In the course of reducing the dosage of antipsychotics olanzapin. Pharmacological action of olanzapine and is indicated before consumption

Olanzapin is a drug from a group of neuroleptics, which is an atypical neuroleptic and antipsychotic drug. Characterized by over-great numbers of sidelines and a wide range antipsychotic infusion, as a matter of fact, with a drug of the first row in folding psychopathological camps, with an urinary control on the first stages of lykuvannya.

Active speech: olanzapine

Form vipusku: tablets, in a shell

Olanzapin is used for:

• All forms of schizophrenia, including schizoaffective disorders.
• Psychosis, unspecified in diagnostics, inorganic ethology.
• Bipolar affective disorder.

Pharmacological injection olanzapin

Until the day olanzapin is kindly taken away serotonovs, dopamines, muscarinovs, histamines and alpha-adrenergic receptors of the central and vegetative nervous system I will get a wide antipsychotic effect. The inflow on the building road is turned weakly, so it is practically not important to see the visible motor views.

Olanzapin is even more effective against productive symptoms, such a yak is a delusional-hallucinatory complex, cognitive-affective problems, more aggressive and aggressive to social, increased adolescence. On the smallest therapeutic effect, Volodya deyakoy smoothness to symptoms, which are often prevented from taking neuroleptics for an hour - emotional dullness, introverted, verbal dislocation.

Olanzapin to achieve an effective decrease in the quality of the emotional experience, decrease in aggression, impulsiveness and innovation, in the form of smoothness to the inflow of more sophisticated mockery. characteristic feature to the drug є lowering the quality of the mental reflex.

A good turn of the hourly characteristics into the flow of the drink - a visible therapeutic effect starts to manifest itself step by step until another month of intensive use of olanzapin, instead of helping to achieve the value of the effect, and the maximum time to be brought to the fourth day.

The drug can be hyperprolactic dyu, which is especially good for sparing in case of trivial stagnation. In addition, there may be damage to motor functions, as a result of direct injection into extrapyramidny systems... To promote, also to increase the amount of oil - close to 450 g per day, the Danish phenomenon is promoted and promoted when the drug is administered.

Olanzapin finish shvidko get wet in the shelter shlunkovo-intestinal tract, Scho do not lie in the reception of the uzhi. The maximum concentration in the blood and tissues is reached after 4-6 years, in the depletion of the fluid, the exchange of words of a particular organism.

Olanzapin is a deyakim carcinogenic effect. Before the test, they showed that a dose of the drug could be used to overtake the therapeutic dose of the drug, and it could stimulate the drug. crayfish, Take in the dynamic development. Previously, they had hemangiomas and hemangiosarcomas of the liver. In addition to circulating stimulation of prolactin, olanzapine stimulates the development of adenoma and adenocarcinoma of lactic acidosis.

No mutagenic effect has been found in Lika.

In laboratory animals, fertility has been revealed for the trivial consumption of olanzapin, and, more importantly, in males.

Significant teratogenic effect of the drug is not revealed, however, there can be a change in the weight of the fetus, the term of vaginosity can be improved and the drug appears in the mother's milk. The last days were carried out on big pike. Pidtverdzhennya about the presence of the drug in young women.

Prototype indications and additions of olanzapine

The inclusion of olanzapine in the drug scheme in women who are breastfeeding is contraindicated.

I can be confused by the drug intake - chronic nirkov and pechinka deficiency, pathology of pre-mucous disease, epileptic attacks of the risky step severity, including - in the anamnesis in advance, parkinsonism, failure of the brain, organ and nonorganic etiology, Alzheimer's ailment, hyperglycemia, decrease in the number of chronic diseases of the blood, stage of the disease cancer milky vines.

Pobichni dii olanzapinu

Nervous system.
You can get lost, part of the headache, even stiffer up to analgesics and coffee, migraine-like problems, spontaneous weakness, asthenia, sleep disturbance on offended sides, stimulation of anxiety amnesia, symptoms of anxiety. In addition, such problems can often be manifested, as a result of trivial treatment with olanzapine - obsessions, compulsions, neuralgia of developmental folding and genesis, disruption of motor functions, epileptic manifestations, disruption of thinking, blood points in the eye, insult, nistagmus, cataract, clouded horns, more views in the eyes and in the ears, noise, deafness, twisting of relish receptors.

The heart-sudin system and the blood-forming system.
You may show hypotensive failures, damage heart rhythm in the direction of more frequent abnormalities, extrasystole, heart disease, cyanosis of mucous and scintillating curvatures, further decrease in the number of blood-borne children, hemorrhagic syndrome.

The system is dyhny.
Rozladi, add up to key signs gostrich respiratory infections- rhinitis, pharyngitis, hardening of the cough reflex, zadishka, exercise of the dyshy rhythm.

The system is herbal.
Bulimic complex on aphids with appetite, dryness of mucous membranes mouthwash, Pidvischene sleepiness, stomatitis, gingiviti, destructiveness herbal functions into the slunker and the small intestine, which manifests itself as a stove, vidryzhkoy, a kind of hickory. In addition to pererakhovannyh vische rozladiv, there are possible mimic acts of defecation and igniting phenomena in the ovens and jovial paths.

Sechostatev system.
Mimovilny acts of sevivipuskannya, pіvischene or a decrease in sechovipuskannya, appearing in the sechі bіlka, gіnіh tіletsі, kіtin krovі. Often there are infectious processes in the secular paths and cuttings, Decrease in sexual activity, decrease in potency, ejaculation of dysfunction, rupture of the menstrual cycle.

Іnshe.
Often there are fiery and dystrophic pathologies in the area of ​​loamy, myostenia, sudomy, pain in the worms, increased sensitivity to light, mid-range conditions, dry lesions in visceral dermatitis, such

Before the hour of the first reception, it is necessary to have a binding stitch for the activity of the patient's liver, especially for the activity of transmiasis. I will look at atypical olanzapina in the plan for the stimulation of suicidal attacks, the obligatory stationary monitoring of patients in the period of the first course of treatment.

For an hour of love, it is necessary to interrupt the be-yak i social activity, SHO VIMAGAє PIDVISCHENO UVAGI, management of transport means and folding mechanisms. welcome alcoholic beverages I am guilty of buty on the basis of victories.

Olanzapin: instructions from the reception and advice

Latin name: Olanzapine

ATX code: N05AH03

Diyucha speech: Olanzapine

Virobnik: Synthon Hispania (Ispania), Pivnichna Zirka (Russia), Ozon (Russia), AT "ALSI Pharma" (Russia)

Description and photo: 21.11.2018

Vikoristovuyt liquor on the basis of olanzapine speech. It is a simple drug-free drug with different trade names, ale the same neuroleptic drug. One of such leaks is the medication "Olanzapin", analogs of it, in its own warehouse, to place the active component.

