinke;
• bronchospasm;
• kropiv'yanka;
• nudota;
• visip;
• blues;
• diarrhea;
• beating in the stomach;
• candidiasis;
• head beel;
• chills;
• fungal infections;
• zamorochennya;
• pseudomembranous colitis;
• m'yazy bill;
• eosinophilia;
• fired ovens;
• feverish woman;
• bile at the breasts;
• sudomi;
• decrease in the clearance of creatine;
• in childish vipadkah - hearing loss in children.

special features

Cefuroxime Sandoz, whether it is the first drug of cefuroxime, can be prescribed only before the drug is consumed, if the bacterial nature of the disease is established. Lykarska dose pick up an okremo for a skin patient. At the same time, the appearance and the severity of the illness, the patient's appearance and the appearance of the concomitant pathologies.

Follow the recommended doses and triviality of the drug. Call the course to take the antibiotic Cefuroxime for 5-7 days. Navi as soon as polіpshennya has come, it is not possible to finish the course of lіkuvannya before an hour. It can lead to the turning of the ailments and the development of the bacteria to antibiotics.

For polishhennya mastery of lykarskogo as a result of yogo come to the right message.

In case of severe interruption of the ailment, it is more possible to consume Cefuroxime parenterally. When completing clinical indications, carry out an act of substitution of an oral administration.

For children younger than 5 years, a suspension of cefuroxime is used.

In vipads, if one of the doses of the drug Bula is missed, it is necessary to take a step. With tsom the implantation of the subdose is hardened.

In case of damage to the function of nirok, it is necessary to correct the dose.

Stagnation with vaginosti

Cefuroxime can penetrate through the hematoencephalic bar, so it is not recommended to use it for the duration of the vagina.

It may be allowed to take the drug Cefuroxime for vaginosis, if it is on the mind of a drug addict for a mother from a child, but not on a child for an unnatural child.

If necessary, take a drink before the hour of lactation, and then interrupt it for the period of the cycle, as the antibiotic is seen in breast milk.

Stagnation in pediatrics

Suspension Cefuroxime is indicated for children from 3 months to 5 years. For lіkuvannya bіlsh older children in the form of pills.

Overdose

• spoiled,
• nudota,
• blues,
• belly beat
• sudomi.

In such cases, it is necessary to secretly pursue medical assistance.

lykarska vzaєmodiya

With an one-hour reception lykarsky zasobiv Mozhlivy development of unreasonable interconnection. With tsom the drug can change lіkuvalnі efekti and this is a bit on the sidelines.

Vzaєmodii Cefuroxime:

• increased potential for the development of bleeding when receiving from the refinery;
• decrease in the number of oral contraceptives;
• with a one-hour reception with erithromycin, the antibacterial effect of both drugs decreases;
• added toxic injection of aminoglycoside antibiotics;
• implantation with antacid zasob pogirshuє vmoktuvannya antibiotic;
• the reception of diuretics for an increase in the number of problems;
• implantation with probenecid and phenylbutazone can be produced to replace lykarsky in blood.

analogs

Cefuroxime is released under different trade names:

• Cefuroxime Sandoz,
• Zinacef,
• Cefurabol,
• Aksetin,
• super,
• ketocef,
• Cefurus,
• Cefurozin,
• Axosef.

All analogs show the same bactericidal effect of one dialectical speech.

International naming

group affiliation

Lykarska form

Pharmacological diya

II generation cephalosporin antibiotic for oral and parenteral administration. Dіє bactericidal (interrupting the synthesis of bacterial cells). Volodya with a wide range of antimicrobial activities.

