Voltaren tablets 50 mg Voltaren (tablets): instruction and administration

Voltaren
Buy Voltaren in pharmacies

LIKARSKI FORMI
tablets 50mg
tablets vkrit_ intestinal-corrosive shell 50mg

VIROBNIKI
Novartis (Switzerland)
Novartis Pharma AG (Switzerland)
virobleno Novartis Pharma S.p.A. (Італія)
Novartis Pharma S.p.A. (Італія)
Pliva (Croatia)
Sandoz Pharma Ltd (Switzerland)
Siba-Geigy (Switzerland)

THE GROUP
Protisapalny zasobi - lost phenylocytic acid

WAREHOUSE
Speech is active - diclofenac sodium.

International non-patented name
diclofenac

SINONIMI
Voltaren Aktі, Voltaren Ophta, Voltaren Rapid, Voltaren Emulgel, Diklak, Diklofenkiy Lipogel, Diklo-F, Diklobene, Doklovoyuti, Diklogen, Diklonat P, Dikloran, Diclofenac, Diclofenkylofen, Diklofenac diclofenac-acos, diclofenac-Acri, diclofenac-Acri retard, diclofenac-Altpharm, diclofenac-MFF, diclofenac-ratiopharm, diclofenac-UFB, diclofenac-FPO, diclofenac-Eskom, Naklofenlo , Ortofer, Ortoflex, Panamor AT-50, Rapten Duo, Rapten Rapid

PHARMAKOLOGICHNA DIA
Non-steroidal anti-burners. Prostaglandin biosynthesis is applied. Prostaglandini play the main role in the development of the main symptoms of inflammation (swelling, temperature, blistering). In case of rheumatic ailments, the anti-fatigue and analgesic power relieve such symptoms as in the case of calmness and in Russia, rank rigidity, swelling of the lobes. I have a strong analgesic effect when I am severe pain non-rheumatic in nature. at ignition processes As soon as there are operations and injuries, spontaneous fires quickly fall, and when Russia changes, the firing bulge changes on the site of the wound. In case of primary dysmenorrhea, I will weaken more and change the bleeding. It causes platelet aggregation. When trivial zasosuvannі nadaє desensitizing dіyu. In ophthalmology - assimilation of myosis, lowering the development of cystic macular tissue during an hour of operations with a cataract drive. Absorption - quickly and efficiently, as well as the speed of absorption. The maximum concentration in plasma is reached in 1-2 years. As a result of the hopeful development of active speech, the maximum concentration of diclofenac prolonged action in the blood plasma is lower than this, as it is established with the introduction of the drug for a short period. With internal injection, the maximum concentration in the plasma is reached after 10-20 quills, with rectal administration - after 30 quills. Bioavailability - 50%. Linkage with blood plasma beads - 99%. With a muscular zasosuvannі dіyucha speech, it is common to get wet through the shkіra. When instilled in the hour of the attainment of the maximum concentration in the horn and conjunctiva - 30 quilins, penetrating into the anterior chamber of the eye, into the systemic circulation in therapeutically significant concentrations does not penetrate. Chi is not cumulativeє. Vivod in viglyadі metabolites through nirki and zhivchyu.

SHOWN BEFORE CHICKENING
Zapalnі zahvoryuvannya suglobіv (revmatoїdny arthritis, rheumatism, ankіlozuyuchy spondilіt, hronіchny podagrichny arthritis), degenerativnі zahvoryuvannya (deformuyuchy osteoarthrosis, osteochondrosis), lumbago, іshіas, nevralgіya, mіalgіya, zahvoryuvannya pozasuglobovih tkanin (tendovagіnіt, bursitis, revmatichne urazhennya m'yakih tkanin) post-traumatic pain syndromes, which are superficial to inflammation, during surgery, pain, gout attack, primary dysmenorrhea, adnexitis, attack of migraine, nirkov and pecinous colka, pneumonia, pneumonia. Missevo - injuries to tendons, ulcers, mucous and lobs, localized forms of rheumatism of soft tissues. In ophthalmology - non-infectious conjunctivitis, post-traumatic inflammation of the disease of penetrating and non-penetrating injuries of the intramural apple, pain syndrome in case of stagnation of the excimer laser, during the surgery

Prototype
Hypersensitivity, hematopoietic damage, twisting of the slurry and two-fingered intestine, "aspirin" bronchial asthma, childish sickness (up to 6 years), the last trimester of vaginosis.

POBICHNA DIYA
On the side of the shlunkovo-intestinal tract: b_l in the shlunk, nudota, bloating, diarrhea, spasms of the shlunk, dyspepsia, flatulence, anorexia. On the side of the central nervous system: head bill, Zapamorochennya, vtoma. On the side of the blood-forming organs: thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia. At mіsci in / m introduction - pechinnya. When victorian sv_chok - m_stseve teasing. On the side of the shkіri: hanging on the shkіri, kropiv'yanka, sverbіzh, pechinnya. In case of trivial zasosuvannі / abo applied on large surfaces - systemic side effects in a lot of resorptive action. At the same time, when burying in the eyes, it is necessary to see the message and / or the lack of clarity.

VZAЄMODIYA
Increased concentration in the blood of lithium, digoxin, indirect anticoagulants, oral anti-diabetic drugs (possibly hypo- so and hyperglycemia), chinolone deceased. Increased toxicity of methotrexate, cyclosporine, the development of side effects of glucocorticoids (slunk-intestinal bleeding), the risk of hypercorticosteroids on the other Concentration in plasma decreases when it is consumed acetylsalicylic acid.

How to save and dozuvannya
Doroslim priznachayut at pochatkov_ dobov_y dose 100-150 mg. In vipadkas with apparently unremarkable symptoms, as well as with trivial therapy, there is a sufficient dose of 75-100 mg / day. I will add a dose, as a rule, it will be increased by 2-3 times. If necessary, take Voltaren in suppositories for a day or so before taking the drug for a day or so before going to bed. Dobova dose of the drug is not guilty of perevischuvati 150 mg. At first algodismenorrhea, add the dose individually, take 50-150 mg. Pochatkova dose can be delivered up to 50-100 mg; if necessary, with a broach menstrual cyclesїї can be adjusted up to 150 mg / day. By taking the drug, you should fix the yakomog earlier when the first symptoms of ailment appear. The triviality of the drug taken to become a few days and lie in the dynamics of regression of symptoms. Tablets should be taken with a cilimi, not roasted, and washed down with a ridinoy. Brush with the drug until you go. For children and adolescents from 6 to 15 years old, only tablets, including the intestinal corns, 25 mg each. The drug is priznachayut in an additional dose of 0.5-2 mg / kg body weight; The dose is distributed by 2-3 doses in the prevalence of symptoms. When juvenile rheumatoid arthritis dobova dose can be increased up to 3 mg / kg, with the maximum additional dose. For children from 16 to 18 years old, you can also take a tablet of 50 mg.

Mind that term zberigannya
When taking all the middle: Symptoms: zamorochennya, headache, hyperventilation, dimness of symptoms, in children - myoclonic sudomi, dislocation of the intestinal tract, the function of the stove and nirok. Likuvannya: symptomatic therapy.

SPECIAL VKAZIVKI
I will take Diclofenac for 30 minutes before the day with the help of a shrewd dosyagnennya bazhany efect of oral form. pislya zyattya contact lines, Zakopuvannya is carried out through 5 hilin. Preparations for muscular storing should be applied only on non-shkodzheni dilyanka shkiri. In case of trivial lykuvanny, it is necessary to periodically update the formulas of blood and liver function, analysis of feces for the admitted roof. In the first 6 months of vagineness, he was guilty of stasis for suvorim shown in the most recent dose. Due to the decrease in the speed of reaction, it is not recommended to use vehicles or robots with mechanisms. Obmezhennya to zasosuvannya. Disruption of the liver function and nirok, heart failure, porphyry, robot, as a result of increased respect, vitality, breast health (later seen as a result of breast health).

UMOVI ZBERIGANNYA
List B. In dry, stolen from light mice, at room temperature.

warehouse

diyucha speech: dermal tablet to revenge 50 mg of diclofenac sodium;

additional speeches:

tablet core:

corn starch, sodium crochmalglycollate, lactose monohydrate, microcrystalline cellulose, coloidal anhydrous silica, Povidon KZO, magnesium stearate;

sub-pocritia:

gastroresistantpokritta:

copolymer of methacrylic acid, talc, polyethylene glycol 8000, simethicone.

color:

hypromelose, talc, zhovtiy zhovty oxide (E172), titanium dioxide (E171), polyethoxylated castor olea 40 hydrogenated, chervonia zaliza oxide (E172).

to describe

Light brown, round, two-shaped tablets, with beveled edges, engravings "CG" from one side and "GT" - from the other.

Pharmacotherapeutic group

Non-steroidal anti-fire and anti-rheumatic diseases. Poor acid

ATX code: М01А В05.