Before taking the drug

Dane antipsychotic zablyaєtsya plant "ALSI Pharma" ZAT in viglyadі light-zhovtih tablets, the form of such nagadu cylindrical double-tubercles.

Інн ліки in chotir'okh dosuvannyah. Skin dosage tablets are given in a gravitational manner. For a dosage of 0.0025 g, it is written "L", for a dose of 0.005 g, the value "FA20" is used. Tablets with 0.0075 g of olanzapin may be gravitated with "F20C", and with 0.01 g of the active ingredient, they may be coated with "N30C".

The structure of the liquor is set up for additional speech, up to which include microcrystalline cellulose, lactose monohydrate, crospovidonium napovnyuvach, magnesium stearate. The number of times grows in two, three times, and in the number of fallen lands due to the addition of olanzapine.

Tablets of all doses are packaged in 7 pieces in blister, which can be packed in 4 or 8 pieces.

With "Olanzapin" instructions for storing antipsychotic antipsychotic drugs, Yakіvіvlyayut spore to serotonic, dopamine, muscarinic, adrenergic and histamine receptor approval.

Vibirkovo decrease in the sleepy activity of the mesolimbic dopaminergic neuron, there is little activity on the striatal nerve conduction, as it regulates the motor function. The strength in the mental reflex is changing, as vikoristovuvati is low dosuvannya, but not viklikє cataleptic sleep.

"Olanzapin" leaks increase the anti-alarming efficiency in the "anxiolytic" test facility at the first visit. Zdіysnyu symptoms of negative and productive in the eyes of luminous ideas and very hallucinogenic.

For whom to vikoristovuyut

Olanzapin tablets are used to appear in the schizophrenic village in the mature age at the stage of aggravation, as I will put down and trivial anti-repetitive drug use. Їх vikoristovuyut in case of psychotic discord with good signs in vigilants of luminous ideas, hallucinogenic visions and in case of negative symptoms such as emotional flattening, change of socially significant events, the improvement of the mobile device.

Likami, the repeated attacks with bipolar razlads, like the tablets, are used to enjoy the maniacal stages.

The drug "Olanzapin" will grow up in case of bipolar affective disorders in patients with monotherapy, either with medications, or with medications, to avenge those lithiasis or valproic acid. Liki vikoristovuyut for the nobility state form a maniac abo zmіshanoi dії, which can be manifested by psychotic signs, as well as mothers shydku zmіnu stages.

Try to use fluoxetine medications for depressive minds, as they are tied with bipolar lines.

Victory Day Rules

Liki "Olanzapin" Instructions on consumption, it is recommended to take 0.005 to 0.02 g orally per day, not being taken into the regimen.

Schizophrenic state of adult ailments elating on the cob at a dose of 0.010 m

The gostru mania is old enough, it is characterized by a bipolar distribution, it is known that there is a good amount of olanzapine in 0.015 g, and it should be administered once. Iakshcho pills vikoristovuvati for damping in injected alcohol with licks on the basis of lithium ions, otherwise it should be given a daily dose of 0.010 g at a time.

Depressive processes in a grown-up vіtsі, viclikanі with bipolar discharges, know an additional amount of 0.005 g, like combining with 0.020 g of fluoxetine speech. If it is necessary, then it is allowed to correct the dosage of medications.

For the lithuanian, ill with the mighty threat of a strong lack of nirok or stove in chronic viglyad, If you see garments, tied with a woman's statute, old men with special features, If you trust the exchange of olanzapine, the number of cob should be reduced to 0.005 m

please

The medication "Olanzapin" is analogous with different trade names. The stench is smelled by both vicious and foreign virobniks.

A number of Russian virobniks see the Tekhnologiya Likiv TOV company with the Olanzapin-TL preparation, in pigultsi form, 0.0025 g each with a plastic coating.

Іnshim vіtchiznyаm medication є zіb "Olanzapіn", which is issued by ZAT "Pivnichna zirka". Іsnu in a tablet viglyadі with plіvkovy pokrittі with a dose of 0.005 m

The Russian plant "Kanonpharma production" ZAT sells the drug "Canon Olanzapin".

Іzraїlskiy likami є medication "Olanzapin-Teva" by the company "Teva Pharmaceutical Industry Ltd."

Slovenian analogue є zalasta Ku tab, in tablets of 0.015 g, for rosmoktuvannya. Viroblyaєatsya by the enterprise "KRKA, Novo mesto". Also given by the plant to release the drug "Zalasta", in tablets.

The Swiss analogue is used for the use of "Ziprex" liquors in vials with lyophilizate in vials, which can be used for the introduction of an internal vial, with a dose of 0.010 m. The stench of the company "Eli Lily Vostok SA" is blowing. On the pharmaceutical market, the presence of powder medication "Zipreksa Adera" with doses of 0.21 m

The Polish enterprise of AT "Polpharma" dispenses "Normiton" liqueurs in tablets with coated pokrity of 0.005 g.

The drug "Olanzapin" analogs of the Ugorsk are used by the company "Gedeon Richter" under the name of the tablet "Parnasan", and the pharmaceutical plant "Egis" breaks down the drug "Egolanza".

Before zasosuvannya drug "Zalasta"

Dane antipsychotic should be referred to antipsychotics. Svitlo-zhovtі tablets may be round, trochid double-convex shape with dark disseminations. Dosing weight: 0.0025 g, 0.005 g, 0.01 g, 0.015 g and 0.02 g olanzapin. Additional inactive components include cellactose, starch in the pregelatinized form and corn, water-borne aerosilicon, magnesium stearate.

For marketed tablet form "Zalasta" instructions on how to describe the meaning of the gravitational form in the view of the meaningful dosage. With the living packaging, serve as contour plates with 7 tablets. There can be 4 or 8 of these blisters.

This neuroleptic zest exhibits broad pharmacological activity. Antipsychotic infusion is associated with blockages of receptor devices of the dopamine type. Sedativeness of viclikan to galvanic adrenergic receptors, which is established in the cells of the cerebral stovbur.

Antibody activity is possible in case of dopamine D 2 receptor dopamine receptor in the critical type zone, which is located in the bluetooth center.

The hypothermic role is healthy when the receptor receptors are blocked by the dopamine form in the hypothalamus.

