Sodium benzoate pharmacopoeia. sodium benzoate

Adequate not less than 38.0% and not more than 42.0% to coffee and not less than 58.0% and not more than 62.0% sodium benzoate in a dry place.

Description Bilium crystalline powder. Hygroscopic.

Distinction. Easily razchinniy in water, razchinniy at kryzhan_y otstovaya acid, approximately razchinniy at alcohol 95%.

Fairness. 1. IR spectrum. Infrared spectrum of the surplus of the substance cut off from the viprobuvanny “Kilkisne viznachennya. Coffee ”, in the disc with calories with bromide, in the area from 4000 to 400 cm -1 for the material setting of smogs, the consumption is guilty of changing the range of standard coffee drinks.

2. Yakisna reaction. Pour 0.5 g of the substance in 3 ml of water, add 1 ml of 10% sodium hydroxide solution, 10 ml of chloroform, and add 1-2 quilins with a stretch. Chloroform solution is filtered through a filter with anhydrous sodium sulfate and vaporized chloroform in a water bath. The surplus gives a reaction of authenticity, as indicated in the statute "Coffee anhydrous", and when hanging at 80 ° to a steady mass, the melting temperature is 234 - 237 °.

3. Yakisna reaction. Substance ratio 1: 100 is a characteristic reaction to benzoate.

4. Yakisna reaction. The substance is a characteristic reaction of B to sodium.

* The transparency of the gap. The amount of 0.5 g of substance in 10 ml of water is guilty but we can see through and is not guilty of getting cloudy or seeing a siege when heated in a close test in a boiling water bath with a stretch of 30 quil. (OFS "Transparency of those steps of kalamutnosti ridin").

* Coloring the difference. Rozchin, otrimaniya from viprobuvannі "The openness of the roschinu", is guilty of being barnless (OFS "Stupin 'barvlennya rіdin", method 2).

Acidity or moisture. 0.25 g of the drug is dispensed in 5 ml of freshly boiled and cold water and add 0.1 ml of 1% phenolphthalein. Rozchin is not guilty of getting bruised in rhyme colir. Rozheva is guilty of being added not more than 0.15 ml of 0.05 M sodium hydroxide.

Waste in weight when hanging. Not more than 5.0% (General Pharmacopoeia Monograph “Vtrata in mass when hanging”, method 1). Closely 0.5 g (exact filling) of the substance hangs at a temperature of 80 ± 2 ºС.

Easily carbonized speech. 0.3 g of the substance is distilled in 3 ml of concentrated hydrochloric acid. Zabarvlennya razchinu is not guilty of being more intensive than etalon B 5 (OFS "Stupin zabarvlennya ridin", method 2). For the substance designated for the virob drugs for parenteral zasosuvannya, tsey rozchin is guilty of butti bezbarvnim.

Sulfati. Not more than 0.02% (OFS "Sulfati", method 1). 0.5 g of the substance is taken from 5 ml of water, add 5 ml of 95% alcohol.

Chloridi. Not more than 0.02% (OFS "Chloridi"). 0.1 g of the substance is calculated in 5 ml of water, add 5 ml of 95% alcohol.

They threw a lot. Not more than 0.001% (OFS "Vazhki Metali"). 1.0 g of the preparation is divided into 10 ml of water.

Zalishkovy organic retailers. Subject to the OFS "Zalishkovy Organizhni Razchinniki".

* Pyrogenicity. Substance is apyrogenic (OFS "Pyrogenism"). Test dose: 10 mg of the substance in 1 ml of 0.9% solution of sodium chloride per 1 kg of rabbit weight.

microbiological purity... According to the General Pharmacopoeia Monograph "Microbiological purity".

Kіlkіsne viznachennya. 1. Sodium benzoate. Closely 0.3 g (exact filling) of the substance, suspended from the front to the end of the mass, dissolve in 2 ml of chloroform, add 40 ml of alkaline anhydride and titrate with 0.1 M solution of perchloric acid in methanol to the first point of the equivalence Potentiometric titration ").

Conduct a control plate in parallel.

1 ml 0.1 M solution of perchloric acid in methanol form 14.41 mg sodium benzoate Z 8 H 10 N 4 O 2.

2. Coffee. Continue the titration from the first one to another point of equivalence, as it starts potentiometrically (OFS "Potentiometric titration").

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Kilkisny chemistry analysis of speech. sodium benzoate

viconave:

student group 5201 KDMU

Mamedova S.N.