Shown up to sucking

igniter degenerative forms rheumatic fever (rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis), pain syndromes with localization at the ridge; extra-articular rheumatism; Gostri attack gout; Post-traumatic and operative pain syndromes, which are superseded by burns and bulges, for example, for dental, surgical and orthopedic interventions; Gynecological illnesses, such as suffering from pain syndrome and inflammation, for example, primary dysmenorrhea or adnexitis; Yak domіzhny zіb in case of important fiery ills ENT organs, which are supervised to experience pain, for example, with pharyngotonsitis, otitis.

Adopt the out-of-the-box therapeutic principles, basically getting caught up in the background with the basic therapy. Likhomanka herself is not indicated for the drug intake.

Prototype

Vіdoma hіperchutlivіst to dіyuchoї speech or to any component of the drug; The last trimester of vaginosti; There is an active twisting of the slunker of the intestine, bleeding or perforation. Inflamed intestinal problems (for example, Crohn's ailment, swelling colitis); Pechinkova lack; Nirkova lack (GFR< 15 мл/мин/1,73м2); Применение диклофенака противопоказано пациентам с установленной застойной сердечной недостаточностью (NYHA II-IV), ischemic ailment heart, peripheral artery disease or cerebrovascular disease; Voltaren, as well as non-steroidal anti-pyretic diseases, contraindications to patients, for those with acetylsalicylic acid and any of the other non-steroidal anti-firing agents, provoking an attack bronchial asthma, Angioneurotic gostry rinita(Tobto reactions of cross-reactivity, wikklicans with non-steroidal anti-firing methods); Diclofenac is a contraindication for pain relief in the perioperative period in times of aortocoronary bypass surgery (for example, with a piece of blood circulation apparatus).

How to store that dosi

Tablets slid kovtati tsilimi, washed down with rіdinoyu, even before іzhі. The dose should be taken individually. Potential events can be minimized with a minimal effective dose for the minimum period necessary for symptom control (div. Alert).

For grown-ups, it is recommended to set the pochatkova dobova dose to be 100-150 mg. In mild cases of discomfort, such as during pre-construction therapy, a sufficient dose of 75-100 mg is given. The initial dose for older adults will last for 2-3 times. If it is necessary to relieve any pain and wound pain, before taking the drug, take Voltaren in the form of rectal suppositories before going to bed. Dobova dose of the drug is not guilty of perevischuvati 150 mg.

In case of primary dysmenorrhea, I will add a dose individually, and in total become 50-150 mg. The pochatkova dose can become 50-100 mg, or, if necessary, it can be used in the course of several menstrual cycles, or not more than 200 mg / dob. Zastosuvannya to the drug after the repair of the yakomog earlier when the first pain symptoms appear; the triviality of lykuvannya, fallen as symptomatology, to become up to a few dib.

Zastosuvannya in special groups of patients.

Children up to 18 years old

Voltaren tablets 50 mg can be used for children aged 14 years and older.

For adults, the dose should be 0.5-2 mg / kg body weight in the presence of severity of symptoms; The dose is increased by 2-3 times. When treating juvenile rheumatoid arthritis, the dose can be increased to the maximum dose of 3 mg / kg. Do not overhaul the maximum additional dose - 150 mg.

Voltaren tablets, in intestinal corrosive shell, 50 mg are not recommended for use in children through a high dose of speech.

Lіtnі paciєnti (65 years old and older)

For a given group of patients, a start dose correction is not necessary. At the same time, when traveling from foreign travel, it is necessary to be protected when the drug is prescribed, especially in the weakened, or there may be a low mass of young patients. Patients due to congestive heart failure(NYHA- I) for meaningful heartrhiziku judgmental factors

In patients from congestive heart deficiency (NYHA-I), for significant factors in the development of heart-vascular disease, diclofenac is allowed to be used only for retailers, and at trivial doses of 4 therapy more< 100 мг в сутки (см. Меры предосторожности).

Patients with damaged functions of nirok

Voltaren contraindications for patients with nirk deficiency(SCF< 15 мл/мин/1,73м2) (см. Противопоказания). Поскольку специальные исследования у пациентов с нарушением функции почек не проводились, конкретные рекомендации по корректировке дозы дать невозможно. Рекомендуется соблюдать осторожность при применении Вольтарена у пациентов с нарушением функции почек (см. Меры предосторожности).

Patients with damaged functions of the stove

Voltaren of contraindications to patients with pechinka deficiency (div. Prototype). Oscillations of special adolescents were not carried out for the patients with the damaged functions of the liver, specific recommendations for correcting the dosage are unfortunate. It is recommended to take care of yourself when you are stuck with Voltaren in patients with mild and moderately damaged liver function (div. Zarezhennya).

Pobichna diya

side reactions classified according to the frequency of the diagnosis: often (> 1/100,< 1/10), нечасто (> 1/1000, < 1/100), редко (> 1/10000, < 1/1000), очень редко (< 1/10000), включая единичные сообщения.

On the side of the blood system lymphatic systems: even more rarely - thrombocytopenia, leukopenia, hemolytic anemia, aplastic anemia, agranulocytosis.

Three sides immune system: rare - hypersensitivity reactions, anaphylactic reactions, including hypotension and anaphylactic shock; even more rarely - an aneurotic nagging (including nagging denunciation).

Psychic problems: even worse - disorientation, depression, sleeplessness, no nightmares, gratitude, psychotic problems.

Three sides nervous system: often - head b_l, zapamorochennya; Ridko - sleepiness; even worse - paresthesia, loss of memory, sudomy, anxiety, tremor, aseptic meningitis, loss of relish, loss of cerebral blood circulation.

On the side of the organ: even worse - good luck, Clouded zoru, diplopia.

On the side of the organs in hearing: often - vertigo; duzhe rіdko - dzvin u wuhah, break your hearing.

Three sidesheart-vascularsystems: infrequently * - myocardial infarction, heart failure, heart disease, bile in the breasts; even worse - arterial hypertension, Vasculitis; incidence of nevdom - Kounis syndrome.

On the side of the organ_v dikhannya: Ridko - asthma (including slowness); even worse - pneumonia.

Three sides shlunkovo-intestinal tract: often - nudity, bloating, diarrhea, dyspepsia, abdominal pain, flatulence, anorexia; Ridko - gastritis, gastrointestinal bleeding, bloody bleeding, hemorrhagic diarrhea, melena, vyrazka of the shlunk or intestines (in the presence of bleeding, stenosis of the SCT or perforation of the water); even more rarely - colitis (including hemorrhagic colitis, ischemic colitis and aggravated colitis, or Crohn's ailments), constipation, stomatitis, glositis, spreads from the side of the duct, diaphragmatic intestinal strictures,

Three sideshepatobiliarysystems: often - adjustments transaminase; Ridko - hepatitis, zhovtyanytsya, hepatitis; even more rarely - bliskavichny hepatitis, liver necrosis, pechinka deficiency.

On the side of the shkiri and the pedigree klitkovini: often - visip; Ridko - Kropiv'yanka; even more rarely - bullosa visip, eczema, erythema, multiforme erythema, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), exfoliative dermatitis, hair loss, photosensitivity reactions, purpura.

Three sidesobvioussystems: often - overlap of the line, embryo and arterial hypertension; even worse - gostre pozhkozhennya nirok (gostra nirkova lack), hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, Nirkovy papillary necrosis.

Headquarters: Ridko - quirks.

* Frequency of visualization of trivial therapy due to high dose intake (150 mg per dose).

describe okremich side effects.

Arteriothromboticappearances

Clinical dosages of thrombotic acceleration (for example, infarction of myocardial infarction) should be taken into account for those who are susceptible to diclofenac.

good luck

Destruction of the dawn, impurity or double in the eyes are characteristic nezazani efekti for the class of oil refineries, who are you werewolves, when you pay the reception. We can use the mechanism to determine the synthesis of prostaglandins and other diseases, as we disrupt the regulation of the blood flow of the bloodstream, and we can get rid of it. It’s like this is broken down for an hour when diclofenac is used for any reasonїх examination should be carried out ophthalmologic examination.

Overdose

typical classic paintings, Typical for overdose of diclofenac, not sleep. Overdoses can be supravodzhuvatisya such symptoms, such as bloating, shlunkovo-intestinal bleeding, diarrhea, zapamorochennya, dzvin in vuhah abo sudomi. In a developed detachment of powerful development of a hostile deficiency, that level of liver.

Likuvannya. lykuvannya hostile detachment Refinery Polyagaє symptomatic therapy... pіdtrimuє i symptomatic lykuvannya It is shown in such accelerated conditions, such as arterial hypotension, nirkov deficiency, sudomy, damage from the side of the intestinal tract and impairment. Special visits, such as forcing duresis, hemodialis or hemoperfusion, do not appear to be corny for the administration of NPZP, including diclofenac, some of the active speeches of such drugs in the form of a significant metabolic link

please welcome active vugilla in case of a potentially toxic overdosing and performing a slurry decontamination (blotting, slurrying) with a potential yaka will load the life overdose.