There is a high activity of generally gram-positive microorganisms, including strains, streptocides to penicilin (for some reason, strains resistant to methicilin), Staphylococcus aureus, Streptococcus pyogenes (tympanitis agroup. mitis (group viridans), more Clostridium spp.);

gram-negative microorganisms (Escherichia coli, Klebsiella spp., Proteus mirabilis, Providencia spp., Proteus rettgeri, Haemophilus influenzae, including ampicilin resistant strains; Haemophilus parainfluenzae, including ampicilin-resistant strains; Moraxella catarrhalis, Neisseria gonorrhoeae, including strains that produce and do not produce penicylinase, Neisseria meningitidis, Salmonella spp., Borrelia burgdorfer, Bordetella pertussis;

gram-positive (Peptococcus spp., Peptostreptococcus spp., Propionibacterium spp.) and gram-negative anaerobes (Fusobacterium spp.).

To cefuroxime insensitive: Clostridium difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus, Listeria monocytogenes, stiki to methicilin with Staphylococcus aureus strains, Staphylococcus epidermidis. , Citrobacter spp., Serratia spp., Bacteroides fragilis.

showing

Prototype

Pobichna diya

Allergic reactions: chills, dizziness, itching, crotchiness, rarely - multiforme erythema (including Stevens-Johnson syndrome), bronchospasm, anaphylactic shock.

Miscellaneous reactions: teasing, infiltration and bleeding, phlebitis.

Three sides sectional system: Sverbіzh in the middle, vagіnіt.

On the side of the central nervous system: sudomi.

On the side of the sechid system: impaired function nirok, dysuria.

On the side of the herbal system: diarrhea, nudity, blues, cramps and pain in the stomach, swelling of the mucous membrane of the empty mouth, candidiasis of the empty mouth, rarely - pseudomembranous colitis.

On the side of the organs there is a sense of hearing loss.

On the side of the blood-forming organs: hemolytic anemia.

Laboratory indicators: adjustment of the activity of "pechink" enzymes, LF, LDH, hyperbilirubinemia.

Prolongation and supplementation

V / m, v / v abo in the middle. Intravenous and intramuscularly we will grow up to receive 750 mg 3 times per dose; in case of severe interruptions - the dose is increased up to 1500 mg 3-4 times per dose (if necessary, the interval between introduced speeds can be up to 6 years). Middle dobova dose- 3-6 m

Children should be given 30-100 mg / kg / dob in 3-4 doses. In case of large infections, the optimal dose is 60 mg / kg / day. Newborns and children up to 3 m / s should take 30 mg / kg / dob at 2-3 times.

In case of gonorrhea - in / m, 1500 mg one-time (or in viglyadi 2 іn'єktsіy 750 mg each with injections in іnі regions, for example, in offense sіdnichnі mujaazi).

In case of bacterial meningitis - IV, 3 g of skin for 8 years; for young and old children - 150-250 mg / kg / dobu in 3-4 priyomy, for neonargenim - 100 mg / kg / day.

During operations on the black empty, pelvic organs and during orthopedic operations - intravenous, 1500 mg with induction of anesthesia, sometimes pre-treatment - intramuscularly, 750 mg, after 8 or 16 years after the operation.

For operations on hearts, legends, stravohods and vessels - intravenous, 1500 mg with induction of anesthesia, sometimes - intramuscularly, 750 mg each 3 times for 24-48 years.

In case of pneumonia - intramuscularly, or intravenously, 1500 mg 2-3 times for a duration of 48-72 years, then switch to a reception in the middle, 500 mg 2 times for a duration of 7-10 days.

when sharpened chronic bronchitis Priznachayut i / m abo i / v, 750 mg 2-3 times for dob, stretching 48-72 years, then go to the middle, 500 mg 2 times for dob, stretching for 5-10 days.

In case of chronic nircovian deficiency, correction is necessary for the dosage regimen: with CC 10-20 ml / hv, intravenous or intramuscularly 750 mg 2 times per dose, with CC less than 10 ml / hv - 750 mg 1 time per add.

Patients who are on uninterrupted hemodialysis from arteriovenous shunt for hemophilia of high fluidity in intensive therapy, assign 750 mg 2 times to dobu; for patients who are on hemofiltration of low fluidity, it is a dose, which is recommended in case of impaired function of nirok.

special requests

Patients who have a history of allergic reactions to penicilinia may have hypersensitivity to cephalosporin antibiotics. In the process of treatment, it is necessary to control the function of nirok, especially in those with ailments, who need a high dose of the drug. Likuvannya continue for 48-72 years for symptoms, in the case of infections, with Streptococcus pyogenes, the course of treatment is not less than 7-10 days.