Liki "Zalasta" instructions on how to get rid of vicarists in case of schizophrenic manifestations. The pills are very effective in treating the symptoms of clinical symptoms for an hour of trivial treatment of the ailments, which may cause a cobbled positive effect on the medication.

You can easily learn the epizodic mania in the middle or folding form. With pills to carry out the repetition of bojevilla in case of bipolar breakdowns in people who may suffer from maniacal epizodia.

Liks are designated for oral one-time pre-release administration. Particles of їzhі do not inject olanzapinu into the process of wetting, which allows you to take pills at any hour. When you take the medication, you should step by step reduce the dose.

For the therapy of schizophrenic disorders, the dose is 0.010 g per dose.

Epizodi manii repair likuvati with an additional dose of 0.015 g, yaku should be administered in one dose or 0.010 g in combination with antipsychotics.

Prevention of repetition of bipolar distribution in the stage of weakening should be carried out with the first dose of 0.010 g per dose. If people accept the Danes in case of epizodic maniacal syndrome, then for the therapy we will use the same dose. As soon as there is a slight increase in the number of symptoms in case of new malignancies or depressive episodic manifestations, as well as add to the mood of ill health.

I will add a dose of medication for the reduction of schizophrenic disorders, maniacal attacks and an increase in repetitions of bipolar cases of vicorosis from 0.005 to 0.020 g, meaning that it is meant to lie in the clinical indicators of ailing.

Lіtnіm people reduce the cob dosuvannya to 0.005 g, do not cheer up, protects it for patients from 65 years, as a factor rizik.

Before taking the drug "Olanzapin Canon"

Daniy is an antipsychotic medication for neuroleptic drugs, which is put in a tablet form with shells. Due to the shape of the tablet, it is rounded with two lumpy gum surfaces, the inner side is of the same color.

I sleep in two doses: 0.005 g and 0.01 g olanzapin each. Prior to additional Ingredients, carry hydroxypropylcellulose with low substitutions, calcium hydrogen phosphate, croscarmellose sodium, beckon, magnesium stearate.

Obolonkovі plyvka approved by zhovtim Opadrai of another type, macrogol, talc, titanium dioxide, gold oxide.

Lіkuvannya drug priznachayut in case of destruction, for a complete anti-relapse stasis we will grow up to patients who suffer from schizophrenic disorders.

Likami to carry out monotherapy, as well as combined with lіtіyovіvіvіvіyu with strong forms of maniacal or malignant attacks bipolar affective distribution, as they fight with psychotic virases in the wake of this change. The medication will be repeated in people with bipolar impairments, when the drug is added to the maniacal stage.

When treating older people with depression, viclikan bipolar discharges, as well as in the style depressive stage, "Canon Olanzapin", a neuroleptic, can be combined with the help of fluoxetine.

Yogo should be taken orally, without the need for a feeding regimen. The instruction recommends that the therapeutic dosage of the medication be administered therapeutically, and that the dose should be added 0.005-0.020 r Kilkist given in vain pidbiraut for skin ailments, fallow in the form of clinical signs.

Schizophrenic children of an overweight patient Likuyut cob add additions of likiv in 0.010 g, yake take at a time.
The standard of the gostroi mania bipolar rozladu assimilates the dosage of the preparation in 0.015 g or 0.010 g of olanzapine to be consumed from the source, to avenge the lithium or valproic acid.

For an hour of bipolar distribution to spend on cob, additional doses of 0.010 m.

Depressive damage, tied with a bipolar distribution of grown-up patients, liquefy every day 0.005 g of olanzapine and 0.020 g of fluoxetin drugs, which should be administered at evening hours.

Antidepressant infusion is manifested by the drug in a quantity of 0.006 to 0.012 g from the average additional dosages of 0.0074 r

The therapeutic step is the form of depression known at once 0.005 g olanzapin and 0.02 g of fluoxetinic solutions, which should be administered once in the evening.

Before taking the drug "Ziprex"

Danish neuroleptic is carried out in a tablet form with a pouch of obolonkov. Insufficient dosage of the preparation: 0.0025 each, 0.005 each, 0.0075 each and 0.010 g each, in the case of those of the type indicated on the surface “LILLY 4112”, “LILLY 4115”, “LILLY 4116”, “LILLY 4117”.

Inactive components in viglyadі zucru dairy, hydroxypropylcellulose, crospovidone, cellulose microcrystalline type, magnesium stearate established the structure of the liquor.

The tablets are packaged in blister, 7 pieces, 4 contour packs per pachts.

The form is also lyophilized, it is intended for preparation internal connections... Zhovta ridina with doses of 0.01 g is packaged in vials. Inactive components vvazayut lactose monohydrate and tartaric acid.

Leaks exhibit an antipsychotic effect.

Active Ingredient medication is used as a ligand, which is associated with serotonin, dopamine, m-choline, H1-histamine and alpha 1 adrenoceptor receptor solutions. Olanzapin nadaє vibrate injection into the mill of the limbichnoy system.

The drug "Zipreksa" is an instruction for stagnation of sickness in patients with severe forms of schizophrenic and psychotic disorders, which are superseded by obvious signs of madness, hallucinations, negativities of rosemary, spirits Likki is designated for the weakening of secondary affective symptoms, vicious schizophrenic disorders.

The Ziprexa tablet is recommended to be taken orally at any hour. On a cob of lіkuvannya a single dose to become 0.010 m

Internally, it is necessary to inject liquids, as it is necessary for the nature of people who may be schizophrenic, bipolar affective and dementia.

Before implantation, the lyophilizate should be diluted in 2.1 ml of an іn'ktsіynoi water medium. Go to the point of view with the help of the message.

Nerve emotional stimulation of schizophrenic and bipolar distribution is given to one-time doses of 0.010 m

I will look at a therapeutic picture of a sick person, re-introduction Dose 0.010 g through 120 quills from the first injection, and insert 0.010 g through 240 quills from another injection.

For a further addiction with the drug "Zipreksa", switch to the tablet form with doses from 0.005 to 0.020 m

Agitation for dementia is known with a dose of one-time internal jar in 0.0025 g. cool picture the patient, another introduced dosage of 0.005 g should be carried out through 120 chilin from the first zasosuvannya.

Before taking the drug "Adera Zipreksa"

Use the drug “Olanzapin” analogs, which are dispensed in a viglyadi powder of 0.405 g olanzapin in vials with a bottle, a syringe and a hollow.

With "Adera Zipreksa" to be referred to antipsychotic drugs in neuroleptic activity.