Revision: A.V. Bukhovets

Kazan, 2014

zm_st

• I... Analysis of the drug "Sodium benzoate"
• II... Kilkisny analysis of the drug "Sodium benzoate" by the method of direct acidimetry with a diameter of 0.05 n. hydrochloric acid
• III... Protocol of titrimetric analysis of sodium benzoate preparation by the method of direct acidimetry with a 0.05 n. hydrochloric acid in the presence of ether
• Vikoristan Literature

I. Analysis of the drug "Sodium benzoate"

1. rosіyskenamelykarskykoshty.

sodium benzoate

Sodium benzoic acid

natrієva sil benzoic acid

sodium benzoate

2. latinnamelykarskykoshty.

Natrii benzoas

Natrium benzoicum

3. Khimichnaformulasmeaningmolarmasi

C 6 H 5 COONa

molarmasa 144,11

4. callview

Bilium crystalline powder, odorless or even with a faint smell, liquorice-salty relish.

5. physicalіхімічніpower

proficiency: 1.44 g / cm 3

discrepancy.

Easy to use in water, important in alcohol.

insightіcolordifference.

The dosage of 1 g of the preparation in 10 ml of freshly boiled and cold water is guilty, but it is clear and barless.

puddleіacidity.

Phenolphthalein is used to add a decal drop to the cut-off size; the guilt is guilty. Rozheva is guilty of not being more than 0.75 ml 0.05 N. the range of liquid soda.

zm_stchloride.

0.15 g of the preparation is razchinyayut in 14 ml of water, add 1 ml of diluted nitric acid and filter. 10 ml of filtrate is guilty of vitrimuvati and viprovannya on chloride (not more than 0.02% in the preparation).

zm_stsulfate.

1.5 g of the preparation is razchinyayut in 25 ml of water, add 5 ml of diluted hydrochloric acid and filter. 10 ml of the amount of vitrimuvati and viprovannya on sulfate (not more than 0.02% in the preparation).

zm_stimportantmetal.

10 ml of the same filtrate is guilty of vitrimuvati important metal(Not more than 0.001% in the preparation).

wastevvaseathanging.

To dry close to 1.5 g of the preparation (exact filling) at 100-105 to the end of the day. Waste in vase is innocent of 3%.

Vologist: not more than 2%.

Note . Sodium benzoate for the preparation of іn'ktsіynyh problems is guilty of pre-treatment and viprobavannya on zalizo: a dose of 0.4 g of the drug in 10 ml is guilty of vitrimuvatie viprobvannya on zalizo (not more than 0.0075% in the preparation_).

6. waysrejecting

Sodium benzoate is distilled according to the reaction of benzoic acid and sodium hydroxide with sodium carbonate:

a) with sodium hydroxide:

sodium benzoate chemical analysis

b) with sodium carbonate:

2+ Na 2 CO 3 2 + H 2 O + CO 2

7. yakisnyanalysis

The drug gives a characteristic reaction to benzoate and reaction B to sodium.

yakisnareactiononbenzoati:

Up to 2 ml of neutral benzoate (0.01-0.02 g of ion benzoate) add 0.2 ml of oxide chloride; to pretend to siege the horny coloru.

6C 6 H 5 COONa + 2FeCl 3 + 10H 2 O (C 6 H 5 COO) 3 Fe Fe (OH) 3 7H 2 O + 6NaCl + 3C 6 H 5 COOH

yakisnareactionontheysodium:

a) Dry reaction. Sil sodium, introduced in a non-barn half-dozen, added to the zhovty kolіr.

b) Z cincuranyl acetate:

Na + + Zn [(UO 2) 3 (CH 3 COO) 8] + CH 3 COOH + 9H 2 O = NaZn [(UO 2) 3 (CH 3 COO) 9] 9H 2 O + H +

c) With the range of pycrine acid (type of crystalline siege)

З 6 H 2 (NO 2) 3 OH + Na +> З 6 H 2 (NO 2) 3 ONa + H +

Methodologyvaluereferencegood lucksovereignpharmacopoeiaX:

0.25 g of the preparation is dispensed in 5 ml of water, add 1 ml of nitric acid, so that the crystals are visible, rinse with water and hang in the descriptor over the acidic acid until the permanent vagina is reached. The temperature of the extrusion benzoic acid and the expensive is 120-124.5 ° C.

schemereactions:

C 6 H 5 COONa + HNO 3 C 6 H 5 COOH + NaNO 3

8. kilkisnyanalysis

Approximately 1.5 g of the preparation (exact filling) is dispensed in 20 ml of water in a flask with a ground cork, 250 ml, add 45 ml of ether, 3-4 drops of the indicator (1 ml of methyl orange and 1 ml of the range of methylene blue) 0.5 n. by the solution of hydrochloric acid until the buzkovy popping appears in the water ball. In the beginning, the titration instead of the flask is kindly crushed.