Women of childbirth, vagina, breast health, fertility

Nemaє danikh, I allow you to give any recommendation to women with a birthday gift.

availability

Suffocating the synthesis of prostaglandins can negatively interfere with vaginosis and internal uterine development fetus. The date of the epidemiological reports indicate about the growth of heart disease and gastroschisis in the fetus for receiving the ingestion of prostaglandins in the synthesis of prostaglandins in the early term of vaginosis The absolute rhizic of the heart-vodinnyh vad is zbіlshuvsya from less than 1% to 1.5%. Get involved in the development of the risky from the increase in dosage and triviality of therapy.

It has been shown that in twins, the introduction of ingibitoria into the synthesis of prostaglandins can lead to the destruction of the implantation of the embryo. In addition, in twins, who have eliminated the synthesis of prostaglandins in the period of organogenesis, the frequency of the development of growth has increased, including the destruction of development. heart-vascular system... Zasosuvannya diclofenac in vagіtny women didn’t get. Voltaren did not mean to signify by stretching out the first two trimesters of vaginosity, as only the cinnamon from his stasis does not transplant the rhiziki for the fetus.

Yak and for the first oil refineries, the prescription of the drug in the third trimester of vaginosity is not indicated. In case of ingibitoris in the synthesis of prostaglandins in the third trimester of vaginosis in the fetus, you can:

Before the closure of the arterial duct and Legeneva hypertension, nirkov dysfunction, with progressing such a development, nirkov lack of oligogidroamnion develops.

When diclofenac is taken in the end of vaginosity, the development of the weakness of the generic capacity and the improvement of the triviality of the canopy is possible. In the mother and in the fetus / newborn, an hour of bleeding may be increased, the antiaggregation effect may be induced by taking low doses of diclofenac.

Bosom year

As a result, diclofenac is seen in small amounts in breast milk. Voltaren not slid zastosovuvati in the period thoracic treatment, To get over the little girl’s reactions.

fertility

Yak and іnshi non-steroidal anti-fumes, Voltaren may have a negative infusion on female fertility, so it is not recommended to prescribe the drug to women who are planning to become overwhelmed. For women who may have problems from conceiving, or to pass the pre-trial period without a plan, then see the progress of the drug Voltaren.

In the creatures, on the basis of current tributes, the deterioration of the number of fertility cannot be included. The relevance of cich visnovks for people is unimportant.

Diclofenac viklikak efekty, which is infused into fertility (the lower level of testosterone, and also reduces the amount of test fat) Similar efficacy was also observed in F1 generations at the onset doses> 1.25 mg / kg in the last two generations. In dogs, the dose of diclofenac sodium 2 mg / kg led to an increase in the number of spermatozoa. More recently, describe the reduced frequency of mating in female shchura after repeated doses of diclofenac> 0.5 mg / kg. There are reasons for pouring yak on a person, so fertility cannot be enabled.

Zapobizhnі come in

Shlunkovo-intestinal efficiency

With all refineries, there may be slunk-intestinal bleeding, anxiety and perforation, which may be fatal and may be fatal during the period of treatment for the period of mid-juvenile symptoms, or during the whole period of illness, in case of severe Zagalom, these are the best things for the children of the summer. As soon as the patients are taking Voltaren, they are developing rapidly, the drug must be taken into account.

For all NPPs, including diclofenac, it is necessary to have medical attention and special care in case of Voltaren's symptoms in patients with symptoms of dislocation of the intestinal tract or with an anamnesis, which may have a history of bleeding. Rhizik of intestinal-intestinal bleeding grows with increased doses of NPZP, as well as in patients with a history of virality, especially, as an accelerated bleeding, either perforated or small mice.

To reduce the risk of toxic infusion on the shlunkovo-intestinal tract in patients with viral history, especially accelerated bleeding and perforation, as well as in patients who have been kidnapped because of this, for another reason.

In the case of vischevkazannyh pupils and pupils who require a congenial payment lykarsky zasobiv To replace small doses of acetylsalicylic acid and any other drugs, which can help reduce the risk of development of unnecessary reactions from the side of the intestinal tract, in order to look at the degree of combination therapy in combination

Patients with slunk-intestinal toxicity in anamnesis, especially lithium, are at fault for occasional abdominal symptoms (especially bleeding in the slunk-intestinal tract). Protection is also required for ailments, who can immediately get rid of the disease, as they can change the risk of a breakdown or bleeding, such as systemic corticosteroids, anticoagulants, anti-thrombocytocytic selectivity

Before an hour of therapy with the drug, it is necessary to take care of the medical care and to take care of the care of the patients with swollen colitis or Crohn's ailment, they may become stricken.

Sertsevo-sudinnіeffectively

Clinical preliminaries and epidemiological data to conclude about the manifestation of the development of arterial thrombotic diseases (for example, myocardial infarction and insult), as s diclofenac consumption, zokrem in high doses (150 mg per dose) and in trivial consumption.

Patients with significant factors in the development of heart-vascular acceleration (for example, arterial hypertension, hypertension, cuckold diabet, Kurinnya), signify diclofenac only as a result of such a view.

In case of a youthful admission of rhizic vascular disease in case of trivial congestion, at high doses, patients should take diclofenac in the smallest effective dose and take the shortest possible hour for half an hour. Slide to periodically reassess the need for relief of symptoms and symptoms during the test.

In patients with congestive heart failure (NYHA-I), there are significant factors in the development of heart disease (e.g., arterial hypertension, hypertension, therapy for diabetic disease) only in doses< 100 мг в сутки.

Patients are guilty of being on the alert when they show symptoms of important arteriothrombotic manifestations (for example, breasts, weakness, weakness, non-viral mova), which may be raptuous. Patients will then instruct about the need for a safe animal to a doctor in some kind of vipad.

hematological efficacy

In case of trivial intake of Voltaren, it is recommended that, in case of trivial intake of Voltaren, it is recommended to control blood analysis. Voltaren, yak і інші NPZP, can be thrombocyte aggregation hourly. To that in patients with damaged hemostasis, a necessary visualization is necessary.

Respiratory efficacy (history of asthma)

Patients with asthma, allergic rhinitis, Nasal mucous membrane (nasal polyp), chronic obstructive diseases of the lungs or chronic infections of the respiratory tract (especially if the smell is tied to the allergic symptoms), Reactions to oil refineries, such as provocation of asthma, kvinke or kropivyanka, occur more often. It is recommended that such children be advised to take care of their care (readiness to extreme situation). It is also possible to be referred to the patients with allergies at their own speeches, for example, with their own reactions, we will get rid of them.

Hepatobiliarnieffectively

Retaliation is necessary if Voltaren is assigned to the patients with damaged functions of the liver, the splinter of their camp can be destroyed.

From the hour to the drug taken, as well as from the hour to the use of other non-steroidal anti-pyretic drugs, one can increase the amount of one or more decalcous liver enzymes. To that, during the trivial therapy with Voltaren in the absence of a foreign approach, it is shown that the function of the liver is regularly updated. As soon as the functional indicators of the liver are damaged on the side of the liver, it is possible to accommodate, or to develop skargi, or the symptoms, which can be caused by the liver disease, and also in that case, if there are any bitter appearances(For example, eosinophilia, visip tosho), Voltaren slid skasuvati.

During the development of liver enzymes, it was caused by one occasional fall of severe liver reactions, including malignancies and in even more rare cases of fulminant hepatitis, liver necrosis and liver disease, as a result of deficiencies It is necessary for mothers on uvaz, that hepatitis on the background of the taken drug can be found without prodromal lesions.

Safety is necessary when Voltaren is diagnosed with pechinka porphyry, some of the drug can provoke an attack on a hostile porphyry.

shkirni reactions

With the intake of NSAIDs, including Voltaren, there have been even more severe cases of fatal, severe reactions, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. samiy high risik The development of these reactions is indicated in the first month of treatment. Voltaren slіd vіdmіniti at the first manifestations of shkіrny visipannya, vyrazok mucous membrane or any other manifestations of hypersensitivity. In patients who have not taken Voltaren before, during the period of treatment with the drug, during the first hour of therapy with other NSAIDs, in some cases, allergic reactions may develop, including anaphylactic reactions.

Efekti z side nirok

Therapy of oil refineries, including Voltaren, can be tied to the front or to the side. Particularly protective is required in case of patients with damaged functions of the heart, or nirok, patients of a sick person, ailments, who have diuretic, And also ailments, for those who have a change in the amount of circulating plasmas of any ethology, for example, in the period before and after massive surgical engagement... Regular monitoring of the function of nirok is recommended for such vapadas for an hour when Voltaren is taken during a foreign call. If you want to change the function to the drug, change the function to the final level.

lіtnі paciєnti

When the drug is used, it is necessary to be protected when the drug is prescribed, especially in the weakened, or there may be a low mass of young patients.

Cooperation with refinery

It is necessary to uniquely take Voltaren's one-hour reception and other non-steroidal anti-fatigues, including ingibitori cyclooxygenase-2, to reduce the risk of additional side effects (div.