Likki assimilate depletion, vikoristovuyutsya for the extinguishing and trivial anti-repetitive treatment of schizophrenic and mental changes with symptoms that are highly productive in lighthouse ideals, hallucinogenic visions and negative flattening.

Medication is used to elicit strong maniacal and combination attacks against a bipolar disposition, when there is a very psychotic manifestation and rapidity of symptoms.

Pochatkova dobovannya dobova vikoristovutsya at 0.010 or 0.015 g. Denne the amount of the drug is taken for a skin patient okremo, vrahoyuchi is a key picture. Name the vicoristovuyut a therapeutic dobovu dose from 0.005 to 0.020 m

Adjustment of dosage may be less if the results are evident in the implementation of the condition. The increase in the amount of the drug will come in stages, through the skin.

Patients of a kidnapped person, if there is a lack of robotics and liver, should be given a dose of 0.005 g.

number of analogs

A great assortment of neuroleptics allows you to vibrate the required drug, such as for quality and partiality. The prices for Olanzapin are not very high. You can buy a package of tablets for 290 rubles.

The price for the medicine "Zalasta" is 1,370 rubles.

Zipreksa Zidis tablets are used in an expensive way. For packaging, the drug requires 2370 rubles. The part of the analogue "Ku-tab Zalast" becomes 1075 rubles.

On the lines of "Zipreks" the price of prompts will reject the negative. A pack of 28 tablets kostuє 4760 rubles.

For non-stolen vernaculars of the population, the medication "Olanzapin" is available, the price of which is much less.

dumki of paciєntiv

About the likes of "Olanzapin" you can see both positive and negative. Bagatom drug additionally helps to fit in with depression and change in quantity negative thoughts in the same place decilkoh days to receive. Yogo vvazayut one of the strong antipsychotics, which calms the patient, assimilates fears and anxieties.

In the midst of a short time, there are uncommon inheritances, which are tied to the hope of exchanging words, as a result of which there is a lot of sick people. There is drowsiness, asthenic syndrome, zamorochennya, you can fit into an arterial grip of the orthostatic type, the swelling of soft tissues and dryness of mucous membranes develop.

For children with ailments, a small dose of spirits as a stench to sleep for 12 years to do.

Human organism is individual, that is, the tablets are used in a way for the skin patient. For the selection of an incoming person, the consultation of a doctor is required.

A neuroleptic with a wide range of pharmacological actions, zooming in with an antagonistic infusion on the receptor. Olanzapin is low spore to serotonin (5-HT2A / C, 5-HT3, 5-HT6), dopaminovym (D1, D2, D3, D4, D5), muscarinic (M1-5), adrenergic (α1), histamine (H1 ) receptors. Sporіdnіst to serotonovyh receptorsі in food, down to dopaminovim. Selectively lowering the wakefulness of mesolimbic neurons, giving a minimal inflow to the reticular formation, so that you can take part in the safe motor functions.
Olanzapin is well absorbed by oral administration; when you do not pour into your absorption. The maximum concentration in the blood plasma is reached after 5-8 hours. At a concentration of 7-1000 ng / ml, 93% olanzapine is bound to blood plasma proteins, especially albumin and α1-acid glycoprotein. When taken in a dose of 1-20 mg olanzapine kinetics have a linear character. Metabolize in the oven by the way of conjugation and oxidation. The main metabolite, which begins in the blood, is 10-N-glucuronide, which does not penetrate through the hematoencephalic bar. In the development of N-desmethyl- and 2-hydroxymethyl-metabolites, cytochrome P450 is the enzyme CYP 1A2 and CYP 2D6. Resentment of the metabolic values ​​may mean a significant decrease in pharmacological activity, clinical efficiency has been discussed by the negative results. The period for which olanzapin is to become 33 years old (21-54 years old). Olanzapine is increased to 57% in vigor metabolites from the cross section. Pharmacokinetics olanzapinu to be found in chicken, stati і vіku. When the functions of the liver are damaged and the hens clears olanzapinu decrease. The period of time for olanzapine in the blood plasma in individuals with severe functional impairments does not change at all.

Shown to preparation Olanzapin

schizophrenia and psychosis with obvious positives (mania, hallucinations, misery, admiration and adolescence) or negative (flattened affect, emotional and social autism, for the reason)

Intake of the drug Olanzapin

The pochatkova dose is 10 mg 1 time per dose, regardless of the amount received. The average dobov dose is 5-20 mg. Fix a sick person with serious damage to the function of the liver and nirok in the case of a kidnapped person with a dose of 5 mg.

Prototype indication prior to consumption of Olanzapin

Sensitivity has been adjusted to olanzapin.

Pobіchnі efekti drug Olanzapіn

Sonlivіst, zbіlshennya masi tіla transiently i in bіlshostі vipadkіv bezsimptomne pіdvischennya rіvnya prolactin plazmі krovі, rіdko - zapamorochennya, akatizіya, pіdvischennya appetite, peripheral character nabryak, ortostatichna gіpotenzіya, vіdchuttya suhostі in rotі, constipation, transient i bezsimptomne pіdvischennya rіvnіv ALT is the ACT, past eosinophilia.

Special orders for the use of the drug Olanzapin

On tlі Priya deyakih neyroleptikіv opisanі vipadki rozvitku zloyakіsnogo neyroleptichnogo Syndrome (NMS), potentsіyno fatal complex of symptoms, yaky proyavlyaєtsya gіpertermієyu, rigіdnіstyu m'yazіv, zmіnoyu psihіchnogo i will Find our avtonomnoї nestabіlnostі (irregular heartbeat abo nestabіlny AT tahіkardіya, profuse potovidіlennya aritmіya i). In addition, there may be an increase in the level of creatine phosphokinase, myoglobinuria (rhabdomyoliz) and the state of the art nirkova lack. With the manifestation of symptoms of ZNS, or a feverish woman, it is necessary to skasuvat all psychotropic diseases, including olanzapin.
With a trivial intake of psychotropic drug addicts, the risk of development of dyskinesia is increased, and when it is diagnosed, it is a sign of symptoms that it is necessary to reduce the dose or skasuvati olanzapin. Symptoms of dyskinesia can be resolved in an hour if you see a message.
Olanzapin is necessary for the protection of ailments due to the increased levels of ALAT or ASAT, in case of damaged liver function, on the basis of the reduction of the functional reserves of the liver, and also due to the deterioration of the liver In case of an increase in ALT and AST on the basis of olanzapine treatment, it is necessary to reduce the dose of the drug and respectfully support for the ailment. Olanzapin followed from the preservation of the sign of ailment with a history of suicide attacks, from leukopenia or neutropenia, regardless of the cause, if there is evidence of anamnestic indications of the function cystic brain vnaslidok drug therapy, Suputn_h ailment, exchange therapy; eosinophilia or proliferative disease of the cystic brain. It should be taken care of when olanzapine is recognized, we are ill for good hyperplasia in front of myuria, paralytic intestinal laxity and glaucoma.
I will look at the surroundings of adolescents to olanzapin during the period of vaginosti, olanzapin can be recognized as vaginals in quiet vapors, if the potential therapeutic effect transforms the risk of negative influx into the future. We are sick with the recommendation that you use your breastfeeding for a single time.
Olanzapin may suffer from drowsiness, but it is necessary to be able to take care of it with vehicles and robots with potentially unsafe mechanisms, as well as the need for increased respect for and quickness of mental reactions.