1 ml 0.5 N. The range of hydrochloric acid is 0.07205 g of sodium benzoate, which is not less than 99.0% when dry.

9. sucking

1 . a drug: sodium benzoate

pharmacologicalgroup: secretolitics and stimulants of motor function dikhalnyh nobles.

Yak vidharkuvalny zasib - independently (per se) and in the warehouse combined preparations... When you take in all the middle, the secretion of mucous dichny nobles.

2 . a drug: Sodium coffee-benzoate

pharmacologicalgroup: stimulants dikhannya, psychostimulants

Zahvoryuvannya, which is supervised by the central nervous system, the functions of the heart-vascular and mental systems(Including Otrunnya by drug addiction, Infectious diseases), Spasms of the brain (including Ch.

10. witherzberigannya

Have good corked tar, in dry, stolen form of light misci.

II. Kilkisny analysis of the drug "Sodium benzoate" by the method of direct acidimetry with a diameter of 0.05 n. hydrochloric acid

1 . daymethod.

The reverse method of carrying out a complete analysis of sodium benzoate preparation is carried out by direct acid-metric titration and is carried out to methods of acid-base titration.

Acidictitling- titremetric methods for determining the concentration of acids, either based on the reaction of neutralization: H 3 O + + OH? = 2H 2 O. Titration in the range of the meadow is called alkalimetry, and titration in the range of acid is called acidimetry. In case of a number of acids - alkalimetry - a working solution є the range of strong acids (call HCl or H 2 SO 4). In case of a large number of marked meadows - Acidimetry - with a working range є reaching a meadow with NaOH or KOH. It is uncomfortable to prepare the titration of acid and concentrated acid.

As soon as the concentration of ions H + is titrated, the concentration of ions H + changes step by step, and the pH range of growth. At the same pH value, the point of equivalence is reached and the titration point is over. When titrated, the concentration of ions in the range changes, and the concentration of ions H + decreases and the pH value changes. However, the pH value at the point of equivalence is not the same for all the drops and the same value, because of the nature of the acid reactant and at the same time.

2 . titrant,standardizationtitrant.

In the obran_y method, titration with titrant є 0.05 N. range of HCl.

It is not possible to prepare a titrant for a fine fat, because hydrochloric acid is volatile. Approximately required concentration is prepared and standardization should be carried out for the installation channels: sodium tetraborate (borax) - Na 2 B 4 O 7 · 10H 2 O, anhydrous sodium carbonate - Na 2 CO 3 and in.

preparingdifferencetitrantroughlyrequiredconcentration:

a) to provide assistance to Masu Reciovini to prepare the price,

b) read the speech on the analytical cars,

c) the speech is entered into the world flask,

d) provide the exact concentration of the difference,

e) provide the correction factor.

preparingdifferenceіnstalyatsіynyspeeches:

The range of the setting speech is prepared similarly to the preparation of the range for the titrant for the exact filling.

vimogi,are presentedbeforeіnstalyatsіynyrechovin:

a) the warehouse of speech is guilty of the formulas,

b) we clean the speech of maє buty,

c) the speech will be good at the water,

d) the speech is strong when it is taken in a clean viglyad, as well as in the context,

e) the installation of the speech can be reacted with a titrant quickly and in stereochemical quantities (as a rule of thumb).

f) it is innocent of any side reactions,

g) the establishment of the speech is responsible for the greater value of the molar mass of the equivalent (less value for the value),

h) the function of the indicator's vibration is to blame.

i) standardization - the process of determining the exact concentration of the range.

Accuracy, in terms of the concentration of a standardized titrant, is intertwined with the accuracy of the method as a whole; The concentration of standard solutions is either directly (as the speech itself is the primary standard), or, bit by bit, as the speech itself is not satisfied with the vimogs, it is presented to the primary standards. From the first vipad to take, there is a lot of speech and it is necessary to expand it to exactly what is possible. In another, the number of words, titrated by the original standard, is important to revenge. The words, which can be seen, as good primary standards, are guilty of a number of important powers: mothers of high steps of purity, but stable to atmospheric infusions, mothers of low hygroscopicity and low ability to reach, high Only the deyakі speech is satisfied with the cim vimogam, that the number of the first standards of the velma is intertwined.

Pervinny standard- standardization for the exact filling

secondary standard- standardization according to the setting speech (the range of the setting speech).