Additional speeches

Voltaren tablets take away lactose, so it is not recommended for patients to drink it because of the slump intolerance to galactose, severe lactose deficiency or glucose-galactose malabsorption.

Infection masking

Diclofenac, both non-steroidal anti-pyretic agents, are used to their pharmacodynamic authorities, they can mask the scarg and symptoms characteristic of infectious-ignited ailments.

Influence on the speed of reaction in case of keruvannas by motor transport or robots with other mechanisms

Patients who have an hour of taking the drug are susceptible to damage, damage to the side of the central nervous system, and not to keruvati by motor transport or due to other mechanisms.

Vzaєmodіya with інshі lіkarskiye zasob and іnshі vidi vzaєmodіy

іngіbіtoriCYP2 C9. It is recommended to take precautions when diclofenac is detected in conjunction with potent CYP2C9 inhibitors (such as voriconazole), which can lead to a significant increase in the maximum concentration of diclofenac in blood plasma through suppression.

Litiy. With a one-hour consumption, diclofenac can increase the concentration of lithium in the blood plasma. Plasma monitoring is recommended.

digoxin. With a one-hour consumption, diclofenac can increase the concentration of digoxin in blood plasma. Plasma digoxin monitoring is recommended. diuretic iantihypertensivecostly. Voltaren, as well as non-steroidal anti-inflammatory drugs, in case of alcohol intake with diuretics or antihypertensive drugs (for example, beta-blockers, calcium channel blockers, antihypertensive enzyme inhibitors) This combination of such drugs should be considered safe, and patients (especially lithium) should periodically control an arterial grip.

Likarski zasobi, yaki viklikayuthyperkalemia. One-hour intake of kalyzberіgayuchihdiuretics, cyclosporine, tacrolimus or trimethoprim can produce to increase the level of calories in the blood. In the case of such a combination of likars' participants, the indicator of slides is often monitored.

Інші NPZP and corticosteroids. One-hour intake of diclofenac and other systemic NSAIDs or corticosteroids can increase the frequency of non-essential lesions on the side of the intestinal tract. A slid of a unique one-hour intake of the drug Voltaren with systemic NSAIDs, including selective inhibitors of cyclooxygenase-2, through the availability of any evidence very good from a synergistic action.

anticoagulants iantiplateletpreparations. In patients of pre-adolescent patients, Voltaren was not injected into the drug for anticoagulants, due to the increase in the risk of bleeding in patients who took Voltaren and the drug at once. In case of such an appointment, it is recommended to have a saw and regular watch over the ailments.

Selective reactions of vigorous serotonin uptake (SIZZS). One-hour reception of systemic refineries and SIZZS can increase the risk of intestinal bleeding.

Protidiabetic drugs. Clinical preliminaries brought, that a powerful one-hour intake of the drug Voltaren and anti-diabetic lykarsky patients, while the effectiveness of the remainder does not change. However, some time about development in such cases, such as hypoglycemia, as well as hyperglycemia, as well as the need for a correct dose of succinic drugs in the course of taking the drug Voltarya. For several reasons, it is recommended to control the level of glucose in the blood every hour of therapy.

Є also about development metabolic acidosis with a one-hour reception of diclofenac and metformin, especially in patients with already persistent nircovymal injuries.

methotrexate. Take care of yourself when you receive a refinery less than 24 years before you take methotrexate, some in such drops can increase the concentration of methotrexate in the blood and as it becomes toxic.

phenytoin. When taking phenytoin with diclofenac, it is recommended to monitor the concentration of phenytoin in the blood plasma through cleansed blood plasma.

cyclosporineіtacrolimus. The injection of NPZP on the synthesis of prostaglandins in nirkahs can enhance the nephrotoxicity of cyclosporin and tacrolimus. Therefore, Voltaren should be prescribed in lower doses, lower than that, as indicated for patients who do not take cyclosporin but rather tacrolimus.

antibacterialhіnoloni. Є Okremі about the development of the court at the ailments, who took over one hour hіnoloni і oil refineries.

mifepristone. I’ll look at how non-steroidal anti-fumes can reduce the effectiveness of myfepristone, which should be taken not earlier than in 8-12 days after the end of myfepristone’s intake.

InductorsCYP2 C9: It is recommended to take precautions when prescribed diclofenac with CYP2C9 inducers (for example, with rifampicin), which can lead to a significant decrease in plasma concentration and exposure to diclofenac.

Pharmacological authorities

Pharmacodynamics

Voltaren is to take revenge on diclofenac sodium, a speech of a non-steroidal structure, like a vyklica, an anti-firing one, an analgesic one for a fever-lowering effect. The main mechanism of diclofenac is the galvanization of prostaglandin biosynthesis. Prostaglandins play an important role in the genesis of inflammation, pain and fever.

In case of rheumatic ailments, the antiapharyngeal and analgesic power of the drug Voltaren will not develop a major defect, which is characterized by significant changes in the incidence of such symptoms and scarg, such as when there is a state of calm early and with

In vitro diclofenac sodium in concentrations, equivalent thymus, can be reached when patients are detected, without causing the biosynthesis of proteoglycans in cartilage tissue. In case of post-traumatic and non-operative igniting symptoms, Voltaren shvidko lays down bil (as spontaneous, as well as that, as it is in Russia) and changes in the igniter

Conducting clinical follow-ups gave a significant analgesic effect to the drug in patients with moderate and severe pain syndrome of non-rheumatic genesis. Clinical preliminaries have also shown that Voltaren has a healthy age and reduces the rate of blood loss in case of primary dysmenorrhea.

Pharmacokinetics

Vsmoctuvannya. When the drug is taken in the middle of the day to the drug Voltaren - diclofenac, it is quickly and more absorbed. Already quickly the speed of absorption, a little bit of dialectical speech, as it is absorbed, does not change. For a single-use administered drug Voltaren in a dose of 50 mg, the maximum concentration is reached after approximately 2 years and becomes 1.5 μg / ml (5 μmol / l). The amount of absorbed daily speech is linearly proportional to the dose. The pill passing through the slider is allowed to take place, if the drug is taken for an hour, or even if it is taken, the amount of absorbed diclofenac does not change. Approximately half of the dose of diclofenac is metabolized within an hour of the first pass through the oven (the effect of "first pass"), the area under the curve "concentration-hour" (AUC) for oral administration of abnormal rectal administration becomes approximately half of the first pass through the oven. At the time of the recommended dosage interval for the accumulation of the drug, the drug was not affected.

The concentration of the drug in blood plasma, which can be reached in children at equivalent doses (mg / kg body weight), is subtle enough to be spontaneous in older adults.

Rozpodil. 99.7% of diclofenac is associated with blood plasma proteins, and most importantly with albumin (99.4%). The clear volume of the rosters behind rosrahunks becomes 0.12 to 0.17 l / kg. Diclofenac penetrates into the synovial groove, reaching maximum concentrations after 3-6 years. In two years, after reaching the peak concentration in the blood plasma, in the active speech in the synovial age, lower in the plasma, and becoming so up to 12 years old.

Biotransformation. Biotransformation of diclofenac is transformed into a small amount of glucuronidation of a molecule, but it is not important for a single-use and multiple hydroxylation and methoxydexylation, it is necessary to lead to a solution of 3 -hydroxy - dihydroxy-3 "hydroxy-4" -methoxy-diclofenac), most of which are converted into glucuron conjugates. Two of the three phenolic metabolites are biologically active, albeit in the minority world, not diclofenac.

Eliminatsiya. Zagalny systemic clearance of diclofenac with plasmas becomes 263 ± 56 ml / hv (mean value ± standard dose). The thermal period from the plasmas becomes 1 to 2 years. Chotiri metabolites, including two activities, may also have a short period of time for plasma production. The period from the plasmas of one metabolite, 3 "hydroxy-4" -methoxy-diclofenac, is significantly more trivial; the protein metabolite is actually inactive.

Nearly 60% of the dose taken by the drug is transformed into a cross section of conjugates of a specific molecule and metabolites, most of which can also be converted into glucuronic conjugates. Less than 1% is vivod in viglyadі of the unconscious spoluke, it is vivodіt in viglyadі metabolites in zhovchu.

Special groups of patients.

Significant indications in vmoktuvanna, metabolism and vivedin the drug are poorly seen in patients not spasmed. However, in children of 15 years old, internal infusion led to an increase in plasma concentration by 50%

Umovi zberigannya

Take at a temperature of 30 ° C out of the reach of children. Oberigati vid di vologi.

package

10 tablets in blister. 2 blisters in a cardboard box at once with instructions for medical storage.

Primary packaging material: aluminum foil - PVC / PE / PVDC ply.

For the recipe for liquor.