In connection with the drug Olanzapin

Olanzapin is an antagonism in relation to dopamine, and theoretically it can reduce the effectiveness of both agonists of levodopia and dopamine, as well as of other neuroleptics. It is necessary to take precautions when recognizing olanzapine for the first time in the center of the community. The metabolism of olanzapine can be disrupted by induced or stimulation of the activity of isoenzymes in cytochrome P450, especially CYP 1A2. Cleansing olanzapine grows in chickens and on the smoked carbamazepine, as the stench stimulates the activity of CYP 1A2. As a result of the CYP 1A2 activity, there may be a decrease in olanzapine clearing. Olanzapin is not a strained antagonist of CYP 1A2, but it is susceptible to changes in the pharmacokinetics of theophilin on the basis of olanzapine. Permanent concentration of olanzapin in the blood does not infuse into the pharmacokinetics of ethanol. However, on the smallest one-hour stagnation, the signs of a synergistic action have been fixed, for example, making the sedative effect stronger. One-hour reception of an asset will reduce the bioavailability of olanzapin by 50-60%.

Overdosing on Olanzapin, symptoms and treatment

Є obmezhenі data about overdose olanzapіnu. In the course of clinical trials, 67 patients were diagnosed with a diagnosis of overdose. In a sick person, having taken 300 mg of olanzapin, the only symptoms were drowsiness and confidence in the movement. In an interconnected group of ailments, who were spared in stationary minds, including a sick person, which took 300 mg of olanzapin, no change was found on the EKG, but indications laboratory dosages... Life's important functions were not damaged.
Specific antidote olanzapine nemaє; to carry out additional therapy. In case of a state of overdose, it is necessary to ensure the availability dikhalnyh nobles, Carry out a probe for washing the slurry, to indicate that the assets are not in the hole. It is necessary to survive on the basis of various visits for the hypothesis and collapse - infusion therapy, Introduced sympathomimetics (norepinephrine). Do not use the drug adrenaline, dopamine and other sympathomimetics, such as β-blocker agonists, so as to stimulate hypotension on the background of α-blockade, viclican olanzapine. I recommend the victoriannya cardiomonitor. Before polіpshennya zagalny camp of ailments is guilty of perebuvati pіd sawn medical visualization.

List of pharmacies where you can buy Olanzapin:

• St. Petersburg

Lykarska form

Tablets 5 mg, 7.5 mg і 10 mg

warehouse

One pill to take revenge

active speech - olanzapine benzoate 6.95 mg, 10.43 mg, 13.91 per pererakhunka for olanzapine 5 mg, 7.5 mg, 10 mg,

additional words - calcium hydrogen phosphate, microcrystalline cellulose, sodium carboxymethylcrochmal (type A), magnesium stearate.

describe

Tablets of light yellow color, round form, two-bump, with "OPN" and "5" markers on one boat and "bza" on the third side (dosage 5 mg).

Tablets of light-yellow color, round form, two-bump, with "OPN" and "7.5" markers on one boat and "bza" on the third side (dose 7.5 mg).

Tablets of light yellow color, round form, two-bump, with "OPN" and "10" markers on one boat and "bza" on the third side (dosage 10 mg).

Pharmacotherapeutic group

Psychotropic drugs. Antipsychotics (Antipsychotics).

Dibenzodiazepini and their origin. Olanzapin.

ATC code N05AH03

Pharmacological authorities"Type =" checkbox ">

Pharmacological authorities

Pharmacokinetics

For oral administration of olanzapine it is good to get wet, and the maximum concentration in blood plasma (TCmax) for oral administration is 5-8 years. Olanzapine is not highly toxic. In pre-adolescents with different doses in the range from 1 mg to 20 mg, it is shown that the concentration of olanzapine in the plasma changes linearly and proportionally to the dose.

Coupling with bottles - 93% in the concentration range from 7 to 1000 ng / ml.

Olanzapin is associated, in the main, with albumin and a1-glycoprotein. Penetrating through gistogematic bar'yri, incl. hematoencephalic bar (GEB).

Metabolize in the liver, active metabolites do not become established, the main circulating metabolite is glucuronide, does not penetrate through the hematoencephalic bar.

Course, become and vik pour on the period of time (T1 / 2) and plasma cleansing. In individuals older than 65 years T1 / 2, become 51.8 years and plasma cleansing - 17.5 l / year; in individuals younger than 65 years - 33.8 h and plasma cleansing - 18.2 l / year. Plasma clearance is lower in ailments with pechinka lack, females and nonsmokers in some cases with different groups of individuals. Protein, step into the flow, stati or the rate of clearance and T1 / 2 of olanzapine is insignificant in relation to the individual variability of pharmacokinetics among other people. It is more important to be found in metabolism (60%).

Olanzapin is metabolized in the oven as a result of the processes of conjugation and oxidation. The main circulating metabolite is 10-I-glucuronide, which theoretically does not penetrate through the hematoencephalic bar. Enzymes CYP1A2 and CYP2D6 cytochrome P450 take part in the approved N-desmethyl- and 2 hydroxymethylmetabolites of olanzapine. Metabolism offense in pre-adolescence is significantly less pronounced in pharmacological activity in vivo than olanzapin. The main pharmacological activity of the drug is summed up by the verbal speech-olanzapin, so that the volodya can penetrate through the histological barriers, including the hematoencephalic bar.

In healthy volunteers for oral administration, the middle period became 33 years old (21-54 years for 5-95%), and the average clearing olanzapin with plasmas was 26 l / year (12-47 l / year for 5-95%).

Pharmacokinetic indicators of olanzapine vary in fallowness from chicken, stati and viku (div. Table):

However, the step of change in the period to the development and clearance of the skin from the significant factors is significant step in the steps of indications of these indicators in the case of certain individuals.