Soyaksaltacidflying,standardrozchinїїit is possible, it is possibleget readyonlyby waystandardizationonsettingspeeches.

1 ) preparingprimarystandard - differencecarbonatesodium.

The amount of Na2CO3 required for the preparation of 100 cm3 0.1 M size, the amount of molar mass equivalent to sodium carbonate in the reaction with hydrochloric acid, is 53 g / mol:

m (Na2CO3) = C (1 / 2Na2CO3) V (Na2CO3) M (1 / 2Na2CO3) = 0.1 mol / dm3 0.1 dm3 53 g / mol = 0.53 m

Already, for the preparation of 100 cm3 0.1 (1/2 Na2CO3), the size of Na2CO3 is required 0.53 m It is important to insure that it is important to the insured that the technical wagons need a quantity of salt, and then they should start using the analytical wagons with an accuracy of up to 0.0002 g.

In a clean mirnu flask of 100 cm3, keep a dry drip and transfer a load of sodium carbonate; A lot of water in the flask is not guilty but more than 2/3. Re-mix the flasks until the salt is re-resolved. Fill the flask with distilled water up to a mint. Dodatok vodi finish with the help of the pipette, add water along the dribbles, trim the flask so that the mite has passed on the level of the eyes. Having prepared the roschin, re-mix it, closing the flask with a cork. To increase the concentration and titer of the prepared sodium carbonate according to the formulas:

2 ) preparing200 cm3roughly0,05 Mdifferencesaltacid.

The range of hydrochloric acid and a given concentration is produced from a larger concentrated range by the dilution method. The amount of anhydrous acid required for the preparation of 200 cm3 of a size should be adjusted to 0.05 mol of HCl in 1 dm 3. For those who have been calculated, the amount of concentrated acid should be measured using an additional hydrometer. The amount of hydrochloric acid is poured into a dry cylinder

bore into a new hydrometer. Draw on the hydrometer scale along the lower scale from the top to the bottom with an accuracy of 0.001 g / cm 3. According to the tables, read the percentage of acid concentration and calculate the amount of difference, in which the amount of hydrochloric acid is needed. Pour ~ 150 cm 3 of distilled water into a beaker with a size of 250-300 cm 3. The cylinder is responsible for insuring the insurance coverage of the HCl range, topping up the beaker with water and topping up to the required amount, approximately 200 cm 3. Prepare the razchin quickly. Razchin hydrochloric acid ready for standardization.

3 ) standardizationdifferencesaltacidroughlyrequiredconcentrationoncarbonatesodium.

Standardization of the range of hydrochloric acid is carried out using the additional primary standard sodium carbonate, prepared with a fine filling. When titrated, the indicator is methyl orange.

Really vimit the burette two with small portions of prepared hydrochloric acid. Vikoristovyuchi funnel, fill the burette with acid so that the bottom edge of the menu rіdini bouv de otch a zero rozpodіla. Then tighten the nose of the burette with a bottle of acid, tightening it from the bottom hose of the bulb. Having removed the funnel, dispense the acid from the burette in such a rank that the lower edge of the menu is at the level of the zero point of the burette scale.

I clean the bag with 10.00 cm3 and clean it with sodium carbonate. At the titration flask, pick the Na2CO3 value with a 10.00 cm3 pipette and add 1-2 drops of methyl orange indicator. In the іnshіy conіchnіy flask, there is a "svіdka" difference.

3 . withercarrying outtitling.

Derzhavna Pharmacopoeia X recommends titrating sodium benzoate in the presence of ether.

4 . valuekintsevopointstitling.

The point of titration is visualized visually according to the change in the color of the indicator, which is present in the discussed range.

In the selection of the methodology, when the points of equivalence of the color of the low indicator (1 ml of methyl orange + 1 ml of methylene blue) are reached, the color changes from green to buzkovy.

5 . sucking.

analysisdrug " sodiumbenzoate" .

Methodology: Transfer close to 1.6 g of the preparation (exact filling) into a 25 ml mirn flask, dispense in freshly boiled and cold water, bring to a mint. Take 10 ml of the neutralized hydrochloric acid for titration, add 18 ml of ether, 2 drops of the indicator (1 ml of methyl orange and 1 ml of the amount of methylene blue) and titrate with 0.5 N of the salt of hydrochloric acid until In the beginning, the titration instead of the flask is kindly crushed. The change in the preparation is guilty but not less than 99.9% in the case of a dry river (the loss in vase in case of hanging is 2.5%).