Virobnik

Novartis Urunlerі

Novartis Urunlery

349112 Kurtkoy, Istanbul, Turkey

applicant

Novartis Pharma AG

Lykarska form

Tablets, in intestinal corrosive shell, 50 mg

warehouse

One pill to take revenge

active speech - diclofenac sodium 50 mg,

additional words: corn starch, lactose, sodium starch glucose (type A), microcrystalline cellulose, silica coloidal anhydrous oxide, povidone K30, magnesium stearate,

shell warehouse: hypromelose, talc, zhovtium oxide (E172), titanium dioxide (E171), macrogolglitserol hydroxystearate (polyoxylated 40 hydrogenized castor oil), 17266 ethanol oxide dispersion 17266 (E172) 1) / copolymer methacrylic acid, macrogol 8000 (polyethylene glycol 8000), silikone foam remover SE2.

lykarskoy form"Type =" checkbox ">

Description of licarskoy form

Tablets of a round shape, with a double-convex surface, in a shell, light brown color, with a bevel, engraving "CG" on one boat and "GT" on the other side.

Pharmacotherapeutic group

Protisapalny and antirheumatic drugs. Non-steroidal antiapalny drugs. Oztovy acid and old. Diclofenac.

ATC code М01А В05

Pharmacological authorities

Pharmacokinetics

When I take the pills in the middle of the pills, covered with the intestinal-corrosive shell, diclofenac will get wet when passed through the slurry. At the time of taking the pill, the drug takes an hour or so when it goes through the slurry to get along (in some cases, until the day is taken), but diclofenac does not get wet. For a single dose of 50 mg of the drug, the maximum concentration in plasma changes after 2 years and becomes 1.5 μg / ml (5 μmol / l). The stage of absorption is located in a straight line according to the size of the dose. For repeated use of the drug, the pharmacokinetic indicators do not change. If the recommended intervals between the doses of the drug are taken into account, the cumulation is not implied. The link with blood cells becomes 99.7%. The link between the two is overloaded with albumin (99.4%). The clear volume of rosodil becomes 0.12-0.17 l / kg. Diclofenac penetrates into the synovial line, so the maximum concentration is reached for 2-4 years before, below the blood plasma. The clear period from the synovial age becomes 3-6 years. After 2 years, after reaching the maximum concentration in the plasma, the concentration of diclofenac in the synovial age, lower in the plasma, and the meaning of being lost for a period of up to 12 years.

Metabolism of diclofenac is supported by a small amount of glucuronization of non-modified molecules, ale, by a head, behind the addition of one-time bagatorase methoxy, which should be produced until the approval of decalcine phenolic metabolites (4- "-hydrox), 5 -digidroxy- and 3 "hydroxy-4" -methoxydiclofenac), most of which are converted into glucuronidated conjugates. Two of the three phenolic metabolites are biologically active, albeit in a significantly lower level, not diclofenac. Zagalny systemic plasma clearance of diclofenac becomes 263 ± 56 ml / min. Kintseviy period should be 1-2 years old. The period for 4 metabolites, including two pharmacologically active ones, is also non-trivial and is 1-3 years old. One of pharmacologically inactive metabolites, 3 "hydroxy-4" -methoxy-diclofenac, most of the trivial period of time.

Close to 60% of the dose of the drug is taken from the section in vigels of conjugates without any active speech, as well as in vigels of metabolites, most of which are glucuronic conjugates. In an uncontested viglyad, less than 1% of diclofenac is injected. Reshta stasis dose of the drug is vivod in viglyadі metabolites through zhovch, with feces.

If the dose is taken in the middle of the rectal administration of the AUC of diclofenac, it changes by half, about half the dose of diclofenac is metabolized for the first hour of the first passage through the oven. The concentration of the drug in plasma when taking equivalent doses of diclofenac in children (mg / kg body weight) was similar to the concentration of the drug in older adults.

Pharmacokinetics in okremich groups of ailments

When a drug is taken, it does not mean that it has any metabolic and metabolic effects on the drug, which are associated with every patient.

In patients with impaired functions of nirok when prescribed the drug Voltaren ® in special single doses, accumulation of diclofenac was not seen. At the same time, if the creatine clearance becomes less than 10 ml / hv, the concentration of hydroxy metabolites in diclofenac is approximately 4 times more important than in healthy patients.

In patients with chronic hepatitis and compensated liver cirrhosis, the pharmacokinetic indicators of diclofenac are similar to those in patients without liver disease.

Pharmacodynamics

Voltaren ® to take revenge on diclofenac sodium, a non-steroidal structure, which is highly anti-rheumatic, anti-fiery, anti-inflammatory and anti-inflammatory. The main mechanism of diclofenac is galvanizing the biosynthesis of prostaglandins, which play an important role in the genesis of fever, pain and fever.

In case of rheumatic illnesses, Voltaren ®, exhibiting antiapalny and analgesic effects, significantly changes the bile in calmness and in Russia, the rank and swelling of the slopes, and also reduces the function of the slopes.

Diclofenac sodium does not induce biosynthesis of proteoglycans in cartilage tissue.

In case of post-traumatic and non-operative ignition events, Voltaren ® is known to be (spontaneous, so it is victorious for an hour), a change in the ignition bulge and the bulge of the operational field.

Significant analgesic effect of the drug was revealed in case of moderate and severe pain syndrome of non-rheumatic genesis. So it is established, that Voltaren ® is a great usuvati more viewsі reduce blood loss in case of primary dysmenorrhea.

Voltaren ®, besides, we need a friendly way to show the attacks of the migraine.

Shown up to sucking

Inflammatory and degenerative forms of rheumatic fever: rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondyloarthritis, ankylosing spondylitis (Bekhturuv's ailment), pain syndrome of rheumatoid arthritis

Gostri attack gout

Post-traumatic and surgical pain syndromes

Gynecological illness, which is supervised by pain syndrome and inflammation (for example, primary dysmenorrhea and adnexitis)

In the warehouse complex therapy in case of important fiery illnesses of vuh, throat and nose, which are against the swelling of pain syndrome (pharyngitis, tonsillitis, otitis media, sinusitis, sinusitis)

How to store that dosi

Within the framework of the external recommendation, the dose of the drug is guilty of being assigned individually. Pobichna diya It can be minimized for additional consumption of the minimum effective dose for the minimum period necessary for symptom control.

old age

The recommended dose of cob is 100-150 mg / day. In admittedly mild cases of illness, as well as for trivial therapy, there is a sufficient dose of 75-100 mg. I will add a dose of 2 - 3 doses.

In case of primary dysmenorrhea, take a dose individually; get 50-150 mg. The pochatkova dose is guilty of becoming 50-100 mg; if necessary, the duration of the menstrual cycle can be adjusted up to 200 mg / day. Take the drug to fix it when the first symptoms appear. Falling from dynamics key symptoms lіkuvannya can be prodovzhuvati over a stretch of decіlkokh days.

Children over 14 years old

Children over 14 years of age and children should be prescribed the drug in a dose of 0.5-2 mg / kg weight / dob (in 2-3 days, it is a heavy disease). For the treatment of juvenile rheumatoid arthritis, the dose can be maximally increased to 3 mg / kg per day (in 2-3 times).

The maximum dobova dose is innocent of 150 mg.

Gerіatrіya (paciєnti vіkom> 65)

Correction of the cob dose is not required for young patients.

Insertion of the heart-vascular system

As a rule, therapy with Voltaren® is not recommended for patients with heart-and-heart disease for uncontrolled hypertension. If necessary, Voltaren ® is assigned to patients with the development of heart-vascular disease, uncontrolled hypertension, or some factors of the risk of heart-vascular disease. ").

Patients with damaged functions of nirok

Voltaren ® of contraindications for patients with disabilities (div. "Prototype").

Because of the reasons for the presence of special dosages among patients with a damaged function, recommendations for special corrections of dosages are unfortunate. It is recommended to take care of the preservation of the drug Voltaren ® in patients with mild and moderate deterioration of the function of nirok (div. "Particularities of storage").

Patients with damaged function of the stove

Voltaren ® of contraindications for patients with pechinka deficiency (div. "Prototype indications").

Because of the reasons for the presence of special dosages in patients with a damaged function of the liver, recommendations for special corrections of dosages are not advisable. It is recommended to take care when storing the drug Voltaren ® in patients with mild and moderately damaged liver function (div. "Specialties of storing").

Tablets slid kovtati tsilimi, not lamyuchi and not roszhoyuchi, washed down with rіdinoyu, bazhano to go.