Every hour of testing, there is a hypothesized direct reaction of Coombs and a hypopositive response to glucose.

Ready before implantation of the rosters can be taken at room temperature for 7 years, in the refrigerator - for 48 years. It is allowed to collect the amount of money for an hour.

In patients who take cefuroxime, if the concentration of glucose in the blood is determined, it is recommended to test with glucose oxidase or hexokinase.

During the transition from parenteral administration to the reception in the middle, the severity of the infection, the sensitivity of microorganisms and the patient's foreign country. Even after 72 years, after receiving cefuroxime in the middle it is not meant to be polyphenated, it is necessary to continue the parenteral administration.

vzaєmodiya

One-hour oral administration of "loop" diuretics for tubular secretion, lowering nirkovy clence, increasing the concentration in plasma and increasing T1 / 2 cefuroxime.

With a one-hour consumption of aminoglycosides and diuretics, a risk of nephrotoxic effects is observed.

LZ, to lower acidity shlunk juice, To change the moisture content of cefuroxime and its bioavailability.

Pharmaceutical sum_sny z water issues, Replace up to 1% lidocaine hydrochloride, 0.9% sodium chloride, 5 and 10% glucose, 0.18% NaCl and 4% glucose, 5% glucose and 0.9% NaCl, Ringer's, Hartman's, sodium lactate, heparin (10 OD / ml і 50 OD / ml) in 0.9% NaCl solution.

Pharmaceutically insane with aminoglycosides, sodium hydroxide solution 2.74%.

Vidgukiv about liki Cefuroxime: 0

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Vials of flasks.

Powder for preparing the size for ін'єкцій white or even white, trocha hygroscopic.

Vials of flasks.

to describe lykarsky drug CEFUROXIM It was based on the officially solidified instructions for the preparation of the drug and was completed in 2011. Renovation date: ..0 r

Pharmacological diya

Cephalosporinum antibiotic II generation for parenteral administration. It is bactericidal, disrupting the synthesis of microorganisms. Volodya with a wide range of activities. Strong up to large β-lactamases. The bactericidal effect of cefuroxime is associated with the suppression of the synthesis of the cell line of bacteria as a result of the connection with the main target targets.

Highly active shodo Staphylococcus aureus, including strains, stike up to penicillin (with the blame of rare strains, resistant to methicilin), Staphylococcus epidermidis, Haemophilus influenzae, Klebsiella spp., Streptococcus spp., Enterobacter spp., Enterobacter spp. , Proteus mirabilis, Salmonella spp. (Including Salmonella typhi, Salmonella typhimurium), Shigella spp., Neisseria spp. (Includes strains of Neisseria gonorrhoeae to produce β-lactamase), Bordetella pertusis.

a drug also active side by side strains Proteus vulgaris, Proteus morganii.

Most strains of Bacteroides fragilis not sensitive before the drug.

Chi is not active apparently Pseudomonas spp., Campilobacter spp., Large Serratia spp. Strains, Clostridium difficile.

Pharmacokinetics

soaktuvannya

Pislya i / m injected in a dose of 750 mg C max is reached after 45-60 minutes and becomes close to 27 μg / ml. When administered intravenously in doses of 750 mg and 1.5 g after 15 minutes, the concentration in plasma becomes 50 μg / ml and 100 μg / ml, apparently, the therapeutic concentration is taken for a period of 5 years and 8 years for certain.

rospodil

The connection with plasma bites - 33-50%.

Therapeutic concentration is offered in cistes, shkiri, soft fabrics, Synovial, pleural, internal genus, gum, phlegm and myocardium. Concentration of cefuroxime, which translates the IPC for a large number of microorganisms, can be reached in knitted fabric, Synovial and internal synonyms.