M (C 7 H 5 NaO 2) = 144.11

III. Protocol of titrimetric analysis of sodium benzoate preparation by the method of direct acidimetry with a 0.05 n. hydrochloric acid in the presence of ether

accuratemasanavishuvannyapowderbenzoatesodium: m = 1.6003 g

schemereactions:

M (C 7 H 5 NaO 2) = 144.11, f eq. = 1

M eq. (C 7 H 5 NaO 2) = 144.11

obsyagstainedtitrant:

V 1 = 7.82 ml

V 2 = 7.80 ml

V 3 = 7.84 ml

5th time. = 7.82 ml

titerdifferencesaltacidonbenzoatesodium:

= = = 0,0072

Rozrahunokpercentagezmistubenzoatesodiumvdrugs:

u = = = 88.04%

Zurahuvannyamwastewagiathanging:

88%*102,5% = 90,24%

perstandardmasovaparcelbenzoatesodiumvdrugsguiltyplay aroundvmezhakh99,0% - 103, 0% .

visnovok: for a percentage instead of sodium benzoate of analyzes, the drug is not suitable for vimogam of the State Pharmacopoeia of the Russian Federation.

Vikoristan Literature

1. Derzhavna Pharmacopoeia SRSP. - 10th ed. - M .: Vidavnistvo "Medicine", 1968.

2. Kharitonov Yu.Ya. Analytical chemistry. Analytics: in 2 books. - 2nd type. - M .: Vischa school, 2003.

3. Bulikov V.G. Pharmaceutical chemistry. At 2 o'clock: Navch. posibnik - M .: MEDpress-inform, 2007 - 624 p.

4. Arzamastsev A.P. Pharmaceutical chemistry: Textbook. posibnik - M .: GEOTAR-MED, 2004 - 640 p.

5. Make sure to take analytical chemistry before laboratory work. Yakisny analysis. Abdullina S.G., Shchukin V.A. - Kazan, 2007.

6. Encyclopedic Dictionary of Brockhaus and Efron: In 86 volumes (82 volumes І 4 additional). - SPb., 1890-1907.

7. Derzhavna Pharmacopoeia Russian Federation/ Vidavnistvo " Science Center Expertise of medical records ", 2008. - 704s.: il.

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8. Put the butts of lykarsky speeches, buildings, such as hexamidine, spread out with the vision of formaldehyde. Write an explanation of the relevant reactions.

9. Can you enter into the reaction of azo dye illumination? Say about the conduct of this reaction and write about chemistry.

10. Introduce techniques that allow the excess of acid and benzoic acid to be detected in benzene. Write a line of reactions.

11. To guide the methods of detecting organically tied fluorine from fluorouracil and flutorafur. Write a line of reactions.

12. Write structural formulas fluorouracil, flutorafur, cytarabine and azidothymidine. Introduce the sounds between the buddov and pharmacological diyu.

13. Vyhodyach from the chemistry budov and likarsky speeches of the group to primidin, decorate the possible methods of the best value.

14. Explain the possibility of storing physical and chemical methods (UV - and ІH-spectroscopy, different types of chromatography) in the pharmaceutical analysis of barbiturates, old uracil and gaxamidin.

16. Make sure that you are taking care of the barbiturats from the point of view of the physical and chemical authorities and the medical institutions.

List of literature for training.

1. Bulikov, chemistry: Textbook. For universities. - Pyatigorsk, 2003.S. 284-292.

2. Pharmaceutical chemistry: Textbook. Posibnik / Ed. ... - 2nd ed., Rev. - M .: GOETAR-Media, 2005.S. 249-293.

BUSY 5

Analysis of medicines,

old purine.

Meta busy:

Investigation of power, reaction of identification and methods of the method of making a decision of lykarsky speeches to a group of purin

zavdannya:

Request for input control;

Vivchity of the power of lykarsky speeches, group purine;

viconati to a robot according to the identification of the speech group and purine, to conduct a pharmacopoeial analysis of the identified speech;

To carry out an analysis of the proponated lykarsky forms in the form of a possibility to the internal pharmacy control of the LF, so that the words of the subordinate and non-postal warehouse should be replaced.

In the process of self-preparation and in busyness, the student is guilty of the following:

nobility:

Reactions of identification of drugs to group purine;

Reactions of the drug, group purine;

Stagnation of Tusli for the most important designation of speech lines of a subordinate and non-permanent warehouse;

Pharmacopeias methods for the analysis of drugs in group purine

vmіti:

identification lykarski speech, Group purine and conduct a pharmacopoeial analysis;

Conduct analysis of the LF, show the words of the sub-base and non-post warehouse;

Make out the documentation.