Adequate indications of average values ​​for the period due to the fact that olanzapin was given to the clearing in plasma in individuals with severely impaired functions, in some cases with normal function nirok, not set. Nearly 57% of olanzapine is produced from the cross-section in the main in viglyadі metabolites.

In people who burn, with insignificant damage to the function of the liver, the clearence of olanzapin is lower, in non-smokers, without damage to the function of the liver.

At a concentration in plasma from 7 to 1000 ng / ml, almost 93% olanzapine is bound to the plasma proteins. Olanzapin is mainly linked with albumin and with a1-acidic glycoprotein. For the part of the European, Japanese and Chinese prodigies, no evidence of olanzapine pharmacokinetics, related to racial affiliation, has been established. The activity of the CYP2D6 isoenzyme to cytochrome P450 is not infused into olanzapine metabolism.

Pharmacodynamics

Olanzapin is an antipsychotic (neuroleptic) with a wide pharmacological spectrum injected onto a number of receptor systems. Established the spore rate of olanzapine with serotonin 5-HT2A / 2C, 5HT3, 5HT6; dopamine D1, D2, D3, D4, D5; muscarinovim M1-5; adrenergic 1 and histamine H1 receptors. The presence of olanzapine antagonism to serotonin, dopamine and cholinergic receptors was revealed. With a large amount of olanzapine volodyne, there is a greater spore rate and activity in serotonin 5HT2 receptors, in proportion to dopamine D2 receptors. Olanzapin selectively reduces the malleability of mesolimbic (A10) dopaminergic neurons, and at the same hour there is little inflow to the secondary (A9) nerves, which take part in the regulation of motor functions. Olanzapin lowering the mental reflex (a test that characterizes antipsychotic activity) in doses of lower, lower doses, that viklikayut catalepsy (distribution, showing a secondary inflow to motor function). Olanzapin underwent anti-anxiety effect during the "anxiolytic" test.

Olanzapin will provide a statistically reliable reduction of both productive (madder, hallucinations and in.), So and negative symptoms.

Shown to sucking

old age

For the liking of schizophrenia

For adaptive therapy for patients who are sensitive to the preparation on the cob stage.

For the lіkuvannya manіkalnyh epіzodіv middle and severe degree of gravity

For the prevention of relapses in patients with bipolar dislocation in patients, in whom the effectiveness of the intake of olanzapine in patients with a maniacal epizode is more effective.

How to store that dosi

All the middle, once for doba. So, since the drug is not injected into the drug, Olanzapin tablets can be taken right away from the drug. At the time of administration of the drug, it is recommended to reduce the dose.

Therapeutic doses of olanzapine are used in a range of 5 mg to 20 mg per dose. To add a dose, it is necessary to pick it up individually from the sick bed. Zbіlshennya dosi ponad standard dobovy dose(10 mg) it is recommended to carry out only a period of general clinical treatment of the patient.

Epizod mania: the cob dose should be 15 mg in one dose with monotherapy or 10 mg per dose in the combined therapy warehouse.

Prevention of relapses in patients with bipolar dislocation: it is recommended to set the cob dose to 10 mg per dose. Patients who take olanzapine for the treatment of a manic epizode, then continue the therapy in quiet doses to prevent relapse. With the discovery of a new maniacal, depressive or depressive episode, it is necessary to continue the treatment with olanzapin (with the selection of the optimal dose, if necessary), additional therapy for the treatment of affective love, in case of manifestation. After an hour of schizophrenia, maniacal epizode and preventing relapses in case of bipolar distribution, a further correction of additional dosage in between 5 to 20 mg is available for additional treatment of an individual healthy standard.

Olanzapin can be taken directly from the reception, although it does not pour into the absorption. When applied olanzapine therapy, the dose should be reduced step by step.

Patients of the kidnapped vik

In a large number of cases, a decrease in the cob dose (up to 5 mg per dose) is not required, however, it can be known when the drug is prescribed for patients of 65 years and older with the presence of key factors.

Patients with damaged functions of nirok and (abo) liver

For such patients, it should be noted that the cob dose is reduced to 5 mg. In the case of small liver deficiencies (class A or B for the classification of liver cirrhosis according to Child-P'yu), the cob dose is guilty of becoming 5 mg, and the dose should be increased after being protected.

curts

For nonsmoking patients, a normal cob dose and a further dosage of the drug in proportion to the chicken patients is not required. You can speed up the metabolism of olanzapine. It is recommended here to be kindly wary of the curtsy patients and, if necessary, to see the possibility of increasing the dosage of olanzapin.

Slide to change the cob dose if more than one factor is present, which can lead to the increase in metabolism (women, children, nonsmoking patients). For such patients, when the dose is adjusted, it is shown that it is necessary to take care of it.

Pobichna diya"Type =" checkbox ">

Pobichna diya

Naybilsh often see side reactions(≥1%) Je: sonlivіst, zbіlshennya tіla Masi, eozinofіlіya, zbіlshennya rіvnya prolactin, cholesterol, glucose i triglіtseridіv, glyukozurіya, pіdvischennya appetite, zapamorochennya, akatizіya, parkіnsonіzm, leykopenіya, neytropenіya, diskіnezіya, ortostatichna gіpotonіya, antiholіnergіchnі efekta transiently bezsimptomne adjustment of liver aminotransferases, visip, asthenia, vtoma, fever, bile in suglobs, growth of puddle phosphatase, adjustment of gamma glutamyltransferase, sech acid, nabolite, creatine phosphatase.

Items in the table list of unwanted reactions

Negative reactions have been added to the whole table. In the skin frequency group, the secondary effects are in order of the decrease in seriosity. The frequency is indicated by the offensive rank: more often (≥ 1/10), often (≥ 1/100 to< 1/10), нечасто (от ≥ 1/1000 до < 1/100), редко (от ≥ 1/10000 до < 1/1000), очень редко (< 1/10000), неизвестно (невозможно установить на основании имеющихся данных).

With trivial stasis olanzapin (not less than 48 years), there is no time for children with important changes in terms of vagi, glucose, glucose, high cholesterol, LPNSH, LPVAL In patients who completed 9 - 12 courses of therapy, the rate of growth of the average value of glucose in the blood was developed in about 6 months.

Dodatkova Information about special groups of patients

In young patients with dementia treatment, olanzapine bulo is associated with a higher frequency of deaths and undesirable reactions from the side of the brain in the case of placebo. In the middle of a group of patients, there were often such undesirable reactions to olanzapin, as the course and fall were abnormal. Often there were spasms of pneumonia, increased temperature, pathological malfunction, erythema, healthy hallucinations and untrammeled slaughter.