Cefuroxime penetrates through the hematoencephalic bar, placental bar, and is seen in breast milk.

Metabolism and viveness

Cefuroxime is not metabolized.

T 1/2 cefuroxime for parenteral administration is approximately 70 min. In new-born children, the period for which cefuroxime is given can be 3-5 times more trivial than in older children.

Become a member of the glomerular filtration and tubular secretion. For 24 years after parenteral administration of cefuroxime, it may increase (85-90%) from a section in an unconfined viglyad, and moreover, a large part of the preparation takes 6 years. Cefuroxime syrovatkov іvnі decrease with dіalіzі.

Shown to sucking

Likuvannya ailments, viclikanikh sensitive to cefuroxime bacteria:

• pneumonia, bronchitis, inflammation of bronchiectasis, abscess of lesions, pislyaoperative Infectious diseases organs of the breast;
• otitis media, sinusitis, angina, pharyngitis;
• meningit;
• polyonephritis, cystitis, asymptomatic bacteriuria;
• gonorrhea;
• furunculosis, erysipelas, early infections;
• osteomyelitis, septic arthritis;
• Infections of the pelvic organs;
• septicemia;
• prevention of infectious diseases during operations.

dosage regimen

The drug is administered intramuscularly or intravenously.

grow up priznachayut 750-1500 mg 3 times / dobu. If necessary, the interval between the speed can be up to 6 years. Dobova dose to the drug - 3-6 m

children the drug is priznachayut in doses of 30-100 mg / kg / day in 3-4 injections. For larger infections, the optimal dose is 60 mg / kg. novonarogenim priznachayut at 30-100 mg / kg / day in 2-3 injections.

at gonorrhea the drug is prescribed in a dose of 1500 mg once a day in viglyadi 1 іn'єktsії or in viglyadі 2 ін'єкцій 750 mg each.

at meningіtі grow up priznachayut i / v for 3 g skin 8 years. For babies and for older children priznachayut i / v in doses of 200-400 mg / kg / day in 3-4 injections. When the optimal therapeutic effect is reached, the dose of the drug can be changed to 100 mg / kg / dose (i / v). novonarogenim prescribe the drug at a cob dose of 100 mg / kg / dob (i / v). When the optimal therapeutic effect is reached, the dose can be changed to 50 mg / kg / dose (i / v).

for preventive measures against operational infections the drug should be administered intravenously at a dose of 1500 mg once an hour with the introduction of anesthesia. If necessary, additional administration of the drug intramuscularly at a dose of 750 mg after 8 years and 16 hours is possible.

We are sick with damaged functions of nirok at CC 10-20 ml / min recommend to inject the drug at a dose of 750 mg 2 times / dobu; at CC less than 10 ml / hv- 750 mg 1 time / day.

We are sick, because they are overworked on the day, in the skin procedure, inject more than 750 mg. at post-peritoneal dialis the drug is priznachayut 750 mg 2 times / dob.

Rules for preparing the drug

For intramuscular injection of up to 750 mg, add 3 ml of water to the drug for injection and gently scrub until the opaque suspension is removed.

For intravenous strumin, 750 mg of the drug should be used in at least 9 ml of water for injections. Yak razchinnik can be vicoristovuvati also izotonic razchin sodium chloride or 5% razchin glucose. Introduce 3-5 min.

Pobichna diya

Allergic reactions: exudative bagatoform eritema, (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), shkirny visip, (including urticaria), itchy skin, Kropiv'yanka, lykarska fever, bronchospasm, syrovatkova ailment, anaphylactic shock.

On the side of the herbal system: nudity, bloating, diarrhea, spasms and blood thinning, pseudomembranous colitis, empty mouth candidiasis, altered activity of liver transaminases (ALT, AST, LDH, LF), hypoperbilis, testis.

On the side of the central nervous system: drowsiness, judgment, impaired hearing.

On the side of the hematopoietic system: eosinophilia, leukopenia, neutropenia, thrombocytopenia, agranulocytosis, hemolytic anemia, impaired laryngeal blood.