Zavdannya for busy:

Conduct an analysis of the LF, to take revenge on the words of the sub-base and non-post warehouse;

Conduct a pharmacopoeial analysis of the substance ( coffee-benzoate sodium, eufilin).

Issue an analytical passport.

The theoretical basis for the analysis of the LF of the sub-base and non-base warehouse.

The principle of racking of titers for sub-base or non-post-storage rivers when analyzing lykarsky forms.

1. For the normative documentation, a statement is established, for which standardization of speech is carried out for a sub-base or non-stationary warehouse, and for a change in a percentage.

2. Based on the method of clicks, the titer is validated.

3. Rozrahoyuti the title of the speech of the subordinate or non-hostile warehouse, the vrahoyuchi actual zmist in the new form begins with the formula:

Tv-va = Topred. connection ∙ 100% / (actual change in data in%)

Razrakhunok titre of preparations in the sub-warehouse (sodium coffee-benzoate, eufilin and іnshі) during the analysis of lykarsky forms with internal pharmacy control.

When express analysis, make sure to carry out one component at a time in the preparation, and to spend on the preparation as a whole.

1. Coffee is sodium benzoate.

The value of sodium benzoate by acidimetry method.

fq. sodium. benzoate = 1 M = 144.11 g / mol.

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In order to develop the titer of sodium benzoate-coffee, it is necessary to know the percentage instead of sodium benzoate in the preparation. Zgіdno GF X vmіst sodium benzoate can be found in the boundaries of 58-62%. If instead of sodium benzoate in the preparation become 60%, then

DIV_ADBLOCK135 ">

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100 g of coffee - sodium benzoate - 40 g of coffee

X - 0.004855 g

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100 g eufilinu - 14 g etilendiamin

X - 0.003050 g

Amiak "href =" / text / category / ammiak / "rel =" bookmark "> ammiak;

2. Reaction with Wagner's reagent. 0.01 g of the preparation, when heated in 0.5-1.0 ml of water, add 1-2 drops of 0.1 mol / l iodine, 1-2 drops of diluted hydrochloric acid and promote an effective reaction.

3. Reaction with tanin. 0.03 g of the preparation is razchinyayut in 2 ml of water, add 01% roschinu tantinu in drops and to promote an effective reaction.

4. Reaction with cobalt chloride. 0.1 g of the preparation is filled with a stretch of 2-3 quiline per ml, and the amount of sodium hydroxide is 0.1 mol / l and filtered. Add 2 dots to the filtrate 2 dots 2% to cobalt chloride and prevent reaction.

5. Reaction with nitrate. 0.05 g of the drug is calculated in the amount of 1 ml of water and 0.5 ml of the amount of ammonia, add 0.5 ml of the amount of nitrate, mix and maintain the reaction effect.

Specific reactions of reference for the elderly purine

Sodium coffee-benzoate.

0.01 - 0.02 g of the preparation is razchinyayut in 1 ml of water, add 1-2 drops of saline chloride (III). The siege of the horny colora (the infusion of tied benzoic acid) takes place.

The sodium cation is brought into microcrystalline reactions with pycrine acid.

Euphilin. 0.02 g of the preparation is razchinyayut in 10 drops of water, add 1 speck of water (II) to sulphate, it appears in the form of a bottle (vyavlennya ethylendiamina).

The substance of coffee is sodium benzoate.

to describe . Bilium crystalline powder, odorless, slightly grippy relish.

discrepancy . Easy to use in water, important in alcohol.

fairness .

Prepare 0.5 g of the preparation in 3 ml of water, add 1 ml of liquid sodium, 10 ml of chloroform and add 1-2 quilins with a stretch. Chloroform solution is filtered through a filter with anhydrous sodium sulfate and vaporized chloroform in a water bath. The surplus gives the reaction of the help characteristic of the coffee.

The solution to the drug is given a reaction to benzoate

Acidity and water content: To a solution of 0.25 g of the preparation in 5 ml of freshly boiled and cold water, add a few drops of phenolphthalein. Rozchin is not guilty of getting bruised in rhyme colir. Rozheva is guilty of being in addition to no more than 0.15 ml 0.05 N. the range of sodium hydroxide.