In patients with lykarsky psychosis (vicious reaction of agonies of dopamine receptors) with Parkinson's ailments, they often heard about the reduction of symptoms of Parkinson's ailments and the appearance of hallucinations in some cases.

In patients with bipolar treatment, combined therapy with valproate and olanzapine resulted in the appearance of neutropenia in 4.1% of the vapors; A motivated official can have a view of the concentration of valproate in the blood plasma. Take olanzapin in combination with lithium or valproate inoculation to an increase in frequency (≥ 10%) in cases of tremor, dryness in mouth, increased appetite and a set of vagi. Likewise, I often heard about the deterioration of movi. It takes an hour to take olanzapin in a combination with lithuania or divalproeks for an hour to take a short-hour trip (not more than 6 days) in 17.4% of patients who have spent more than 7% of the time. Trivale treatment with olanzapin (up to 12 months) for the prevention of recurrences of bipolar distribution was associated with an increase in weight of ≥ 7% of cob in 39.9% of patients.

Prototype

Sensitivity has been adjusted to olanzapine of any of the other components in the preparation

Childish up to 18 years old (efficiency and safety is not established)

lactation period

Ridky recessions of problems of galactose intolerance, Lapp lactase deficiency or deterioration of the absorption of glucose-galactose.

Revealing the development of glaucoma to rhizik

For protection:

Nirkova lack

pechinkova lack

Hyperplasia in front of the microorganism

Paraltic intestinal imperfection

epilepsia, sudominal syndrome in anamnesis

Leukopenia і / abo neutropenia of the disease

Mієlosuppression of growth genesis, incl. myloproliferative disease

hypereosinophilic syndrome

Cardiovascular and cerebrovascular disease in any case, which can lead to hypotension

Vrodzhena zbіlshennya QT іntervalu on elektrokardіogramі (EHC) (zbіlshennya korigovanogo іntervalu QT (QTc) in EHC) abo at nayavnostі minds potentsіyno zdatnih viklikati zbіlshennya іntervalu QT (napriklad, odnochasne priznachennya preparatіv, SSMSC podovzhuyut іnterval QT, zastіyna Sertsevy nedostatnіst, gіpokalієmіya, gіpomagnієmіya)

abduction vik

One-hour reception of the central

diy

immobilization

availability

likarskі vzaєmodії

potential likarskі vzaєmodії, Pour on olanzapin

The olanzipin ossicles are metabolized by the CYP1A2 enzyme, speech, which can, zokrem, inducuvati, or induction of the Danish isoenzyme, can be infused into the pharmacokinetic parameters of olanzapin.

Inductors CYP1A2

Metabolism of olanzapine can occur in patients who burn, or with a one-hour intake of carbamazepine, which can lead to a decrease in the concentration of olanzapine in the blood. Spostering the lichen is insignificant as well as the promotion of olanzapin to the clearing. Clinical inheritance, however, will be interconnected, it is recommended to use it with caution, so that the changes in the dose can be adjusted to the drug.

іngіbіtory CYP1A2

Fluvoxamin is a specific CYP1A2 ingibitor - it significantly reduces the metabolism of olanzapine. In patients who are taking fluvoxamine, or be it the first CYP1A2 inhibitor (for example, ciprofloxacin), olanzapine therapy is recommended to start at lower doses. A change in olanzapine dosage may also be required before CYP1A2 therapy.

decreased availability

Activation of vugіll decreases the bioavailability of olanzapine in case of oral administration by 50-60%, which should be taken not less than 2 years before, if not, when taken olanzapin.

Fluoxetine (ingibitor CYP 2D6), a single dose of magnesium, or aluminum to replace antacids, or cimetidine, does not affect the pharmacokinetics of olanzapine.

Potential for olanzapinu in vwlv on theinshi likarski vasobi.

Olanzapin can be used for direct and indirect agonizing of dopamine receptors.

Olanzapin does not drive the main isoenzymes of CYP450 (for example, 1A2, 2D6, 2C9, 2C19, ZA4). Otzhe, the recognition of some special interactions maloimovirne. Olanzapin does not induce the metabolism of active active substances: tricyclic antidepressant (which is the most important metabolic rate CYP2D6), warfarin (CYP2C9), theophilin (CYP1A2) and diazepam (CYP3A).

It is not caused by interchange with a one-hour zastosuvannі from lіtієm or biperіdenom.

Therapeutic monitoring in place of valproic acid in plasma has shown that, with a one-hour appointment with olanzapine, a change in doses of valproic acid is not required.

You should be careful when consuming a drug in particular, when you take alcohol and take drugs, which can reduce the central nervous system.

Interval QТс

If you start taking care of olanzapine when you are stuck with alcohol, then you can increase the QTc interval.

special requests"Type =" checkbox ">

special requests

Behavioral problems and / for psychosis, linked to dementia

Olanzapin is not recommended until patients with psychosis and (or) impaired behavior on the basis of dementia due to increased mortality and risk of severe impairment of cerebral blood circulation. The factor of risk, which, if possible, can be reduced to an increased mortality rate in the middle of the patients in the group, include those over 65 years of age, dysphagia, sedation, malnutrition and anemia, pathological lesions (for example, aspirin For those older than 75 years and multi-infarction / change in dementia, they are significant in terms of the factors in the risk of developing CPE in conjunction with olanzapine.

Malicious neuroleptic syndrome (NNS).

ZNS is potentially not safe for life, dressing with antipsychotic drugs. In case of olanzapine treatment, the development of the ZNS was also observed on one occasion. Clinical manifestations of ZNS include the value of increased temperature, muscle rigidity, change in mental status and vegetative impairment (irregular pulse or unstable AT, tachycardia, heart disease) Additional signs can include the adjustment of the level of creatine phosphokinase, myoglobinuria (rhabdomyoliz) and gostru nirkova lack... Clinical manifestations of ZNS, for the meaning of an increase in temperature without any other symptoms of ZNS, can lead to the use of all antipsychotics, including olanzapine.

Hyperglycemia and diabetics.

Hyperglycemia і / abo development or sharpening of diabetics, associated with ketoacidosis abo diabetic coma, Including fatal patches, infrequently appear in ailments. Some people think about those who have a chance to grow fat, which can be a factor.