On the side of the secular system: deterioration of the function of nirok due to the increase in the level of creatine and / or nitrogen of the sechovine.

On the side of the status system: sverbіzh in the interim, vision, vaginitis (with the development of candidiasis).

Miscellaneous reactions: bіl, razdratuvannya і infiltrate at mіsci introduction with i / m injected, phlebitis, thrombophlebitis - with i / v injected.

special requests

Patients with anaphylactic reaction to penicillin and beta-lactam antibiotics in anamnesis should be especially careful when the drug is prescribed.

It is safe to use the drug for new-born children, premature babies, patients with severely impaired functions of nirok, with low blood pressure.

Pislya usunennya symptoms of ill health lіkuvannya continued to last 48-72 years.

In case of elimination of changes in children, there was a decrease in hearing of mild and middle degree of severity, while in the cerebrospinal line, a positive culture of Haemophilus influenzae began after 18-36 years of therapy. Some of the manifestations were also indicated when some antibiotics were consumed, but they are not clinically significant.

Pseudomembranous colitis is susceptible to occur with vicoristan wide range antibiotics, the possibility of this diagnosis is necessary for mothers on the respect of children with a hard time, for an hour or so, for taking the course of treatment with antibiotics.

One-hour reception with "loop" diuretics (furosemid) improves tubular secretion, decreases nirkovy clence, increases the concentration in plasma and extracts T 1/2 cefuroxime, which induces erythrocytes.

Probenecid decreases tubular secretion, decreases nirkovy clerance.

Pharmaceutically insane with the range of aminoglycosides (it is not possible to change in one syringe).

Є contraindication. Consult a doctor before harvesting.

Name your merchandise outside the cordon (outside the cordon) - Altacef-OD, Alurix, Brelmocef, Cefabiot, Cefasyn, Ceftin, Ceftum, Cefudura, Cefuhexal, Cefurim Eco, Ceroxim, Elobact, Furion, Magnaspor, Micrefivx, Microbot, Micro Supacef, Vinecef, Xorimax, Zinadol, Zoref, Zyroxime.

Antibacterials are not antibiotics.

It is possible to send food or fill in the message about the leaks (be a weasel, do not forget to mention the name of the drug in the text of the occasion).

Preparations for revealing Cefuroxime (Cefuroxime, ATC code (ATC) J01DC02):

Zinnat (original Cefuroxime axetil for reception in the middle) - official instructions for storing. Prescription drug, the information is designated only for the health protection fahivts!

Clinical-pharmacological group:

Cephalosporin II generation.

Pharmacological diya

Cefuroxime axetil is an alternative to cefuroxime, which is used to cephalosporin antibiotics of the second generation. Cefuroxime is active in a relatively wide range of plants, including strains that produce β-lactamases. Cefuroxime is potent up to the number of bacterial β-lactamases, thus it is effective for ampicilin-resistant and amoxicilin-resistant strains.

The bactericidal effect of cefuroxime is associated with the suppression of the synthesis of the cell line of bacteria as a result of the connection with the main target targets.

In vitro, cefuroxime is active against such microorganisms: gram-negative aerobias (Haemophilus influenzae / including ampicilin-resistant strains /, Haemophilus parainfluenzae, Moraxella catarrhalis products, Neisseria gonorrhea proteins) , Providencia spp., Providencia rettgeri; gram-positive aerobias (Staphylococcus aureus / include strains, which produce penicylinase, ale, which include methicilin-resistant strains /, Staphylococcus epidermidis / include alimentary strains, інші beta-hemolytic streptococcus, Streptococcus pneumoniae, Streptococcus group B / Streptococcus agalactiae /; anaerobic (gram-positive and gram-negative coca / including Peptococcus spp. and Peptostreptococcus spp. /, gra mnegative sticks / including Bacteroides spp. і Fusobacterium spp./, gram-negative spirochetes / Borrelia burgdorferi /).