Waste in weight when hanging. Closely 0.5 g (exact filling) to dry at 80C to a steady state. Waste in weight when hanging is not guilty of changing 5%

Kіlkіsne viznachennya.

coffee: Closely 0.3 g (exact filling) the preparation is razchinyayut in 30 ml of water and in a flask of 100 ml. 10 ml of diluted sirchanoic acid, 50 ml of iodine solution (0.1 mol / l, UCh ½ I2), add the volume to the range with water until it is mixed and mix. Pislya vidstoyuvannya with a stretch of 15 chilins of roses, quickly filter through a ball of cotton into a dry flask, attaching the funnel with a year-old slope. First drop 10-15 ml of filtrate. Transfer 50 ml of filtrate into a flask and the excess iodine is triturated with sodium thiosulfate (0.1 mol / l) until it is sourced (indicator - starch). Conduct a control plate in parallel.

sodium benzoate, sodium benzoic acid.

Cheerful authorities

Sodium benzoate, why not? Sodium benzoic acid sodium, widely used as a preservative. It is a bilious powder, odorless or with a dim smell benzaldehyde ... Chemical formula: C6H5CO2Na... Zgіdno Pharmacopoeia, molecular weight s'єdnannya = 144.1 grams per mole. Rechovina Bula vіdkrito in 75 rotsі 19 th century as a deputy. We began to use it as a preservative for 20 tablespoons on the cob. In small doses, speech can be found in cranes, apples, cinnamon and cinnamon.

Sasib to stop:

• in yakosti kharchovoy additives E102,E110, E124, E104, E122і E129;
• in the presence of a preservative; in pharmaceutical and cosmetic industries;
• in medicine, as a vidharkuvalny zasib;
• in pyrotechnics and aviatsii for the opening of a special paper, for the storage of parts for aluminum and galvanized covers.

Skoda Benzoatu Natriyu

At the moment, nutrition about those who have a high-quality Danish component will be left behind. So yak in other products Harchuvannya is often present lactic acid, barvniks and stabilizers, calcium sorbate і Sodium benzoate. Rechovina is allowed until victorian in the lands of the SND and Europe. Yogo can be added to mayonnaise, ribna virobi, ketchup and margarine, liquorice, gas, jam and berry products. However, there are a number of scientific robots, such as talking about a preservative Skoda, about its high oxidative stress, about mutagenic activity by reducing to mitochondrial DNA. molecular biologist Peter W. Piper vvazhaє, that speech can be victorious of neurodegenerative illnesses i. According to the recommendations of the World Health Organization, the speech was accepted as admittedly not shy. In childbirths, spoluca wiklik is chemically sensitive, aggravating symptoms i.

Pharmacological diya

Vidharkuvalny.

Pharmacodynamics and pharmacokinetics

What about Sodium Benzoate? Infusion of sodium benzoate on organisms

Have great concentration lykarskiy zasib driving on the life of flowers and other fungi, driving the activity of enzymes, which are suspected for the excess of ODS, so they break up starch and fat. When taking in the middle of the speech, it stimulates the processes of seeing mucus, increasing mucociliary clearing.

Shown to sucking

I would like to acknowledge when complex treatment igniter get sick dykhalnyh nobles, as supervised, tracheitis , .

Prototype

It is contraindicated before taking on the active component.

Pobichna diya

Even more rare Sodium Benzoate can be susceptible to allergic reactions, hanging on the screen.

Instructions for suction (Method and add-on)

The preparation of the given speech means the middle.

Falsely given to the type of cough, vikoristovyu lykarski formi... The course of lіkuvannya in the middle becomes from 10 days to 2 days.

Overdose

About an overdose of the drug,

vzaєmodiya

Nemaє danih about lykarsku vzaєmodiyu costly.

Mind the sale

Non-prescription admission.

special requests

Sodium benzoate went as far as the recommendations described in the instructions before the preparation. Do not accept the end of the term of attachment.

With vaginosis and lactation

Rechovina can be accepted by year old women for the show of the doctor. Yakshcho potential for perevishchu risik for the health of the child.

Preparations in which revenge (Analogues)

Rechovina in combination with, annis, extract thermopsis і licorice enter the warehouse. It is also worth taking revenge in preparations: Amtersol , Mixture for cough for dry children , Manisoft , Tos-May , Extratherm .

1. Russian name Likarsky zasobu.

sodium benzoate

Sodium benzoic acid

Sodium benzoic acid sodium

sodium benzoate

2. The Latin name is lykarsky zasobu.

Natrium benzoicum

3. Chemical formula based on molar mass values

molar masa 144,11

4. Zovnishn_y viglyad

Bilium crystalline powder, odorless or even with a faint smell, liquorice-salty relish.

5. Physical and chemical authorities

Alcohol content: 1.44 g / cm3

Distinction.

Easy to use in water, important in alcohol.