Based on the principles of antipsychotic drug intake, it is recommended to carry out an on-going clinical monitoring, for example, the level of glucose in the blood until the ear is consumed, after 12 months of drinking an ear of corn Patients who recognize whether antipsychotics, including olanzapin, are advised to be cautious about identifying symptoms of hypertension (such as polydipsia, polyuria, polyphysiotomy) the type of indications, regular monitoring with the appearance of an indication is a sign of depletion of glucose control. Follow them regularly, for example, before the cob of treatment, after 4, 8 and 12 months, after the cob, turn over with olanzapin, and later on the cob.

Injection on lіpіdniy obmin

At the children with a display with a high rizik the development of a display of change of indicators in the course of life in the course of a series of events. Given the principles of antipsychotic intake, it is necessary to regularly start a summer profile of patients, so that they can take on antipsychotic problems, including olanzapines, for example, before picking them up through 12 months of age.

Damaged function of the stove

At the early stages of therapy, taking the drug overnight, is asymptomatic to the development of pechin transaminases (AST and ALT). Particular care is needed in case of advanced AST and / or ALT in patients with a lack of liver function, due to the functional reserve of the liver, or in patients who receive the potential for hepatotoxicity. In cases of diagnosed hepatitis (including hepatocellular, cholestatic or liver failure), olanzapin is treated with olanzapine.

neutropenia

Patients with low leukocyte counts and / or neutrophils, due to any reasons, including admission drugs, Iakіkіyut neutropenia, attributable to the function of the cystic brain, we will summarize supporters, Exchange or chemotherapy in anamnesis, as well as hypereosinophilia or myoloproliferative illness. In small cases, neutropenia of Bula was registered with an one-hour consumption of olanzapine and valproate.

vidmini syndrome

In case of severe treatment with olanzapine in small drops, the following symptoms develop: fatigue, sleeplessness, tremor, anxiety, tediousness or bloating (> 0.01% i<0,1 %).

Inflow per QT interval

When kombіnovanomu lіkuvannі of іnshimi preparations SSMSC dostovіrno viklikayut podovzhennya іntervalu QT, slіd priznachati olanzapіn of oberezhnіstyu, Especially lіtnіm patsієntam, patsієntam s syndrome vrodzhenim podovzhenogo іntervalu QT, patsієntam of hronіchnoyu Sertsevy nedostatnіstyu, s gіpertrofієyu Sertsevy m'yaza, gіpokalієmієyu abo gіpomagnієmієyu.

thromboembolism

In small cases, there was a history of ulceration after an hour, or of olanzapine therapy and venous thrombosis (> 0.1% and<1 %). Причинно-следственная связь между развитием венозной тромбоэмболии и приемом оланзапина не установлена. Пациенты с шизофренией предрасположены к развитию венозной тромбоэмболии, в связи с чем необходимо идентифицировать и принять превентивные меры для предупреждения возникновения всех возможных факторов риска венозной тромбоэмболии, к числу которых может относиться, например, иммобилизация (неподвижность) пациентов.

Significant activity of the central nervous system

I will look at the fact that olanzapin is in the main infusion on the central nervous system, then you should be careful with one-hour consumption of olanzapin with other drugs, which is infused on the central nervous system, and with alcohol. Oscillations in the in vitro minds olanzapine appears to antagonize dopamine receptors, it can be weakened by both direct and indirect agonists of dopamine receptors.

epileptic seizures

Olanzapin followed the protection of ailments with epileptic seizures in anamnesis or those who were sick before the inflow of officials in the risk of lowering the threshold of shipwash readiness. Epileptic seizures in patients with olanzapine treatment are rare. In a large number of cases of epileptic seizures, the history of epileptic seizures is indicated, or a tendency before the inflow of epileptic seizures into the attack.

dyskinesia

During trivial therapy, olanzapine increases the risk of dyskinesis, and in the event of signs and symptoms of dyskinesis, it is recommended to lower the dose or intake of olanzapine. Symptoms of dyskinesia may appear as a build-up or when the drug is taken.

postural hypotension

Raptova sertseva death

In the period of post-marketing caution for olanzapine, there was a problem with raptus heart disease in patients who had taken olanzapin. Rizik of the transmission of rapid heart death in patients, who had been eliminated olanzapin, about two times overwhelmed such in patients who did not take antipsychotics.

availability

Adequate and strictly controlled clinical monitoring was not carried out in case of vaginosis. Patients have gone ahead about the need to inform their own doctor in case of a plan for the duration of the treatment with olanzapin. Through the concatenated stasis, olanzapin during vaginosis in people, olanzapin is followed by stasis, only when cinnamon is cleaned for the mother, it is truly a potential risik for the fetus.

In newborns, who are aware of the infusion of neuroleptics (including olanzapine) during the third trimester of vaginosity, the risk of development of side reactions, including extremal symptoms or even abstinence syndrome, such as Otrimanno about the problems of agitation, arterial hypertension, hypotension, tremors, drowsiness, impaired behavior and deterioration. At the connection with chim, new people are guilty of perebuvati for real visibility.

reproductive function

Infusion on reproductive function is unavoidable.

Particularities in pouring Likarsky zasobu on the building of keruvati with transport means or potentially not safe mechanisms.

It should be shown that you are safe in case of keruvanny with potentially unsafe mechanical problems, including a car, some olanzapines, wickedness and drowsiness.

Overdose

Symptoms: even more frequent (> 10%) in case of overdose with olanzapine є tachycardia, abnormalities / aggression, dysarthria, decreased extrapiracy symptoms, decrease in the level of evidence in the form of hypoglycemia to the Komi; less in 2% of cases, there are delirii, convulsions, coma, malignant neuroleptic syndrome, impairment, aspirations, adduction or decrease arterial vise, Heart arrhythmias; in the worst cases of the heart-legeneva lack. The minimum dose of olanzapin in case of an overdose with a lethal result is 450 mg, registered maximum dose in case of an overdose with a successful result (vision) -1500 mg.

Likuvannya: not a specific antidote. It is not recommended to provoke blues. It is necessary to carry out the washing of the slurry, receiving the active vugil (lowering the bioavailability of olanzapin by 60%), symptomatic lykuvannya under the control of vital important functions, including the treatment of arterial hypotension and convulsive collapse, the adjustment of the function of dysfunction. It is not recommended to use adrenaline, dopamine or other sympathomimetics with beta-adrenergic activity, because it may not be possible to manage hypotension.

Form vipusku i packaging

For 7 tablets, put in a contoured charunk package from aluminum foil or aluminum polyvinyl chloride and aluminum foil.

For 4 blisters at a time with instructions for medical storage with sovereign and Russian movs, put into a pack of cardboard.

vul. Castello, no. 1, Paul Salinas, Sant Boi de Llobregat, 08830, Barcelona, ​​Spain