Pobichna diya

Often (from> 1/100 to<1/10)

Head b_l, zamorochennya

vertigo

Nudota, bloating, diarrhea, dyspepsia, abdominal pain, flatulence, anorexia

Pidvischennya rivnya transaminaz

Uncommon (≥1 / 1000 to<1/100)

Myocardial infarction, heart failure, accelerated heart rate, lump in the breasts

Ridko (from> 1/10000 to<1/1000)

Hypersensitivity reactions, anaphylactic / anaphylactic reactions, including hypotension

sleepiness

Asthma (including dyspnea)

Gastritis, intestinal tract bleeding (crooked blues, melena, diarrhea with house blood), flanking of the intestinal tract, appearing or perforating bleeding

Hepatitis, zhovtyanitsya, impaired liver function

Kropiv'yanka, teased by shkiri

Duzhe rіdko (<1/10000)

Thrombocytopenia, leukopenia, hemolytic anemia (including hemolytic and aplastic anemia), agranulocytosis

angioedema

Disorder, depression, sleeplessness, no nightmares, gratitude, psychotic problems

Paresthesia, memory impairment, sudomiya, triviality, tremor, aseptic meningitis, dysgeusia, cerebral blood circulation impairment

Destruction of the zoru, fogging zir, diplopia

Dzvin u wuhah, impaired hearing

Hypertension, vasculitis

pneumonia

Colitis (including hemorrhagic colitis and aggravated colitis or Crohn's ailment), constipation, stomatitis, glosses, lesions on the side of the duct, intestinal diaphragm seizure, pancreatitis

Bliskavichny hepatitis, necrotic hepatitis, pechinka deficiency

Bullosa dermatitis, eczema, erythema, multiforme erythema, Stevens-Johnson syndrome, toxic epidermal necrolis (Lyll's syndrome), exfoliative dermatitis, alopecia, photosensitivity reaction, purpura, purpura-Shurpura

Gostra nirkova deficiency, hematuria, proteinuria, nephrotic syndrome, tubulointerstitial nephritis, nircovy papillary necrosis

Prototype

Sensitivity to diclofenac is increased and be-a kind of ingredintev drug

Virazkov ailment of the slunk or intestines in the stage of aggravation, bleeding or perforation

Frequency and Period of Breast Care

pechinkova lack

Nirkova lack

Important heart failure

History of attacks of asthma, spillage, gastric rhinitis, associated with suction of acetylsalicylic acid and any other non-steroidal anti-inflammatory drugs

Infection of the hematopoietic system

Treatment of surgical pain during coronary artery bypass surgery or blockage of unit blood circulation

Childish vіk up to 14 years old

likarskі vzaєmodії

Strong Ingibitories CYP2C9

It is recommended to take precautions when diclofenac has been identified with highly toxic CYP2C9 inhibitors (such as voriconazole), which can lead to a significant reduction in the maximum concentration in blood plasma and expression through diclofenac.

Litiy, digoxin

Voltaren ® can increase the concentration of lithium and digoxin in blood plasma. It is recommended to control the level of lithium and digoxin in the blood.

diuretic

Voltaren ®, as it is itself and the only non-steroidal anti-pyretic drugs (NPZP), can change the frequency of diuretic action. One hour the storage of kalyzbergyayuchih diuretics can produce up to the growth of kaliyu in the blood (in the case of such an admission of likars' possessions, the indicator is regularly monitored).

Likarski zasobi, yak, yak vidomo, viklikyut hyperkalієmiyu

Supplementing with kalizberigayuchimidiuretics, cyclosporine, tacrolimus or trimethoprim can be associated with increased calories in syrovattsi, but also, can be regularly monitored.

NSAIDs and corticosteroids

One-hour systemic intake of non-steroidal anti-inflammatory drugs (NSAIDs) can increase the incidence of non-steroidal diseases.

anticoagulant

If there is no anti-coagulant drug in the clinics, Voltaren® is not used for anticoagulants, if there is an increase in the risk of bleeding in patients who have taken Voltaren® and the drug at one time. That, in the time of such a day of likarsky zasobіv, it is recommended to saw and regularly watch over the ailments.

Selective serotonin poisoning (SIZZS)

The consumption of systemic refineries, including diclofenac, and SSRIs can reduce the risk of intestinal bleeding.

antidiabetic drugs

With a one-hour consumption of the drug Voltaren ® and anti-diabetic drugs, the effectiveness of the remaining drugs does not change. However, depending on the development of hypoglycemia, as well as hyperglycemia, it is necessary to change the dosage of sucrose-negative drugs during the hour of consumption of Voltaren®.

phenytoin

In case of vikorstanny phenytoin spilo with diclofenac, it is recommended to monitor the concentration of phenytoin in the blood plasma in the course of the improved stage of exposure to phenytoin.

methotrexate

After taking care of the prescribed non-steroidal anti-inflammatory drugs (NSAIDs), less than 24 years before or when taken with methotrexate, some of these types of drugs may show a toxic concentration of methotrexate in the blood.

cyclosporine

The injection of non-steroidal anti-inflammatory drugs (NSAIDs) on the synthesis of prostaglandins in nirkahs can enhance the nephrotoxicity of cyclosporin

Antibacterials - lost hinolon

Є About the occasion of the development of the court in ailments, who immediately removed the lost chinolone and non-steroidal anti-inflammatory drugs (NSAP).

special requests

In case of stagnation of all refineries, including diclofenac, a diagnosis of intestinal bleeding is registered, an increase in intestinal bleeding, or perforation, which can be fatal, and it may become fatal at any hour in the process of intestinal symptoms due to the presence of lateral path. Evidence to call forth more serious inheritance from the children of the kidnapped child. Even in patients who take diclofenac, it means the symptoms of intestinal bleeding;

In case of stagnation of non-steroidal anti-inflammatory diseases, including diclofenac, for patients with symptoms, it is possible to indicate a breakdown on the side of the shlunkovo-intestinal tract, data on the appearance of perforation in the history of bleeding, and special safety. The risk of bleeding, swelling or perforation in the intestinal tract is increased with an increase in the dose of NPZP, including diclofenac, and patients with a particularly rapid bleeding in anamnesis. To reduce the risk of such a toxic infusion on the intestinal tract, it is necessary to fix it and reduce it with minimal effective doses.

For such patsієntіv and takozh quiet, hto potrebuє co-current zastosuvannі lіkarskih zasobіv scho mіstyat nizkі Dozy atsetilsalіtsilovoї acids abo іnshih lіkarskih zasobіv, SSMSC, ymovіrno, pіdvischuyut rizik nebazhanoї dії on shlunkovo-kishkovogo path, slіd rozglyanuti supply about zastosuvannya kombіnovanoї terapії іz zastosuvannyam zahisnih zasobiv (for example, proton pump ingibitoriv or misoprostol).

Injection to the heart-vascular system

Therapy due to the intake of NPZP, including diclofenac, zokrem at high doses and triviality may be associated with insignificant changes in the risk of important heart-vascular thrombotic processes (including cardiac infarction).

As a rule, therapy with Voltaren® is not recommended for patients with heart disease (congestive heart failure, ischemic heart disease, peripheral arterial ailment) for uncontrolled hypertension. When neobhіdnostі Voltaren ® priznachaєtsya patsієntam of vstanovlenim Sertsevy-sudinnim zahvoryuvannyam, nekontrolovanoyu gіpertonієyu, abo іstotnimi factors riziku Sertsevy-sudinnogo zahvoryuvannya (gіpertenzіya, gіperlіpіdemіya, tsukrovy dіabet i kurіnnya) tіlki pіslya retelnoї otsіnki i tіlki in furrows Dobovo doses ≤ 100 mg razі terapії trivial 4 days.

I will look at the young growth of risiks from the side of the heart-vascular system as a result of the dosage and triviality of the exposure, it is necessary to take the minimum effective dose of diclofenac during the minimum period. It is necessary to periodically re-assess the consumption in the reduction of symptoms and indications of the patient's therapy, of the cream during the triviality of the therapy for 4 days.

Patients who are guilty have been informed about the risk of diagnosing serous thrombotic diseases (lump in the breasts, sluggishness, weakness, breakdown), as they can be diagnosed at any hour without symptoms. In the whole vipadku slid inaccurately turn up to the lykar.

Infusion for hematological indicators

If the given drug is recognized for a trivial period, it is recommended (as for the other oil refineries) to regularly monitor the blood picture. Diclofenac, which is the only NPZP, can be triggered for an hour by platelet aggregation, so it is necessary to control patients with impaired hemostasis.

Infusion to the spinal system (history of asthma)

In patients with asthma, seasonal allergic rhinitis, nasal mucous membrane enlargement (for example, nasal polyp), chronic obstructive diseases of the lungs or chronic infections of the respiratory tract (especially in cases of allergic diseases, associated such side effects, such as aggravated asthma (this is the name of intolerance to analgesics or analgesic asthma), Kvinke or kropivyanka. At the connection with such ailments, we need special extra help (readiness to get some extra help). Visitors can also be afraid of patients with allergic manifestations in case of the intake of other drugs, for example, visip, sverbinny or sprinkling.
Injection to the stove

A retinal medical look is required for a patient, if Voltaren ® is assigned to patients with damaged functions of the liver, some of them may fail. Yak і in case of stagnation of the other non-steroidal anti-pyretic substances, including diclofenac, the level of one abso-decile enzymes

the ovens can move.