The onset microorganisms are not sensitive to cefuroxime: Clostridium difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus, Listeria monocytogenes, methicilin-resistant Staphylococcus spp. , Citrobacter spp., Serratia spp., Bacteroides fragilis.

Pharmacokinetics

soaktuvannya

When taken in the middle, cefuroxime axetil gets wet from the intestinal tract and rapidly hydrates in the mucous membrane of the intestine and blood from the vivial cefuroxime. It is optimal for cefuroxime axetil to get wet with the drug taken immediately.

When taking cefuroxime Cmax tablets (2.9 mg / l for a dose of 125 mg and 4.4 mg / l for a dose of 250 mg), the intake of tablets is delayed approximately in 2.4 hours when the drug is taken.

When taken with a suspension of Cmax of cefuroxime (2-3 mg / l for a dose of 125 mg and 4-6 mg / l for a dose of 250 mg), it starts to develop in about 2-3 years after taking the drug.

rospodil

The linkage of cefuroxime with blood plasmas becomes 33-50%.

Cefuroxime penetrates the hematoencephalic bar, crosses the placenta and is seen in breast milk.

metabolism

Cefuroxime is not metabolized into organisms.

vivedennya

Seeing the way of glomerular filtration and tubular secretion. Cefuroxime syrovatkov іvnі decrease with dіalіzі.

T1 / 2 warehouse 1-1.5 h.

Shown before zasosuvannya drug ZINNAT®

Likuvannya infectious-igniting ailments, viclikanikh sensitive to the drug microorganisms:

• іnfections of the upper dichny paths, ENT organs (sinusitis, tonsillitis, pharyngitis, otitis media);
• іnfektsії of lower dichally nobles (hospitality bacterial bronchitis і aggravated chronic bronchitis, pneumonia);
• іnfektsії sečovivіdnyh shlakhіv (polyonephritis, cystitis, urethritis);
• іnfektsії shkіri and m'yakіkh tissues (furunculosis, pioderma, impetigo);
• gonorrhea, gonorrhea urethritis and cervicitis;
• lykuvannya Lyme ailments on early stage and prophylaxis new stages of this ailment among older adults and children over 12 years old.

Cefuroxime is also allowed to be taken by the viglyad. sodium salt(Preparation Zinacef®) for parenteral administration. Within the framework of the frequent therapy, it is recommended to switch from the parenteral form to the oral form of cefuroxime.

Stage therapy is indicated in the treatment of pneumonia and acute chronic bronchitis.

dosage regimen

The standard course of therapy is 7 days (may vary from 5 to 10 days). For optimal absorption, the preparation should be taken into account.

older:

Children from 3 rocks:

Otitis media for the most important infections - 250 mg (1 tablet of 250 mg or 2 tablets of 125 mg) 2 times for extra. The maximum dobov dose is 500 mg.

stage of therapy

Cefuroxime is also used for parenteral administration in sodium salts (Zinacef® drug), which allows the use of the same antibiotic, if there is a need to switch from parenteral to oral therapy. The drug Zinnat® is effective for parenteral administration to the drug Zinatsef® for the treatment of pneumonia and aggravation of chronic bronchitis.

The triviality of parenteral and oral courses of treatment begins with a degree of severity of infection and a clinical picture.

Pneumonia. The drug Zinatsef® (cefuroxime in viglyadi sodium salt) in a dose of 1.5 g 2-3 (i / v or i / m) lasting 48-72 years, sometimes - the drug Zinnat® (cefuroxime axetil) in a dose of 500 mg 2 times for doba stretching 7-10 days.

Sharpening of chronic bronchitis. The drug Zinacef® (cefuroxime in viglyadi sodium salt) at a dose of 750 mg 2-3 times per dose (i / v or i / m) lasting 48-72 years, at the same time - a course of treatment with the drug Zinnat® (cefuroxime axetil) orally at a dose of 500 mg 2 times for doba for 5-10 days.