Transparency and color distribution.

The dosage of 1 g of the preparation in 10 ml of freshly boiled and cold water is guilty, but it is clear and barless.

Potency and acidity.

Phenolphthalein is used to add a decal drop to the cut-off size; the guilt is guilty. Rozheva is guilty of not being more than 0.75 ml 0.05 N. the range of liquid soda.

0.15 g of the preparation is razchinyayut in 14 ml of water, add 1 ml of diluted nitric acid and filter. 10 ml of filtrate is guilty of vitrimuvati and viprovannya on chloride (not more than 0.02% in the preparation).

1.5 g of the preparation is razchinyayut in 25 ml of water, add 5 ml of diluted hydrochloric acid and filter. 10 ml of the amount of vitrimuvati and viprovannya on sulfate (not more than 0.02% in the preparation).

10 ml of the same filtrate is guilty of vitrimuvati and viprovannya on important metal (no more than 0.001% in the preparation).

Waste in vase when hanging.

To dry close to 1.5 g of the preparation (exact filling) at 100-105 to the end of the day. Waste in vase is innocent of 3%.

Vologist: not more than 2%.

Note. Sodium benzoate for the preparation of іn'ktsіynyh problems is guilty of pre-treatment and viprobavannya on zalizo: a dose of 0.4 g of the drug in 10 ml is guilty of vitrimuvatie viprobvannya on zalizo (not more than 0.0075% in the preparation_).

6. Ways to deny

Sodium benzoate is distilled according to the reaction of benzoic acid and sodium hydroxide with sodium carbonate:

a) with sodium hydroxide:

sodium benzoate chemical analysis

b) with sodium carbonate:

2+ Na 2 CO 3 2 + H 2 O + CO 2

7. Yakisny analysis

The drug gives a characteristic reaction to benzoate and reaction B to sodium.

Yakisna reaction on benzoate:

Up to 2 ml of neutral benzoate (0.01-0.02 g of ion benzoate) add 0.2 ml of oxide chloride; to pretend to siege the horny coloru.

6C 6 H 5 COONa + 2FeCl 3 + 10H 2 O (C 6 H 5 COO) 3 Fe Fe (OH) 3 7H 2 O + 6NaCl + 3C 6 H 5 COOH

Yakisna reaction to ionic sodium:

a) Dry reaction. Sil sodium, introduced in a non-barn half-dozen, added to the zhovty kolіr.

b) Z cincuranyl acetate:

Na + + Zn [(UO 2) 3 (CH 3 COO) 8] + CH 3 COOH + 9H 2 O = NaZn [(UO 2) 3 (CH 3 COO) 9] 9H 2 O + H +

c) With the range of pycrine acid (type of crystalline siege)

З 6 H 2 (NO 2) 3 OH + Na +> З 6 H 2 (NO 2) 3 ONa + H +

Methodology for the identification of authenticity from the State Pharmacopoeia X:

0.25 g of the preparation is dispensed in 5 ml of water, add 1 ml of nitric acid, so that the crystals are visible, rinse with water and hang in the descriptor over the acidic acid until the permanent vagina is reached. The temperature of the extrusion benzoic acid and the expensive is 120-124.5 ° C.

Reaction scheme:

C 6 H 5 COONa + HNO 3 C 6 H 5 COOH + NaNO 3

8. Quick analysis

Approximately 1.5 g of the preparation (exact filling) is dispensed in 20 ml of water in a flask with a ground cork, 250 ml, add 45 ml of ether, 3-4 drops of the indicator (1 ml of methyl orange and 1 ml of the range of methylene blue) 0.5 n. by the solution of hydrochloric acid until the buzkovy popping appears in the water ball. In the beginning, the titration instead of the flask is kindly crushed.

1 ml 0.5 N. The range of hydrochloric acid is 0.07205 g of sodium benzoate, which is not less than 99.0% when dry.

9. Gagging

1. Preparation: Sodium benzoate

Pharmacological group: secretolitics and stimulants of motor functions of mental health.

Yak vіdharkuvalny zіb - independently (per se) and in the warehouse of combined preparations. When you take in all the middle, the secretion of mucous dichny nobles.

2. Preparation: Sodium coffee-benzoate

Pharmacological group: stimulants dikhannya, psychostimulants

Intoxication, supravodzhuyutsya to the central nervous system, functions of the heart-vascular and mental systems (incl. in children, impaired dyhannya (periodically dichanna, idiopathic apnea) in newborns (including premature babies).

10. Umovi zberigannya

Have good corked tar, in dry, stolen form of light misci.