After an hour of tricky treatment with the Voltaren ® preparation, a regular observation of the function of the liver and of the liver enzymes in the background of a trip is indicated. If the function of the liver is damaged, it may be lost or it may be lost, and there are some important signs, or symptoms may be associated with progressive liver damage, or it may be that the preparation appears (for example) Perebіg sickness, such as hepatitis, may pass without prodromal symptoms. Awareness is necessary in vipadku, as Voltaren ® stays with the children with pechinka porphyry, through the imovirnist provocation of the attack.

shkirni reactions

In connection with the congestion of NPZP, including the drug Voltaren®, in even more rare cases of boules, serious reactions have been registered from the side of the shkiri (some of them are fatal), including non-toxic dermatitis, toxicity syndrome - jaundice. In the patients, a high risk of cich reactions appeared on the ear of the course of therapy: the reaction of the reaction was determined in a large number of reactions in a stretch of the first month of treatment. Stagnation of the Voltaren ® preparation must be pinched at the first appearance of the shkirny visipu, severe mucous membrane, or any signs of increased sensitivity.

Inflow to nirki

Oskіlki at lіkuvannі NPZZ, vklyuchayuchi diclofenac zareєstrovanі vipadki zatrimki rіdini i nabryakіv, Especially uwagi slіd pridіliti patsієntam of torn down funktsії sericite abo nirok, arterіalnoyu gіpertenzієyu in anamnezі, patsієntam Pokhil vіku, patsієntam, SSMSC otrimuyut terapіyu dіuretikami abo preparations SSMSC suttєvo vplivayut on funktsіyu nirok, as well as to patients with hundreds of reductions in post-mortem volume of a child for any reason, for example, to the point of serious surgical involvement. It is recommended to monitor the function of nirok in such vipadkas in the quality of a foreign call. Pryinennya therapy zzvychay to bring up to turning to the camp, as if overduging likuvannya.

Zastosuvannya at the special age

It is necessary to protect the use of the drug for people who have been kidnapped, according to the main medical practice. Zokrem is recommended to indicate the minimum effective dose for weakening patients of summer age or for patients of summer age with little body.

Cooperation with refinery

Slid unique one-hour consumption of the drug Voltaren ® from systemic refineries, including selective ingibitori COG-2, on the basis of non-essential infusion.

Mask to show infectious diseases

Voltaren ®, as the only non-steroidal anti-fatigues, can mask symptoms of infectious diseases if they are used by their pharmacodynamic authorities.

The drug should not be used by individuals with decay intolerance to fructose, Lapp lactase deficiency, malabsorption glucose - galactose.

Frequency and Period of Breast Care

Zasosuvannya diclofenac in vagіtny women didn’t get. Voltaren ® is not meant to signify the first two trimesters of vaginosity, as only the corny of the disease does not transplant the rhiziki for the fetus. For other refineries, the prescription of the drug in advance of the third trimester of vaginosity is not indicative of the development of the weakness of the generic activity of the uterus and / or early closure of the arterial duct.

As a result, diclofenac is seen in small amounts in breast milk. In such a rank, Voltaren ® did not go to waste in the period of a year of breastfeeding;

As well as non-steroidal anti-fatigues, Voltaren ® may negatively infuse fertility on women, so it is not recommended to prescribe the drug to women who are planning to become overwhelmed. For women who may have problems because of conception or to pass the drive beforehand, then they will see the accuracy of the drug Voltaren ®.

Special features in pouring likarsky into the building of keruvati by means of transport or potentially not safe mechanisms

Patients who see Voltaren ® for an hour on the day of taking the drug are frozen or inappropriate to see from the side of the central nervous system, including a damaged gap, not due to the mechanism of transport by means of storage.

Overdose

Symptoms: blues, shlunkovo-intestinal bleeding, diarrhea, zapamorochennya, noise in the vuhah abo sudomi. In the case of a heavy detachment of the powerful development of a hostile deficiency and a loss of liver.

Likuvannya: admitting and symptomatic therapy. Stagnation of forced duresis, hemodialysis or hemoperfusion is not very effective for the administration of non-steroidal anti-inflammatory drugs (NSAIDs), since the active speech of these drugs in a significant world is associated with intense plasma It is possible to discern the possibility of storing an active substance in case of an overdose of the drug, as well as a slurry decontamination (for example, bluing, washing a slurry).

Termіn zberіgannya

Do not fix the message for the end of the term of accessibility indicated on the package.

Mind that term zberigannya

For the recipe

Virobnik

Novartis Urunlerі

Kurtkoyu, 34912 Istanbul

Medication for Voltaren 50 is administered to a group of non-steroidal anti-inflammatory drugs (NSAIDs) and vicious in case of advanced degenerative and ignition pathologies. A high level of efficiency and a wide range of activities explain the popularity of the drug.

Form vipusk and warehouse

The drug is used for rectal suppositories, tablets and sizes for internal injection.

1 tablet vmschuє 25, 50 or 100 mg of the active ingredient - diclofenac. Other row warehouses:

lactose;
copolymer of methacrylic and polyacrylic acids;
hydroxy stearate polyethylene glycol glyceryl;
hypromelose;
sodium carboxymethyl starch;
povidone K30;
corn starch;
magnesium stearate;
microcrystalline cellulose;
anhydrous aerosil (coloidal silicon dioxide).

Tablets are packed in contour strips of 10 pcs. 1 box contains 1, 2 or 3 strips.

Rectal suppositories include 25, 50 or 10 mg of the active ingredient in their warehouse. Dodatkovі Ingredієnti - hard fats. Installed in blister 5 pcs. In 1 cardboard box there are 1 or 2 blisters.

25 mg of diclofenac are available in 1 ml of the drug. Dodatkovі speeches:

sodium hydroxide;
sodium disulfite;
benzyl alcohol;
manit;
ін'єкційна Рідина;
propylene glycol.

Distribution of rooms in ampoules of 3 ml. The carton pack contains 5 ampoules.

Pharmacological diya Voltaren 50

Chinniy іngredієnt to the medication (diclofenac) is feverish, febrile and anti-fiery power.

The principle of the drug is primed on the strangled prostaglandin viroblast, as it is vicious a fever, bile and fiery.

The medicine quickly assimilates the pain, reduces the swelling and ignition process.

Diclofenac is rapidly absorbed from the strainer. Boundary concentration of active speech in the blood plasma is recruited in 1.5-2 years (in the case of the expiration of an early breakdown, the terms change to 20 quilins). Rivn vmoktuvannya to lay down for the duration.

Ja galm the passage of liquor through the intestines. Kintseviy term napivvydennya - from 1 to 2 years. Up to 60% of the dose is given with nirkas. Іnsha part of the liking vivoditsya at once zhovchyu.

Voltaren's show before sucking 50

Refinery is recognized in the following categories:

money-generating and fiery forms of rheumatic pathologies: osteoarthritis, arthritis, spondylitis (for the first time);
pathology of the musculoskeletal device (for pills and tablets);
ailments of the ridge, scho suprovodzhuyutsya pain;
zhovchna і nirkova kolka (for infusion razchina);
gynecological pathology, which is supervised by heat and pain;
in complex therapy of ignition and infectious diseases of ENT organs: otitis media, tonsillitis, pharyngitis;
m_gren (for rectal flukes);
varicose veins, scho supravodzhuєtsya discomfort in children;
attack gout (for іn'єktsіyny і pills).

Victory in the eyes of an infusion-related problem is very important for the very ear of a sharpening of degenerative and fiery pathologies.

How to secure

The tableted form of the refinery is designated for oral administration. For regular patients, the average dose should be 100-150 mg per day. For the treatment of lung pathologies, add 75-100 mg of the drug for doba. Denna dose is guilty but not more than 150 mg.

For children with a carriage more than 25 kg, a dose of lykarsky is taken from a dose of 0.5-2 mg per 1 kg of oil.

For children who change 25 kg, the dose should be paid for an analogue of tablets.

Ін'єкційний разчин is introduced into the sydnichny m'yaz. It is not advisable to inject the drug into the tissue. The average dose is 75 mg / day.

In important situations, 2 doses of 75 mg can be administered at intervals of 2-3 years. When the stove is affected, the guilt is taken up individually.

Voltaren's Little Girls 50

At a refinery station, there are some negative manifestations:

etching system: anorexia, glositis, stomatitis (aphthous), shlunkov_ spasms, penetration, nudota, bloating, pain in the epigastric state, pancreatitis, constipation, staggering Crohn's ailment, or malfunctioning ailment;
nervous system: loss of memory, vessels of the disease, depressive conditions, increased nervousness, paresthesia, loss of memory, headache, aseptic form of meningitis, tremor, sleep disturbance;
organ sensitive: impaired hearing and healthy function, impaired relish, hum in wuhah;
shkirni reactions: sprinkling, bulging visibility, Lyell's syndrome, multiforme erythema, hair loss, purpura, photosensitivity;
CCC: beating behind the breastbone, increasing the arterial grip, sharpening the congestive lack of heart, making the heart stronger;
secular system: swelling, aggravated lack of nirok, proteinuria, hematuria, papillary form of necrosis, interstitial nephritis;
hematopoietic system: thrombocytopenia, agranulocytosis, anemia (aplastic and hemolytic), leukopenia;
allergic manifestations: bronchial spasms, anaphylactic and ana lytic reactions, pneumonitis, vasculitis;
local reactions: aggravated hemorrhoids (in case of vikorystanny svichyk), deflation and bile in the mice in'n'ktsiy (for razchin).