Pobichna diya

Non-desirable occurrences, presented lower, are re-covered in the presence of anatomical and physiological classifications and the frequency of nationality. The frequency of the population begins with an offensive rank: even more often (> 1/10), often (> 1/100 and<1/10), нечасто(>1/1 000 i<1/100), редко (>1/10 000 i<1/1 000), очень редко (<1/10 000, включая отдельные случаи). Категории частоты были сформированы на основании клинических исследований препарата и пострегистрационного наблюдения.

Infections: often - superinfection with fungi of the genus Candida.

On the side of the hematopoietic and lymphatic system: often - eosinophilia; infrequently - chemopositive Coombs 'reaction (cephalosporin is absorbed on the surface of the cell membrane of erythrocytes, which are associated with antibodies to cephalosporins, so that the result of the Coombs' test is hibopositive before even worse - hemolytic anemia.

On the side of the nervous system: often - headache, zapamorochennya.

On the side of the herbal system: often - diarrhea, nudota, abdominal pain; infrequently - blues; Ridko - pseudomembranous colitis.

On the side of the stove and zhovchivіdnyh shlakhіv: often - at the time of the adjustment of the enzyme in the stove ALT, ACT, LDH; even more rarely - zhovtyanitsya (overwhelmingly cholestatic), hepatitis.

On the side of the pediatric adipose tissue: even more rarely - multiforme erythema, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Allergic reactions: infrequently - visibility on the screen; rіdko - kropiv'yanka, sverbіzh; even worse - lykarska fever, syrovatkova ailment and anaphylaxis.

Prototype indication prior to consumption for ZINNAT®

• phenylketonuria (for suspension for receiving vseredin);
• for tablets - a childish vіk up to 3 months (for children from 3 months to 3 months, the preparation Zinnat® slid zastosovuvati in suspension form);
• sensitivity to antibiotics of the group of cephalosporins is increased.

Slid after being aware of the care given to the patients with damaged functions; discomfort in the intestinal tract (including in the anamnesis, as well as in cases of inferior colitis); Vagitnym women, in the period of lactation.

Prolongation of the drug ZINNAT® with vaginosis and years of breastfeeding

The drug Zinnat® slid vikoristovuvati in the same way, as there is a potential for cinnamon for a mother, I change a potent risik for a child.

Experimental evidence of diabetic and teratogenic effects in cefuroxime axetil is nematic, but also in the case of stagnation of some drugs, the need to be careful when it is detected at an early period of time.

It is necessary to take care of it for mothers who are diagnosed with it, because the drug appears in breast milk.

Zasosuvannya in children

Children from 3 rocks:

Most infections - 125 mg 2 times per additional dose. The maximum dobov dose is 250 mg.

Otitis media for more important infections - 250 mg 2 times per day. The maximum dobov dose is 500 mg.

The preparation Zinnat® in the form of a suspension is for use in all the recommendations for consumption in children from 3 months. I am not aware of the use of Zinnat® in children who are younger than 3 months old.

If the value of the fixed dose is important, then in case of a large amount of infection, it is recommended to take 125 mg 2 times per dose. Children in the age of 2 years and older in patients with middle otitis media, or in case of more severe infections, should be given 250 mg 2 times per dose; the maximum dose is 500 mg.

When children are not sick and children are sick, it is necessary to take a dose in the fallowing area in the form of oil and water. With a large infectious dose for numb and for children from 3 months to 12 months to become 10 mg / kg 2 times for dobu, or not more than 250 mg for dobu. In case of middle otitis and more important infections, a dose of 15 mg / kg is recommended, 2 times per dob, or not more than 500 mg per dobu.

At the onset tables, the dosage is set in the fallowness as a form of and masi tila ditini for the dosage of Zinnat® 125 mg / 5 ml suspension with 5 ml spoonfuls, which is added to the package.