Prototype

Oil refinery plant is protected by vikoristovuvati when:

proctitis (for rectal testicles);
intestinal and slurry paths;
incomplete vіtsі (for іn'єktsіy razchіy);
vaginosti (for retail).

special requests

During the period of the refinery’s storage, the patient needs to have a clear view of the hotel.

Lіkіnіm paіnіnіm lіki is given carefully, especially with a small mass of tіla and in case of deteriorated function nirok.

I’ll look at those who, with the use of non-steroidal anti-fiery fires, can get lost and lost, and then go out of control in the whole period of transport.

Stagnation during vaginosis and during lactation

Ін'єкційний Roschin does not become vicious when the fetus is adorned. Tablets and suppositories are used for protection.

If it is necessary to pierce the course of the difference in the period of lactation, then, as a result of breastfeeding, it is necessary to use it.

Zasosuvannya in children

Candles and tablets are indicated for use. Dozuvannya rorakhoyuyutsya in the fallow of the land. Ін'єкційна suspension is suggested for storage in an incomplete vіtsі.

Overdose

Not a typical clinical picture of an overdose of diclofenac.

Symptomatic / susceptible entry is indicated in case of a lack of nirok, a low grip, sudoma, bad or damaged in the robotic herbal system.

In addition, the ailing person needs to clean the slurry pipe and the vipity of the water.

likarska vzaєmodiya

Diclofenac is a healthy plasma solution for digoxin and lithium when given with similar drugs.

Medication for lowering diyu diuretics.

The refinery will need to start carefully with oral hypoglycemia, and the development of hypoglycemia.

The drug can cause nephrotoxicity to cyclosporine.

Terms and conditions

Liks are required to be taken at room temperatures, to save from a dream and a doctor. The tablets do not consume their pharmacological activity for 5 years, rectal suppositories - for 3 times, and for 2 times.

Mind that term zberigannya

Refinery maє recipe output.

Price

Tablets - 304 rubles. for 20 pcs.

Rectal suppositories - from 319 rubles. for 5 pcs.

Shot for injections - from 300 rubles. for 5 ampoules of 3 ml.

analogs

Good substitutes for the drug:

Diclofenac (gel, tablets and infusion roschin);
Naklofen Duo;
Naklofen SR;
Dock;
Diclofenac-Solofarm;
Ortofen (gel);
Diclac (gel);
Diklonat (rozchin).

Vidgooks

Inna Smirnova, 42 rocky, m Ufa

Dіevy zestboluyuyu drug. For usunennya headache or toothache vistachє 2 tablets. In case of pomіrnyh attacks, add і 1 tablet. If you change the dose, then you will fix the pain of the shlunny.

Varvara Drobisheva, 39 rockiv, m Yekaterinburg

Nabuwala tsey medication once. Yogo zebooluvalnuyu action manifests itself promptly. Kindly know more of the great adventures. It is released immediately in decile forms, which will expand the scope of the drug's consumption.

Petro Suchkov, 40 rockiv, m Saint Petersburg

Feeling that the drug is inoperable, then I get a cup of tea in overhauled pharmacies. I am very aware of the fever and help you to get in with the pain and aches in everything.

You can be tsikavo:

Porivnyannya Diclofenac and Mydocalma

Vipusku form

pills

warehouse

1 tablet to take revenge: diclofenac sodium 50 mg. Auxiliary words: silica coloide anhydrous oxide - 6 mg, microcrystalline cellulose - 10 mg, lactose - 25 mg, magnesium stearate - 1.5 mg, corn starch, carboxylic acid 30 mg - 74.5 mg sodium - 20 mg. Composition of the shell: hypromelose - 3.29 mg, macrogol glitserylhydroxystearate - 150 μg, barvnik zaliza zhovtiy oxide - 310 mcg, barvnik zaliza cervonium oxide - 20 mcg, talc - 2.92 mg, titanium dichloromethane - 310 mcg. copolymer of methacrylic acid and ethyl acrylate (1: 1) - 12.42 mg, macrogol 8000 - 1.24 mg, silikonova anti-foaming emulsion SE2 - 100 μg, talc - 1.24 mg. zhovtium oxide - 130 mcg, barvnik zaliza chervonia oxide - 10 mcg, talc - 1.25 mg, titanium dioxide - 130 mcg.

pharmacological effect

prototypalnu Mistseve

Pharmacokinetics

Absorption and growth in organisms. The amount of diclofenac, which is absorbed systemically from the Voltaren plaster lasting 24 years, is similar to that with the intake of an equivalent amount of the drug Voltaren Emulgel (gel for the lasting intake of 1%). 99.7% of diclofenac is associated with syrovatous beads, mostly with albumin (99.4%). Eliminatsiya. Zagalny systemic clearance of diclofenac with plasmas becomes (263 ± 56) ml / min. The terminal T1 / 2 in blood plasma becomes 1-2 years. Chotiri metabolites, including two active ones, may also have a short T1 / 2 - 1-3 hours. One metabolite - 3 "hydroxy-4" -methoxy-diclofenac - little more trivial period of time, prote, є inactive. Diclofenac and its metabolism are mainly found in the urine. In patients who suffer from chronic hepatitis or undecompensated cirrhosis, the kinetics and metabolism of diclofenac undergo the same scheme, as in patients who do not suffer from liver disease. Doklіnnіchnі doslіdzhennya showed the safety of the drug.

showing

pain in the back with fiery and degenerative diseases of the ridge (radiculitis, osteoarthritis, lumbago, ishias); pain in the slopes (swelling of the fingers, colony and in.) with rheumatoid arthritis, osteoarthritis, pain in the joints (as a result of stretching, overstraining, clogged muscles, injuries); fiery and thickening of soft tissues and loops in the event of injuries and rheumatic diseases (tendovaginitis, bursitis, uterine articular tissue).

Prototype

sensitivity to diclofenac or other components in the drug was adjusted, sensitivity to attacks in bronchial asthma, asthma attacks, or in cases of acute rhinitis in case of intake of acetylsalicylic acid and some refineries; vagіtnіst (III trimester); damage to the integrity of small curves in the process of transferring paste to plaster; breast vigoduvannya, childish vіk (up to 15 years). erosive-virazkovі uzhennya shlunkovo-intestinal tract; severe damage to the function of the stove and nirok; chronic heart failure; bronchial asthma; abducted vіk.

Stagnation during vaginosis and breastfeeding

Vikorstannya to the drug in vaginal not injected, that the transdermal plastir Voltaren is not guilty of stagnation in the length of vaginosity, especially in the III trimester through the possibility of a decrease in the tone of the uterus, or for the early clotting of the arterial duct of the fetus. , canopy, embryonic and postemmbral development. There is no information about the penetration of the drug into breast milk, so the transdermal Voltaren plastir is not recommended to be used for breastfeeding for an hour.

How to store that dosi

The dose is taken individually, it is recommended to take the drug in the smallest effective dose, as soon as possible with the shortest possible treatment period. In relatively mild cases of illness, as well as for trivial therapy, 75-100 mg / day is sufficient. I will add a dose of follow-up to a few cases. if the total dose is not to blame, it is not guilty to change 150 mg. get 50-150 mg. The pochatkova dose is guilty of becoming 50-100 mg; if necessary, the duration of the menstrual cycle can be adjusted up to 150 mg / day. Take the drug to fix it when the first symptoms appear. The dynamics of clinical symptoms can be continued for a period of several days. For children aged 1 and older, the drug should be prescribed in a dose of 0.5-2 mg / kg body weight / add (in 2-3 days, hard times). For the treatment of rheumatoid arthritis, the dose can be maximally increased to 3 mg / kg (in a few doses). The maximum dobov dose is 150 mg.

Pobichna diya

Undesirable reactions are mainly characterized by small and small manifestations in the process of applying plasters.

Overdose

On the edge of the systemic absorption of active components and the drug form, the drug is practically ill-advised to prevent overdose in case of excessive consumption.

Interaction with other drugs

Plastir Voltaren can be used with diy drugs, which allows for photosensitivity reactions. No significant interaction with other medicinal products is described.

special requests

Transdermal plastir Voltaren has been pasted only on non-shkodzhenu shkira, uniquely hitting on wounds. Do not allow the preparation to be consumed in the eyes and on the mucous membrane. When the transdermal Voltaren plaster is consumed for another three hours, it is impossible to develop the possibility of developing systemic unwelcoming reactions. With an additional dose of diclofenac in the form of diclofenac, followed by a dose of diclofenac in the plaster, the maximum additional dose of diclofenac (150 mg / dose) should not be transferred. Not injectedє.