A dose of 10 mg / kg of fat, which is indicated in case of large infections:

A dose of 15 mg / kg body weight per dose, which is indicated in cases of otitis media and more important infections:

Prototype indications:

• childish vіk up to 3 mіs (for suspension for reception in the middle);
• for tablets - childish up to 3 months (for children from 3 months to 3 months, the drug Zinnat® slid stastosovuvati in suspension form).

special requests

Precautions should be taken when the drug is prescribed to patients with an allergic reaction to beta-lactam antibiotics in anamnesis.

In the process of treatment, it is necessary to control the function of nirok, especially in patients, who dispense the drug at high doses.

During the period of taking the drug Zinnat®, a hypopositive reaction to glucose is possible.

In case of vicious antibiotics, the trivial implantation of Zinnat® can lead to an overgrowth of fungi in the genus Candida. Trivially, it is possible to reduce the growth of the least resistant microorganisms (Enterococcus and Clostridium difficile), but also to reduce the growth of the disease.

Pseudomembranous colitis is susceptible to pseudomembranous colitis in patients with vicious antibiotics in a wide range of children, so it is necessary to carry out a differential diagnosis of pseudomembranous colitis in patients with severe disease, as soon as they are antibiotics for an hour or so.

The reaction of Yarish-Herxheimer was diagnosed in case of boreliasis (Lyme ailment) when taking the drug Zinnat® and the bactericidal activity of the drug was explained by the cause of the disease of the spirochete Borrelia burgdorferi. Patients who are guilty are informed about the symptoms є a typical inheritance of antibiotics in case of ailments.

Even though a key effect cannot be reached for 72 years from the ear of the drug, the parenteral course of therapy is guilty of being continued.

Before the cob of step therapy, ask for information in the obvious presenters of cefuroxime sodium salt (Zinacef® drug).

Zinnat® tablets cannot be used for lamati and krishiti. This is given a likarska form not to be stagnant for the treatment of patients with difficult coaching, incl. small children who cannot get the whole pill.

Slide vrahovuvati instead of sucrose in the Zinnat® suspension for patients with diabetic diabetes.

5 ml of the prepared Zinnat® suspension should be dispensed with 0.25 chlorine units (HO).

Inflow to the building of keruvati by transport means and mechanisms

Oscillations of cefuroxime aksetil can be wiped out, it is necessary to get ahead of the patients about getting in when driving a vehicle, or robots with mechanisms, which will collapse.

Overdose

Symptoms: an overdose of cephalosporins can lead to increased malnutrition of the brain with a developmental trial.

Likuvannya: carry out symptomatic therapy. Cefuroxime concentration decreases in hemodialysis and peritoneal dialysis.

lykarska vzaєmodiya

Preparations that change the acidity of the slunk juice may reduce the bioavailability of cefuroxime in case of impairment and prevent the intake of the drug from being taken, as well as to reduce the effect of the intake of the preparation.

Yak and іnshі antibiotics, the drug Zinnat® can be infused into the intestinal microflora, which can be used to reduce the reabsorption of estrogens, as inheritances, to reduce the effectiveness of oral hormonal combined contraceptives.

When carrying out a ferrocyanide test, it is possible to promote negative results, so for the purpose of determining the level of glucose in the blood and / or plasma, it is recommended to use glucose oxidase or hexokinase methods.

The drug Zinnat® is not infused into the amount of creatinine by the method.

One-hour reception with "loop" diuretics increases tubular secretion, decreases nircovy clearing, increases the concentration in plasma and increases the period of time for cefuroxime.

One-hour introduction of cefuroxime and probenecid to increase the AUC by 50%.

With a one-hour reception with aminoglycosides and diuretics, the risk of nephrotoxic effects is increased.

Mind that term zberigannya

The drug is available for a prescription.

Mind that term zberigannya

Tablets should be taken at a temperature of 30 ° C. Term of adherence - 3 rocks.

Granules for preparing a suspension of slides at a temperature of 30 ° C. Term of accessibility - 2 rocks.

I will prepare a suspension of the ice in the refrigerator at a temperature of 2-8 ° C for no more than 10 days.

Zberigati out of reach for children.

Instructions to be quoted behind the materials of the pharmaceutical website